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公开(公告)号：US07820808B2
公开(公告)日：2010-10-26
申请号：US10551705
申请日：2004-04-01
申请人： Michael James Moser , David J. Marshall , James R. Prudent , Christopher V. Van Hout , Christine A. Larsen
发明人： Michael James Moser , David J. Marshall , James R. Prudent , Christopher V. Van Hout , Christine A. Larsen
CPC分类号： C12Q1/48
摘要： The present invention provides nucleic acid based polymerase inhibitors and methods for reducing non-specific polymerase extension and amplification in nucleic acid amplification reactions. The polymerase inhibitors provide a double stranded nucleic acid portion that is recognized by a polymerase enzyme as a template for extension but is incapable of being extended by the polymerase enzyme. The polymerase binds to the polymerase inhibitor which sequesters the enzyme until the temperature achieves a level that denatures the double stranded portion of the inhibitor after which the polymerase is released and can then catalyze nucleic acid extension.
摘要翻译： 本发明提供了基于核酸的聚合酶抑制剂和用于在核酸扩增反应中减少非特异性聚合酶延伸和扩增的方法。 聚合酶抑制剂提供双链核酸部分，其被聚合酶识别为扩增模板，但不能被聚合酶延伸。 聚合酶结合聚合酶抑制剂，其将酶螯合，直到温度达到使抑制剂的双链部分变性的水平，其后聚合酶被释放，然后可以催化核酸延伸。
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公开(公告)号：US07515784B2
公开(公告)日：2009-04-07
申请号：US11110604
申请日：2005-04-20
申请人： Ketan Bhalla , Andre Lortie , Kyle Edginton , James Moser , Gamal Refai-Ahmed , Marc Nadeau , Ross Saunders , Lee Shyue Choong
发明人： Ketan Bhalla , Andre Lortie , Kyle Edginton , James Moser , Gamal Refai-Ahmed , Marc Nadeau , Ross Saunders , Lee Shyue Choong
IPC分类号： G02B6/28
CPC分类号： H04J14/02 , H04J3/04 , H04J3/1611 , H04J2203/0025 , H04J2203/0026 , H04Q11/0071
摘要： A field reconfigurable muxponder for use in an optical transport system. The muxponder includes one or more tributary cards, where each tributary card is adapted to receive an optical data signal and conditions the optical data signal into an intermediate data signal constituted in accordance with a tributary interface format. In this way, the muxponder is able to aggregate optical data signals having different protocols and/or different data rates. The muxponder further includes a chassis that is adapted to receive a predefined number of tributary cards and outputs an optical system signal independently from the availability of the optical data signals from the tributary cards. The tributary cards and the chassis integrally form one line card.
摘要翻译： 一种用于光传输系统的现场可重配置复用应答器。 复用器包括一个或多个辅助卡，其中每个支路卡适于接收光学数据信号，并将光学数据信号调节成根据支流接口格式构成的中间数据信号。 以这种方式，复用器能够聚合具有不同协议和/或不同数据速率的光数据信号。 复用器还包括适于接收预定数量的辅助卡并且独立于来自辅助卡的光学数据信号的可用性而输出光学系统信号的机箱。 支流卡和底盘一体形成一张线卡。
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公开(公告)号：US20130040287A1
公开(公告)日：2013-02-14
申请号：US13627894
申请日：2012-09-26
申请人： Michael James Moser
发明人： Michael James Moser
CPC分类号： C12Q1/703 , C12Q1/6827 , C12Q1/6832 , C12Q1/6858 , C12Q2600/156 , C12Q2527/107 , C12Q2525/161 , C12Q2525/101 , C12Q2549/119
摘要： Disclosed are methods and kits for identifying and characterizing polynucleotide sequences in a sample which may include a heterogeneous sample. Some of the methods and kits are directed to the identification and characterization of a virus in a sample, which may include HIV capable of cause AIDS or AIDS-like symptoms. The virus may be HIV-1, and may also include drug resistant mutations. The methods may include reacting a mixture that includes, in addition to nucleic acid isolated from the sample, at least one oligonucleotide capable of specifically hybridizing to HIV nucleic acid where the oligonucleotide includes at least one non-natural base. In addition, the methods may include detection of one or more mutations in HIV nucleic acid that are associated with drug resistance.
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公开(公告)号：US08313932B2
公开(公告)日：2012-11-20
申请号：US12884575
申请日：2010-09-17
申请人： Michael James Moser , David J. Marshall , James R. Prudent , Cristopher V. Van Hout , Christine A. Larsen
发明人： Michael James Moser , David J. Marshall , James R. Prudent , Cristopher V. Van Hout , Christine A. Larsen
CPC分类号： C12Q1/48
摘要： The present invention provides nucleic acid based polymerase inhibitors and methods for reducing non-specific polymerase extension and amplification in nucleic acid amplification reactions. The polymerase inhibitors provide a double stranded nucleic acid portion that is recognized by a polymerase enzyme as a template for extension but is incapable of being extended by the polymerase enzyme. The polymerase binds to the polymerase inhibitor which sequesters the enzyme until the temperature achieves a level that denatures the double stranded portion of the inhibitor after which the polymerase is released and can then catalyze nucleic acid extension.
摘要翻译： 本发明提供了基于核酸的聚合酶抑制剂和用于在核酸扩增反应中减少非特异性聚合酶延伸和扩增的方法。 聚合酶抑制剂提供双链核酸部分，其被聚合酶识别为扩增模板，但不能被聚合酶延伸。 聚合酶结合聚合酶抑制剂，其将酶螯合，直到温度达到使抑制剂的双链部分变性的水平，其后聚合酶被释放，然后可以催化核酸延伸。
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15.发明申请公开(公告)号：US20120122095A1
公开(公告)日：2012-05-17
申请号：US11652702
申请日：2007-01-11
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： Disclosed are methods and kits for identifying a virulent bacteria in a sample, which may include virulent bacteria belonging to the Bacillus genus (e.g., Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis). Typically, the methods include (a) reacting a mixture that includes, in addition to nucleic acid isolated from the sample, (i) at least one oligonucleotide capable of specifically hybridizing to nucleic acid of plasmid pX01; and (ii) at least one oligonucleotide capable of specifically hybridizing to nucleic acid of plasmid pX02. In addition, the mixture may include control nucleic acid. In the methods, nucleic acid of plasmid pX01 and nucleic acid of plasmid pX02 are detected, and optionally control nucleic acid is detected, thereby identifying the virulent bacteria.
摘要翻译： 公开了用于鉴定样品中的有毒细菌的方法和试剂盒，其可以包括属于芽孢杆菌属（例如炭疽芽孢杆菌，蜡状芽孢杆菌和苏云金芽孢杆菌）的毒力细菌。 通常，所述方法包括（a）除了从样品分离的核酸之外还包括（i）至少一种能够与质粒pX01的核酸特异性杂交的寡核苷酸的混合物反应; 和（ii）能够与质粒pX02的核酸特异性杂交的至少一种寡核苷酸。 此外，混合物可以包括对照核酸。 在该方法中，检测质粒pX01的核酸和质粒pX02的核酸，并检测任选的对照核酸，从而鉴定有毒细菌。
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公开(公告)号：US20070022549A1
公开(公告)日：2007-02-01
申请号：US11427769
申请日：2006-06-29
申请人： Gregory Siegle , Roger Juneau , Edward Desporte , Michael Major , Gene Adoue , Sherriel Johnson , James Moser , Brian Tanner
发明人： Gregory Siegle , Roger Juneau , Edward Desporte , Michael Major , Gene Adoue , Sherriel Johnson , James Moser , Brian Tanner
CPC分类号： B08B11/02 , A61L2/186 , A61L2202/122 , B08B7/00 , B08B9/00 , H04R25/654 , H04R2460/17
摘要： A method and apparatus for cleaning a hearing aid provides a housing having a motor drive and speed control. A rotary chamber is mounted to the housing and driven by the motor drive. A drive shaft can be provided connecting the motor drive and the rotary chamber. The rotary chamber has a wall with at least one receptacle for holding a hearing aid. The rotary chamber can have two openings, one for a hearing aid and a second opening for another hearing aid or a counterweight. The rotary chamber can be counterweighted to compensate for the weight of a single hearing aid or any other arrangements of multiple hearing aids. Each receptacle is configured to hold a hearing aid. The motor drive is powered sufficiently to rotate the hearing aid at the speed of between about 2800 and 3200 rpm in order to generate a G-force on the hearing aid of about 270 G's. Preferably, the motor drive rotates at a rotational speed sufficient to remove earwax, rotation lasting for a period of time of between about 5 and 45 (preferably 18-22) seconds.
摘要翻译： 用于清洁助听器的方法和设备提供具有马达驱动和速度控制的壳体。 旋转室安装到壳体并由电动机驱动驱动。 可以提供连接电动机驱动器和旋转室的驱动轴。 旋转室具有至少一个用于容纳助听器的容器的壁。 旋转室可以具有两个开口，一个用于助听器，另一个用于另一助听器或配重。 旋转室可以配重以补偿单个助听器的重量或多个助听器的任何其它布置。 每个插座被配置为容纳助听器。 马达驱动器被充分供电以以约2800至3200rpm的速度旋转助听器，以便在助听器上产生约270G的G力。 优选地，马达驱动器以足以移除耳垢的旋转速度旋转，旋转持续约5至45（优选18-22秒）的时间。
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公开(公告)号：US5168548A
公开(公告)日：1992-12-01
申请号：US525079
申请日：1990-05-17
申请人： Steven Kaufman , James Moser , Ronald N. Parente
发明人： Steven Kaufman , James Moser , Ronald N. Parente
CPC分类号： G06F19/3487 , G06F17/243 , G10L15/26 , Y10S379/905 , Y10S379/908
摘要： In the reporting system disclosed herein, a speech recognizer is used to select sections of text from a report form stored in a computer and to insert recognized terms in the text thereby to generate a report text under voice control. A command interpreter, also responsive to spoken words, initiates creation of the report text and its subsequence storing, printing and transmission. The command processor is responsive to respective spoken commands to select a destination telephone number and to cause the report text to be sent to apparatus for converting report text to image data and for modulating an audio band signal with the image data for facsimile transmission over telephone lines.
摘要翻译： 在本文公开的报告系统中，语音识别器用于从存储在计算机中的报告表格中选择文本部分，并在文本中插入可识别的术语，从而生成语音控制下的报告文本。 命令解释器也响应于口头词，启动了报告文本的创建及其后续存储，打印和传输。 命令处理器响应于相应的口头命令来选择目的地电话号码，并且使报告文本被发送到用于将报告文本转换为图像数据的装置，并且用于通过电话线传真传输图像数据来调制音频信号 。
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