Abstract:
A technique is provided for reducing the discoloration of an aqueous composition containing a halogenated isoquinoline derivative during high-temperature preservation. An aqueous composition comprising a compound represented by Formula (1): wherein X represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, and a β blocker.
Abstract:
It is an object of the present invention to provide a novel form of (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, which is useful for preventing and/or treating diseases such as dyslipidemia.(S)-trans-{4-[({2-[({1-[3,5-bis(Trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid hydrochloride.
Abstract:
The present invention provides a novel corneal thickness modulating agent. The present invention pertains to a corneal thickness modulating agent containing 1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof or a solvate thereof.
Abstract:
It is an object of the present invention to provide a novel form of (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, which is useful for preventing and/or treating diseases such as dyslipidemia.(S)-trans-{4-[({2-[({1-[3,5-bis(Trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid hydrochloride.
Abstract:
A hand joint supporter which can reduce the load on hand joints includes a first anchor section for tightening the wearer's forearm with a tubular knitted fabric, a second anchor section for tightening the palm and back of the wearer's hand with the fabric and a hole anchor section formed as a roughly circular through-hole in the vicinity of the second anchor section. A supporting section extends lengthwise in the fabric across the part covering the caprometacarpal joint and is joined to the first anchor section and the hole anchor section so as to support the wearer's hand joints. Stretch resistance, in the circumferential direction of the fabric of the first anchor part is larger than that of a base fabric section, and stretch resistance, in the length width direction of the fabric, of the supporting section is larger than that of the base fabric section.
Abstract:
The present invention provides a method for the prevention and treatment of complications after cataract surgery such as secondary cataract and anterior capsule contraction that occur after cataract operation.The present invention relates to a preventive/therapeutic method comprising administering to a subject a medicine containing 4-fluoro-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline (Ripasudil) or a salt thereof, or a solvate thereof as an active ingredient.
Abstract:
An intraocular lens insertion tool including: a cylindrical tool body provided with a placement part at which is placed an intraocular lens having an optical part, and a pair of support parts extending from either side of the optical part; and a plunger for pushing out the intraocular lens; the intraocular lens insertion tool being provided in a state in which the intraocular lens is preset in the placement part, wherein at least one of the front support part extending toward a tip end of the tool body and the rear support part extending toward a rear end of the tool body is pre-deformed by abutting against an abutting projection disposed inside the placement part.
Abstract:
An object of the present invention is to provide a drug that contains a compound for inhibiting neutral lipid accumulation in cardiovascular tissue or cells and has an excellent prophylactic or therapeutic effect on cardiovascular complications of diabetes. The present invention relates to a prophylactic and/or therapeutic agent for cardiovascular complications of diabetes, the agent containing a compound (preferably a medium-chain fatty acid and/or a medium-chain triglyceride) for inhibiting neutral lipid accumulation.
Abstract:
An intraocular lens wherein an outer edge of a support part has a curved concave shape at a base thereof and extends therefrom toward a tip thereof with a curved convex shape having a radius of curvature of 5.25 to 7.50 mm. In a region where a Y coordinate of an orthogonal coordinate system is 1.0 mm or greater, an origin of the coordinate system being a geometric center of an optical part, an inner edge of the support part is positioned between shapes obtained by offsetting the outer edge of the support part by 0.2 mm and by 1.0 mm towards the X-axis origin. The tip of the support part is positioned in a region where the Y coordinate is greater than a radius of the optical part, outside a circle with a radius of 5.0 mm centered on the origin.
Abstract:
It is an object of the present invention to provide a novel form of (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, which is useful for preventing and/or treating diseases such as dyslipidemia.(S)-trans-{4-[({2-[({1-[3,5-bis(Trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid hydrochloride.