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    DEVICE FOR COLLECTION AND ASSAY OF ORAL FLUIDS
    11.
    发明申请
    DEVICE FOR COLLECTION AND ASSAY OF ORAL FLUIDS 审中-公开
    口服液的收集和测定装置

    公开(公告)号：US20120149124A1

    公开(公告)日：2012-06-14

    申请号：US13301067

    申请日：2011-11-21

    申请人： Ronald W. MINK ,  Andrew S. GOLDSTEIN ,  Robert C. BOHANNON

    发明人： Ronald W. MINK ,  Andrew S. GOLDSTEIN ,  Robert C. BOHANNON

    IPC分类号： G01N30/90

    CPC分类号： A61B10/0051 ,  A61B2010/0006 ,  G01N30/90 ,  Y10S435/974 ,  Y10S436/81

    摘要： A method and a device for collection and assay of oral fluids are disclosed. The method places an assay device into an oral cavity, removes the device, and determines the presence or absence of an analyte. The assay device comprises an assay portion housing a lateral flow assay strip, a neck portion extending from the assay portion and forming a channel for fluid delivery to the assay strip; a collection strip in fluid communication with the lateral flow assay strip; and a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip. The channel is defined by a narrow part proximal to the assay portion and a part which receives oral fluid and has a substantially wider channel width. The collection strip has a first portion disposed within the channel and a second portion protruding outwardly from the neck opening.

    摘要翻译： 公开了用于收集和测定口腔液体的方法和装置。 该方法将测定装置放入口腔，去除装置，并确定分析物的存在或不存在。 测定装置包括容纳侧流测定条的测定部分，从测定部分延伸的颈部，并形成用于流体输送到测定条的通道; 与侧流测定条流体连通的收集条; 以及连接在侧流测定条和收集条之间并与其流动连通的阻挡条。 通道由靠近测定部分的狭窄部分和接收口腔液体的部分限定，并且具有基本更宽的通道宽度。 收集带具有设置在通道内的第一部分和从颈部开口向外突出的第二部分。

    DIAGNOSTIC DEVICE AND METHOD FOR SENSING HYDRATION STATE OF A MAMMALIAN SUBJECT
    12.
    发明申请
    DIAGNOSTIC DEVICE AND METHOD FOR SENSING HYDRATION STATE OF A MAMMALIAN SUBJECT 失效
    诊断装置和感染MAMMALIAN主题水文状态的方法

    公开(公告)号：US20120083711A1

    公开(公告)日：2012-04-05

    申请号：US13249521

    申请日：2011-09-30

    申请人： Andrew S. Goldstein ,  Frank Bellizzi

    发明人： Andrew S. Goldstein ,  Frank Bellizzi

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

    摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

    摘要翻译： 在预定体积容量的液体收集元件中收集唾液的定时感测可以用于确定唾液分泌速率，这可以指示脱水或脱水的状态。 通过感测唾液中至少一种分析物的浓度（例如，通过在侧流装置中进行的免疫色谱测定）来进一步增强唾液流速的感测，以便确定脱水或脱水的状态。 可以刺激唾液的产生，并且可以分析收集的唾液以产生指示所收集的唾液中至少一种分析物的浓度的存在和/或相关性的分析物检测信号，以感测脱水或脱水的状态。

    Device for collection and assay of oral fluids
    13.
    发明授权
    Device for collection and assay of oral fluids 有权
    用于收集和测定口腔液的装置

    公开(公告)号：US06303081B1

    公开(公告)日：2001-10-16

    申请号：US09292293

    申请日：1999-04-15

    申请人： Ronald W. Mink ,  Andrew S. Goldstein

    发明人： Ronald W. Mink ,  Andrew S. Goldstein

    IPC分类号： G01N3090

    CPC分类号： A61B10/0051 ,  A61B2010/0006 ,  G01N30/90 ,  Y10S435/974 ,  Y10S436/81 ,  Y10T436/25

    摘要： A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.

    摘要翻译： 公开了一种用于将含水流体从口腔收集和输送到用于测试的侧向色谱条的装置。 侧向色谱条放置在限定在壳体中的空腔内并沿其延伸。 提供至少一个侧向色谱条的检查位置，以便检查侧向色谱条上的选定位点以便测试结果。 多孔芯材料在一端从外壳突出到外壳的收集位置，并在另一端与侧向色谱条连通。 多孔芯材料具有颗粒结构，颗粒吸附口腔液体，以将流体从嘴部输送到侧向色谱条而无需实质吸收。 多孔芯材料的颗粒被结合在一起以限定用于要输送的口腔液体的流动的连续间隙体积，并被处理为与吸附的口腔液体亲水。 多孔芯材料容易地将口腔液体释放到侧向色谱条上。 由于多孔芯材料的迂回流动路径，防止从侧向色谱条带逆向流入口腔。 咬合板联接到壳体并且可插入患者的牙齿之间，以将多孔芯放置在口腔中以收集口腔液体。 咬合板通常通过牙齿的咬合力（优选地为臼齿和/或双尖牙）保持在适当的位置，以将多孔芯放置在口腔空间中。 在测试装置处于口中时，通过观察侧向色谱条即可得到结果。

    Method of detecting AIDS virus infection
    16.
    发明授权
    Method of detecting AIDS virus infection 失效
    检测艾滋病毒感染的方法

    公开(公告)号：US4904581A

    公开(公告)日：1990-02-27

    申请号：US877609

    申请日：1986-06-23

    申请人： Denis R. Burger ,  Andrew S. Goldstein

    发明人： Denis R. Burger ,  Andrew S. Goldstein

    IPC分类号： C07K16/10

    CPC分类号： C07K16/1045 ,  Y10S435/974 ,  Y10S530/808 ,  Y10S530/809 ,  Y10S530/864

    摘要： A method is disclosed for detecting the presence of HTLV III infected cells in a medium. The method comprises contacting the medium with monoclonal antibodies against an antigen produced as a result of the infection and detecting the binding of the antibodies to the antigen. The antigen may be a gene product of the HTLV III virus or may be bound to such gene product. On the other hand the antigen may not be a viral gene product but may be produced as a result of the infection and may further be bound to a lymphocyte. The medium may be a human body fluid or a culture medium. A particular embodiment of the present method involves a method for determining the presence of a AIDS virus in a person. The method comprises combining a sample of a body fluid from the person with a monoclonal antibody that binds to an antigen produced as a result of the infection and detecting the binding of the monoclonal antibody to the antigen. The presence of the binding indicates the presence of a AIDS virus infection. Also disclosed are novel monoclonal antibodies, noval compositions of matter, and novel diagnostic kits.

    摘要翻译： 公开了一种用于检测培养基中HTLV III感染细胞的存在的方法。 所述方法包括使所述培养基与针对感染结果产生的抗原的单克隆抗体接触并检测抗体与抗原的结合。 抗原可以是HTLV III病毒的基因产物，或者可以与该基因产物结合。 另一方面，抗原可能不是病毒基因产物，但可以作为感染的结果产生，并且可能进一步结合淋巴细胞。 培养基可以是人体液或培养基。 本方法的一个具体实施方案涉及一种用于确定个体中AIDS病毒存在的方法。 该方法包括将来自该人的体液样品与结合与感染结果产生的抗原结合的单克隆抗体并检测单克隆抗体与抗原的结合。 结合物的存在表明艾滋病病毒感染的存在。 还公开了新型单克隆抗体，物质的noval组合物和新型诊断试剂盒。

    Synthetic oral fluid standard
    17.
    发明授权
    Synthetic oral fluid standard 失效
    合成口服液标准

    公开(公告)号：US5736322A

    公开(公告)日：1998-04-07

    申请号：US608431

    申请日：1996-02-28

    申请人： Andrew S. Goldstein

    发明人： Andrew S. Goldstein

    IPC分类号： G01N33/50 ,  C12Q1/70 ,  A61K38/47 ,  A61K7/28 ,  A01N59/08

    CPC分类号： G01N33/50

    摘要： A substitute oral fluid standard for testing, calibration, and standardization of devices and methods for collection, storage, and analysis of oral fluids. The oral fluid standard comprises a mucin and a protease inhibitor.

    摘要翻译： 用于口腔液收集，储存和分析的装置和方法的测试，校准和标准化的替代口服液标准。 口服液标准品包括粘蛋白和蛋白酶抑制剂。

    Container for immunoassay with frangible nipple
    19.
    发明授权
    Container for immunoassay with frangible nipple 失效
    用易碎乳头进行免疫测定的容器

    公开(公告)号：US5234001A

    公开(公告)日：1993-08-10

    申请号：US863756

    申请日：1992-04-06

    申请人： Andrew S. Goldstein ,  David F. Zogg

    发明人： Andrew S. Goldstein ,  David F. Zogg

    IPC分类号： A61B10/00 ,  B01L3/00 ,  G01N33/53 ,  G01N33/68

    CPC分类号： B01L3/502 ,  A61B10/0051 ,  G01N33/5302 ,  G01N33/6854 ,  A61B2010/0003 ,  A61B2010/0009

    摘要： A container for storing collected substances for subsequent testing having an open upper end adapted to be sealed with a removable stopper and a lower end having an opening communicating the interior of the container with the outside. The opening is selectively sealed by a frangible nipple during storage of the substances and unsealed for removal of the collected substances for subsequent testing. The distal end of the frangible nipple is enlarged, preferably in the form of a ball.

    摘要翻译： 用于储存用于随后测试的收集物质的容器，其具有适于用可移除塞子密封的敞开的上端，下端具有将容器的内部与外部连通的开口。 在储存物质期间，开口由易碎的乳头选择性地密封，并且用于去除所收集的物质用于随后的测试。 易碎乳头的远端被放大，优选地以球的形式。