公开(公告)号：US20070032429A1

公开(公告)日：2007-02-08

申请号：US11544507

申请日：2006-10-05

Applicant: David Wright ,  D. Parks

Inventor： David Wright ,  D. Parks

IPC: A61K38/54 ,  A61K38/10

CPC classification number: A61K38/10 ,  A61K38/204 ,  C07K5/0212 ,  C07K7/02

Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract translation: 本发明提供了使用衍生自具有15至约40个氨基酸的白细胞介素-6（IL-6）的逆转换肽的治疗方法，并且包括相对于SEQ ID NO：1反向逆转的序列，即其中 所述肽包含序列D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D -Ala-D-Leu-D-Ala-D-Glu。 本发明的肽具有与天然IL-6相同的活性并具有神经营养活性。 由于它们的D-氨基酸连接，本发明的肽也不太容易在体内蛋白水解降解。

公开(公告)号：US20070054854A1

公开(公告)日：2007-03-08

申请号：US11501948

申请日：2006-08-09

Applicant: David Wright ,  D. Parks

Inventor： David Wright ,  D. Parks

IPC: A61K38/17 ,  A61K38/10

CPC classification number: C07K14/5403 ,  A61K38/10

Abstract: The invention provides methods of treatment using retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. These peptides of the invention have the same activity as native IL-3 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract translation: 本发明提供了使用衍生自具有12至约40个氨基酸的白细胞介素-3（IL-3）的逆转换肽并包括相对于SEQ ID NO：1的反向逆转的序列进行治疗的方法。 本发明具有与天然IL-3相同的活性，并且具有神经营养活性。 由于它们的D-氨基酸连接，本发明的肽也不太容易在体内蛋白水解降解。

公开(公告)号：US20070049520A1

公开(公告)日：2007-03-01

申请号：US11501975

申请日：2006-08-09

Applicant: David Wright ,  D. Parks

Inventor： David Wright ,  D. Parks

IPC: A61K38/16

CPC classification number: A61K38/10 ,  A61K38/16 ,  C07K5/0212 ,  C07K7/02 ,  C07K14/5415

Abstract: The invention provides methods of treatment using retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native LIF and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract translation: 本发明提供了使用衍生自具有18至约40个氨基酸的白血病抑制因子（LIF）的逆转换肽的治疗方法，并且包括相对于SEQ ID NO：1的反向逆转序列。本发明的肽 具有与天然LIF相同的活性，并具有神经营养活性。 由于它们的D-氨基酸连接，本发明的肽也不太容易在体内蛋白水解降解。

公开(公告)号：US11510511B2

公开(公告)日：2022-11-29

申请号：US17164484

申请日：2021-02-01

Applicant: David Wright

Inventor： David Wright

IPC: A47G9/06

Abstract: A compact, lightweight beach towel assembly including a ground cover and circumscribing sidewall having an elastomeric band, the ground cover weighted with sand bags, optionally including flexible rods.

公开(公告)号：US20220214607A1

公开(公告)日：2022-07-07

申请号：US17142867

申请日：2021-01-06

Applicant: David Wright

Inventor： David Wright

IPC: G03B21/58

Abstract: An outdoor home theater system that facilitates rapid and easy extension and storage thereof. The home theater system fully encloses a viewing screen for protection of the elements and has two doors that open at its bottom for extension of the viewing screen. The screen is easily retractable using a spring assembly found within the system.

公开(公告)号：US20160323448A1

公开(公告)日：2016-11-03

申请号：US14700139

申请日：2015-04-29

Applicant: Krista McBrearty ,  Uri Reich ,  Arno Sosna ,  Ted Wallach ,  Edward Gee ,  Weiwei Jia ,  David Wright ,  Jing Zhuang

Inventor： Krista McBrearty ,  Uri Reich ,  Arno Sosna ,  Ted Wallach ,  Edward Gee ,  Weiwei Jia ,  David Wright ,  Jing Zhuang

IPC: H04M3/51

CPC classification number: H04M3/5183 ,  G06Q10/00 ,  H04M3/2218

Abstract: Systems and methods for generating call reports which may allow access to the child call for each selected attendee via the group call, and enable users to capture data and make edits to detailing and sampling information unique to each attendee directly in the child call. Access to controls within the attendees section may enable mass entry of supported activities for a subset of attendees.

Abstract translation: 用于生成呼叫报告的系统和方法，其可以允许通过群组呼叫访问每个所选参加者的子呼叫，并且使得用户能够捕获数据并进行编辑以直接在子呼叫中详细描述和采样每个参与者唯一的信息。 访问与会者部分中的控制可以使得参与者的一小部分能够大量地输入支持的活动。

公开(公告)号：US09309739B2

公开(公告)日：2016-04-12

申请号：US14083754

申请日：2013-11-19

Applicant: David Wright

Inventor： David Wright

IPC: E21B17/046 ,  E21B33/038 ,  F16L37/086

CPC classification number: E21B33/038 ,  E21B17/046 ,  F16L37/086

Abstract: Systems and methods enable connection of, and are usable to connect, well servicing equipment to other well equipment, including wellheads, blowout preventers, and other well servicing equipment. The systems comprise connecting apparatus having a male connector and female connector. The male connector comprises an elongate body having an axial bore extending therethrough and a plurality of protrusions extending from the elongate body at an angle relative to the axial bore. The female connector can be adapted for connection with the male connector, wherein engagement between the male connector and female connector communicates the axial bore of the male connector with a bore of the female connector to define a flowpath for communicating a medium. The systems and methods enable the ability to connect or disconnect well equipment remotely without the need of a diver, an ROV, and without the need to bring the well equipment to the surface for disassembly.

Abstract translation: 系统和方法使得能够将维修设备连接到其他井设备（包括井口，防喷器和其他井服务设备）上并且可用于连接。 该系统包括具有公连接器和母连接器的连接装置。 阳连接器包括具有延伸穿过其中的轴向孔的细长主体和从细长体相对于轴向孔以一定角度延伸的多个突起。 阴连接器可以适于与阳连接器连接，其中阳连接器和阴连接器之间的接合将阳连接器的轴向孔与阴连接器的孔连通，以限定用于传送介质的流路。 这些系统和方法能够远程连接或断开井设备，而不需要潜水员，ROV，并且不需要将井设备带到地面进行拆卸。

公开(公告)号：US08970230B2

公开(公告)日：2015-03-03

申请号：US13340667

申请日：2011-12-29

Applicant: Rajagopal Narayanasamy ,  Mahadevan Krishnamurthy Narayana Swamy ,  David Wright ,  Steven Kolokowsky

Inventor： Rajagopal Narayanasamy ,  Mahadevan Krishnamurthy Narayana Swamy ,  David Wright ,  Steven Kolokowsky

IPC: G01R27/26 ,  G06F3/041 ,  G06F3/045 ,  H03K17/96 ,  G01D5/24 ,  G06F3/044 ,  H03K17/60

CPC classification number: G06F3/044 ,  G01D5/2405 ,  G06F3/016 ,  G06F2203/04101 ,  G06F2203/04106 ,  H03K17/602 ,  H03K17/962 ,  H03K2017/9602 ,  H03K2217/960715 ,  H03K2217/960725 ,  H03K2217/960755

Abstract: An embodiment of an integrated circuit device may comprise an integrated circuit package, a sensor element attached within the integrated circuit package, a capacitance sensor coupled with the sensor element and situated within the integrated circuit package, wherein the capacitance sensor is configured to measure a capacitance of the sensor element, and an output pin positioned at the exterior of the integrated circuit package, wherein the output pin is configured to carry a signal based on the measured capacitance of the sensor element.

Abstract translation: 集成电路器件的实施例可以包括集成电路封装，附接在集成电路封装内的传感器元件，与传感器元件耦合并位于集成电路封装内的电容传感器，其中电容传感器被配置为测量电容 以及位于所述集成电路封装外部的输出引脚，其中所述输出引脚被配置为基于所测量的所述传感器元件的电容来承载信号。

公开(公告)号：US08570073B2

公开(公告)日：2013-10-29

申请号：US13100876

申请日：2011-05-04

Applicant: David Wright ,  Jason Muriby ,  Erhan Hancioglu

Inventor： David Wright ,  Jason Muriby ,  Erhan Hancioglu

IPC: H03B1/00

CPC classification number: H03K17/687 ,  H03K19/0016 ,  H03K19/00369

Abstract: A method for driving a load includes driving a load to an initial voltage within a voltage window, the voltage window based on an input voltage and an offset voltage, and driving the load to approximately the input voltage.

Abstract translation: 用于驱动负载的方法包括将负载驱动到电压窗内的初始电压，基于输入电压和偏移电压的电压窗口，并将负载驱动到大约输入电压。

公开(公告)号：US20120245133A1

公开(公告)日：2012-09-27

申请号：US13454503

申请日：2012-04-24

Applicant: Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

Inventor： Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

IPC: A61K31/57 ,  A61P25/00

CPC classification number: A61K31/57

Abstract: Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

Abstract translation: 提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。 所述方法包括包含孕酮恒定或两级给药方案的治疗。 在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。 两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。