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11.发明授权公开(公告)号：US11223479B1
公开(公告)日：2022-01-11
申请号：US17398340
申请日：2021-08-10
申请人： CyLogic, Inc.
摘要： A unique identifier id(f) is generated for file f and stored on a content address server. A symmetric encryption key KF is generated for file f. File f is divided into n segments. A unique identifier id(si) is generated for each segment si. Each segment si of the n segments is encrypted using the symmetric key KF using a symmetric encryption algorithm, producing n encrypted segments esi. Each encrypted segment esi is stored with its identifier id(si) on the first peer device and at least one other peer device. For each encrypted segment esi, the identifier id(si) is stored on the content address server with the identifier id(f). A public key KU2 of a second user is retrieved, the symmetric key KF is encrypted with key KU2, producing wrapped key KW2=EAKU2(KF), and key KW2 is stored on the content address server with identifier id(f).
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公开(公告)号：US11134882B1
公开(公告)日：2021-10-05
申请号：US16561304
申请日：2019-09-05
申请人： Guangren Chen , Jia Li Chen , Rong Yang
发明人： Guangren Chen , Jia Li Chen , Rong Yang
摘要： Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients or to a set of rules developed from the database. An ST segment and one or more ST subwaveforms within the ST segment are identified from the plurality of subwaveforms and discontinuity points based on the comparison. The ECG waveform with the one or more ST subwaveforms within the ST segment is displayed.
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13.发明授权公开(公告)号：US11107666B2
公开(公告)日：2021-08-31
申请号：US17087051
申请日：2020-11-02
发明人： Ronald F. Bonner , Stephen A. Tate
IPC分类号： H01J49/00
摘要： Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample.
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公开(公告)号：US10813447B2
公开(公告)日：2020-10-27
申请号：US16270384
申请日：2019-02-07
发明人： Kevin Chunhao Tsai
摘要： The present disclosure relates to a support system for a gaming table including a first support bar of a gaming-table support, a second support bar of a gaming-table support, a third support bar of a gaming-table support, and a gaming-table support locking apparatus. The third support bar has an arcuate shape and is in a pivotable connection with the second support bar. The gaming-table support locking apparatus includes a first locking bar and a second locking bar. The second locking bar is configured to be in one of two states of being: a first state that allows the third support bar to rotate with respect to the second support bar; and a second state that prevents the third support bar to rotate with respect to the second support bar.
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公开(公告)号：US10732156B2
公开(公告)日：2020-08-04
申请号：US15303690
申请日：2015-04-14
发明人： Gordana Ivosev
摘要： Systems and methods are provided for calculating the area of a peak profile using information from one or more correlated peak profiles. One or more compounds are separated from a mixture over time using a separation device. Traces of the one or more compounds are monitored during the separation using a tandem mass spectrometer. A plurality of intensity measurements are received using a processor. A first peak profile for a compound of interest is detected from the plurality of intensity measurements for a first trace and one or more correlated peak profiles for the compound of interest are detected from the plurality of intensity measurements for one or more other traces using the processor. An area of the first peak profile is calculated based on the one or more correlated peak profiles using the processor.
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16.发明授权公开(公告)号：US10651019B2
公开(公告)日：2020-05-12
申请号：US16320111
申请日：2017-07-19
摘要： A system is disclosed for identifying a precursor ion of a product ion in a scanning DIA experiment. A precursor ion mass selection window is scanned across a precursor ion mass range of interest, producing a series of overlapping windows across the precursor ion mass range. Each overlapping window is fragmented and mass analyzed, producing a plurality of product ion spectra for the mass range. A product ion is selected from the spectra. Intensities for the selected product ion are retrieved for at least one scan across the mass range producing a trace of intensities versus precursor ion m/z. A matrix multiplication equation is created that describes how one or more precursor ions correspond to the trace for the selected product ion. The matrix multiplication equation is solved for one or more precursor ions corresponding to the selected product ion using a numerical method.
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公开(公告)号：US10395908B2
公开(公告)日：2019-08-27
申请号：US15310845
申请日：2015-05-07
摘要： At least one product ion mass spectrum produced by a tandem mass spectrometer is received. A chemical structure of a compound that corresponds to the at least one product ion mass spectrum is received. One or more elemental compositions are assigned to at least one peak in the at least one product ion spectrum based on the chemical structure using the processor. At least one elemental composition of the one or more assigned elemental compositions is selected for the at least one peak using the processor. The mass of the at least one peak is converted to the mass of the selected at least one elemental composition using the processor, producing a product ion mass spectrum with higher mass accuracy.
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公开(公告)号：US10256083B2
公开(公告)日：2019-04-09
申请号：US15089527
申请日：2016-04-02
发明人： Takashi Baba
摘要： Systems and methods for identifying precursor ions of product ions from combined product ion spectra are provided. N precursor ions are selected. N groups of the N precursor ions are created. The tandem mass spectrometer is instructed to perform multiplexed precursor ion selection on the continuous beam of ions, fragment each of the N−1 precursor ions, and measure the intensities of the product ions, producing N product ion spectra. A heat map is plotted, producing N heat maps. The N product ion spectra are combined into a combined product ion spectrum. A corresponding precursor ion of a peak is identified by finding a heat map of the N heat maps that does not have data for the mass of the peak and determining that a precursor ion of the N precursor ions that is not included in a group that produced the heat map is the corresponding precursor ion.
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19.发明授权公开(公告)号：US10141169B2
公开(公告)日：2018-11-27
申请号：US14427564
申请日：2013-10-16
发明人： Stephen A. Tate , Ronald F. Bonner
摘要： Systems and methods are provided for identifying a precursor ion without using any a priori precursor ion information. In one method, a sample is analyzed using a tandem mass spectrometer, producing at least one measured product ion spectrum from a precursor mass-to-charge ratio range. The at least one measured product ion spectrum are received. A subset of measured product ions is selected from the at least one measured product ion spectrum. A list of candidate compounds is created by searching a dictionary of potential compounds that includes one or more predicted product ions for each of the potential compounds using the subset of measured product ions. A candidate compound on the list is selected as the identified compound. In another method, the measured product ions are assumed to correspond to shortened forms of the peptide and a protein database is searched for shortened forms of the peptide.
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公开(公告)号：US10079137B2
公开(公告)日：2018-09-18
申请号：US15544021
申请日：2016-01-29
发明人： Nic G. Bloomfield
CPC分类号： H01J49/0045 , H01J49/0031 , H01J49/04 , H01J49/063
摘要： A sample is ionized using an ion source and the ion beam is received using a tandem mass spectrometer. An m/z range is divided into two or more precursor ion isolation windows. Two or more values for a fragmentation parameter are selected. A first value of the two or more values for the fragmentation parameter has a level that fragments a minimal amount of ions of the ion beam. The one or more additional values have increasingly aggressive levels that produce increasingly more fragmentation of the ions of the ion beam. For each precursor ion isolation window, the tandem mass spectrometer is instructed to perform a selection and fragmentation of the ion beam using the precursor ion isolation window and the first value and is instructed to perform one or more additional selections and fragmentations of the ion beam using the precursor ion isolation window and using the one or more additional values.
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