公开(公告)号：US20070032429A1

公开(公告)日：2007-02-08

申请号：US11544507

申请日：2006-10-05

Applicant: David Wright ,  D. Parks

Inventor： David Wright ,  D. Parks

IPC: A61K38/54 ,  A61K38/10

CPC classification number: A61K38/10 ,  A61K38/204 ,  C07K5/0212 ,  C07K7/02

Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract translation: 本发明提供了使用衍生自具有15至约40个氨基酸的白细胞介素-6（IL-6）的逆转换肽的治疗方法，并且包括相对于SEQ ID NO：1反向逆转的序列，即其中 所述肽包含序列D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D -Ala-D-Leu-D-Ala-D-Glu。 本发明的肽具有与天然IL-6相同的活性并具有神经营养活性。 由于它们的D-氨基酸连接，本发明的肽也不太容易在体内蛋白水解降解。

公开(公告)号：US07006635B2

公开(公告)日：2006-02-28

申请号：US09943433

申请日：2001-08-30

Applicant: Allen D. Parks ,  Gregory A. Balchin ,  Scott E. Spence

Inventor： Allen D. Parks ,  Gregory A. Balchin ,  Scott E. Spence

IPC: H04L9/00 ,  H04L5/00 ,  H04L7/00 ,  G06F1/12 ,  G06F13/42

CPC classification number: H04L7/0075

Abstract: A method for synchronizing a master clock to a slave clock located in master and slave devices communicating with one another via a laser signal beam and a communications channel, each of the devices including a homodyne detector for determining a respective correlation pattern with respect to a phase tuned local oscillator includes steps for recording master and slave correlation patterns while the signal beam cycles between first and second operating modes, transmitting the master correlation pattern and associated first and second times at which the signal beam shifted between the first and second operating modes and between the second and first operating modes over the communications channel, comparing a portion of the master correlation pattern between the first and second times to the slave correlation pattern to thereby determine the time offset between the master and slave correlation patterns, and applying the time offset to the slave clock. A corresponding clock synchronization system is also described.

公开(公告)号：US06337623B1

公开(公告)日：2002-01-08

申请号：US09373961

申请日：1999-08-13

Applicant: J. Adam Krugh, IV ,  Mark J. Catanzaro ,  James D. Parks

Inventor： J. Adam Krugh, IV ,  Mark J. Catanzaro ,  James D. Parks

IPC: B60Q152

CPC classification number: B60Q1/2611

Abstract: A supplemental warning apparatus for school buses which is mounted on the roof of the bus in a vertical plane spaced above the usual warning sign which is carried on the side of the bus, the warning apparatus including a display member carried by a base which display member is shiftable between a retracted position and an upright vertically extended warning position. The supplemental warning apparatus may be coupled with the warning sign assembly on the side of the school bus; the passenger door of the school bus; or may be directly operated by the driver of the bus, all to the end that a warning is given from the roof of the bus which can be seen by surrounding traffic when the view of the normal warning sign on the side of the bus is blocked by such traffic.

Abstract translation: 一种用于校车的补充警告装置，其安装在公共汽车屋顶上的垂直平面上，该垂直平面间隔在公共汽车侧面上的通常的警告标志之上，警告装置包括由基座承载的显示构件，显示构件 可以在缩回位置和垂直垂直延伸的警告位置之间移动。 补充警告装置可以与校车一侧的警告标志组合连接; 校车乘客门; 或者可以由公共汽车的司机直接操作，一旦公共汽车一侧的正常警告标志的视图被阻挡，从公共汽车屋顶发出的警告信息可以被周围的交通工具看到 通过这样的交通。

公开(公告)号：US5962274A

公开(公告)日：1999-10-05

申请号：US41987

申请日：1998-03-13

Applicant: Griffith D. Parks

Inventor： Griffith D. Parks

IPC: C07K14/21 ,  C07K16/32 ,  C12N9/12 ,  C12N9/24 ,  C12P19/34 ,  C07H21/04

CPC classification number: C12N9/1211 ,  C07K14/21 ,  C07K16/32 ,  C12N9/2402 ,  C12Y302/01018 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/02

Abstract: Disclosed are compositions comprising viral vectors derived from the paramyxovirus, simian virus 5 (SV5). The SV5 vectors of the present invention are designed so that the HN protein that binds to sialic acid is not expressed, and in certain embodiments a foreign membrane bound protein is expressed on the viral surface that targets the virus to particular cells or tissues. The vector then is able to deliver a toxin or cytotoxic agent to the target cell. Also disclosed are nucleic acid segments useful as viral genomes and methods of producing viral vectors.

Abstract translation: 公开了包含衍生自副粘病毒，猿猴病毒5（SV5））的病毒载体的组合物。 本发明的SV5载体被设计成使得结合唾液酸的HN蛋白质不被表达，并且在某些实施方案中，外源膜结合的蛋白质在靶向病毒的特定细胞或组织的病毒表面上表达。 然后载体能够将毒素或细胞毒性剂递送至靶细胞。 还公开了可用作病毒基因组的核酸区段和产生病毒载体的方法。

公开(公告)号：US5588681A

公开(公告)日：1996-12-31

申请号：US283735

申请日：1994-08-01

Applicant: Alan D. Parks

Inventor： Alan D. Parks

IPC: F16L5/00

CPC classification number: E03C1/025 ,  F16L5/00 ,  Y10T137/6977 ,  Y10T137/698

Abstract: A valve mounting device holds a valve in a fixed position and prevents rotation of the valve during operation of the valve handle. The device includes a tubular sleeve dimensioned to receive a valve body and in one embodiment has a notch for receiving a valve supply tube exit typical in angle stop valves. The sleeve is affixed to a guide tube which bends the flexible pipe through a predetermined arc for engaging the valve and holding the sleeve end valve in position. The guide tube is affixed to a rigid structure such as a wall or partition member thereby holding the valve and pipe in a rigid position. Escutcheon plates are adapted to provide support to the guide tube and sleeve.

Abstract translation: 阀安装装置将阀保持在固定位置，并且在阀手柄的操作期间阻止阀的旋转。 该装置包括尺寸适于接收阀体的管状套筒，并且在一个实施例中具有用于接收通常在角度截止阀中的阀供应管出口的凹口。 套筒固定在引导管上，该引导管弯曲柔性管通过预定的弧线，用于接合阀门并将套管端阀保持在适当的位置。 引导管被固定到诸如壁或分隔构件的刚性结构，从而将阀和管保持在刚性位置。 护耳板适于为导管和套筒提供支撑。

公开(公告)号：US5370386A

公开(公告)日：1994-12-06

申请号：US57047

申请日：1993-04-30

Applicant: Alan D. Parks

Inventor： Alan D. Parks

IPC: A63B63/00 ,  A63B69/00 ,  A63B69/40

CPC classification number: A63B63/00 ,  A63B2024/005 ,  A63B2063/002 ,  A63B2102/18 ,  A63B2102/22 ,  A63B69/0002

Abstract: A sports training target useful in developing accuracy and technique in delivering a projectile such as a baseball or hockey puck is provided. A series of nested and adjustable shutters are formed about a frame so as to protect the frame and absorb the energy of the projectile and eliminate concern from the player of being hit by a rebounded projectile thus allowing the player to concentrate on the training objectives. A target opening includes elements to establish a target for a particular drill. By way of example, the elements can be arranged for pitching to the target at shortened distances compared to the standard mound to plate distance. The target elements are then arranged to compensate for a side arm or other styled pitcher. With the combination of element placement within the target opening and the energy absorbent characteristics of the target, training takes place in confined areas without concern for the safety of the pitcher because of rebounded balls. Batting drills close to the target are also safely made using the shutters as targets because of the high absorption characteristics of the shutter material and target construction.

Abstract translation: 提供了一个运动训练目标，有助于提高射弹如棒球或冰球冰球的准确性和技术。 围绕框架形成一系列嵌套和可调节的百叶窗，以便保护框架并吸收射弹的能量，并消除玩家被反弹的射弹撞击的关注，从而允许玩家专注于训练目标。 目标开放包括为特定钻探建立目标的要素。 作为示例，元件可以布置成与标准堆垛至板距离相比以缩短的距离对目标进行俯仰。 然后将目标元件布置成补偿侧臂或其他风格的投手。 通过将目标开口内的元件放置与目标的能量吸收特性的组合，在受限区域进行训练，而不考虑由于反弹球的投手的安全性。 由于快门材料和目标结构的高吸收特性，靠近目标的击球也可以使用百叶窗作为目标进行安全制作。

公开(公告)号：US5129384A

公开(公告)日：1992-07-14

申请号：US754077

申请日：1991-09-03

Applicant: James D. Parks

Inventor： James D. Parks

IPC: A21B1/26

CPC classification number: A21B1/44 ,  A21B1/26

Abstract: An air return system for a rotatable rack baking oven having a heat source and a blower associated therewith for providing a flow of heated air across a baking chamber of the oven. The outlet end of the blower is connected via ductwork to an air outlet vent which introduces the heated air into the baking chamber. The air outlet vent includes a lattice of fixed vanes which are elongated in the direction of intended air flow. This arrangement channels the heated air to exit normal to the outlet vent to maintain a well defined column of air with less turbulence. An air return vent is located opposite the air inlet vent and is operatively associated with the heating means and the inlet side of the blower. The air return vent includes a panel having a plurality of holes through which the air may be drawn. A number of return holes in the return vent are blocked such that their numbers vary in inverse proportion to the drawing force produced by the inlet of the blower. This produces a uniform draw of air from the baking chamber, aiding in the uniform flow across the chamber.

Abstract translation: 一种用于具有热源的可旋转齿条烘烤炉的空气回流系统和与其相关联的鼓风机，用于在烘箱的烘烤室中提供加热的空气流。 鼓风机的出口端通过管道系统连接到通风口，将出风口引入烘箱。 出气口包括固定叶片的格子，其在预期空气流动的方向上是细长的。 这种布置使加热的空气垂直于出口排出口，以保持具有较少湍流的良好界定的空气柱。 空气返回通风口位于空气入口通风口的对面，并且与加热装置和鼓风机的入口侧可操作地相关联。 空气返回通风口包括具有多个孔的面板，空气可以被抽出。 返回通气孔中的多个返回孔被阻塞，使得它们的数量与鼓风机入口产生的拉力成反比。 这产生了来自烘烤室的均匀的空气抽吸，帮助穿过室的均匀流动。

公开(公告)号：USD286324S

公开(公告)日：1986-10-21

申请号：US507762

申请日：1983-06-27

Applicant: James D. Parks ,  Charles A. Moss ,  Kermit W. Dyer ,  James F. Corn

Designer： James D. Parks ,  Charles A. Moss ,  Kermit W. Dyer ,  James F. Corn

公开(公告)号：USD269663S

公开(公告)日：1983-07-12

申请号：US230353

申请日：1981-01-30

Applicant: Gary E. Smith ,  Edward D. Parks

Designer： Gary E. Smith ,  Edward D. Parks

公开(公告)号：US20200301172A1

公开(公告)日：2020-09-24

申请号：US16896153

申请日：2020-06-08

Applicant: Alan D. Parks

Inventor： Alan D. Parks

IPC: G02C7/16 ,  G02C7/10

Abstract: An apparatus is provided to create a focal zone for mindfulness meditation. The apparatus includes a first member extending between a first edge and a second edge, the first member having a translucent portion, a first elongated side member attached adjacent the first edge of the first member, and a second elongated side member attached adjacent the second edge of the first member, the first and second elongated members being generally parallel to another and lying in a single horizontal plane.