公开(公告)号：US20210162192A1

公开(公告)日：2021-06-03

申请号：US17174533

申请日：2021-02-12

Applicant: Cytiva Sweden AB

Inventor： Eric Faldt ,  Klaus Gebauer

IPC: A61M39/10 ,  A61M39/16 ,  F16L39/00 ,  A61M39/18

Abstract: Aseptic connectors are described. An aseptic connector includes a first connection unit and a second connection unit provided with at least one first and second openings orientated to substantially coincide when said first and second connection units are connected to each other. The first and second openings are sealed by at least one film, so that the contact between the film and each connection unit is aseptic. The at least one film is adapted to be mated with a corresponding film on the other connection unit; and the mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings are mated aseptically.

公开(公告)号：US20210096059A1

公开(公告)日：2021-04-01

申请号：US16078727

申请日：2017-02-27

Applicant: Cytiva Sweden AB

Inventor： Hanno Ehring

IPC: G01N21/03 ,  G01N21/33 ,  G01N21/05

Abstract: The present invention relates to an apparatus for measuring the absorbance of a substance in a solution, comprising at least one sample cell arranged to contain said solution that is at least partially transparent to light of a predefined wavelength spectrum, at least two light passages through said at least one sample cell, each of said light passages having a known path length, an LED light source arrangement comprising at least two LEDs, each arranged to emit a light output with a wavelength within said predefined wavelength spectrum, wherein a plurality of optical fibers, one for each light passage, is arranged at each LED for receiving said light output and guiding it to the light passages. The invention also relates to a method for measuring the absorbance of a substance in a solution.

公开(公告)号：US20210079220A1

公开(公告)日：2021-03-18

申请号：US17107773

申请日：2020-11-30

Applicant: CYTIVA SWEDEN AB

Inventor： David Moore ,  Matthew Jeremiah Misner ,  Hongyi Zhou ,  Patrick McCloskey ,  Matthew Rainka

IPC: C08L81/06 ,  B01D71/68 ,  C08G75/20 ,  C08G65/40 ,  B01D71/80 ,  B01D71/82 ,  C08L71/00 ,  C08L101/00

Abstract: Multicomponent copolymers including two or more types of repeat units is presented. In one example, the multicomponent copolymer includes at least one repeat unit AC having a structure (I), at least one repeat unit DC having a structure (II), and at least one repeat unit BC having a structure (III) or (V). The multicomponent copolymer may be cross-linked via a cross-linking agent. A polymer blend including the multicomponent copolymer or a cross-linked copolymer and a second polymer is also provided. The multicomponent copolymer may be a random or a block copolymer. The structural units of the multicomponent copolymers provide improved, tunable properties, such as improved biocompatibility and hydrophilicity, protein fouling, and mechanical properties, to the copolymers and/or the membranes fabricated from the copolymers.

公开(公告)号：US10926191B2

公开(公告)日：2021-02-23

申请号：US15533405

申请日：2015-12-10

Applicant: Cytiva Sweden AB

Inventor： Bjorn Markus Olovsson

IPC: B01D15/16 ,  B01D15/22 ,  B01F3/08 ,  G01N30/32 ,  G01N30/34 ,  B01F5/04 ,  B01F15/00 ,  B01F15/02 ,  G01N30/86

Abstract: A system for preparing solutions for chromatography application is disclosed. The system comprises a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution. The T-joint receives the second solution from a solution supply unit connected to the T-joint. Further one or more low pressure pumps supply the one or more first solutions into the T-joint. The high pressure pump collects the buffer solution and delivers it to a chromatography apparatus.

公开(公告)号：US12276601B2

公开(公告)日：2025-04-15

申请号：US18481117

申请日：2023-10-04

Applicant: Cytiva Sweden AB

Inventor： Mikael Anders Hornqvist

IPC: G01N21/33 ,  G01N21/05 ,  G01N21/85 ,  G01N30/74 ,  G01N21/31 ,  G01N30/02

Abstract: Disclosed is a method for measuring the absorbance of light of a substance in a solution in a measuring cell, said method comprising the steps of: transmitting a first light beam from a light source towards a beam splitter; dividing the first light beam into a signal light ray and a reference light ray by the beam splitter; modulating the signal light ray; modulating the reference light ray; providing the measuring cell such that the signal light ray passes through the measuring cell; detecting a signal in a detector, which signal is the combined signal intensity of the signal light ray and the reference light ray detected by the detector; performing synchronous detection of the detected signal in order to reconstruct the intensities of the signal light ray and the reference light ray from the combined signal detected by the detector, said synchronous detection being based on the modulation performed to the signal light ray and the reference light ray. Disclosed also is a measuring device for carrying out said method.

公开(公告)号：US12264306B2

公开(公告)日：2025-04-01

申请号：US17296711

申请日：2019-12-10

Applicant: Cytiva Sweden AB

Inventor： Bjorn Olovsson ,  Andreas Lundin ,  Klaus Gebauer ,  Tim Francois ,  Kerstin Erickson

IPC: C12M1/00

Abstract: A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold (12; 112; 212; 312) comprising: ⋅o at least four fluid connection tubes (14), wherein each fluid connection tube (14) comprises a first end (18) for fluid connection and an opposite second end (20) ⋅o a central common compartment (30; 130; 230; 330) to which the second ends (20) of each of the fluid connection tubes (14) are connected, whereby the first ends (18) of each of the fluid connection tubes (14) can be in fluid communication with the central common compartment (30; 130; 230; 330) ⋅—at least three pinching members (41) which are provided in connection with one fluid connection tube (14) of the flow distribution manifold (12; 112; 212; 312) each, wherein each of said pinching members (41) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members (41) the pinching member pinches one of the fluid connection tubes (14) such that fluid flow is prevented between the first end (18) and the second end (20) of this fluid connection tube (14).

公开(公告)号：US20250068794A1

公开(公告)日：2025-02-27

申请号：US18948020

申请日：2024-11-14

Applicant: Cytiva Sweden AB

Inventor： Krishna Kumar Swaminathan ,  Sridhar Dasaratha ,  Sittal George ,  Vinay Bhaskar Jammu ,  Alok Singh Chauhan ,  Nagaraju Konduru ,  Neelima Boddapati ,  Ankita Bhatia ,  Mithilesh Mohanty ,  Harsha Aeron ,  Andreas Castan

IPC: G06F30/20

Abstract: A method for predicting outcome of a process used for manufacturing a sample in a bioreactor, the process belonging to a category. The method comprises selecting a process model based on the category; accessing historic data related to past process runs for manufacturing the sample; accessing current data obtained from a current process run of the process. The obtained current data, which is based on the selected process model, comprises: process strategy data, bioreactor instrument data, data from online sensors and/or data from offline sensors. The method further comprises predicting an outcome of at least one selected parameter of the current process run for manufacturing the sample based on the accessed historic data and current data.

公开(公告)号：US12188911B2

公开(公告)日：2025-01-07

申请号：US17602701

申请日：2020-04-16

Applicant: CYTIVA SWEDEN AB

Inventor： Jens Widehammar ,  Key Hyckenberg ,  Örjan Grelsson ,  Lars Mattsson ,  Kjell Karlsson

IPC: G01N30/86 ,  B01D15/20 ,  G01N30/02 ,  G01N30/46

Abstract: A chromatography system arranged to perform automated chromatography column efficiency testing for a specific column to determine efficiency parameters and to further provide guidance to the user. The system has a controller arranged to automatically access data to enable the calculation of a column compression plate height, said data being derived from at least stored parameters of the specific column and the resin to be used in the column, to calculate the efficiency of the column.

公开(公告)号：US20240425799A1

公开(公告)日：2024-12-26

申请号：US18824731

申请日：2024-09-04

Applicant: Cytiva Sweden AB

Inventor： Victor Jose ,  Andreas Axen ,  Klaus Gebauer ,  Veena B N Rao ,  Patric Fricking ,  Hanish Lakhani

IPC: C12M1/36 ,  C12M1/00 ,  G16H10/40

Abstract: A bio-processing system (100) is presented. The bio-processing system (100) includes one or more bio-processing units (110-114), one or more process supporting devices (116, 118), one or more sensors (120-132), and a bio-processing workflow controller (104) wirelessly coupled to at least one of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-132). The bio-processing workflow controller (104) includes a processor (202) configured to create a reconfigurable bio-processing workflow, and where the reconfigurable bio-processing workflow is representative of an arrangement of one or more of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-132) to perform at least one bio-processing operation.

公开(公告)号：US12158453B2

公开(公告)日：2024-12-03

申请号：US17430915

申请日：2020-02-24

Applicant: Cytiva Sweden AB

Inventor： Lars Mattsson ,  Ioana Erlandsson ,  Therese Westman ,  Enrique Carredano ,  Jenny Dunker

IPC: G01N30/34 ,  G01N30/02 ,  G01N30/32 ,  G01N30/64 ,  G01N30/74 ,  G01N30/88

Abstract: The present invention relates to a computer-implemented method for controlling preparation of a liquid mixture comprising an acid and its conjugate base or a base and its conjugate acid. The method comprises obtaining (S11) a composition for the liquid mixture to be prepared and determining (S12) a plurality of settings for controlling a preparation of the liquid mixture in one or more automated processes. The plurality of settings are provided (S13) to one or more control systems of the one or more automated processes. The present invention also relates to a buffer tool configured to perform the computer-implemented method, a buffer management system comprising the buffer tool, and a computer readable storage medium (25), having stored thereon a computer program which, when executed in a buffer tool, causes execution of the computer-implemented method.