公开(公告)号：US11185395B2

公开(公告)日：2021-11-30

申请号：US16217250

申请日：2018-12-12

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD ,  ROBOTOO INNOVATION LTD

Inventor： Uri Barak ,  Eyal Tarazi

IPC: A61B34/30 ,  A61C13/00 ,  A61C13/107 ,  A61C5/77 ,  A61C5/80 ,  A61C1/08 ,  A61C5/82 ,  A61B34/20 ,  A61C5/90 ,  A61C1/00 ,  A61C5/00 ,  A61C9/00

Abstract: A system and method of automated formation of a preparation stub, based on an a priori created computational geometrical model, configured to conform to a prefabricated fixed dental prosthesis, is described. The system includes a digital imaging facility with an image acquiring device and a three-dimensional data digitizer, a modeling facility with an exterior surface design module and an interior surface design module, a fabrication facility operatively with a computer-aided manufacturing module, as well as an application facility including an ablation tool and in-situ preparation module; application facility preferably includes an intra-oral feedbacking appliance with a distance measurement probe for automated feedback-controlled formation of a preparation stub.

公开(公告)号：US20210260311A1

公开(公告)日：2021-08-26

申请号：US17254103

申请日：2019-06-20

Applicant: Yissum Research Development Company of the Hebrw University of Jerusale Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Tomer BATASH ,  Sigal SHAFRAN-TIKVA ,  Avner EHRLICH ,  Yaakov NAHMIAS ,  Amnon BUXBOIM ,  Yaron BLINDER ,  Yoav MINTZ ,  Elchanan FRIED ,  Dan ORBACH

IPC: A61M15/00 ,  A61M13/00 ,  A61M11/00 ,  A61M16/06

Abstract: There are provided herein methods, devices, kits and systems utilizing respiratory mask for delivering pressurized fluid to a subject via inhalation in an efficient manner. The fluid may include gas and/or drug and by utilizing the methods, devices, kits and systems provided, efficient drug delivery to the subject's airways is achieved. The systems, devices, kits and methods further allow inducing insufflation/exsufflation in particular in subjects having impaired suffering from low neuromotor capacity, such as spinal cord injuries (SCI) patients.

公开(公告)号：US11034753B2

公开(公告)日：2021-06-15

申请号：US15899621

申请日：2018-02-20

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Dan Deutsch ,  Amir Haze ,  Anat Blumenfeld

IPC: A61K38/39 ,  C07K14/78

Abstract: A method of treating an injury to hyaline cartilage in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of amelogenin.

公开(公告)号：US20210052523A1

公开(公告)日：2021-02-25

申请号：US16977722

申请日：2019-03-06

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Eithan GALUN ,  Hilla GILADI ,  Chofit CHAI ,  Nofar ROSENBERG ,  Dayana YAISH ,  Zohar SHMUELIAN

IPC: A61K31/167 ,  A61P35/00 ,  A61P35/04

Abstract: The present invention provides compositions having one or more agents capable of increasing expression of one or more endogenous tumor suppressive mi RNAs in one or more producing cells, such that the endogenous mi RNAs can affect one or more target cancer cells. Further provided are method and uses thereof for treating cancer.

公开(公告)号：US10828308B2

公开(公告)日：2020-11-10

申请号：US15969181

申请日：2018-05-02

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Yaron Ilan ,  Doina Cosma Roman ,  Michael Hayden ,  Einat Amit-Romach

IPC: A61K31/52 ,  A61K9/28 ,  A61P1/16 ,  A61K9/00 ,  A61K9/20 ,  A61K45/06

Abstract: Methods of treating patients suffering from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), including those also suffering from type II diabetes mellitus (T2DM), with a delayed release pharmaceutical composition comprising 6-mercaptopurine are disclosed.

公开(公告)号：US20200340057A1

公开(公告)日：2020-10-29

申请号：US16630547

申请日：2018-07-13

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Yuval DOR ,  Ruth SHEMER ,  Benjamin GLASER ,  Judith MAGENHEIM ,  Daniel NEIMAN ,  Roni WERMAN ,  Hai ZEMMOUR ,  Joshua MOSS ,  Ilana FOX ,  Sheina PIYANZIN

IPC: C12Q1/6883 ,  C12Q1/686

Abstract: A method of ascertaining the methylation status of a double-stranded, cell-free DNA molecule in a specimen is disclosed. The method comprises ascertaining the methylation status of at least two methylation sites of the same double-stranded cell-free DNA molecule, wherein said double-stranded, cell-free DNA molecule comprises a nucleotide sequence which comprises no more than 300 base pairs and is comprised in a sequence as set forth in any one of SEQ ID NOs: 2-117 or 121-177.

公开(公告)号：US10695270B2

公开(公告)日：2020-06-30

申请号：US14900160

申请日：2014-06-19

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Ishay Benuri-Silbiger

IPC: A61J15/00 ,  A61M25/02 ,  A61M39/08

Abstract: Ostomy tubes, particularly gastrostomy tubes, with improved retention means are provided. More specifically, retention structures, such as bolsters, for gastrostomy tubes are provided, configured to removably assemble to one end of a gastrostomy tube to facilitate replacement and removal of the tube. The retention structures provided herein may comprise one or more removably assembled retention elements. Further provided are gastrostomy tubes comprising such retention structures, and methods for percutaneous endoscopic gastrostomy utilizing same.

公开(公告)号：US20200061355A1

公开(公告)日：2020-02-27

申请号：US16461383

申请日：2017-11-16

Applicant: Ramot at Tel-Aviv University Ltd. ,  Tel HaShomer Medical Research Infrastructure and Services Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Ofer BARNEA ,  Omer DORON

IPC: A61M27/00 ,  A61M25/10

Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.

公开(公告)号：US10525009B2

公开(公告)日：2020-01-07

申请号：US15185204

申请日：2016-06-17

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Itzhak E. Lerner ,  Moshe Flashner-Barak ,  Erwin v Achthoven ,  Hans Keegstra ,  Ruud Smit

IPC: A61K31/52 ,  A61K31/522 ,  A61K9/16 ,  B01J2/16

Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.

公开(公告)号：US10392617B2

公开(公告)日：2019-08-27

申请号：US15109879

申请日：2015-01-06

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Hilla Giladi ,  Alina Simerzin ,  Yael Hantz ,  Sagit Arbel Alon ,  Eithan Galun

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7105 ,  A61K45/06 ,  A61K31/713 ,  A61K31/7088

Abstract: The present invention provides miR-122* as a functional microRNA molecule, compositions comprising the same and uses thereof for treatment of various conditions, such as, cancer. Further provided are methods for increasing the expression, stability and/or activity of p53 in a target cell or method for inducing cancer cell death, the methods comprising introducing into the cell a miR-122* polynucleotide molecule or a vector expressing or encoding the same.