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17 条记录 (耗时 0.016 秒)

    B-lactam-like chaperone inhibitors
    11.
    发明授权
    B-lactam-like chaperone inhibitors 有权
    β-内酰胺样分子伴侣抑制剂

    公开(公告)号：US06495539B1

    公开(公告)日：2002-12-17

    申请号：US09252792

    申请日：1999-02-19

    申请人： Scott J. Hultgren ,  Fredrik Almqvist ,  Gabriel Soto

    发明人： Scott J. Hultgren ,  Fredrik Almqvist ,  Gabriel Soto

    IPC分类号： C07D50100

    CPC分类号： C07D499/00 ,  C07D277/12

    摘要： Compounds of the formula and the salts, esters and amides thereof wherein Z is S, SO, SO2 or O; each of R1, R2 and R3 is independently H or substituted or unsubstituted alkyl (1-10C), substituted or unsubstituted alkenyl, substituted or unsubstituted acyl (2-11C), substituted or unsubstituted aryl (6-14C), substituted or unsubstituted arylcarbonyl (7-15C), substituted or unsubstituted arylalkyl (7-15C), substituted or unsubstituted pyridyl wherein substituents on any alkyl, alkenyl, or acyl moiety are selected from the group consisting of halo, and RO, wherein R is H or alkyl (1-6C), and substituents on any aryl or pyridyl moiety are selected from the group consisting of halo, and RO, where R is H or alkyl (1-6C), —CN and —CF3; with the proviso that R1 is not H and R1 and R3 are not identical and with the proviso that in formula (1), the B ring may contain one double bond that is located between positions 2 and 3, and in formula (2), the B ring may contain one double bond that can be located between positions 2 and 3 or positions 3 and 4 are useful as antibacterial agents.

    摘要翻译： 式中的化合物及其盐，酯和酰胺，其中Z为S，SO，SO 2或O; R 1，R 2和R 3各自独立地为H或取代或未取代的烷基（1-10C），取代或未取代的烯基，取代或未取代的酰基 （2-11C），取代或未取代的芳基（6-14C），取代或未取代的芳基羰基（7-15C），取代或未取代的芳基烷基（7-15C），取代或未取代的吡啶基，其中任何烷基，链烯基或酰基 部分选自卤素和RO，其中R是H或烷基（1-6C），任何芳基或吡啶基部分上的取代基选自卤素和RO，其中R是H或 烷基（1-6C），-CN和-CF3; 条件是R1不是H，R1和R3不相同，条件是在式（1）中，B环可以含有位于2和3之间的一个双键，而在式（2）中， B环可以含有一个可以位于2和3位之间的双键，或3或4位可用作抗菌剂。

    CATALYST
    17.
    发明申请
    CATALYST 审中-公开
    催化剂

    公开(公告)号：US20120321533A1

    公开(公告)日：2012-12-20

    申请号：US13439232

    申请日：2012-04-04

    申请人： Fredrik Almqvist ,  Basudeb Basu

    发明人： Fredrik Almqvist ,  Basudeb Basu

    IPC分类号： B01J31/04 ,  B01J19/00 ,  B01J31/08

    CPC分类号： C07C67/343 ,  B01J23/44 ,  B01J31/08 ,  B01J31/165 ,  B01J37/06 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C1/321 ,  C07C17/263 ,  C07C37/18 ,  C07C41/30 ,  C07C2523/44 ,  C07C2531/08 ,  C07C2603/24 ,  C07D213/61 ,  C07D401/04 ,  C07D413/04 ,  C07D491/147 ,  C07C15/14 ,  C07C25/18 ,  C07C69/618 ,  C07C69/65 ,  C07C43/205 ,  C07C39/15

    摘要： The present invention relates to a method of producing a heterogeneous catalyst suitable for catalyzing Heck, Suzuki-Miyaura Sonogashira coupling and Buchwald-Hartwig reactions, comprising the steps of: a) providing a macroporous carrier, said macroporous carrier consisting of a core and a plurality of ion exchange groups covalently bonded to the surface of said core, where at least 90% of the ions bound to said carrier are formate ions; b) swelling said carrier in a polar solvent; c) providing a palladium (II) salt; d) suspending said carrier in an organic solvent thereby obtaining a suspension; e) adding said palladium salt to said suspension and allowing the resulting mixture to react at a temperature within the range of 0-70° C. until said carrier has turned black; f) washing said carrier in water; g) drying said carrier under vacuum.

    摘要翻译： 本发明涉及适用于催化Heck，Suzuki-Miyaura Sonogashira偶联剂和Buchwald-Hartwig反应的多相催化剂的制备方法，包括以下步骤：a）提供大孔载体，所述大孔载体由核和多个 共价结合到所述芯的表面上的离子交换基团，其中与所述载体结合的至少90％的离子是甲酸根离子; b）在极性溶剂中溶胀载体; c）提供钯（II）盐; d）将所述载体悬浮在有机溶剂中，从而获得悬浮液; e）将所述钯盐加入到所述悬浮液中，并使得到的混合物在0-70℃的温度下反应，直到所述载体变黑; f）在水中清洗载体; g）在真空下干燥所述载体。