公开(公告)号：US20160199224A1

公开(公告)日：2016-07-14

申请号：US14997520

申请日：2016-01-16

Applicant: ZOLL Circulation, Inc.

Inventor： Wade A. Keller ,  Timothy R. Machold

IPC: A61F7/12

CPC classification number: A61F7/12 ,  A61B18/00 ,  A61B18/082 ,  A61B18/245 ,  A61B2017/00084 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61F7/007 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0086 ,  A61F2007/0095 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/00 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0078 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/366 ,  A61M2206/10 ,  A61M2230/50

Abstract: Catheter devices and methods for intravascular heating and/or cooling of human or veterinary patients. The catheter devices generally comprise catheters having inflow and outflow lumens and at least one curvilinear balloon connected to the inflow and outflow lumens such that heat exchange fluid may be circulated through the balloon(s). The catheter is inserted into the vasculature and heated or cooled fluid is circulated through the balloon(s) to heat or cool blood flowing in heat-exchange proximity to the balloon(s), thereby effecting heating or cooling of all or a portion of the patient's body.

公开(公告)号：US09385706B2

公开(公告)日：2016-07-05

申请号：US14281653

申请日：2014-05-19

Applicant: Zoll Circulation, Inc.

Inventor： David Deam

IPC: G05F1/10 ,  G05F3/02 ,  H03K17/30 ,  H02M1/08 ,  H02M1/36 ,  H02J7/00 ,  H02J7/04

CPC classification number: H03K17/302 ,  H02J7/0031 ,  H02J7/0036 ,  H02J7/0057 ,  H02J7/047 ,  H02J2007/0059 ,  H02M1/08 ,  H02M1/36 ,  H03K2217/0027 ,  H03K2217/0054 ,  H03K2217/0081 ,  Y10T307/50

Abstract: A boost converter for driving the gate of n-channel MOSFET power devices is described. The boost converter includes a monitoring circuit and a kick start circuit to quickly bring the boost converter online when required to drive the MOSFET on.

Abstract translation: 描述了用于驱动n沟道MOSFET功率器件的栅极的升压转换器。 升压转换器包括监控电路和踢脚启动电路，以便在需要驱动MOSFET时快速使升压转换器处于在线状态。

公开(公告)号：US20160131127A1

公开(公告)日：2016-05-12

申请号：US14534718

申请日：2014-11-06

Applicant: Zoll Circulation, Inc.

Inventor： Austin Reid Hendricks ,  Christo Petrov Pamichev ,  Venkata Vishnu Gurukula ,  Jeremy Thomas Dabrowiak

IPC: F04B43/12 ,  A61F7/12

CPC classification number: F04B43/1223 ,  A61F2007/0054 ,  A61M5/14232 ,  F04B43/1276 ,  F04B43/1284

Abstract: A peristaltic pump has an arcuate raceway with a partially concave inner surface extending through an arc of at least one hundred eighty degrees (180°). The arc defines a midpoint, and a rotor faces the inner surface of the raceway and is both rotatable relative to the raceway and translationally movable relative to the raceway between a pump position, wherein the rotor is spaced from the midpoint a first distance, and a tube load position, wherein the rotor is spaced from the midpoint a second distance greater than the first distance. A motor is coupled to the rotor to rotate the rotor plural are rollers arranged on the rotor to contact tubing disposed between the rotor and the raceway when the rotor is in the pump position. The motor is prevented from stopping at a predetermined angular position to facilitate loading and unloading tubing.

Abstract translation: 蠕动泵具有弓形滚道，其具有延伸通过至少一百八十度（180度）的弧的部分凹入的内表面。 弧定义中点，并且转子面向滚道的内表面，并且可相对于滚道旋转，并且在泵位置之间可相对于滚道平移地相对于滚道移动，其中转子与第一距离的中点间隔开， 管装载位置，其中转子与中点间隔大于第一距离的第二距离。 当转子处于泵位置时，电动机联接到转子以使转子旋转多个布置在转子上的辊，以接触设置在转子和滚道之间的管道。 电机被阻止在预定角度位置停止以便于装载和卸载管道。

公开(公告)号：US20150272513A1

公开(公告)日：2015-10-01

申请号：US14639816

申请日：2015-03-05

Applicant: ZOLL Circulation, Inc.

Inventor： Qing Tan ,  Gary A Freeman

IPC: A61B5/00 ,  A61B5/026 ,  A61B5/01 ,  A61F7/12

Abstract: Endovascular heat exchange systems and methods wherein a heat exchange catheter is positionable within the vasculature of a patent to exchange heat with the patient's flowing blood. The rate at which heat is being exchanged is determined and quantitative blood flow determinations may be made based on the rate of heat exchange. The system provides notification(s) to personnel when one or more blood flow-related events occur(s), such as a) resumption or continuation of effective spontaneous circulation; b) cessation of absence of effective spontaneous circulation, c) the occurrence of spontaneous or cardiac-compression-generated circulation that is below a minimum effective blood flow rate and e) the occurrence of spontaneous or cardiac-compression-generated circulation that is at or above a minimum effective blood flow rate.

Abstract translation: 血管内热交换系统和方法，其中热交换导管可定位在专利脉管系统内以与病人的流动血液交换热量。 确定热交换的速率，并且可以基于热交换速率进行定量的血流测定。 当一个或多个血液流动相关事件发生时，该系统向人员提供通知，例如a）恢复或继续有效的自发循环; b）停止不存在有效的自发循环，c）低于最低有效血流速率的自发或心脏压迫产生的循环的发生，以及e）发生自发或心脏压缩产生的循环， 高于最低有效血流速率。

公开(公告)号：US09138344B2

公开(公告)日：2015-09-22

申请号：US14181297

申请日：2014-02-14

Applicant: ZOLL CIRCULATION, INC.

Inventor： Paul M. Stull

IPC: A61F7/00 ,  A61F7/12

CPC classification number: A61F7/123 ,  A61F2007/0022 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0095

Abstract: A balloon catheter is used in a closed-loop heat exchange system for manipulating the temperature of a patient. The balloon catheter is positioned in the stomach of the patient, and then expanded with a heat exchange fluid delivered through a lumen formed in the shaft of the catheter. The balloon catheter comes into contact with the wall of the stomach, and the stomach substantially conforms around the expanded balloon catheter. The heat exchange fluid is allowed to flow continuously into and out of the balloon catheter. Heat is exchanged between the balloon catheter and the stomach so as to controllably alter the temperature of at least a portion of the patient. Anti-shivering mechanisms and automatic control based on temperature feedback from the patient may be used in connection with the heat exchange system.

Abstract translation: 气囊导管用于闭环热交换系统，用于操纵患者的温度。 气囊导管定位在患者的胃中，然后通过在导管的轴中形成的内腔递送的热交换流体膨胀。 气囊导管与胃壁接触，胃部基本上与扩张的气囊导管相适应。 允许热交换流体连续地流入和流出气囊导管。 在球囊导管和胃之间交换热量，以便可控地改变患者的至少一部分的温度。 基于来自患者的温度反馈的防颤动机构和自动控制可以与热交换系统结合使用。

公开(公告)号：US20150223972A1

公开(公告)日：2015-08-13

申请号：US14175545

申请日：2014-02-07

Applicant: Zoll Circulation, Inc.

Inventor： JEREMY THOMAS DABROWIAK

IPC: A61F7/00 ,  A61F7/12 ,  A61F7/08 ,  F28D9/00

CPC classification number: A61F7/0085 ,  A61F7/02 ,  A61F7/12 ,  A61F2007/0054 ,  A61F2007/126 ,  F28D9/0068 ,  F28D9/0075 ,  F28D9/0081

Abstract: Cold plates through which refrigerant flows define a slot between them that can receive a cassette through which sterile working fluid with a relatively low flow rate flows from an intravascular heat exchange catheter. The working fluid from the catheter is heated or cooled by heat exchange with the cold plates through the walls of the cassette to maintain the sterility of the working fluid. On the other hand, high flow rate working fluid chambers surround the cold plates and non-sterile working fluid from an external heat exchange pad flows through the high flow rate working fluid chambers to exchange heat through direct contact with the cold plates.

Abstract translation: 制冷剂流过的冷板在它们之间限定一个狭槽，该狭缝可以容纳一个盒，通过该盒可以从血管内热交换导管流出具有较低流速的无菌工作流体。 来自导管的工作流体通过与冷板通过盒的壁进行热交换来加热或冷却，以保持工作流体的无菌性。 另一方面，高流量工作流体室围绕冷板，来自外部热交换垫的非无菌工作流体流过高流量工作流体室，以通过与冷板直接接触来交换热量。

公开(公告)号：US20150025607A1

公开(公告)日：2015-01-22

申请号：US14509271

申请日：2014-10-08

Applicant: ZOLL CIRCULATION, INC.

Inventor： Alex L. Lim ,  Venkata Vishnu Gurukula ,  Jeremy T. Dabrowiak ,  Richard A. Helkowski

IPC: A61F7/12 ,  A61F7/00

CPC classification number: A61F7/12 ,  A61F7/0085 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0094 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/00 ,  A61M2025/0004 ,  A61M2205/18 ,  A61M2205/3368

Abstract: A catheter has an inner sleeve through which refrigerant circulates to and from a source of refrigerant. The catheter also has an outer sleeve surrounding the inner sleeve, including a distal end thereof. The outer Sleeve is filled with a frozen biocompatible substance. The refrigerant is separated from the biocompatible substance by one or more walls of the inner sleeve such that the refrigerant is isolated from a patient in whom the catheter is positioned by both the inner sleeve and the frozen biocompatible substance. The refrigerant circulates through the catheter when the catheter is positioned in the patient to maintain the biocompatible substance frozen as heat is transferred from the patient to the biocompatible substance.

Abstract translation: 导管具有内套筒，制冷剂通过该内套筒从制冷剂源流出。 导管还具有围绕内套筒的外套筒，包括其远端。 外套装有冷冻生物相容性物质。 制冷剂通过内套筒的一个或多个壁与生物相容性物质分离，使得制冷剂与内套筒和冷冻生物相容性物质由导管定位的患者隔离。 当导管位于患者体内时，制冷剂通过导管循环，以便当热量从患者转移到生物相容性物质时，使生物相容性物质保持冷冻。

公开(公告)号：US08888729B2

公开(公告)日：2014-11-18

申请号：US13934798

申请日：2013-07-03

Applicant: Zoll Circulation, Inc. ,  The Regents of the University of California

Inventor： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

IPC: A61M37/00 ,  A61F7/00 ,  A61F7/12 ,  A61M5/44 ,  A61B18/00 ,  A61M1/36 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/0009 ,  A61M25/1011

Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

Abstract translation: 导管适于与诸如血管的体导管中流动的体液（例如血液）进行热交换。 导管包括设置在其远端处具有热交换区域的轴。 该区域可以包括中空纤维，其适于接收远离冷却的热交换流体，优选地在与体液相反的方向上流动。 中空纤维增强了接触的表面积，以及两种热交换流体和体液的混合。 导管可以定位成在身体的选择性区域产生低体温，或者定位成系统地冷却整个身体系统。

公开(公告)号：US08870819B2

公开(公告)日：2014-10-28

申请号：US13652787

申请日：2012-10-16

Applicant: Zoll Circulation, Inc.

Inventor： Blair D. Walker ,  Scott M. Evans ,  David P. Balding ,  Peter Barker

IPC: A61F7/12 ,  A61M31/00 ,  A61M37/00 ,  A61M39/00 ,  A61M25/02 ,  A61F7/00 ,  A61M25/00 ,  A61M25/10 ,  A61M1/36 ,  A61M5/44 ,  A61B17/00

CPC classification number: A61F7/12 ,  A61B2017/00084 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/00 ,  A61M25/002 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/02 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0036 ,  A61M2025/1013 ,  A61M2205/36 ,  A61M2205/366

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract translation: 一套零件包括使用具有热交换元件的中心静脉导管的系统和用于控制患者体温的说明书。 中心静脉导管设置有一个或多个腔，用于提供对患者的中央血液供应的通路，以及用于将热交换流体传递到热交换元件的附加腔。 热交换流体温度通过反馈回路来控制，其中感测患者温度并用于控制包括与热交换流体热交换关系的加热装置和/或冷却装置的温度控制单元。 管组在中央静脉管路和温度控制单元之间输送热交换流体，其中泵用于将流体循环在系统中的封闭流体回路中。

公开(公告)号：US20140277304A1

公开(公告)日：2014-09-18

申请号：US14181297

申请日：2014-02-14

Applicant: ZOLL CIRCULATION, INC.

Inventor： Paul M. Stull

IPC: A61F7/12

CPC classification number: A61F7/123 ,  A61F2007/0022 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0095

Abstract: A balloon catheter is used in a closed-loop heat exchange system for manipulating the temperature of a patient. The balloon catheter is positioned in the stomach of the patient, and then expanded with a heat exchange fluid delivered through a lumen formed in the shaft of the catheter. The balloon catheter comes into contact with the wall of the stomach, and the stomach substantially conforms around the expanded balloon catheter. The heat exchange fluid is allowed to flow continuously into and out of the balloon catheter. Heat is exchanged between the balloon catheter and the stomach so as to controllably alter the temperature of at least a portion of the patient. Anti-shivering mechanisms and automatic control based on temperature feedback from the patient may be used in connection with the heat exchange system.

Abstract translation: 气囊导管用于闭环热交换系统，用于操纵患者的温度。 气囊导管定位在患者的胃中，然后通过在导管的轴中形成的内腔递送的热交换流体膨胀。 气囊导管与胃壁接触，胃部基本上与扩张的气囊导管相适应。 允许热交换流体连续地流入和流出气囊导管。 在球囊导管和胃之间交换热量，以便可控地改变患者的至少一部分的温度。 基于来自患者的温度反馈的防颤动机构和自动控制可以与热交换系统结合使用。