公开(公告)号：US20030049697A1

公开(公告)日：2003-03-13

申请号：US10243035

申请日：2002-09-13

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, C.N.R.S.

Inventor： Michel Lazdunski ,  Florian Lesage ,  Francois Maingret

IPC: G01N033/567

CPC classification number: C07K14/705 ,  A61K38/00

Abstract: A mechanosensitive human potassium channel, referred to as nullhTRAAKnull for human TWICK-Related AA-Activated Knull channel, which is activated by polyunsaturated fatty acids as well as by the neuroprotective agent riluzole. The properties of the channels of the TRAAK family as well as their tissue distribution give these channels a primordial role in the transport of potassium in a large number of cell types.

Abstract translation: 机械敏感的人类钾通道，被称为“hTRAAK”用于人类TWICK相关AA激活的K +通道，其由多不饱和脂肪酸以及由神经保护剂利鲁唑激活。 TRAAK家族的通道的特性及其组织分布使得这些通道在大量细胞类型中的钾的输送中起原始作用。

公开(公告)号：US12240785B2

公开(公告)日：2025-03-04

申请号：US17312541

申请日：2019-12-09

Applicant: IMERTECH SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITÉ DE LIMOGES

Inventor： Murielle Perronnet ,  Marie Arnoult ,  Sylvie Rossignol

IPC: C04B28/00 ,  C04B38/02 ,  C04B38/10 ,  C04B103/42 ,  C04B111/28 ,  C04B111/40

Abstract: A geopolymer foam composition, an article comprising a geopolymer foam composition, methods for making a geopolymer foam composition, and uses of a geopolymer foam composition.

公开(公告)号：US12196662B2

公开(公告)日：2025-01-14

申请号：US17606101

申请日：2020-04-24

Applicant: HORIBA ABX SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE MONTPELLIER

Inventor： Pierre Taraconat ,  Damien Isebe ,  Simon Mendez ,  Franck Nicoud

IPC: G01N15/12 ,  G01N15/01

Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

公开(公告)号：US11814685B2

公开(公告)日：2023-11-14

申请号：US16758624

申请日：2018-10-24

Applicant: UNIVERSITÉ PARIS CITÉ ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Sandrine Bourdoulous ,  Anaïs Domingot ,  Camille Faure

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: This invention relates to a method for diagnosing and/or prognosticating HER2-dependent cancer in a subject, comprising a) measuring the amount of one or more miRNA selected from the group consisting of miRNA 429-3p, miRNA 29c-3p, miRNA 29a-3p, miRNA 29b-3p, miRNA 200a-3p, miRNA 200b-3p, miRNA 200c-3p, miRNA 141-3p, miRNA 15a-5p, miRNA 15b-5p, miRNA 16-5p, miRNA 424-5p, miRNA 497-5p, miRNA 615-3p, miRNA 451a-3p and miRNA 542-5p in a sample from the subject; b) comparing the amount of one or more miRNA measured in step a) to a reference value; c) finding a deviation or no deviation of the amount of one or more miRNA measured in step a) from the reference value; and d) attributing said finding of deviation or no deviation to a particular diagnosis and/or prognosis of HER2-dependent cancer in the subject.

公开(公告)号：US20230037289A1

公开(公告)日：2023-02-09

申请号：US17789073

申请日：2020-12-24

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  UNIVERSITE GRENOBLE ALPES ,  C.N.R.S. ,  INSTITUT POLYTECHNIQUE DE GRENOBLE

Inventor： Thomas LAUWERS ,  Skandar BASROUR ,  Jean-Guillaume COUTARD ,  Alain GLIERE ,  Guillaume LAFFONT

IPC: G01D5/353

Abstract: The invention relates to a device and method for detecting an acoustic wave propagating toward a membrane, the membrane carrying a waveguide comprising an optical cavity defining a resonant frequency. Under the effect of a vibration of the membrane, the resonance frequency of the optical cavity varies. The device includes a light source for directing a light wave into the optical cavity, and a servo circuit for servo-controlling the wavelength of the light wave to the resonant wavelength of the optical cavity. Monitoring the variation in the wavelength of the light wave allows an amplitude of the acoustic wave to be estimated.

公开(公告)号：US20220220316A1

公开(公告)日：2022-07-14

申请号：US17655717

申请日：2022-03-21

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE PAUL SABATIER TOULOUSE III

Inventor： Christophe LE ROUX ,  Francois MARTIN ,  Pierre MICOUD ,  Angela DUMAS

IPC: C09C1/30 ,  C01B33/44 ,  C09C1/00

Abstract: A method for preparing a composition including mineral particles functionalized by at least one organic group and having a specific surface defined according to the BET method greater than 500 m2/g, involves: —choosing a phyllosilicate composition, including mineral particles having a thickness of less than 100 nm, a largest dimension of less than 10 μm and belonging to the family of lamellar silicates; —choosing at least one functionalizing agent, from the group formed from the oxysilanes and oxygermanes having at least one organic group, —bringing the phyllosilicate composition into contact with a functionalizing solution including the functionalizing agent, so as to obtain a phyllosilicate composition including mineral particles functionalized by the organic group, while choosing the organic group from the group formed from the cationic heteroaryl groups, the quaternary ammonium groups and the salts of same. The phyllosilicate composition obtained by the method is also described.

公开(公告)号：US20220196538A1

公开(公告)日：2022-06-23

申请号：US17606101

申请日：2020-04-24

Applicant: HORIBA ABX SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE MONTPELLIER

Inventor： Pierre TARACONAT ,  Damien ISEBE ,  Simon MENDEZ ,  Franck NlCOUD

IPC: G01N15/10 ,  G01N15/12 ,  G01N15/02

Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

公开(公告)号：US20210230009A1

公开(公告)日：2021-07-29

申请号：US15733291

申请日：2018-12-21

Applicant: IMERTECH SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITÉ PAUL SABATIER TOULOUSE III

Inventor： Christophe LE ROUX ,  François MARTIN ,  Pierre MICOUD ,  Suzanne FÉRY-FORGUES ,  Mathilde POIRIER ,  Cyril AYMONIER ,  Christel CARÊME ,  Marie CLAVERIE

IPC: C01B33/40 ,  A61K8/25 ,  A61Q17/04

Abstract: The present invention relates to methods for producing mixtures comprising noble metal and phyllomineral, and compositions obtained from said methods.

公开(公告)号：US10906016B2

公开(公告)日：2021-02-02

申请号：US14382200

申请日：2013-02-28

Applicant: ISL—Institut franco-allemand de recherches de Saint-Louis ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Denis Spitzer ,  Vincent Pichot ,  Benedikt Risse

IPC: B01J3/08 ,  C06B25/04 ,  C06B25/34 ,  C01B32/26

Abstract: The present invention relates to the field of manufacturing nanoparticles, and specifically to a method for manufacturing diamond nanoparticles, or nanodiamonds, by detonation at least one explosive charge, wherein said at least one explosive charge is nanostructured.

公开(公告)号：US20200347457A1

公开(公告)日：2020-11-05

申请号：US16758624

申请日：2018-10-24

Applicant: UNIVERSITE PARIS DESCARTES ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Sandrine BOURDOULOUS ,  Anaïs DOMINGOT ,  Camille FAURE

IPC: C12Q1/6886

Abstract: This invention relates to a method for diagnosing and/or prognosticating HER2-dependent cancer in a subject, comprising a) measuring the amount of one or more miRNA selected from the group consisting of miRNA 429-3p, miRNA 29c-3p, miR-NA 29a-3p, miRNA 29b- 3p, miRNA 200a-3p, miRNA 200b-3p, miRNA 200c-3p, miRNA 141-3p, miRNA 15a-5p, miRNA 15b-5p, miRNA 16-5p, miRNA 424-5p, miRNA 497-5p, miRNA 615-3p, miRNA 451a-3p and miRNA 542-5p in a sample from the subject; b) comparing the amount of one or more miRNA measured in step a) to a reference value; c) finding a deviation or no deviation of the amount of one or more miRNA measured in step a) from the reference value; and d) attributing said finding of deviation or no deviation to a particular diagnosis and/or prognosis of HER2-dependent cancer in the subject.