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公开(公告)号：US20100152464A1
公开(公告)日：2010-06-17
申请号：US11719737
申请日：2005-11-18
申请人： Bertrand M. C. Plouvier , Doug Ta Hung Chou , Grace Jung , Lewis Siu Leung Choi , Tao Sheng , Anthony G. M. Barrett , Marco S. Passafaro , Martin Kurz , Daniel Moeckli , Pirmin Ulmann , Alfred Hedinger
发明人： Bertrand M. C. Plouvier , Doug Ta Hung Chou , Grace Jung , Lewis Siu Leung Choi , Tao Sheng , Anthony G. M. Barrett , Marco S. Passafaro , Martin Kurz , Daniel Moeckli , Pirmin Ulmann , Alfred Hedinger
IPC分类号： C07D207/12
CPC分类号： C07D207/12 , C07C213/02 , C07C231/12 , C07C269/06 , C07C2601/14 , C07D207/273 , C07C217/52 , C07C235/40 , C07C271/56
摘要： Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
摘要翻译： 公开了制备立体异构基本上为氨基环己基醚化合物如反 - （1R，2R） - 氨基环己基醚化合物和/或反 - （1S，2S） - 氨基环己基醚化合物以及各种中间体和底物的方法。
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公开(公告)号：US20090105256A1
公开(公告)日：2009-04-23
申请号：US11547423
申请日：2005-03-31
申请人： Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Adewale Eniale , Bertrand M.C. Plouvier
发明人： Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Adewale Eniale , Bertrand M.C. Plouvier
IPC分类号： A61K31/4015 , C07D207/12 , C07D207/40 , C07D401/12 , C07D413/12 , C07F9/572 , A61K31/5377 , A61K31/496
CPC分类号： C07D209/94 , A61K47/54 , A61K47/555 , A61K47/60 , A61K51/04 , C07B2200/05 , C07C257/06 , C07D207/12 , C07D209/88 , C07F9/572 , C07H15/203
摘要： Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing such prodrugs.
摘要翻译： 离子通道调节化合物的前药，包括例如下式的离子通道调节化合物的前药：本文描述，以及制备和使用这些前药和含有这些前药的药物组合物的方法。
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公开(公告)号：US08344162B2
公开(公告)日：2013-01-01
申请号：US13297846
申请日：2011-11-16
IPC分类号： C07D207/40 , C07D207/416
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
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公开(公告)号：US20120271057A9
公开(公告)日：2012-10-25
申请号：US13297846
申请日：2011-11-16
IPC分类号： C07D207/12
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
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公开(公告)号：US08163938B2
公开(公告)日：2012-04-24
申请号：US12833423
申请日：2010-07-09
申请人： Grace Jung , Bertrand M. C. Plouvier , Yuzhong Liu , Jeff Jiqun Zhu , Tao Sheng , Anthony G. M. Barrett , Lewis Siu Leung Choi , Doug Ta Hung Chou
发明人： Grace Jung , Bertrand M. C. Plouvier , Yuzhong Liu , Jeff Jiqun Zhu , Tao Sheng , Anthony G. M. Barrett , Lewis Siu Leung Choi , Doug Ta Hung Chou
IPC分类号： C07D207/12 , A61K31/40
CPC分类号： A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译： 公开了氨基环己基醚化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了化合物和组合物的用途，包括治疗心律失常。
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16.发明授权公开(公告)号：US08022098B2
公开(公告)日：2011-09-20
申请号：US12713605
申请日：2010-02-26
申请人： Doug Ta Hung Chou , Bertrand M. C. Plouvier , Peter Pang , James Gee Ken Yee , Jeffery Jerome Wheeler , Aregahegn S. Yifru , Allen W. Davidoff
发明人： Doug Ta Hung Chou , Bertrand M. C. Plouvier , Peter Pang , James Gee Ken Yee , Jeffery Jerome Wheeler , Aregahegn S. Yifru , Allen W. Davidoff
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D207/12
摘要： This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same.
摘要翻译： 本发明涉及氘代氨基环己基醚化合物及其制备方法及其使用方法。
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公开(公告)号：US20100273724A1
公开(公告)日：2010-10-28
申请号：US12831804
申请日：2010-07-07
申请人： Elizabeth L. S. Cheu , Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Alan M. Ezrin , Grace Jung , Bertrand M.C. Plouvier , Aregahegn S. Yifru
发明人： Elizabeth L. S. Cheu , Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Alan M. Ezrin , Grace Jung , Bertrand M.C. Plouvier , Aregahegn S. Yifru
IPC分类号： A61K31/4015 , C07D403/12 , C07D401/12 , C07D417/14 , C07D513/04 , A61K31/496 , A61K31/4439 , A61K31/4155 , A61K38/08 , A61K31/55 , A61K31/501 , A61P9/06 , C12N5/00
CPC分类号： C07H15/203 , A61K47/54 , A61K47/555 , A61K47/60 , A61K51/04 , C07B2200/05 , C07C257/06 , C07D207/12 , C07D209/88 , C07D209/94 , C07F9/572
摘要： This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed
摘要翻译： 本发明涉及某些离子通道调节化合物的PEG衍生物，药物偶联物和同位素衍生物。 还公开了药物组合物和使用方法
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公开(公告)号：US07767830B2
公开(公告)日：2010-08-03
申请号：US11690361
申请日：2007-03-23
申请人： Grace Jung , Bertrand M. C. Plouvier , Yuzhong Liu , Jeff Jiqun Zhu , Tao Sheng , Anthony G. M. Barrett , Lewis Siu Leung Choi , Doug Ta Hung Chou
发明人： Grace Jung , Bertrand M. C. Plouvier , Yuzhong Liu , Jeff Jiqun Zhu , Tao Sheng , Anthony G. M. Barrett , Lewis Siu Leung Choi , Doug Ta Hung Chou
IPC分类号： A61K31/40 , C07D207/12
CPC分类号： A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译： 公开了氨基环己基醚化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了化合物和组合物的用途，包括治疗心律失常。
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19.发明授权公开(公告)号：US08618311B2
公开(公告)日：2013-12-31
申请号：US13612539
申请日：2012-09-12
IPC分类号： C07D207/40 , C07D207/416
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
摘要翻译： 本发明涉及式（I）或式（II）化合物或其药学上可接受的盐，酯，酰胺，络合物，螯合物，包合物，溶剂合物，多晶型物，立体异构体，代谢物或前药的立体选择性合成; 其中R 3，R 4和R 5在本文中定义。 已知式（I）和式（II）的化合物可用于治疗心律失常。
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20.发明申请公开(公告)号：US20130090483A1
公开(公告)日：2013-04-11
申请号：US13612539
申请日：2012-09-12
IPC分类号： C07D207/12
CPC分类号： C07D207/12 , C07C235/14 , C07C2601/14 , C07D207/40
摘要： This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
摘要翻译： 本发明涉及式（I）或式（II）化合物或其药学上可接受的盐，酯，酰胺，络合物，螯合物，包合物，溶剂合物，多晶型物，立体异构体，代谢物或前药的立体选择性合成; 其中R 3，R 4和R 5在本文中定义。 已知式（I）和式（II）的化合物可用于治疗心律失常。
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