公开(公告)号：US09056100B2

公开(公告)日：2015-06-16

申请号：US14311102

申请日：2014-06-20

Applicant: Almirall, S.A.

Inventor： Maria Dolors Fernandez Forner ,  Maria Prat Quinones ,  Maria Antonia Buil Albero

IPC: A61K31/439 ,  A61K31/56 ,  A61K31/4745 ,  A61K45/06 ,  C07D453/02

CPC classification number: A61K31/439 ,  A61K9/0073 ,  A61K9/0075 ,  A61K31/4745 ,  A61K31/56 ,  A61K45/06 ,  A61K47/26 ,  C07D453/02 ,  Y10S514/826 ,  A61K2300/00

Abstract: Provided is a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide and methods of using the same.

Abstract translation: 提供了包含3（R） - （2-羟基-2,2-二噻吩-2-基乙酰氧基）-1-（3-苯氧基丙基）-1-氮鎓双环[2.2.2]辛烷溴化物的粉末吸入剂和使用 相同。

公开(公告)号：US20150111971A1

公开(公告)日：2015-04-23

申请号：US14398875

申请日：2013-05-13

Applicant: Almirall, S.A.

Inventor： Dirk-Heinrich Evers ,  Sabine Fielhauer ,  Sascha Gorissen ,  Michael Herbig ,  Henning Mallwitz ,  Christoph Willers

IPC: A61K31/137 ,  A61K47/18

CPC classification number: A61K31/137 ,  A61K9/06 ,  A61K31/17 ,  A61K47/18 ,  A61K47/26 ,  A61K2300/00

Abstract: The present invention relates to a topical pharmaceutical composition comprising, based on the total weight of the composition: a) from 1.5 wt. % to 5 wt. % of terbinafine or any pharmaceutically acceptable salt thereof; b) from 15 wt. % to 35 wt. % of urea; and c) more than 25 wt. % of water.

Abstract translation: 本发明涉及局部药物组合物，其包含基于组合物的总重量：a）1.5wt。 ％至5wt。 特比萘芬或其任何药学上可接受的盐的百分比; b）15wt。 ％〜35重量％ 尿素％ 和c）大于25wt。 ％的水。

公开(公告)号：US20150000657A1

公开(公告)日：2015-01-01

申请号：US14373563

申请日：2013-01-17

Applicant: Almirall, S.A.

Inventor： Martin Herder ,  Gerhard Ludanek ,  Ingo Mett ,  Joachim Schmidt

IPC: A61M15/00

CPC classification number: A61M15/0066 ,  A61M15/0016 ,  A61M15/0026 ,  A61M15/0065 ,  A61M15/0073 ,  A61M15/0081 ,  A61M15/0091 ,  A61M15/0095 ,  A61M15/0096 ,  A61M2202/064 ,  A61M2205/584 ,  A61M2206/16 ,  F04C2270/0421

Abstract: The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when pressed by the patient. Said dosage key (5) while being pressed is only temporarily engaged with said transportation mechanism such that a metering cycle while be completed and the transportation mechanism and/or the metering means will be reset even if said dosage key (5) will be held in depressed condition.

Abstract translation: 本发明涉及一种由吸入引起的气流由患者接收的粉末药物的吸入装置，其包括至少一个粉末储存器，用于从贮存器反复计量粉末剂量的计量装置，用于移动所述计量 从填充位置的装置，用于将粉末剂量接收到用于将所述粉末剂量释放到粉末通道中的排空位置，用于由患者手动操作的至少一个致动装置，所述致动装置可操作地连接到所述运输机构，使得在操作 正在计量单一粉剂量，所述活化装置包括当由患者按压时作用在所述运输机构上的剂量密钥（5）。 所述剂量键（5）在被按压时仅暂时与所述运送机构接合，使得即使所述剂量密钥（5）将被保持在中，也可以完成计量循环，并且运送机构和/或计量装置将被重置 沮丧的状况。

公开(公告)号：US20140349981A1

公开(公告)日：2014-11-27

申请号：US14371045

申请日：2012-12-18

Applicant: ALMIRALL, S.A.

Inventor： Fritjof Evers ,  Sabine Fielhauer ,  Henning Mallwitz ,  Hagen Trommer ,  Christoph Willers

IPC: A61K31/573 ,  A61K31/192

CPC classification number: A61K31/573 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/192 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K2300/00

Abstract: Topical pharmaceutical compositions are described comprising: (a) bexarotene; (b) a corticosteroid; and (c) a carrier or vehicle. Said compositions are useful for the treatment of skin disorders.

Abstract translation: 描述了局部药物组合物，其包含：（a）贝沙罗烯; （b）皮质类固醇; 和（c）承运人或车辆。 所述组合物可用于治疗皮肤病症。

公开(公告)号：US20140038928A1

公开(公告)日：2014-02-06

申请号：US14048344

申请日：2013-10-08

Applicant: ALMIRALL, S.A.

Inventor： Thorsten RUF ,  Eric Massana Montejo

IPC: A61K31/4704 ,  A61M15/00 ,  A61K45/06

CPC classification number: A61K31/4704 ,  A61K45/06 ,  A61M15/0065 ,  C07D215/26

Abstract: The present invention provides a compound which is a hydroxyquinolinone derivative of formula (I), in the form of a racemate, a stereoisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for use in a method of treating a pulmonary disease or condition associated with β2 adrenergic receptor activity in a mammal, in which the compound is administered by the inhalatory route at a metered nominal dose of less than 5 μg.

Abstract translation: 本发明提供一种化合物，其为式（I）的羟基喹啉酮衍生物，其为外消旋体，立体异构体或其立体异构体或其药学上可接受的盐或溶剂化物的混合物形式，用于治疗肺部 与哺乳动物中的β2肾上腺素能受体活性相关的疾病或病症，其中化合物以小于5杯的计量标称剂量通过吸入途径给药。

公开(公告)号：US20140000602A1

公开(公告)日：2014-01-02

申请号：US13921779

申请日：2013-06-19

Applicant: ALMIRALL, S.A.

Inventor： Martin Herder ,  Gerhard Ludanek ,  Ingo Mett

IPC: A61M15/00

CPC classification number: A61M15/0091 ,  A61M15/0015 ,  A61M15/0026 ,  A61M15/0065 ,  A61M15/007 ,  A61M15/0076 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0096 ,  A61M2202/064 ,  A61M2205/583 ,  A61M2205/8293

Abstract: To provide an inhalation device which has improved use properties, particularly advanced moisture protection while in use, an inhalation device (1) for powder drugs is proposed comprising at least one storage chamber (13) for accommodating a plurality of drug powder doses and a dosing device which includes at least one dosing slider (15) which is movable approximately with a translatory movement in a dosing slider passage (16) at least from a filling position into an emptying position, wherein the inhalation device (1) further includes a device for inhalation-triggered automatic movement of the dosing slider (15) from its filling position into the emptying position and a return device for automatic movement of the dosing slider (15) back into the filling position.

Abstract translation: 为了提供具有改进的使用特性的吸入装置，在使用时特别是高度的防潮保护，提出了一种用于粉末药物的吸入装置（1），其包括至少一个用于容纳多个药物粉末剂量的储存室（13） 装置，其包括至少一个计量滑块（15），所述至少一个计量滑块（15）可在至少从填充位置到排空位置的大体上在定量滑块通道（16）中大致移动，其中吸入装置（1）还包括用于 吸入触发自动将定量滑块（15）从其填充位置自动移动到排空位置，以及用于将定量滑块（15）自动移动到填充位置的返回装置。

公开(公告)号：US20130189317A1

公开(公告)日：2013-07-25

申请号：US13692032

申请日：2012-12-03

Applicant: Almirall, S.A.

Inventor： Rosa Lamarca CASADO ,  Gonzalo De Miquel Serra

IPC: A61K31/439 ,  A61K45/06

CPC classification number: A61K31/439 ,  A61K9/0075 ,  A61K31/167 ,  A61K31/46 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder of a pharmaceutically acceptable salt in admixture with a pharmaceutically acceptable dry powder carrier, providing a metered nominal dose of aclidinium equivalent to about 400 micrograms aclidinium bromide.

Abstract translation: 本公开涉及用于吸入的药物组合物，其包含与药学上可接受的盐的干燥粉末形式的药物组合物，其与药学上可接受的干粉载体混合，提供计量的标称剂量的吖啶鎓当量至约400微克溴化吖啶鎓。

公开(公告)号：US11000517B2

公开(公告)日：2021-05-11

申请号：US16019855

申请日：2018-06-27

Applicant: Almirall, S.A.

Inventor： Rosa Lamarca Casado ,  Gonzalo De Miquel Serra

IPC: A61K31/439 ,  A61K9/00 ,  A61K31/46 ,  A61K31/167 ,  A61K45/06

Abstract: The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder of a pharmaceutically acceptable salt in admixture with a pharmaceutically acceptable dry powder carrier, providing a metered nominal dose of aclidinium equivalent to about 400 micrograms aclidinium bromide.

公开(公告)号：US10828433B2

公开(公告)日：2020-11-10

申请号：US14373568

申请日：2013-01-17

Applicant: Almirall, S.A.

Inventor： Martin Herder ,  Gerhard Ludanek ,  Ingo Mett ,  Joachim Schmidt

IPC: A61M15/00

Abstract: The invention refers to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when actuated by the patient. According to the invention, said transportation mechanism furthermore comprises a dosage lever (6) acting on said metering means, said dosage lever (6) being locked in the inhalation position of said metering means after said dosage key (5) has been properly pressed down by the patient. The dosage lever (6) in the inhalation position engages a trigger member and is releasable by actuation of the trigger member. The trigger member comprises at least one cam surface and the dosage lever (6) engages the cam surface tangentially in said locked inhalation position.

公开(公告)号：US10512740B2

公开(公告)日：2019-12-24

申请号：US14373572

申请日：2013-01-17

Applicant: Almirall, S.A.

Inventor： Martin Herder ,  Gerhard Ludanek ,  Ingo Mett ,  Joachim Schmidt

IPC: A61M15/00

Abstract: The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when pressed by the patient. The inhalation device further comprises an advancing mechanism for advancing a counter means each time the inhalation device has been activated by the patient so that a powder dose has been released into the powder channel. The counter means comprises a mechanical index coupled to a locking mechanism blocking the dosage key (5) and/or the activating device and/or the transportation mechanism after a predetermined number of metering cycles after detection of the index. Moreover, the locking mechanism includes a locking lever (7) for positive engagement with the dosage key (5) and/or the activating device and/or the transportation mechanism in the blocked condition. The inhalation device (1) is characterized in that the locking lever includes signaling means integrally formed therewith engaging the index after said predetermined number of metering cycles.