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公开(公告)号：US20230321261A1
公开(公告)日：2023-10-12
申请号：US17957302
申请日：2022-09-30
Applicant: GENMAB A/S
Inventor： Julia BOSHUIZEN , Esther BREIJ , Louise KOOPMAN , David SATIJN , Edward VAN DEN BRINK , Dennis VERZIJL , Rob DE JONG , Riemke VAN DIJKHUIZEN RADERSMA , Daniel PEEPER , Paul PARREN
CPC classification number: A61K47/6803 , A61K39/001102 , A61K45/06 , A61K47/6801 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6869 , A61P35/00 , C07K16/2863 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/77 , C07K2317/92
Abstract: Antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of melanoma in combination with one or more MAPK pathway inhibitors such as, e.g., a BRAF inhibitor and/or a MEK inhibitor.
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172.发明公开公开(公告)号：US20230312758A1
公开(公告)日：2023-10-05
申请号：US18025204
申请日：2021-09-10
Applicant: GENMAB A/S
Inventor： Brian ELLIOTT , Tahamtan AHMADI , cHRISTOPHER W.L. CHIU , Esther C.W. BREIJ , Ida HIEMSTRA , Maria N. JURE-KUNKEL
CPC classification number: C07K16/468 , A61P35/00 , C07K2317/565 , C07K2317/31
Abstract: Provided are methods of clinical treatment of follicular lymphoma (for example, relapsed and/or refractory follicular lymphoma) in human subjects using a bispecific antibody which binds to CD3 and CD20 in combination with standard of care regimens of rituximab and lenalidomide.
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公开(公告)号：US20230310599A1
公开(公告)日：2023-10-05
申请号：US18023808
申请日：2021-09-02
Applicant: GENMAB A/S
Inventor： Hreinn BENONISSON , Jim MIDDELBURG , Thorbald VAN HALL , Isil ALTINTAS , Kristel KEMPER , Janine SCHUURMAN , Katy Ann LLOYD , Vitalijs OVCINNIKOVS , Gijsbertus ZOM
CPC classification number: A61K39/42 , A61P35/00 , A61P37/04 , A61K2039/545
Abstract: The present invention relates to combination therapy within the field of oncology; in particular to combination therapy with vaccines and binding agents binding to CD3 and to a target antigen on tumor cells.
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公开(公告)号：US20230227570A1
公开(公告)日：2023-07-20
申请号：US17923317
申请日：2021-05-07
Applicant: GENMAB A/S
Inventor： Tahamtan AHMADI , Manish GUPTA , Tommy R. LI , Roberto OLIVERI , Dena DEMARCO , Ida HIEMSTRA , Christopher CHIU , Brian ELLIOTT , Ada AZARYAN
CPC classification number: C07K16/2887 , C07K16/2809 , A61P35/00 , C07K2317/31 , A61K39/00
Abstract: The present invention relates to bispecific antibodies (bsAbs) and the use of such antibodies in the treatment of disease in subjects. Moreover, advantageous treatment regimens are provided for the treatment of B-cell Non-Hodgkin Lymphoma (B-NHL).
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公开(公告)号：US20230132049A1
公开(公告)日：2023-04-27
申请号：US17938523
申请日：2022-10-06
Applicant: GENMAB A/S
Inventor： David SATIJN , Patrick Engelberts , Kristel Kemper , Esther C.W. Breij , Simone OOSTINDIE , Farshid ALEMDEHY
Abstract: The invention relates to multispecific antibodies binding to CD3 and CD30. The invention further provides pharmaceutical compositions comprising antibodies of the invention, nucleic acids encoding the antibodies, host cells that produce the antibodies, methods of producing the antibodies and uses of the antibodies, in particular for cancer therapy.
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Patent Agency Ranking
公开(公告)号：US11578141B2
公开(公告)日：2023-02-14
申请号：US16667369
申请日：2019-10-29
Applicant: GENMAB A/S
Inventor： Joost J. Neijssen , Joyce I. Meesters , Bart De Goeij , Aran Frank Labrijn , Paul Parren , Janine Schuurman
Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
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公开(公告)号：US20220389101A1
公开(公告)日：2022-12-08
申请号：US17739940
申请日：2022-05-09
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil ALTINTAS , Patrick ENGELBERTS , Janine SCHUURMAN , Paul PARREN
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US11512140B2
公开(公告)日：2022-11-29
申请号：US16548883
申请日：2019-08-23
Applicant: GENMAB A/S
Inventor： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
IPC: C07K16/30 , G01N33/574 , A61P35/00 , A61K39/395 , C07K16/28 , A61K45/06 , C07K16/40 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US11485796B2
公开(公告)日：2022-11-01
申请号：US16783720
申请日：2020-02-06
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Edward Norbert Van Den Brink , Janine Schuurman , Paul Parren
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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公开(公告)号：US20220323582A1
公开(公告)日：2022-10-13
申请号：US17502774
申请日：2021-10-15
Applicant: GENMAB A/S
Inventor： Sandra VERPLOEGEN , Marije OVERDIJK , Riemke VAN DIJKHUIZEN , Willem Karel BLEEKER , Patrick VAN BERKEL , Paul PARREN , Steen LISBY
IPC: A61K39/395 , A61K51/10 , C07K16/28 , A61K47/68 , A61K31/7088 , A61K35/17 , A61K35/76 , A61K38/16 , A61K38/19 , A61K45/06 , C07K16/18
Abstract: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.
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