公开(公告)号：US09868956B2

公开(公告)日：2018-01-16

申请号：US13376068

申请日：2010-06-02

Applicant: Duy P. Nguyen ,  Heinz Neumann ,  Alexander Deiters ,  Jason Chin ,  Hrvoje Lusic

Inventor： Duy P. Nguyen ,  Heinz Neumann ,  Alexander Deiters ,  Jason Chin ,  Hrvoje Lusic

IPC: C12P21/06 ,  C12N15/67 ,  C07C233/49 ,  C07C271/22 ,  C12N9/00 ,  C12P21/02

CPC classification number: C12N15/67 ,  C07C233/49 ,  C07C271/22 ,  C12N9/93 ,  C12P21/02

Abstract: The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same.

公开(公告)号：US06523298B2

公开(公告)日：2003-02-25

申请号：US09747225

申请日：2000-12-22

Applicant: Robert Heinz Neumann

Inventor： Robert Heinz Neumann

IPC: A01M120

CPC classification number: A01N65/08 ,  A01N37/18 ,  A01N65/00 ,  A01N65/38

Abstract: A method for exterminating existing infestations of ants, termites, insects or other living organisms in structures, soils and other materials using a capsicum-containtg killing solution in either a liquid or vapor form, including the steps of delivering the killing solution to the infested portions of the structure, and contacting the termites, insects or other living organisms forming the infestation. The method obviates the need for toxic or environmentally unsafe chemical compounds, and capsicum is readily available and economical. More importantly, the novel pesticide and method of use of the present invention is highly effective against termites in dry areas, wet areas, inaccessible and exposed areas, including around and under foundations, in ceiling and in wall portions of structures. Boring small holes into the structure, from either the inside or the outside and penetrating into the interior wall, ceiling and foundation spaces will allow the capsicum based killing solution to be pumped directly therein. Additionally, the killing solution can be applied underneath vapor barriers into the soil to eliminate nematodes in soil prior to other agricultural activities.

Abstract translation: 一种消除结构物，土壤和其他物质中的蚂蚁，白蚁，昆虫或其他生物体的现有侵染的方法，使用液体或蒸气形式的包含辣椒的杀菌溶液，包括将杀死溶液递送至侵染部分的步骤 的结构，并接触形成感染的白蚁，昆虫或其他生物体。 该方法避免了对有毒或环境不安全的化学化合物的需要，并且辣椒易于获得和经济。 更重要的是，本发明的新型杀虫剂和使用方法对于干燥区域，潮湿区域，不可接近和暴露的区域，包括在地基的周围和底部，天花板和结构的壁部分的白蚁是非常有效的。 在内部或外部从内部或外部钻出小孔，天花板和基础空间将使辣椒基杀伤溶液直接泵送到其中。 此外，杀虫溶液可以在蒸汽屏障下面施加到土壤中，以在其他农业活动之前在土壤中消除线虫。

公开(公告)号：US4105907A

公开(公告)日：1978-08-08

申请号：US717529

申请日：1976-08-25

Applicant: Walter Hagenlocher ,  Karl-Heinz Neumann ,  Martin Muller ,  Karl Kleebaur ,  Gunter Sokol ,  Jurgen Molt

Inventor： Walter Hagenlocher ,  Karl-Heinz Neumann ,  Martin Muller ,  Karl Kleebaur ,  Gunter Sokol ,  Jurgen Molt

IPC: H01R39/06 ,  H01R39/08 ,  H01R39/10 ,  H01R39/34 ,  H02K13/00 ,  H02K13/02

CPC classification number: H01R39/34

Abstract: A support carrier of electrically conductive material is secured to the shaft of the machine. A plurality of slip rings are secured to the support carrier, one of the slip rings being fixed thereto directly so that the support carrier will form one terminal of the electrical connection for the slip rings, and an insulating layer is placed over the support carrier over which the other slip ring is located. Preferably, the support carrier is formed with a flange which is notched, one of the notches serving to form an electrical connection for the wire of the field of the machine for connection to the slip ring which is directly secured to the support carrier, the other notch in the flange being wider and gripping around the insulation of the other wire of the field, the wire of the field then being connected to the slip ring which is carried on the insulation. That slip ring, preferably, is also formed with an external flange to which its connecting wire can be secured, for example by soldering. The support carrier may be a solid stub shaft for attachment to the shaft of the alternator, or a tube to be slipped thereover.

Abstract translation: 导电材料的支撑载体固定在机器的轴上。 多个滑环固定到支撑载体上，其中一个滑环直接固定到滑环上，使得支撑载体将形成用于滑环的电连接的一个端子，并且绝缘层放置在支撑载体上方 另一个滑环位于哪个。 优选地，支撑载体形成有凹口的凸缘，其中一个凹口用于形成用于连接到直接固定到支撑载体的滑环的机器的电线的电连接，另一个 法兰中的凹口更宽，并围绕场的另一根线的绝缘夹紧，然后电场的导线连接到承载在绝缘体上的滑环。 优选地，该滑环也形成有外部凸缘，例如通过焊接，可以将连接线固定到该外部凸缘。 支撑载体可以是用于附接到交流发电机的轴的实心短轴，或者在其上滑动的管。

公开(公告)号：US20120190825A1

公开(公告)日：2012-07-26

申请号：US13499340

申请日：2010-10-01

Applicant: Heinz Neumann ,  Jason Chin

Inventor： Heinz Neumann ,  Jason Chin

IPC: C12P21/02 ,  C12N1/21 ,  C07K14/435 ,  C12N15/63 ,  C12N9/00 ,  C12N15/52

CPC classification number: C12P21/02 ,  C12N9/93

Abstract: The invention relates to a tRNA synthetase capable of binding Nε-acetyl lysine, wherein said synthetase comprises a polypeptide having at least 90% sequence identity to the amino acid sequence of MbPyIRS, and wherein said synthetase comprises a L266M mutation.

Abstract translation: 本发明涉及能够结合N-乙酰基赖氨酸的tRNA合成酶，其中所述合成酶包含与MbPyIRS的氨基酸序列具有至少90％序列同一性的多肽，并且其中所述合成酶包含L266M突变。

公开(公告)号：US20070246368A1

公开(公告)日：2007-10-25

申请号：US11575219

申请日：2005-09-12

Applicant: Günther Huber ,  Reinhard Ottl ,  Manfred Munzinger ,  Heinz Neumann ,  Martina Shulz ,  Matthias Stahl ,  Gerhard Ruf ,  Ralph Hamleser ,  Hans-Jurgen Bender ,  Volker Esswein

Inventor： Günther Huber ,  Reinhard Ottl ,  Manfred Munzinger ,  Heinz Neumann ,  Martina Shulz ,  Matthias Stahl ,  Gerhard Ruf ,  Ralph Hamleser ,  Hans-Jurgen Bender ,  Volker Esswein

IPC: H01M4/02

CPC classification number: C25C3/02 ,  C25C7/005 ,  C25C7/04

Abstract: The invention relates to an electrolysis cell for preparing liquid alkali metal from a liquid alkali metal-heavy metal alloy, which comprises a tube (1) which is arranged essentially horizontally and has a closure device (4) at each of the two ends of the tube (1), at least one solid electrolyte tube (12) arranged in the tube (1), which conducts alkali metal ions and is closed at one end and has an opening (11) at the other end, with the solid electrolyte tube (12) being arranged concentrically in the tube (1) and having the opening (11) facing one end of the tube (1) so that a first annular gap (13) for conducting the liquid alkali metal-heavy metal alloy which forms one anode is present between the inside of the tube (1) and the outside of the solid electrolyte tube (12), an interior space (14) in the solid electrolyte tube (12) for accommodating the liquid alkali metal which can be utilized as cathode, where the closure device (4) comprises an alkali metal-heavy metal alloy inlet (8) or outlet (9) opening into the first annular gap (13), a holder for the solid electrolyte tube (12), an alkali metal outlet (15) connected to the interior space (14) of the solid electrolyte tube (12) and a sealing system for sealing the interior space (14) of the solid electrolyte tube (12) and the alkali metal outlet (15) off from the first annular gap (13), the alkali metal-heavy metal alloy inlet (8) or outlet (9) and from the surroundings of the electrolysis cell.

Abstract translation: 本发明涉及一种用于从液态碱金属 - 重金属合金制备液态碱金属的电解槽，该电解槽包括基本上水平布置的管（1），并在其两端的每一端具有闭合装置（4） 管（1），设置在管（1）中的至少一个固体电解质管（12），其传导碱金属离子并且在一端封闭并且在另一端具有开口（11），与固体电解质管 （12）同心地布置在所述管（1）中，并且所述开口（11）面向所述管（1）的一端，使得用于导入液态碱金属 - 重金属合金的第一环形间隙（13）形成一个 阳极存在于管（1）的内部和固体电解质管（12）的外部之间，固体电解质管（12）中的内部空间（14）用于容纳可用作阴极的液态碱金属 ，其中封闭装置（4）包括碱 通入第一环形间隙（13）的金属重金属合金入口（8）或出口（9），固体电解质管（12）的保持器，连接到内部空间（14）的碱金属出口（15） 的固体电解质管（12）和用于密封固体电解质管（12）的内部空间（14）和碱金属出口（15）的第一环形间隙（13）的密封系统， 重金属合金入口（8）或出口（9）和电解池周围。

公开(公告)号：US5387402A

公开(公告)日：1995-02-07

申请号：US66301

申请日：1993-05-21

Applicant: Michael Tacke ,  Peter Ahrens ,  Hugo Grimm ,  Heinz Neumann ,  Egon Winkler ,  Arend Werner ,  Walter Beitelschmidt ,  Bruno Triebskorn

Inventor： Michael Tacke ,  Peter Ahrens ,  Hugo Grimm ,  Heinz Neumann ,  Egon Winkler ,  Arend Werner ,  Walter Beitelschmidt ,  Bruno Triebskorn

IPC: B01J8/02 ,  C01B17/80 ,  F28D7/00 ,  B01D50/00 ,  F01N3/10

CPC classification number: B01J8/0285 ,  B01J8/0278 ,  C01B17/803 ,  B01J2208/00132

Abstract: To effect a quasi-isothermal catalytic reaction of SO.sub.2 to SO.sub.3, a plurality of consecutive rows of banks of cooling tubes, are provided in the bed of shaped catalyst bodies in a contact reactor in such a manner that the banks of succeeding rows are staggered from the banks of the preceding rows. The distance between the cooling tubes in the banks is so selected that a penetration of entire catalyst bodies into the banks will virtually be prevented. The banks are so designed that the pressure drop of the gas in the banks is approximately the same as the pressure drop in the layer of catalyst between the bank. The distance between the banks is larger than the width of the banks.

Abstract translation: 为了实现SO2与SO3的准等温催化反应，在接触反应器中的成形催化剂体床中设置多个连续排的冷却管排，使得后续排的排与 前一行的行。 两组中的冷却管之间的距离如此选择，从而实际上可以防止整个催化剂体渗入到组中。 这些堤设计成使得堤岸中的气体的压降几乎与堤岸之间的催化剂层的压降相同。 银行之间的距离大于银行的宽度。

公开(公告)号：US4834954A

公开(公告)日：1989-05-30

申请号：US67658

申请日：1987-06-26

Applicant: Karl H. Dorr ,  Hugo Grimm ,  Heinz Neumann ,  Rudolf Gerken ,  Gunter Lailach

Inventor： Karl H. Dorr ,  Hugo Grimm ,  Heinz Neumann ,  Rudolf Gerken ,  Gunter Lailach

IPC: F23J15/00 ,  B01D53/34 ,  B01D53/50 ,  B01D53/68 ,  B01D53/77 ,  F23J15/08

CPC classification number: B01D53/34 ,  B01D53/507 ,  B01D53/68 ,  F23J15/08

Abstract: Cleaned flue gases normally accumulate as steam-saturated gases with temperatures of from 40.degree. to 55.degree. C. after wet cleaning processes for the removal of sulfur and/or nitrogen compounds. Before being let off through a stack, however, these gases have to be heated to at least 72.degree. C.This invention relates to a process for reheating flue gases after wet cleaning.

Abstract translation: 清洁的烟道气体通常在湿法清洗过程中作为蒸汽饱和气体积聚，温度为40-55℃，以除去硫和/或氮化合物。 然而，在通过堆放出之前，这些气体必须被加热到至少72℃。本发明涉及在湿清洗后再加热烟道气的方法。

公开(公告)号：US20110027829A1

公开(公告)日：2011-02-03

申请号：US12739247

申请日：2008-10-27

Applicant: Heinz Neumann ,  Jason Chin

Inventor： Heinz Neumann ,  Jason Chin

IPC: C12P21/00 ,  C12N9/00 ,  C07H21/00 ,  C07K2/00 ,  C07K14/00 ,  C12N15/63 ,  C12N1/00

CPC classification number: C12P21/02 ,  C12N9/93

Abstract: The invention relates to a tRNA synthetase capable of binding N⊂-acetyl lysine, in particular, the invention relates to a tRNA synthetase capable of binding N∈-acetyl lysine wherein said synthetase comprises a polypeptide having at least 90% sequence identity to the amino acid sequence of MbPy1RS. The invention also relates to a method of making a polypeptide comprising N∈-acetyl lysine comprising arranging for the translation of a RNA encoding said polypeptide, wherein said RNA comprises an amber codon, wherein said translation is carried out in the presence of a polypeptide according to any of claims 1 to 11 and in the presence of tRNA capable of being charged with N∈-acetyl lysine, and in the presence of N∈-acetyl lysine.

Abstract translation: 本发明涉及能够结合N-乙酰赖氨酸的tRNA合成酶，特别地，本发明涉及能够结合Nε-乙酰赖氨酸的tRNA合成酶，其中所述合成酶包含与氨基具有至少90％序列同一性的多肽 MbPy1RS的酸序列。 本发明还涉及一种制备包含Nε-乙酰赖氨酸的多肽的方法，包括安排编码所述多肽的RNA的翻译，其中所述RNA包含琥珀密码子，其中所述翻译在多肽存在下进行， 权利要求1至11中任一项，并且在存在能够被Nε-乙酰赖氨酸加载的tRNA存在下，并且在Nε-乙酰赖氨酸存在下。

公开(公告)号：US20100105565A1

公开(公告)日：2010-04-29

申请号：US12516230

申请日：2007-11-28

Applicant: Jason Chin ,  Kaihang Wang ,  Heinz Neumann

Inventor： Jason Chin ,  Kaihang Wang ,  Heinz Neumann

IPC: C40B30/00 ,  C07H21/02 ,  C12P21/06 ,  C12N1/21

CPC classification number: C12N15/11 ,  C12N15/111 ,  C12N2320/13 ,  C12P21/02 ,  C40B10/00 ,  C40B40/08

Abstract: There is provided a method for evolving an orthogonal rRNA molecule, comprising the steps of: providing one or more libraries of mutant orthogonal rRNA molecules and introducing the libraries into cells such that the orthogonal rRNA is incorporated into ribosomes to provide orthogonal ribosomes; providing one or more orthogonal mRNA molecules which (i) are not translated by natural ribosomes, and (ii) comprise one or more orthogonal mRNA codons; assaying the translation of the of the orthogonal mRNA and selecting the orthogonal rRNA molecules which translate the orthogonal mRNA, wherein the assay in step (c) requires translation of one or more orthogonal mRNA codons in the orthogonal mRNA; and orthogonal ribosomes incorporating such rRNA molecules.

Abstract translation: 提供了用于进化正交rRNA分子的方法，包括以下步骤：提供一个或多个突变正交rRNA分子文库，并将文库引入细胞，使得正交rRNA被并入核糖体中以提供正交核糖体; 提供（i）不被天然核糖体翻译的一个或多个正交mRNA分子，和（ii）包含一个或多个正交mRNA密码子; 测定正交mRNA的翻译并选择翻译正交mRNA的正交rRNA分子，其中步骤（c）中的测定需要在正交mRNA中翻译一个或多个正交mRNA密码子; 并结合这样的rRNA分子的正交核糖体。

公开(公告)号：US07094923B2

公开(公告)日：2006-08-22

申请号：US11083746

申请日：2005-03-17

Applicant: Reinhard Langer ,  Lars Rodefeld ,  Karl Heinz Neumann

Inventor： Reinhard Langer ,  Lars Rodefeld ,  Karl Heinz Neumann

IPC: C07C309/00 ,  C07C51/16 ,  C07C51/255 ,  C07C51/23 ,  C07C51/15

CPC classification number: C07C303/22 ,  C07C201/12 ,  C07C309/58 ,  C07C205/57 ,  C07C205/58 ,  C07C205/61

Abstract: The present invention relates to the preparation of nitrobenzoic acids by oxidizing particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers in the presence of nitric acid at elevated temperature and elevated pressure. It has been found that the particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers may be oxidized particularly reliably and in high yields using nitric acid to the benzoic acid derivatives when they are metered into the nitric acid.

Abstract translation: 本发明涉及通过在高温和高压下在硝酸存在下氧化特定的硝基甲苯，硝基苄醇，酯和/或醚来制备硝基苯甲酸。 已经发现，当特定的硝基甲苯，硝基苄基醇，酯和/或醚可以特别可靠地被氧化并且当它们被计量到硝酸中时，使用硝酸对苯甲酸衍生物是高产率的。