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公开(公告)号:US11878984B2
公开(公告)日:2024-01-23
申请号:US17274988
申请日:2019-06-03
Inventor: Hee Jae Shin , Byeoung Kyu Choi , Hwa Sun Lee , Hyi Seung Lee , Yeon Ju Lee , Jong Seok Lee , Ji Hoon Lee
IPC: A61K31/35 , A61P25/28 , C07D493/16
CPC classification number: C07D493/16 , A61K31/35 , A61P25/28 , C07B2200/07
Abstract: The present invention relates to new compounds derived from marine actinomycetes Streptomyces, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.
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172.
公开(公告)号:US20230373604A1
公开(公告)日:2023-11-23
申请号:US17813846
申请日:2022-07-20
Inventor: Hee Jin KANG , Jang Pyo HONG
IPC: B63H9/02
CPC classification number: B63H9/02
Abstract: An upright tank-based propulsion assistance rotor sail system is proposed. The system may include an upright tank fixed to a hull of a ship, and a rotor sail in a form of a cylindrical shape having a length and diameter greater than or equal to the upright tank, and installed to surround part or all of an outer circumferential surface of the upright tank. The rotor sail may be rotatably installed while surrounding the upright tank concentrically with the upright tank, and may be movable along a height direction of the outer circumferential surface of the upright tank depending on situations to maintain a predetermined height. In addition, a vessel equipped with the upright tank-based propulsion assistance rotor sail system is proposed, The fuel tank may be installed to stand upright on the vessel so that the rotor sail is installed to be movable in the vertical direction.
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173.
公开(公告)号:US11608366B2
公开(公告)日:2023-03-21
申请号:US16997198
申请日:2020-08-19
Applicant: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY
Inventor: Geun Joong Kim , Hye Ji Choi , Dae Eun Cheong , Su Kyoung Yoo , Dong Hyun Lee , Jae Hong Park , Jung Hyun Lee , Hyung Soon Yim , Young Jun An , Kyeong Won Lee
Abstract: A recombinant vector according to an embodiment of the present invention may produce fibroblast growth factor 19 (FGF19) having enhanced solubility. The synonymous codon substitution variant fibroblast growth factor 19 (scvhFGF19) and chaperone ΔssDsbC may be simultaneously and independently expressed in a host cell into which the recombinant vector is introduced, thereby it is possible to overexpress the fibroblast growth factor 19 in a soluble state.
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公开(公告)号:US11286020B2
公开(公告)日:2022-03-29
申请号:US16307117
申请日:2018-03-28
Inventor: Hee Jin Kang , Jin Choi , Hae Seong Ahn , Kwang Soo Kim , Geun Tae Yim , Myoung Soo Kim
IPC: B63B1/32 , B63B73/10 , B63B73/20 , B63B3/16 , B63B3/38 , B63B13/00 , B63B39/03 , B63B39/06 , B63B11/00
Abstract: A ballast water-free ship using a difference in the depth of the bottom shell plate between the bow/stern and the midship section and a construction method thereof. A stepped portion is formed between either the bow or the stern and the midship section, such that the depth of the bottom shell plate of either the bow or the stern differs from the depth of the bottom shell plate of the cargo containment in the midship section, so that cargo can be loaded and unloaded without ballast water operation.
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公开(公告)号:US20220033413A1
公开(公告)日:2022-02-03
申请号:US17274988
申请日:2019-06-03
Inventor: Hee Jae SHIN , Byeoung Kyu CHOI , Hwa Sun LEE , Hyi Seung LEE , Yeon Ju LEE , Jong Seok LEE , Ji Hoon LEE
IPC: C07D493/16
Abstract: The present invention relates to new compounds derived from marine actinomycetes Streptomyces, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.
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公开(公告)号:US20210355151A1
公开(公告)日:2021-11-18
申请号:US17257255
申请日:2019-03-08
Inventor: Hee Jae Shin , Byeoung Kyu Choi , Hwa Sun Lee , Hyi Seung Lee , Yeon Ju Lee , Jong Seok Lee , Ji Hoon Lee , Chan Hong Park
Abstract: Disclosed are a novel rhamnolipid compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof in the present disclosure. The novel rhamnolipid compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof selectively exhibits cytotoxicity to human cancer cell lines, thereby inhibiting the growth of cancer cells, and thus has particularly excellent preventive or therapeutic effects against the above-mentioned types of cancers.
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公开(公告)号:US10913515B2
公开(公告)日:2021-02-09
申请号:US16613778
申请日:2018-05-29
Inventor: Hyun Uk Kwak , Jae Sang Jung , Dong Woo Jung , Byung Won Park , In Bo Park , Suk Kyu Cho , Dong Ho Jung , Hong Gun Sung
Abstract: The present invention provides a ship mooring device using a spring bellows structure, wherein the ship mooring device temporarily or permanently fixes a state in which the ship is spaced at a preset distance from a vessel or a pier, the ship mooring device including: a main body configured of a plurality of frames in which opposite ends of each of the frames are hinge-coupled to facing ends of adjacent frames to form foldable hinge joints, wherein diagonally opposed non-adjacent hinge joints of the frames are fixed to the ship and the pier, respectively; and a plurality of wires which are installed inwards in diagonal lines with respect to the frames of the main body to connect the diagonally opposed non-adjacent hinge joints together, with an elastic member interposed in a center portion of the radially disposed wires to generate predetermined dynamic stability when the ship is moved.
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178.
公开(公告)号:US20200317309A1
公开(公告)日:2020-10-08
申请号:US16301396
申请日:2016-08-12
Inventor: Key Yong HONG , Kang Su LEE , Kyong Hwan KIM , Jong Su CHOI , Se Wan PARK , Sung Youn BOO , Steffen A. SHELLEY , Dae Jun KIM
Abstract: A platform for a semi-submersible floating type offshore structure according to an exemplary embodiment of the present invention includes a main body which is installed on the sea and has an arrangement structure in which a plurality of pontoons is combined to form a plurality of polygonal shapes; and a protrusion member connecting unit which extends from each corner of the main body and connects a protrusion member outwardly protruding from the main body to the main body.
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179.
公开(公告)号:US20200231253A1
公开(公告)日:2020-07-23
申请号:US16649333
申请日:2018-08-20
Inventor: Kang Su LEE , Do Youb KIM , Byoung Jae PARK , Hyun Seok KIM
Abstract: A floating offshore mooring chain apparatus for preventing collision with a ship is proposed. The mooring chain apparatus includes a buoyant body floating on the water surface to transfer resources to a transport ship, a plurality of mooring chains fixed to the seabed to locate the buoyant body in position on the water surface, and a plurality of spider buoys disposed to a lower portion of the buoyant body such that the mooring chains laterally penetrate through the spider buoys, respectively, and extend toward the seabed in different directions, so that the mooring chains are moved by a rotating force along the extension directions thereof to displace the buoyant body.
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公开(公告)号:US10605237B2
公开(公告)日:2020-03-31
申请号:US15249753
申请日:2016-08-29
Inventor: Jin Hwan Ko , Patar Ebenezer Sitorus , Jin Soon Park
IPC: F04B17/06 , F03D5/06 , F03D9/28 , F03B13/26 , F03B17/06 , F04B17/00 , F04B19/22 , F04B23/06 , F04B53/10 , F04B53/14 , F04B53/16
Abstract: A multiple oscillating water pumping device includes: a wing member disposed in fluid to generate a lifting force using the flow energy of the fluid; a rotation device to reciprocally rotate the wing member to periodically change the direction of the lifting force acting on the wing member; an arm is rotatably coupled to the wing member, the arm being reciprocally rotated about a pivot shaft by the lifting force acting on the wing member; and a cylinder where fluid enters and exits according to the internal pressure that is periodically increased and decreased by the reciprocating motion of a piston that is connected with the arm through a connecting rod. The multiple oscillating water pumping device is configured to minimize the supply of a power source required for operation and to minimize the loss of head when pumped water flows toward a reservoir along a conduit.
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