公开(公告)号：US07396589B2

公开(公告)日：2008-07-08

申请号：US11687697

申请日：2007-03-19

Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Achuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Achuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC: B32B5/16

CPC classification number: A61K49/183 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/904 ,  Y10T428/2991

Abstract: Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles comprise a core represented as FexMavZy and a shell of an inner-transition element Mb or the compound thereof, wherein Ma is an inner-transition element, Z is an element of the group Vla, x is greater or equal to 0, and v, y are positive numbers. The surface of the shell is optionally modified by liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.

Abstract translation: 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒包含一个表示为Fe x Si x Z y的核， 过渡元素M b或其化合物，其中M a是内部过渡元素，Z是基团Vla的元素，x大于或等于0， v，y为正数。 壳的表面任选地被脂质体，聚合物，脂族化合物，芳族化合物或其组合改性。

公开(公告)号：US08513405B2

公开(公告)日：2013-08-20

申请号：US12935681

申请日：2008-04-02

Applicant: Pei-Shin Jiang ,  Yu-Ting Su ,  Kun-Chan Wu ,  Hui-Ju Cho ,  Wen-Hsun Kuo ,  Yuh-Jiuan Lin ,  Yi-Ling Li ,  Cheng-Chun Kuan

Inventor： Pei-Shin Jiang ,  Yu-Ting Su ,  Kun-Chan Wu ,  Hui-Ju Cho ,  Wen-Hsun Kuo ,  Yuh-Jiuan Lin ,  Yi-Ling Li ,  Cheng-Chun Kuan

IPC: C07H21/02 ,  C07H21/00

CPC classification number: C07H1/06 ,  C07H21/00 ,  C12N15/1013

Abstract: Disclosed are a chaotropic agent; a reagent including a chaotropic agent and a lithium salt; a reagent kit including a chaotropic agent; a chaotropic agent, a reagent, a reagent kit, and a method for isolating a nucleic acid by use of a magnetic cellulose material; a method for binding a nucleic acid to a magnetic cellulose material; a method for isolating a nucleic acid; and a method for purifying a chromosome DNA. It is required that each of the chaotropic agents, the reagents, and the reagent kits works with at least one solid-phase, magnetic cellulose-containing carrier to isolate a nucleic acid from non-nucleic acid substances. In addition, each chaotropic agent includes an alcohol substance and a substrate solution for adjusting the alcohol substance to an appropriate concentration and thereby promoting binding of the nucleic acid in a sample to the magnetic cellulose.

Abstract translation: 公开了一种离液剂; 包含离液剂和锂盐的试剂; 包含离液剂的试剂盒; 离液剂，试剂，试剂盒和通过使用磁性纤维素材料分离核酸的方法; 将核酸与磁性纤维素材料结合的方法; 分离核酸的方法; 以及纯化染色体DNA的方法。 需要每种离液剂，试剂和试剂盒与至少一种固相含磁性纤维素的载体一起工作，以将核酸与非核酸物质分离。 此外，各离液剂包括醇物质和用于将醇物质调节至适当浓度的底物溶液，从而促进样品中的核酸与磁性纤维素的结合。

公开(公告)号：US20060165601A1

公开(公告)日：2006-07-27

申请号：US11316822

申请日：2005-12-27

Applicant: Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

Inventor： Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

IPC: A61K49/10 ,  C08F8/42

CPC classification number: A61K49/124

Abstract: A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.

Abstract translation: 公开了以下结构的树枝状化合物：PD n-Z-L。 在上述结构中，P是X - （CH 2 CH 2 CH 2 -O）n - ，r是1000至4000的整数 ，X是OH，NH 2或OR，R是C 1至C 10烷基，C 1 -C 6烷基， 是分支C 3〜C 30多元醇化合物的残基，n是支链化合物的残基的层数，并且是等于或大于1的整数， L是金属阳离子，Z是具有多官能团的C 3 O 3至C 30+化合物的残基。 上述官能团可以是羧基，氨基，酰胺基或螯合基。 羧基，酯基，氨基或酰胺基结合于D n N，螯合基团与金属阳离子结合。

公开(公告)号：US20060120964A1

公开(公告)日：2006-06-08

申请号：US11336347

申请日：2006-01-20

Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC: A61K49/16 ,  A61K49/08

CPC classification number: B82Y5/00 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/183 ,  Y10S977/777 ,  Y10S977/904 ,  Y10S977/915 ,  Y10T428/2982

Abstract: Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles are represented as (FewGdx)Zy, wherein w is from 99.9% to 97.5%, x is from 0.1% to 2.5%, Z is an element of the group VIa, and v, y are positive numbers.

Abstract translation: 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒表示为（Fe x Gd x Z z）Z y y，其中w为99.9％至97.5％，x为0.1 ％至2.5％，Z为VIa族的元素，v，y为正数。

公开(公告)号：US20050025971A1

公开(公告)日：2005-02-03

申请号：US10741238

申请日：2003-12-19

Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC: A61K47/48 ,  A61K49/18 ,  B32B5/16 ,  B32B15/02 ,  B32B23/02 ,  B32B27/02

CPC classification number: B82Y5/00 ,  A61K47/6923 ,  A61K49/1818 ,  A61K49/183 ,  Y10T428/2991

Abstract: A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation. The magnetic nanoparticle is characterized as comprising at least an inner-transition element, represented as FexMavZy, wherein Ma is an inner-transition element, Z is an element of the group VIa, x is greater or equal to 0, and both v and y are positive numbers. The magnetic nanoparticle may further comprise a shell to form a core-shell structure, wherein the shell is an inner-transition element Mb or the compound thereof.

Abstract translation: 适用于成像，诊断，治疗和生物材料分离的磁性纳米颗粒。 磁性纳米颗粒的特征在于至少包含内部过渡元素，表示为FexMaAvZy，其中M是>内部过渡元素，Z是VIa的元素，x大于或等于 0，v和y均为正数。 磁性纳米颗粒还可以包含壳形成核 - 壳结构，其中壳是内部过渡元素M或其化合物。