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11.发明授权Stimulation of gonadotropic hormones with mineral mixtures containing amino acid chelates 失效用含氨基酸螯合物的矿物混合物刺激促性腺激素
公开(公告)号：US4774089A
公开(公告)日：1988-09-27
申请号：US744923
申请日：1985-06-14
申请人： Harvey H. Ashmead
发明人： Harvey H. Ashmead
IPC分类号： A61K31/28 , A61K31/315 , A61K38/04 , A61K33/08 , A61K37/14
CPC分类号： A61K38/04 , A61K31/28 , A61K31/315
摘要： A composition and method for stimulating gonadotropin hormone production and maintaining intracullar mineral balance in the reproductive organs of mammals. The composition consists of a mineral mixture containing effective amounts of manganese, iron and zinc as amino acid chelates in appropriate ratios. Preferable the composition also contains effective amounts of one or more minerals selected from the group consisting of copper, magnesium and potassium all of which are present at least in part as amino acid chelates or complexes. When magnesium and potassium are present at least some of these are present in inorganic form. Vitamins, other minerals such as calcium and phosphorus, and fillers may also be utilized.The composition is orally administered to female mammals to both induce estrus and bring about a stronger and more noticable estrus. In the male both libido and spermatogenesis are improved by the oral administration of the composition.
摘要翻译： 用于刺激促性腺激素生成并维持哺乳动物生殖器官内的矿物质平衡的组合物和方法。 该组合物由适当比例的含有有效量的锰，铁和锌作为氨基酸螯合物的矿物混合物组成。 优选的组合物还含有有效量的一种或多种选自铜，镁和钾的矿物质，其全部至少部分作为氨基酸螯合物或复合物存在。 当镁和钾存在时，其中至少一些以无机形式存在。 也可以使用维生素，钙和磷等其他矿物质和填充剂。 该组合物经口施用于雌性哺乳动物以诱发发情，并产生更强烈和更明显的发情。 在雄性中，通过口服施用组合物来改善性欲和精子发生。
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公开(公告)号：US4491464A
公开(公告)日：1985-01-01
申请号：US495269
申请日：1983-05-17
申请人： Harvey H. Ashmead , Hsin-Hung Hsu
发明人： Harvey H. Ashmead , Hsin-Hung Hsu
CPC分类号： C05B13/06
摘要： The effectiveness of a potassium polyphosphate fertilizer is enhanced resulting in higher intake of phosphorus and potassium into plant tissues and higher crop yields by the foliar application to growing plants of a composition comprising a blend of potassium and ammonium polyphosphates which also contains an effective amount of a protein hydrolysate.
摘要翻译： 钾多磷酸肥料的有效性增强，导致植物组织中磷和钾的摄入量增加，并且通过叶面施用于生长植物的组合物，其中包含多磷酸钾和铵的混合物，其中还含有有效量的 蛋白质水解产物。
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公开(公告)号：US4216143A
公开(公告)日：1980-08-05
申请号：US843969
申请日：1977-10-20
申请人： Harvey H. Ashmead
发明人： Harvey H. Ashmead
CPC分类号： C05D9/02 , A23L33/165
摘要： Non-ferrous metal proteinates or chelates of essential bivalent metals with hydrolyzed protein are rendered soluble without destroying the chelate and are more readily assimilated by plants and animals.
摘要翻译： 具有水解蛋白质的必需二价金属的有色金属蛋白质或螯合物在不破坏螯合物的情况下变得可溶，并且更容易被植物和动物吸收。
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公开(公告)号：US4103003A
公开(公告)日：1978-07-25
申请号：US680078
申请日：1976-04-26
申请人： Harvey H. Ashmead
发明人： Harvey H. Ashmead
CPC分类号： A23K20/30 , A23K20/142 , A23K20/147 , A23K20/163 , A23L33/165
摘要： A combination of a protein hydrolysate metal chelate and a sugar-metal chelate exhibit a synergistic effect on biological development in that a biological organism grows at a more rapid rate and biological tissues assimilate a substantially greater amount of essential polyvalent metals when the metals are administered in the form of an exogenically prepared composition of both hydrolyzed protein-metal and sugar-metal chelate. Unique methods of preparation of the synergistic composition include (a) forming a protein hydrolysate metal chelate and sugar-metal chelate separately and thereafter mixing the chelates; (b) hydrolyzing protein, adding metal and thereafter combining the hydrolyzed protein and metal with hydrolyzed sugar, starches or carbohydrates, the pH of the conbination being thereafter adjusted until the chelates are formed; (c) hydrolyzing protein and sugar or starch together, adding a soluble metal compound and thereafter adjusting the pH with an alkaline solution until the chelates are formed; (d) using a quicklime strong base solution to hydrolyze either the protein or the sugar or starch for use in the methods above described, and (e) making metal available for chelation by electrolytically treating ore waste products and the like.
摘要翻译： 蛋白质水解物金属螯合物和糖 - 金属螯合物的组合表现出对生物发育的协同效应，因为生物体生物以更快的速度生长，并且当金属被施用时，生物组织吸收基本上更多量的必需多价金属 水解的蛋白质金属和糖金属螯合物的外源制备的组合物的形式。 制备协同组合物的独特方法包括（a）分别形成蛋白质水解物金属螯合物和糖金属螯合物，然后混合螯合物; （b）水解蛋白质，加入金属，然后将水解的蛋白质和金属与水解糖，淀粉或碳水化合物结合，此后调节结合的pH直到形成螯合物; （c）一起水解蛋白质和糖或淀粉，加入可溶性金属化合物，然后用碱性溶液调节pH直到螯合物形成; （d）使用生石灰强碱溶液水解上述方法中使用的蛋白质或糖或淀粉，和（e）通过电解处理矿石废物等制备可用于螯合的金属。
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公开(公告)号：US4599152A
公开(公告)日：1986-07-08
申请号：US738065
申请日：1985-05-24
申请人： Harvey H. Ashmead
发明人： Harvey H. Ashmead
IPC分类号： C07K14/00 , C07C67/00 , C07C227/00 , C07C227/14 , C07C229/76 , C07D263/04 , C07K1/113 , C07K5/06 , C09K3/00 , C25B3/00 , C25B3/02 , C25B1/02
CPC分类号： C07C229/76 , C25B3/02
摘要： Pure amino acid chelates and a method of their production are disclosed. The amino acid chelates are free of contaminating inorganic anions. The chelate consists of a metal ion comprising iron, zinc, manganese, magnesium, copper, calcium and mixtures thereof. The metal ion is chelated to one or more ligands comprising alpha amino acids, protein hydrolysates, polypeptides, dipeptides, and combinations thereof. A novel process is disclosed wherein the amino acid ligand is brought into reactive contact with a divalent metal ion in an environment which is completely anion free but otherwise conducive to the interaction between the amino acid ligand and the metal ion, with the formation of an amino acid chelate in pure form or, at least, which can readily be recovered from the reactive environment in pure form.
摘要翻译： 公开了纯氨基酸螯合物及其生产方法。 氨基酸螯合物没有污染的无机阴离子。 螯合物由包含铁，锌，锰，镁，铜，钙及其混合物的金属离子组成。 金属离子与包含α氨基酸，蛋白质水解物，多肽，二肽及其组合的一种或多种配体螯合。 公开了一种新方法，其中氨基酸配体在完全无阴离子的环境中与二价金属离子发生反应性接触，但是有利于氨基酸配体和金属离子之间的相互作用，形成氨基 酸性螯合物是纯形式的，或者至少可以容易地以纯形式从反应性环境中回收。
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公开(公告)号：US4830716A
公开(公告)日：1989-05-16
申请号：US882150
申请日：1986-07-03
申请人： Harvey H. Ashmead
发明人： Harvey H. Ashmead
IPC分类号： C07F1/08 , C07C51/41 , C07C67/00 , C07C227/00 , C07C227/16 , C07C227/18 , C07C227/28 , C07C229/76 , C07C325/00 , C07C391/00 , C07F3/02 , C07F3/06 , C07F9/00 , C07F11/00 , C07F13/00 , C07F15/02 , C07F15/06 , C07K1/107 , C07K14/00 , C25B3/00
CPC分类号： C07C51/41
摘要： Pharmaceutical grade amino acid chelates, free of interfering anions, are made by reacting an amino acid ligand with a metal member selected from the group consisting of elemental metals, metal oxides, metal hydroxides and metal carbonates in an aqueous environment wherein the ligand to metal mole ratio is at least 2:1 and recovering the amino acid chelate from said aqueous environment by means of spray or drum drying. The reaction may be carried out in the presence of non-interfering anions such as anions from citric acid, ascorbic acid, acetic acid, carbonic acid and ammonium and alkali metal salts thereof.
摘要翻译： 通过使氨基酸配体与选自元素金属，金属氧化物，金属氢氧化物和金属碳酸盐的金属成分在水性环境中反应制备药物级氨基酸螯合物，其中配体与金属摩尔 比例为至少2:1，并通过喷雾或滚筒干燥从所述水性环境中回收氨基酸螯合物。 反应可以在非干扰性阴离子例如柠檬酸，抗坏血酸，乙酸，碳酸及其铵及其碱金属盐的阴离子存在下进行。
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公开(公告)号：US4169717A
公开(公告)日：1979-10-02
申请号：US843970
申请日：1977-10-20
申请人： Harvey H. Ashmead
发明人： Harvey H. Ashmead
摘要： A combination of (1) metal proteinates consisting of chelation products of an essential bivalent metal with at least two ligands which are protein hydrolysates consisting of polypeptides, peptides and naturally occurring amino acids and (2) a plant growth hormone consisting of auxins, cytokinins and gibberellin(s) singularly or in combination.
摘要翻译： 由（1）由必需二价金属的螯合产物与至少两种配体组成的金属蛋白质的组合，所述配体是由多肽，肽和天然存在的氨基酸组成的蛋白质水解产物，和（2）由生长素，细胞分裂素和细胞分裂素组成的植物生长激素 赤霉素单独或组合使用。
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公开(公告)号：US4020158A
公开(公告)日：1977-04-26
申请号：US658243
申请日：1976-02-17
申请人： Harvey H. Ashmead , Paul A. Little
发明人： Harvey H. Ashmead , Paul A. Little
CPC分类号： A61K31/295 , A23K20/142 , A23K20/147 , A23K20/24 , A23K20/30 , A23K50/30 , A61K38/012
摘要： The levels of nutritionally essential metals in biological tissue are improved by administering corrective dosages of the metals found to be deficient, the metal being administered in the form of metal proteinates. General health of animals is improved by increasing the levels of metals in biological tissues through the administration of multiple metals in the form of metal proteinates.
摘要翻译： 生物组织中营养必需金属的水平通过施用发现缺陷的金属的修正剂量来改善，金属以金属蛋白质的形式施用。 通过以金属蛋白质形式施用多种金属来增加生物组织中金属的含量来改善动物的总体健康。
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