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    Method for making a needle-free jet injection drug delivery device
    12.
    发明授权
    Method for making a needle-free jet injection drug delivery device 有权
    无针喷射药物输送装置的制造方法

    公开(公告)号：US08591457B2

    公开(公告)日：2013-11-26

    申请号：US11200971

    申请日：2005-08-10

    申请人： Scott J. Gilbert

    发明人： Scott J. Gilbert

    IPC分类号： A61M5/30

    CPC分类号： A61M5/30 ,  A61M5/19 ,  A61M5/2046 ,  A61M5/2053 ,  A61M5/3007 ,  A61M5/31511 ,  A61M2205/587 ,  A61M2205/59 ,  A61M2210/0612 ,  A61M2210/0618

    摘要： A method for making a jet injection drug delivery device wherein the drug delivery device has at least one drug reservoir and at least one injection nozzle includes the steps of: identifying a drug desired to be delivered; identifying a volume of the drug desired to be delivered; establishing a reservoir diameter for the at least one drug reservoir; establishing a nozzle diameter for the at least one injection nozzle; identifying a tissue model for delivery of the drug; identifying a penetration depth in the tissue model for the delivery of the drug; and injecting the drug into the tissue model under variable pressure until the desired penetration depth is achieved. The method also includes identifying an optimal pressure range for the drug delivery device that achieves the desired penetration depth.

    摘要翻译： 一种制备喷射药物输送装置的方法，其中所述药物递送装置具有至少一个药物储存器和至少一个注射喷嘴，包括以下步骤：鉴定期望被输送的药物; 确定期望送达的药物的体积; 建立所述至少一个药物储存器的储存器直径; 为所述至少一个喷嘴建立喷嘴直径; 识别用于递送药物的组织模型; 识别用于递送药物的组织模型中的穿透深度; 并在可变压力下将药物注入组织模型中，直到达到期望的穿透深度。 该方法还包括识别实现期望的穿透深度的药物递送装置的最佳压力范围。

    CONTROLLED RELEASE FORMULATIONS OF OPIOID AND NONOPIOID ANALGESICS
    15.
    发明申请
    CONTROLLED RELEASE FORMULATIONS OF OPIOID AND NONOPIOID ANALGESICS 审中-公开
    阿片类和非诺贝特药物的控制释放配方

    公开(公告)号：US20130209525A1

    公开(公告)日：2013-08-15

    申请号：US13781420

    申请日：2013-02-28

    申请人： ALZA CORPORATION

    发明人： Evangeline Cruz ,  Atul D. Ayer ,  Brenda J. Pollock ,  Carmelita Garcia ,  Sherry Li ,  Alfredo M. Wong ,  Lawrence G. Hamel ,  Cheri Enders Klein ,  Yihong Qiu ,  Ye Huang

    IPC分类号： A61K31/485 ,  A61K9/20 ,  A61K31/167

    CPC分类号： A61K9/2086 ,  A61K9/0004 ,  A61K9/209 ,  A61K9/4808 ,  A61K9/5084 ,  A61K31/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

    摘要： Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.8 ng/mL/mg and 7.9 ng/mL/mg and an AUC for acetaminophen of between about 28.6 ng*hr/mL/mg and about 59.1 ng*hr/mL/mg (per mg acetaminophen administered) after a single dose.

    摘要翻译： 提供了持续释放剂型，每天两次口服给予患者以缓解疼痛。 持续释放剂型包括速释组分和持续释放组分，其中速释组分和持续释放组分共同含有治疗有效量的阿片样镇痛剂和治疗有效量的非阿片类止痛剂。 在优选的实施方案中，非阿片类镇痛剂是对乙酰氨基酚，阿片类镇痛剂是氢可酮及其药学上可接受的盐，并且在优选的实施方案中，药学上可接受的盐是酒石酸氢盐。 剂型在患者中产生血浆曲线，其特征在于氢可酮的C max为约0.6ng / mL / mg至约1.4ng / mL / mg，氢可酮的AUC为约9.1ng * hr / mL / mg至约 19.9ng * hr / mL / mg（每毫克给予的氢可酮酮可乐酮），对乙酰氨基酚的C max为约2.8ng / mL / mg至7.9ng / mL / mg，对乙酰氨基酚的AUC为约28.6ng * hr / mL / mg和约59.1ng * hr / mL / mg（施用每mg对乙酰氨基酚）。

    Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms
    16.
    发明授权
    Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms 有权
    用于确定多层药物剂型的制剂取向的方法和装置

    公开(公告)号：US08323691B2

    公开(公告)日：2012-12-04

    申请号：US12402075

    申请日：2009-03-11

    申请人： Johan H. Geerke ,  Steven F. Stone

    发明人： Johan H. Geerke ,  Steven F. Stone

    IPC分类号： A61K9/24 ,  A61K9/62 ,  G01J3/46

    CPC分类号： A61K9/0004 ,  G01N21/9508

    摘要： Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.

    摘要翻译： 需要快速准确地测定多层胶囊形片剂相对于片剂相对的窄而圆形端部附近的不同内部制剂层的制剂取向。 通过在多层渗透片中包含适当的配色方案，可以通过检测对应于一种或另一种制剂层的片剂一侧上的斑点位置处的颜色或两种制剂的一种或另一种界面来检测制剂取向的检测 取决于片剂的制剂取向。

    Two-part electrotransport device
    17.
    发明授权
    Two-part electrotransport device 有权
    两部分电转运装置

    公开(公告)号：US08301238B2

    公开(公告)日：2012-10-30

    申请号：US13250031

    申请日：2011-09-30

    申请人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    发明人： Zita S. Netzel ,  John Lemke ,  David Seward ,  Brian W. Read ,  Bradley E. White ,  Corinna X. Chen ,  Paul Hayter

    IPC分类号： A61N1/30

    CPC分类号： A61N1/08 ,  A61N1/0412 ,  A61N1/0448 ,  A61N1/325 ,  Y10T29/49117

    摘要： A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.

    摘要翻译： 描述了开关操作的治疗剂递送装置。 该装置包括两个部件，它们在使用之前由使用者组装。 第一部分包含设备的电源和电路; 并且第二部分包括含有要递送的治疗剂的电极和储存器。 组合装置的两个部分的动作导致两个部分不可逆地耦合在一起，完成两部分之间的电连接，并闭合一个或多个开关，从而将诸如电池的电源连接到装置的 电路，从而为设备供电以使其准备使用。 然后，该装置可以附接到患者，他们可以通过按正确的顺序按下按钮来操作该装置。

    Electrotransport device having a reservoir housing having a flexible conductive element
    18.
    发明授权
    Electrotransport device having a reservoir housing having a flexible conductive element 有权
    具有具有柔性导电元件的储存器壳体的电子运输装置

    公开(公告)号：US08224435B2

    公开(公告)日：2012-07-17

    申请号：US10814705

    申请日：2004-03-30

    申请人： J. Richard Gyory

    发明人： J. Richard Gyory

    IPC分类号： A61N1/30

    CPC分类号： A61N1/044 ,  A61N1/0448

    摘要： This invention relates to an electrotransport device, which incorporates a flexible conductive element within the reservoir housing of the device, which permits electrical communication from within the housing to outside of the housing without the use of opening, which require various methods of sealing the opening against leaks and moisture.

    摘要翻译： 本发明涉及一种电输送装置，其将柔性导电元件结合在装置的储存器壳体内，其允许从壳体内部到壳体外部的电连通而不使用开口，这需要各种将开口密封的方法抵靠 泄漏和潮湿。

    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
    19.
    发明授权
    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权

    公开(公告)号：US07761147B2

    公开(公告)日：2010-07-20

    申请号：US11084628

    申请日：2005-03-18

    申请人： Wendy A. Young ,  Michel J. N. Cormier

    发明人： Wendy A. Young ,  Michel J. N. Cormier

    IPC分类号： A61N1/30 ,  A61K9/22

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    Electrotransport delivery device with voltage boosting circuit
    20.
    发明授权
    Electrotransport delivery device with voltage boosting circuit 失效
    带升压电路的电子输送装置

    公开(公告)号：US07708731B2

    公开(公告)日：2010-05-04

    申请号：US10999504

    申请日：2004-11-30

    申请人： Thomas A. Riddle ,  Larry A. McNichols ,  John D. Badzinski

    发明人： Thomas A. Riddle ,  Larry A. McNichols ,  John D. Badzinski

    IPC分类号： A61M31/00

    CPC分类号： A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

    摘要： An electrotransport device (10) for delivering therapeutic agents includes an adjustable voltage boos multiple controller (100, 200) for boosting the voltage from a power source (102, 202) to a working voltage Vw having a value just sufficient to provide the desired therapeutic current level II through the electrodes (108, 112), at least of which contains the therapeutic agent to be delivered.

    摘要翻译： 用于递送治疗剂的电输送装置（10）包括用于将来自电源（102,202）的电压升高到具有刚好足以提供所需治疗剂的值的工作电压Vw的可调节电压波形多重控制器（100,200） 电流水平II通过电极（108,112），其至少包含待递送的治疗剂。