公开(公告)号：US20210077365A1

公开(公告)日：2021-03-18

申请号：US16620284

申请日：2018-06-06

Applicant: SHISEIDO COMPANY, LTD.

Inventor： MARIANNE AYAKA TOUATI ,  Satoshi YAMAKI ,  Yurika WATANABE ,  Takahiro KATORI

IPC: A61K8/06 ,  A61K8/92 ,  A61K8/25 ,  A61K8/365 ,  A61K8/36 ,  A61K8/46 ,  A61K8/49 ,  A61K8/891 ,  A61K8/40 ,  A61K8/96 ,  A61Q17/04

Abstract: A water-in-oil emulsified cosmetic preparation that, even without substantially comprising a UV scattering agent, exhibits a high UV protection effect. This water-in-oil emulsified cosmetic preparation includes: 6%-40% by mass of a UV absorber (A); at least 15% by mass of a non-volatile polar oil component (B) containing an ester bond (and not including the UV absorber (A)); and 0.5%-15% by mass of an oil phase thickener (C). It is particularly preferable that the present invention also includes a powder (D) having an average particle diameter of no more than 15 μm.

公开(公告)号：US10898426B2

公开(公告)日：2021-01-26

申请号：US16509901

申请日：2019-07-12

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Reiji Miyahara ,  Takashi Oka ,  Makoto Uyama ,  Saori Tanabe ,  Tetsuro Yonezawa ,  Miho Yajima ,  Noriko Ohira ,  Saori Nishikawa

IPC: A61K8/86 ,  A61K8/06 ,  A61Q19/00 ,  A61K8/19 ,  A61K8/81 ,  A61K8/92 ,  A61K8/34 ,  A61K8/41 ,  A61K8/891 ,  A61K8/37

Abstract: The present invention addresses the problem of providing an α-gel formation composition and an α-gel composition that uses the α-gel formation composition, wherein said compositions are highly stable, do not deposit crystals, become more viscous over time, and, when used in a preparations for external use, are refreshing during application and have high skin-moisturizing action after application. A gel composition that includes a polyoxyethylene dialkyl ester and/or a polyoxyethylene dialkyl ether, a polyoxyethylene alkyl ester and/or a polyoxyethylene alkyl ether, and, preferably, a polyoxyethylene sterol ether and water.

公开(公告)号：US20210009736A1

公开(公告)日：2021-01-14

申请号：US16982328

申请日：2019-03-22

Applicant: Shiseido Company, Ltd.

Inventor： Yuki SUGIYAMA ,  Ryushi FUKUHARA

IPC: C08F220/28 ,  C08F212/08 ,  C08G65/08 ,  A61K8/81 ,  A61K8/86 ,  A61K8/06

Abstract: Provided are: a core-corona polymer particle excellent in emulsion stability and feeling of use, and a raw material for a cosmetic and an oil-in-water emulsion cosmetic comprising the particle. Certain embodiments of the present invention provide a core-corona polymer particle obtained by radical-polymerizing a polyethylene oxide macromonomer represented by formula (1) and one or two or more of hydrophobic monomers represented by formulas (2) and (3) under conditions (A) to (D).

公开(公告)号：US20210007945A1

公开(公告)日：2021-01-14

申请号：US16982348

申请日：2019-03-22

Applicant: Shiseido Company, Ltd.

Inventor： Yuki SUGIYAMA ,  Ryushi FUKUHARA

IPC: A61K8/02 ,  A61K8/06 ,  A61K8/85 ,  A61Q19/00

Abstract: Provided are: a core-corona polymer particle excellent in emulsion stability and feeling of use, and a raw material for a cosmetic and an oil-in-water emulsion cosmetic comprising the particle. Certain embodiments of the present invention provides a core-corona polymer particle obtained by radical-polymerizing a polyethylene oxide macromonomer represented by formula (1) and one or two or more of hydrophobic monomers represented by formulas (2) and (3) under conditions (A) to (D).

公开(公告)号：US20210003560A1

公开(公告)日：2021-01-07

申请号：US16978088

申请日：2019-03-11

Applicant: Shiseido Company, Ltd.

Inventor： Yumiko ISHIMATSU ,  Tsutomu SOMA ,  Jiro KISHIMOTO

IPC: G01N33/50

Abstract: Provided is an identification method for dermal sheath cup cells (DSCC) in hair follicle-derived cells, said method being characterized by comprising using the expression level of GREM2 gene as an index. Also provided is a method for evaluating a composition for hair follicle regeneration which contains hair follicle-derived cells, said method being characterized by comprising determining the ratio and/or activity of dermal sheath cup cells (DSCC) in the hair follicle-derived cells with the use of the expression level of GREM2 gene as an index.

公开(公告)号：US20200371027A1

公开(公告)日：2020-11-26

申请号：US16966276

申请日：2019-01-31

Applicant: Shiseido Company, Ltd.

Inventor： Kouichi NAGAI ,  Kei UJIMOTO ,  Marianne Ayaka TOUATI ,  Yuko NAGARE ,  Satoshi YAMAKI

IPC: G01N21/59 ,  G01N33/15

Abstract: The purpose of the present invention is to newly provide a method with which it is possible to appropriately evaluate the protective effect of an external preparation for skin such as a sunscreen cosmetic, particularly to evaluate how a UV-ray protective effect is affected by heat. This evaluation method is characterized by including (1) a step for forming a coating film of an external preparation for skin on a substrate, (2) a step for heat-treating the coating film of the external preparation for skin, and (3) a step for measuring the UV-ray protective effect of the heat-treated coating film of the external preparation for skin. The heat treatment is preferably carried out for at least one minute at a temperature of 30-70° C. The step for measuring the UV-ray protective effect preferably includes at least one selected from testing methods that involve comparing some kind of UV-ray protective effect with SPF measurement, UVAPF or PFA measurement, critical wavelength measurement, absorbance measurement, and transmittance measurement. This evaluation method can also be performed in vivo or in vitro.

公开(公告)号：US20200345592A1

公开(公告)日：2020-11-05

申请号：US16642597

申请日：2018-08-29

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Kanako NOGUCHI ,  HIRUMA Yukiko ,  KAWANO Sayoko ,  FUJITA Junko

IPC: A61K8/03 ,  A61K8/02 ,  A61K8/34 ,  A61K8/25 ,  A61K8/29 ,  A61K8/894 ,  A61K8/36 ,  A61K8/81 ,  A61K8/26

Abstract: The present invention provides a multilayer type powder-containing cosmetic preparation which can be variously formulated and in which the powder ingredient has excellent re-dispersibility without being required to have undergone a surface treatment. The a multilayer powder-containing cosmetic preparation includes (a) to (c) components: (a) a 60-95% by mass lower alcohol; (b) a powder ingredient (excluding a (c) component); and (c) a finely particulate powder which has an average primary-particle diameter of 10-550 nm and includes silica or titanium dioxide as a core.

公开(公告)号：US20200330069A1

公开(公告)日：2020-10-22

申请号：US16841812

申请日：2020-04-07

Applicant: SHISEIDO COMPANY, LTD. ,  NATIONAL UNIVERSITY CORPORATION TOYOHASHI UNIVERSITY OF TECHNOLOGY ,  HONDA ELECTRONICS CO., LTD.

Inventor： Yuki OGURA ,  Naohiro HOZUMI ,  Sachiko YOSHIDA ,  Kazuto KOBAYASHI ,  Yusuke HARA

IPC: A61B8/08 ,  A61B8/00 ,  G01B17/02

Abstract: An ultrasonic measurement method includes irradiating an object to be measured with an ultrasonic wave, acquiring a reflection wave from the object, calculating at a processor an acoustic impedance in a depth direction of the object from the reflection wave, and estimating and outputting a thickness of the object based upon an inflection point determined by second-order differentiation of the acoustic impedance.

公开(公告)号：US20200289400A1

公开(公告)日：2020-09-17

申请号：US16649342

申请日：2018-09-28

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Minori NAKAJIMA ,  Keita NISHIDA ,  Yurika WATANABE ,  Daiki ARAI ,  Taichi HARADA

IPC: A61K8/92 ,  A61K8/06 ,  A61K8/73 ,  A61Q17/04

Abstract: An oil-in-water-type emulsion cosmetic contains an ultraviolet ray scattering agent and which has preparation stability in a system where a water-soluble alkyl-substituted polysaccharide derivative and another emulsifying agent coexist is further improved. The oil-in-water-type emulsion cosmetic containing (A) a water-soluble alkyl-substituted polysaccharide derivative, (B) a nonionic surfactant and (C) an ultraviolet ray scattering agent, wherein the blend ratio [(A)/(B)] of the water-soluble alkyl-substituted polysaccharide derivative (A) to the nonionic surfactant (B) is 1.54 or less, and the blend ratio [(A)/(C)] of the water-soluble alkyl-substituted polysaccharide derivative (A) to the ultraviolet ray scattering agent (C) is 0.02 or less.

公开(公告)号：US20200232972A1

公开(公告)日：2020-07-23

申请号：US16632185

申请日：2018-07-17

Applicant: Shiseido Company, Ltd.

Inventor： Tomonobu EZURE ,  Misato TOYODA

IPC: G01N33/50 ,  C12N5/071 ,  A61K8/9789

Abstract: The purpose of the invention is to develop a method for screening anti-aging substances. The present inventors have found a phenomenon in which a dermis aging factor secreted by senescent cells acts on normal cells to promote the decomposition of dermal components and a reduction in the production of dermal components, and have arrived at developing a method for screening anti-aging substances by employing the dermis aging factor as an indicator.