公开(公告)号：US07855186B2

公开(公告)日：2010-12-21

申请号：US12586167

申请日：2009-09-17

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： C07H21/04

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/11 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.

公开(公告)号：US07829696B2

公开(公告)日：2010-11-09

申请号：US12590252

申请日：2009-11-04

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： C07H21/04

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/11 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APP.

摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对APP的核苷酸序列的那些。

公开(公告)号：US07816512B2

公开(公告)日：2010-10-19

申请号：US12590097

申请日：2009-11-02

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： C07H21/04

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/11 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for proto-oncogene MET.

公开(公告)号：US07811969B2

公开(公告)日：2010-10-12

申请号：US10535589

申请日：2003-11-04

申请人： Rainer Domesle ,  Thomas Kreuzer ,  Egbert Lox

发明人： Rainer Domesle ,  Thomas Kreuzer ,  Egbert Lox

IPC分类号： B01J21/04

CPC分类号： B01J37/0018 ,  B01J35/0006 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0217 ,  F01N2250/02 ,  F01N2330/10

摘要： The invention relates to a process for the coating of a catalyst support with a catalytically active coat using a coating dispersion, the catalyst support containing at least two partial structures which differ in their absorptivity for the coating dispersion. The process is characterized in that the absorptivity of the partial structures is modified relative to one another by precoating of the catalyst support with a material which can be burnt out or with liquid, and the catalytic coat is then applied to the filter body in a known manner, dried and/or calcined.

摘要翻译： 本发明涉及一种使用涂料分散体涂覆具有催化活性涂层的催化剂载体的方法，所述催化剂载体含有至少两种对于涂料分散体的吸收率不同的部分结构。 该方法的特征在于，部分结构的吸收率相对于彼此通过用可燃烧或用液体的材料预涂覆催化剂载体而改变，然后将催化涂层以已知的方式施加到过滤器体上 方式，干燥和/或煅烧。

公开(公告)号：USD622757S1

公开(公告)日：2010-08-31

申请号：US29350023

申请日：2009-11-10

申请人： Jean Mouclier

设计人： Jean Mouclier

公开(公告)号：US07735312B2

公开(公告)日：2010-06-15

申请号：US10589424

申请日：2005-02-04

申请人： Martin Votsmeier ,  Juliane Kluge ,  Ulrich Goebel ,  Jürgen Gieshoff ,  Thomas Kreuzer

发明人： Martin Votsmeier ,  Juliane Kluge ,  Ulrich Goebel ,  Jürgen Gieshoff ,  Thomas Kreuzer

IPC分类号： F01N3/00

CPC分类号： F01N11/005 ,  B01D53/9495 ,  F01N3/0871 ,  F01N3/0885 ,  F01N2430/06 ,  F01N2550/03 ,  Y02T10/20 ,  Y02T10/47

摘要： When a nitrogen oxide storage catalyst is being regenerated, the regeneration may be terminated for example as a result of a premature load change in the engine, which can lead to incomplete emptying of the storage catalyst. The residual filling level which remains in the catalyst following an incomplete regeneration of this nature is used as the starting value for calculation of the filling level during the next storage phase. After incomplete regeneration, the nitrogen oxide conversion rate is initially greater than would be expected, on account of the residual filling level. By taking this increased conversion rate into account when calculating the filling level during the storage phase, it is possible to further improve the accuracy of the calculation.

摘要翻译： 当再生氮氧化物储存催化剂时，例如由于发动机过早的负荷变化的结果，再生可能终止，这可导致储存催化剂的不完全排空。 在这种性质的不完全再生之后残留在催化剂中的残余填充量被用作在下一个储存阶段期间计算填充量的起始值。 在不完全再生之后，氮氧化物转化率最初大于预期的，因为残留的填充量。 通过在存储阶段计算填充水平时考虑到提高的转换率，可以进一步提高计算的准确性。

公开(公告)号：USD615881S1

公开(公告)日：2010-05-18

申请号：US29310079

申请日：2008-07-24

申请人： Arnaud Chastaingt

设计人： Arnaud Chastaingt

公开(公告)号：USD614050S1

公开(公告)日：2010-04-20

申请号：US29342005

申请日：2009-08-17

申请人： Jacques Diltoer

设计人： Jacques Diltoer

公开(公告)号：USD611987S1

公开(公告)日：2010-03-16

申请号：US29332895

申请日：2009-02-27

申请人： Jean Mouclier

设计人： Jean Mouclier

公开(公告)号：US07678896B2

公开(公告)日：2010-03-16

申请号：US11818938

申请日：2007-06-15

申请人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

发明人： Anastasia Khvorova ,  Angela Reynolds ,  Devin Leake ,  William Marshall ,  Steven Read ,  Stephen Scaringe

IPC分类号： A61K31/70 ,  C07H21/04

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/11 ,  G06F19/18

摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to STK12.

摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对STK12的那些。