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公开(公告)号：US08609614B2
公开(公告)日：2013-12-17
申请号：US13022357
申请日：2011-02-07
申请人： Carl G. Hellerqvist , Changlin Fu
发明人： Carl G. Hellerqvist , Changlin Fu
IPC分类号： A61K38/17 , A61K38/03 , C07K14/435
CPC分类号： A61K31/7088 , A61K39/00 , A61K39/395 , C07H21/04 , C07K14/00 , C07K16/00 , C12Q1/02 , G01N33/566 , G01N33/567
摘要： Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
摘要翻译： 提供了通过施用至少一种GBS毒素受体多肽或其至少一种免疫原性片段来预防或减弱病原体病症的方法。 还提供了包含GBS毒素受体多肽的组合物和制备这种组合物的方法。 在本发明的另一个实施方案中，免疫动物还接受GBS毒素，与GBS毒素受体的免疫相容抗体和/或扩增的自体T细胞至GBS毒素受体。 本发明还包括鉴定另外的GBS毒素受体的方法。
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公开(公告)号：US07410640B2
公开(公告)日：2008-08-12
申请号：US10823506
申请日：2004-04-12
申请人： Carl G. Hellerqvist , Changlin Fu
发明人： Carl G. Hellerqvist , Changlin Fu
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K14/705 , A61K38/00
摘要： A novel GBS toxin receptor and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides and antibodies to GBS toxin receptor are provided, as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides, polypeptides and antibodies.
摘要翻译： 提供了一种新型的GBS毒素受体及其制备和使用方法。 提供GBS毒素受体多核苷酸和GBS毒素受体的多肽和抗体，以及检测，筛选和治疗方法以及涉及这种多核苷酸，多肽和抗体的药物组合物。
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公开(公告)号：US06476002B1
公开(公告)日：2002-11-05
申请号：US09429587
申请日：1999-10-28
IPC分类号： A61K31715
CPC分类号： A61K31/715 , Y10S514/825 , Y10S514/886 , Y10S514/908
摘要： A method of treating a chronic inflammatory disease such as rheumatoid arthritis or psoriasis includes treating a patient with a toxin derived from Group B &bgr;-hemolytic Streptococcus bacteria. The purified GBS toxin, or CM101, may be administered. intravenously to the patient in repeated doses.
摘要翻译： 治疗慢性炎性疾病如类风湿性关节炎或牛皮癣的方法包括用来源于B组溶血性链球菌的毒素治疗患者。 可以施用纯化的GBS毒素或CM101。 以重复剂量静脉内给予患者。
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公开(公告)号：US06407069B1
公开(公告)日：2002-06-18
申请号：US09269634
申请日：1999-03-30
申请人： Carl G. Hellerqvist
发明人： Carl G. Hellerqvist
IPC分类号： A01N4304
摘要： A method for purifying a polysaccharide from group B &bgr;-hemolytic Streptococcus (GBS) bacteria includes contacting a bacterial fermentation stock with a hydrophobic interaction chromatography (HIC) resin. Additional steps may include a phenol/saline extraction and an ion exchange chromatography. The method results in a product having very high purity. The product of the purification provides a composition which is highly useful in both research and therapeutic settings.
摘要翻译： 从B组β-溶血性链球菌（GBS）细菌中纯化多糖的方法包括使细菌发酵原液与疏水相互作用色谱（HIC）树脂接触。 附加步骤可以包括苯酚/盐水萃取和离子交换层析。 该方法产生具有非常高纯度的产物。 纯化的产物提供了在研究和治疗环境中非常有用的组合物。
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公开(公告)号：US5981508A
公开(公告)日：1999-11-09
申请号：US791857
申请日：1997-01-29
IPC分类号： A61K31/726 , A61K35/74 , A61K38/16 , A61P25/28 , A01K43/04 , A61K31/715
CPC分类号： A61K38/164
摘要： Neural injury of the type resulting from trauma or surgery may be advantageously treated with a polysaccharide toxin derived from Group B .beta.-hemolytic Streptococcus (GBS) bacteria. Additionally, diseases characterized by neuronal degeneration or impairment of neuronal connectivity, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis may be treated with the GBS toxin. The GBS toxin is administered to the patient before, during, or after infliction of the neural injury and acts by minimizing gliosis and promoting the reestablishment of neuronal connectivity.
摘要翻译： 可以有利地用来源于B组β-溶血性链球菌（GBS）细菌的多糖毒素处理由创伤或手术引起的类型的神经损伤。 此外，可以用GBS毒素治疗以神经元变性或神经元连通性损伤为特征的疾病，例如阿尔茨海默病，帕金森病，肌萎缩性侧索硬化和多发性硬化。 GBS毒素在神经损伤之前，期间或之后施用于患者，并通过最小化胶质细胞增生并促进神经元连通性的重建来起作用。
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公开(公告)号：US5939396A
公开(公告)日：1999-08-17
申请号：US28972
申请日：1998-02-24
申请人： Carl G. Hellerqvist
发明人： Carl G. Hellerqvist
摘要： A method for purifying a polysaccharide from group B .beta.-hemolytic Streptococcus (GBS) bacteria includes contacting a bacterial fermentation stock with a hydrophobic interaction chromatography (HIC) resin. Additional steps may include a phenol/saline extraction and an ion exchange chromatography. The method results in a product having very high purity. The product of the purification provides a composition which is highly useful in both research and therapeutic settings.
摘要翻译： 从B组β-溶血性链球菌（GBS）细菌中纯化多糖的方法包括使细菌发酵原料与疏水相互作用层析（HIC）树脂接触。 附加步骤可以包括苯酚/盐水萃取和离子交换层析。 该方法产生具有非常高纯度的产物。 纯化的产物提供了在研究和治疗环境中非常有用的组合物。
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公开(公告)号：US5858991A
公开(公告)日：1999-01-12
申请号：US791763
申请日：1997-01-29
IPC分类号： A61K31/715 , A61K35/74 , A61P17/02 , A61P43/00 , A61K39/09
CPC分类号： A61K31/715 , A01N1/0226
摘要： The method of the present invention provides a means of treating a patient having a wound, especially by minimizing scarring and accelerating wound healing, by administering CM101 or GBS toxin isolated from Group B .beta.-hemolytic streptococcus bacteria. The method of the present invention also includes administration of CM101 or GBS toxin to surgery patients having tumors in order to facilitate wound healing and minimize the likelihood of tumor progression.
摘要翻译： 本发明的方法提供了通过施用从B组β-溶血性链球菌细菌分离的CM101或GBS毒素来治疗患有伤口的患者，特别是通过最小化瘢痕形成和加速伤口愈合的方法。 本发明的方法还包括将CM101或GBS毒素施用于具有肿瘤的手术患者，以便于伤口愈合并使肿瘤发展的可能性最小化。
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