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    CLINICAL DECISION-MAKING ARTIFICIAL INTELLIGENCE OBJECT ORIENTED SYSTEM AND METHOD
    174.
    发明申请
    CLINICAL DECISION-MAKING ARTIFICIAL INTELLIGENCE OBJECT ORIENTED SYSTEM AND METHOD 审中-公开

    公开(公告)号：US20190333636A1

    公开(公告)日：2019-10-31

    申请号：US16403683

    申请日：2019-05-06

    Applicant: Indiana University Research and Technology Corporation ,  Centerstone Research Institute

    Inventor： Casey C. Bennett ,  Kris Hauser

    IPC: G16H50/00 ,  G16H50/20

    Abstract: The present invention involves a system and method of providing decision support for assisting medical treatment decision-making. A patient agent software module processes information about a particular patient. A doctor agent software module processes information about a health status of a particular patient, beliefs relating to patient treatments, and the actual effects of treatment decisions. By filtering information over time from the patient agent into the doctor agent, a plurality of decision-outcome nodes are created and formed into a patient-specific outcome tree with the plurality of decision-outcome nodes. An optimal treatment is determined by evaluating the plurality of decision-outcome nodes with a cost per unit change function to output the optimal treatment. When additional information is available from at least one of the patient agent and the doctor agent, the filtering, creating, and determining steps are repeated thus allowing for the system to “reason over time”, continuously updating and learning as new information is received.

    System and method for reducing biological damage in proton therapy
    176.
    发明授权
    System and method for reducing biological damage in proton therapy 有权

    公开(公告)号：US10449391B2

    公开(公告)日：2019-10-22

    申请号：US15327337

    申请日：2015-07-24

    Applicant: Indiana University Research and Technology Corporation

    Inventor： Jeffrey Buchsbaum

    IPC: A61N5/10

    Abstract: Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative biological effectiveness of a beam on a region of a human body, and a beam applicator in electrical communication with the processor, wherein a characteristic of the beam can be adjusted based on the measured relative biological effectiveness are disclosed. Methods of treatment comprising measuring, by a processor capable of detecting potential biological hot spots, a relative biological effectiveness of a beam on a region of a human body, designing a beam therapy treatment plan based on the measured relative biological effectiveness, and applying a beam to a patient with a region in need of beam therapy with a beam applicator in electrical communication with the processor capable of detecting potential biological hot spots are also disclosed.

    COMPOSITIONS AND SYSTEMS FOR CONFERRING DISEASE RESISTANCE IN PLANTS AND METHODS OF USE THEREOF
    179.
    发明申请
    COMPOSITIONS AND SYSTEMS FOR CONFERRING DISEASE RESISTANCE IN PLANTS AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20190256864A1

    公开(公告)日：2019-08-22

    申请号：US16395070

    申请日：2019-04-25

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

    Inventor： Roger William INNES ,  Matthew David HELM

    IPC: C12N15/82 ,  C07K14/415 ,  C12N9/50 ,  C12N15/52

    Abstract: Compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins inside plant cells. Briefly, the compositions, systems and methods are based upon plant substrate proteins that are targeted by pathogen-specific proteases and that activate nucleotide binding site-leucine rich repeat (NB-LRR) disease resistance proteins when cleaved by the protease. These substrate proteins are modified such that the endogenous protease recognition sequence is replaced by a protease recognition sequence specific to a different pathogen protease (i.e., a heterologous protease recognition sequence). The modified plant substrate protein therefore can be used in connection with its corresponding NB-LRR protein to activate resistance in response to cleavage by the heterologous pathogen-specific protease. When activated by the plant pathogen-specific protease, the pair initiates host defense responses thereto, including programmed cell death.

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