公开(公告)号：US5136051A

公开(公告)日：1992-08-04

申请号：US772814

申请日：1991-10-08

Applicant: Ludwig Schuster ,  Ulrich Koehler

Inventor： Ludwig Schuster ,  Ulrich Koehler

IPC: C07D201/08 ,  C07D207/26 ,  C07D207/267

CPC classification number: C07D207/267 ,  C07D201/08

Abstract: A process for the preparation of a 2-pyrrolidinone of the general formula I ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1 -C.sub.20 -alkyl, or C.sub.3 -C.sub.8 -cycloalkyl optionally substituted by C.sub.1 -C.sub.4 -alkyl, or phenyl optionally substituted by C.sub.1 -C.sub.4 -alkyl,by reacting a 3-cyanopropionate of the general formula II ##STR2## in which R.sup.1 and R.sup.2 have the meanings stated above and R.sup.3 denotes C.sub.1 -C.sub.8 -alkyl,with hydrogen at elevated temperature and pressure, wherein the reaction is carried out in the presence of ammonia and in contact with a catalyst containing cobalt, manganese, and phosphorus.

Abstract translation: 制备通式I（I）的2-吡咯烷酮的方法，其中R 1和R 2独立地是氢，C 1 -C 20 - 烷基或任选被C 1 -C 4 - 烷基取代的C 3 -C 8 - 环烷基 或任选被C 1 -C 4 - 烷基取代的苯基，通过使通式II的3-氰基丙酸酯（II）（其中R 1和R 2具有上述含义，R 3表示C 1 -C 8 - 烷基）与氢 在升高的温度和压力下，其中反应在氨的存在下进行并与含有钴，锰和磷的催化剂接触。

公开(公告)号：US4963672A

公开(公告)日：1990-10-16

申请号：US448899

申请日：1989-12-12

Applicant: Franz Merger ,  Rolf Fischer ,  Wolfgang Harder ,  Claus-Ulrich Priester ,  Uwe Vagt

Inventor： Franz Merger ,  Rolf Fischer ,  Wolfgang Harder ,  Claus-Ulrich Priester ,  Uwe Vagt

IPC: B01J23/46 ,  C07B61/00 ,  C07D201/08 ,  C07D201/16

CPC classification number: C07D201/08 ,  Y02P20/52

Abstract: Caprolactam is prepared in a process comprising the following steps:(a) reacting the 5-formylvaleric ester with liquid ammonia as reaction medium and hydrogen in the presence of a ruthenium catalyst in liquid phase at from 80.degree. to 140.degree. C. under a hydrogen partial pressure of from 40 to 100 bar,(b) replacing the reaction medium ammonia by an aromatic hydrocarbon having a boiling point of from 80.degree. to 240.degree. C. which is liquid under the reaction conditions,(c) heating the resulting mixture in liquid phase under superatmospheric pressure at 230.degree.-350.degree. C. to form caprolactam, and(d) isolating caprolactam from the resulting reaction mixture.

Abstract translation: 己内酰胺以包括以下步骤的方法制备：（a）使5-甲酰基戊酸酯与液氨作为反应介质和氢在钌催化剂存在下在液相中在80-140℃下在氢气 分压为40〜100巴，（b）在反应条件下用沸点为80〜240℃的芳烃替代反应介质氨，（c）将所得混合物加热 液相在超大气压下在230-350℃下反应形成己内酰胺，和（d）从所得反应混合物中分离己内酰胺。

公开(公告)号：US4873326A

公开(公告)日：1989-10-10

申请号：US231232

申请日：1988-08-11

Applicant: Wolfgang Jakob ,  Wolfgang Alewelt ,  Erhard Tresper

Inventor： Wolfgang Jakob ,  Wolfgang Alewelt ,  Erhard Tresper

IPC: C07D201/08 ,  C07D223/10

CPC classification number: C07D223/10

Abstract: This invention relates to a process for the preparation of N-alkylated caprolactams by the cyclization of N-alkylated caproic acids.

Abstract translation: 本发明涉及通过N-烷基化己酸的环化制备N-烷基化己内酰胺的方法。

公开(公告)号：US4800227A

公开(公告)日：1989-01-24

申请号：US642011

申请日：1984-08-20

Applicant: Michael S. Matson

Inventor： Michael S. Matson

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: A one-step method for the reductive amination of a heterocyclic to produce a nitrogen-containing heterocyclic. The feedstock is contacted with a mixed metal catalyst in which the metal comprises palladium and one of ruthenium, rhodium or rhenium.

Abstract translation: 用于还原胺化杂环以制备含氮杂环的一步法。 原料与其中金属包含钯和钌，铑或铼之一的混合金属催化剂接触。

公开(公告)号：US4760068A

公开(公告)日：1988-07-26

申请号：US871386

申请日：1986-06-06

Applicant: Shinji Terao ,  Kohei Nishikawa

Inventor： Shinji Terao ,  Kohei Nishikawa

IPC: C07C51/363 ,  C07D201/08 ,  C07D213/26 ,  C07D213/30 ,  C07D213/32 ,  C07D213/50 ,  C07D213/55 ,  C07D213/57 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07F9/54 ,  A61K31/44 ,  C07D401/06

CPC classification number: C07D213/30 ,  C07C51/363 ,  C07D201/08 ,  C07D213/26 ,  C07D213/32 ,  C07D213/50 ,  C07D213/55 ,  C07D213/57 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07F9/5407

Abstract: Novel compound of the formula: ##STR1## wherein R.sup.1 is pyridyl group, R.sup.2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts having an inhibitory action on bio-synthesis of thromboxane A.sub.2 (TXA.sub.2) and an effect of accelerating the productivility of prostaglandin I.sub.2 (PGI.sub.2), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

公开(公告)号：US4731454A

公开(公告)日：1988-03-15

申请号：US55380

申请日：1987-05-29

Applicant: Masayuki Otake ,  Isamu Fukushima

Inventor： Masayuki Otake ,  Isamu Fukushima

IPC: C07D201/08 ,  C07D207/26 ,  C07D207/267 ,  C07D207/12

CPC classification number: C07D207/267 ,  C07D201/08

Abstract: A method for producing a lactam having the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, or a straight chain or branched chain alkyl group having from 1 to 5 carbon atoms, and R.sup.2 is an organic group having at least 2 carbon atoms, and connected at both ends to the cyclic acid imide group, which comprises reducing a cyclic acid imide having the formula: ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, or its precursor, with hydrogen by means of a cobalt-based catalyst comprising (a) cobalt and (b) at least one modifier component selected from the group consisting of molybdenum, tungsten and rhenium.

Abstract translation: 一种制备具有下式的内酰胺的方法：其中R1是氢原子，或具有1至5个碳原子的直链或支链烷基，R2是具有至少2个碳原子的有机基团 碳原子，并且两端连接到环状酰亚胺基团，其包括用氢气还原具有下式的其中R1和R2如上所定义的环状酰亚胺或其前体，其中通过 钴基催化剂，其包含（a）钴和（b）至少一种选自钼，钨和铼的改性剂组分。

公开(公告)号：US4731445A

公开(公告)日：1988-03-15

申请号：US007585

申请日：1987-01-28

Applicant: Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester

Inventor： Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester

IPC: B01J23/00 ,  B01J23/74 ,  B01J23/78 ,  B01J25/00 ,  C07B61/00 ,  C07D201/08

CPC classification number: C07D201/08 ,  Y02P20/52

Abstract: Caprolactam is prepared by a process in which(a) the 5-formylvalerate is reacted with excess ammonia and hydrogen in the presence of an alkanol as the solvent and in the presence of a hydrogenation catalyst under superatmospheric pressure in the liquid phase at from 40.degree. to 130.degree. C.,(b) excess ammonia and hydrogen are separated off from the reaction mixture,(c) the resulting reaction mixture is reacted with water at elevated temperatures with simultaneous removal of alkanols, and(d) the reaction mixture thus obtained is heated to 150.degree.-370.degree. C. and .epsilon.-caprolactam is obtained.

Abstract translation: 己内酰胺通过以下方法制备：其中（a）5-烷基戊酸酯与过量的氨和氢在作为溶剂的链烷醇存在下和氢化催化剂存在下，在超大气压下在40℃的液相中反应 （b）从反应混合物中分离出过量的氨和氢，（c）将所得的反应混合物在高温下与水反应，同时除去链烷醇，和（d）由此得到的反应混合物 加热至150-370℃，得到ε-己内酰胺。

公开(公告)号：US4730041A

公开(公告)日：1988-03-08

申请号：US7789

申请日：1987-01-28

Applicant: Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester ,  Heinz-Walter Schneider ,  Wolfgang Richter

Inventor： Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester ,  Heinz-Walter Schneider ,  Wolfgang Richter

IPC: B01J23/74 ,  B01J23/78 ,  B01J25/00 ,  C07B61/00 ,  C07D201/08

CPC classification number: C07D201/08 ,  Y02P20/52

Abstract: Caprolactam is prepared by a process in which(a) a 5-formylvalerate is reacted with excess ammonia and hydrogen in the presence of an alkanol as a solvent and in the presence of a hydrogenation catalyst under superatmospheric pressure in the liquid phase at from 40.degree. to 130.degree. C.,(b) excess ammonia and hydrogen are separated off from the reaction mixture and(c) the reaction mixture thus obtained is heated to 150.degree.-250.degree. C. and .epsilon.-caprolactam is obtained.

Abstract translation: 己内酰胺通过以下方法制备：其中（a）5-烷基戊酸酯与过量的氨和氢在烷醇作为溶剂的存在下和氢化催化剂的存在下在超大气压下在40℃的液相中反应 至130℃，（b）从反应混合物中分离出过量的氨和氢，（c）将所得反应混合物加热至150-250℃，得到ε-己内酰胺。

公开(公告)号：US4152331A

公开(公告)日：1979-05-01

申请号：US898214

申请日：1978-04-18

Applicant: Peter J. N. Meijer ,  Leonardus H. Geurts

Inventor： Peter J. N. Meijer ,  Leonardus H. Geurts

IPC: C07D207/267 ,  C07D201/08 ,  C07D207/26

CPC classification number: C07D201/08

Abstract: A process is described for preparing N-substituted pyrrolidones from succinonitriles by hydrogenation and hydrolysis.

公开(公告)号：US3988319A

公开(公告)日：1976-10-26

申请号：US506148

申请日：1974-09-16

Applicant: Frantisek Mares

Inventor： Frantisek Mares

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: Caprolactam is obtained in high yield and in short reaction time by completely dissolving 6-aminocaproic acid in methanol or ethanol and heating the solution at 170.degree.-200.degree. C.

Abstract translation: 通过将6-氨基己酸完全溶解在甲醇或乙醇中并在170-200℃下加热溶液，以高产率和短的反应时间获得己内酰胺。