公开(公告)号：US20120301436A1

公开(公告)日：2012-11-29

申请号：US13117477

申请日：2011-05-27

Applicant: JEN-CHANG YANG ,  SHENG-YANG LEE ,  HAW-MING HUANG ,  DIAN-YU JI ,  HONG-DA WU ,  CHEN-FENG MA

Inventor： JEN-CHANG YANG ,  SHENG-YANG LEE ,  HAW-MING HUANG ,  DIAN-YU JI ,  HONG-DA WU ,  CHEN-FENG MA

IPC: A61K35/12 ,  A61P13/00 ,  A61K38/02 ,  A61K38/18 ,  A61K47/42

CPC classification number: A61K9/10 ,  A61K9/0024 ,  A61K47/34 ,  A61K47/36

Abstract: The invention provides a polyelectrolyte complex gel comprising a chitosan and a γ-polyglutamic acid (γ-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof, wherein the chitosan and the γ-PGA are swollen with an aqueous solution. Also provided is a soft tissue augmentation implant, comprising a polyelectrolyte complex gel of the invention as a carrier or a filler and an optional additive. The polyelectrolyte complex gel and the soft tissue augmentation implant containing the same has long degradation time and better supportability so as to provide good maintenance for soft tissue.

Abstract translation: 本发明提供一种包含分子量约1kDa至约400kDa的壳聚糖和γ-聚谷氨酸（γ-PGA）或其盐的聚电解质复合凝胶，其中壳聚糖和γ-PGA用 水溶液。 还提供了软组织增强植入物，其包含作为载体或填料的本发明的聚电解质复合物凝胶和任选的添加剂。 聚电解质复合凝胶和含有它的软组织增补植入物具有长的降解时间和更好的支撑性，从而为软组织提供良好的维护。

公开(公告)号：US20070231375A1

公开(公告)日：2007-10-04

申请号：US11589198

申请日：2006-10-30

Applicant: Tsuimin Tsai ,  Chin-Tin Chen ,  Ruey-Long Hong ,  Hong-Da Wu

Inventor： Tsuimin Tsai ,  Chin-Tin Chen ,  Ruey-Long Hong ,  Hong-Da Wu

IPC: A61K9/127 ,  A61K31/555 ,  A61K31/409 ,  A61N5/06

CPC classification number: A61K9/1271 ,  A61K31/409 ,  A61K31/555 ,  A61K41/0071

Abstract: The present invention relates to a liposome combination, which wrapped hydrophilic drugs in water layer and wrapped hydrophobic drugs in lipid bilayer; hydrophobic drugs are photosensitizers. Using light with appropriate wavelength to activate the photosensitizer in the hydrophobic layer can result in the production of singlet oxygen and the free radical, and cause the oxidizing and breaking of the carbon chain of the phospholipid, and influences the stability of the liposome and the releases of the drug. The singlet oxygen and the free radical will attack the cancer cells at the same time as a result of combining the photodynamic- and chemo-effects.

Abstract translation: 本发明涉及脂质体组合，其在水层中包裹亲水性药物并在脂质双层中包裹疏水性药物; 疏水性药物是光敏剂。 使用具有适当波长的光激活疏水层中的光敏剂可导致单线态氧和自由基的产生，并引起磷脂的碳链的氧化和断裂，并影响脂质体的稳定性和释放 的药物。 由于结合光动力学和化学效应，单线态氧和自由基将同时侵袭癌细胞。