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11.发明申请TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN 审中-公开作为MITOTIC MOTO蛋白质的调节剂的四氢吲哚并噻唑和四氢吲哚衍生物公开(公告)号：US20100022530A1
公开(公告)日：2010-01-28
申请号：US12520451
申请日：2007-11-22
Applicant: Kai Schiemann , Dirk Finsinger , Frank Zenke
Inventor： Kai Schiemann , Dirk Finsinger , Frank Zenke
IPC: A61K31/5377 , A61P35/00 , C07D261/20 , A61K31/42 , C07D413/12 , A61K31/4453
CPC classification number: C07D261/20 , C07D231/56 , C07D333/72 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
Abstract: Compounds of the formula (I) in which A1, A2, R1, X1, X2, X3, Y, R2, Cy and n have meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
Abstract translation: 其中A1，A2，R1，X1，X2，X3，Y，R2，Cy和n具有权利要求1所述的含义的式（I）化合物特别可用于治疗肿瘤。
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12.发明申请Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 有权用作有丝分裂运动蛋白的调节剂的四氢喹啉Eg5公开(公告)号：US20080200451A1
公开(公告)日：2008-08-21
申请号：US11917309
申请日：2006-06-02
Applicant: Kai Schiemann , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Frank Zenke
Inventor： Kai Schiemann , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Frank Zenke
IPC: A61K31/47 , C07D215/14 , C07D215/54 , C07D487/08 , A61K31/55 , A61P35/00
CPC classification number: C07D471/08 , C07D215/12 , C07D215/42 , C07D215/54 , C07D221/06 , C07D405/04 , C07D409/04
Abstract: Compounds of the formula (I), in which W, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
Abstract translation: 其中W，R，R 1，R 2，R 3，R 4，R 4，R 4， R 5，R 6，R 7和R 7具有权利要求1中所示的含义，特别可以用于 治疗肿瘤。
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公开(公告)号：US20060199844A1
公开(公告)日：2006-09-07
申请号：US10532574
申请日：2003-10-08
Applicant: Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
Inventor： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC: A61K31/444 , C07D401/02 , A61K31/44 , C07D213/53
CPC classification number: C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
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公开(公告)号：US08420820B2
公开(公告)日：2013-04-16
申请号：US13002168
申请日：2009-06-04
Applicant: Margarita Wucherer-Plietker , David Bruge , Dirk Finsinger , Ulrich Graedler , Dieter Dorsch , Christina Esdar
Inventor： Margarita Wucherer-Plietker , David Bruge , Dirk Finsinger , Ulrich Graedler , Dieter Dorsch , Christina Esdar
IPC: C07D471/02 , C07D413/00
CPC classification number: C07D471/04
Abstract: Compounds of the formula I in which X, R1, R2, R3, R4 and R6 have the meanings indicated in Claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.
Abstract translation: 其中X，R 1，R 2，R 3，R 4和R 6具有权利要求1所述含义的式I化合物是细胞增殖/细胞活力的抑制剂，可用于治疗肿瘤。
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15.发明授权Tetrahydroquinolines for use as modulators of the mitotic motor protein Eg5 有权用作有丝分裂运动蛋白Eg5的调节剂的四氢喹啉公开(公告)号：US08207345B2
公开(公告)日：2012-06-26
申请号：US11917309
申请日：2006-06-02
Applicant: Kai Schiemann , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Frank Zenke
Inventor： Kai Schiemann , David Bruge , Hans-Peter Buchstaller , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Frank Zenke
IPC: C07D405/00 , C07D215/00
CPC classification number: C07D471/08 , C07D215/12 , C07D215/42 , C07D215/54 , C07D221/06 , C07D405/04 , C07D409/04
Abstract: Compounds of the formula (I), in which W, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumors.
Abstract translation: 其中W，R，R 1，R 2，R 3，R 4，R 5，R 6和R 7具有权利要求1所述的含义的式（I）化合物，尤其可用于治疗肿瘤。
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Patent Agency Ranking
公开(公告)号：US20080234299A1
公开(公告)日：2008-09-25
申请号：US11913149
申请日：2006-03-17
Applicant: Hans-Peter Buchstaller , Dirk Finsinger , Kai Schiemann , Ulrich Emde
Inventor： Hans-Peter Buchstaller , Dirk Finsinger , Kai Schiemann , Ulrich Emde
IPC: A61K31/517 , C07D239/88 , A61P35/00
CPC classification number: C07D239/91 , C07D239/90
Abstract: Compounds of the formula (I), in which R, R1, R2, R3, R4, R5, R6, R7, R8, Z1, Z2, Z3, k and Y1 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
Abstract translation: 式（I）化合物，其中R 1，R 2，R 2，R 3，R 4， R 5，R 6，R 7，R 8，Z 1，...， Z 2，Z 3，Z和Y 1具有权利要求1中所示的含义，特别可以用于 治疗肿瘤。
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公开(公告)号：US20080194615A1
公开(公告)日：2008-08-14
申请号：US11916952
申请日：2006-05-17
Applicant: Kai Schiemann , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Nina Heiss , Frank Zenke
Inventor： Kai Schiemann , Ulrich Emde , Dirk Finsinger , Christiane Amendt , Nina Heiss , Frank Zenke
IPC: A61K31/4375 , C07D491/052 , A61K31/436 , C07D471/04
CPC classification number: C07D215/42 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D491/052
Abstract: Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things.
Abstract translation: 公开了式（I）的化合物，其中W，R，R 1，R 2，R 3，R 4， R 5，R 6，R 7和R 7具有权利要求1所述的含义。 所述化合物可用于治疗肿瘤等。
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公开(公告)号：US20070219246A1
公开(公告)日：2007-09-20
申请号：US11579336
申请日：2005-04-28
Applicant: Dirk Finsinger , Soheila Anzali , Matthias Frech , Johannes Gleitz , Nina Heiss , Bjoern Hock , Kai Schiemann , Frank Zenke
Inventor： Dirk Finsinger , Soheila Anzali , Matthias Frech , Johannes Gleitz , Nina Heiss , Bjoern Hock , Kai Schiemann , Frank Zenke
IPC: A61K31/4523 , A61K31/381 , C07D333/54 , C07D409/06
CPC classification number: C07D333/54 , C07D333/56 , C07D333/58 , C07D333/60 , C07D333/64 , C07D409/04
Abstract: Compounds of the formula (I) in which W, R1, R2, R3, R4, and q have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours.
Abstract translation: 其中W，R 1，R 2，R 3，R 4，R 4，R 4， 和q具有权利要求1所述的含义，可以特别用于治疗肿瘤。
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公开(公告)号：US20070149594A1
公开(公告)日：2007-06-28
申请号：US10579825
申请日：2004-10-26
Applicant: Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
Inventor： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC: A61K31/401 , C07D207/30 , A61K31/40
CPC classification number: C07D207/337 , C07D401/12
Abstract: Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
Abstract translation: 其中X，Y，Z和Ar具有权利要求1所述含义的式（I）化合物是Raf激酶的抑制剂，并且可以用于治疗肿瘤
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公开(公告)号：US06995238B2
公开(公告)日：2006-02-07
申请号：US10183410
申请日：2002-06-28
Applicant: Jörg Meyer , Alfred Jonczyk , Berthold Nies , Horst Kessler , Dirk Finsinger , Martin Kantlehner
Inventor： Jörg Meyer , Alfred Jonczyk , Berthold Nies , Horst Kessler , Dirk Finsinger , Martin Kantlehner
IPC: C07K5/10
CPC classification number: C07K7/64 , A61K38/00 , Y02P20/125
Abstract: Disclosed herein is a process for promoting the integration of a biocompatible device or implant into a tissue of a subject. The process comprises covalently bonding to the surface of the device or implant a compound of the formula I R-Q-X I wherein R is cyclo-(Arg-Gly-Asp-Z), and wherein Q, X and Z are as defined herein.
Abstract translation: 本文公开了一种用于促进生物相容性装置或植入物整合到受试者的组织中的方法。 该方法包括共价键合至装置的表面或植入化合物
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