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    Flexible threading system
    11.
    发明授权
    Flexible threading system 有权
    柔性线程系统

    公开(公告)号：US08434390B2

    公开(公告)日：2013-05-07

    申请号：US12547873

    申请日：2009-08-26

    Applicant: Brandon Seth Cross ,  Matthew Steven Larson ,  Derek James Nash ,  James Joseph Uttley ,  Ronald A. Wenzel, Jr.

    Inventor： Brandon Seth Cross ,  Matthew Steven Larson ,  Derek James Nash ,  James Joseph Uttley ,  Ronald A. Wenzel, Jr.

    IPC: B25B13/46

    CPC classification number: B23G1/265 ,  B25B13/44 ,  B25B13/461 ,  B25B13/463

    Abstract: A wrench has a socket defined by a plurality of flat faces and a handle. A first threading tool is provided having a shape and dimension to fit into the socket. An adapter that retains a second threading tool includes a connector having the same shape and the dimension as the first threading tool that fits into the socket. A retaining member is rotatably mounted to the body for movement between a first position and a second position for locking the adapter and the die in the socket. The retaining member has a second plurality of flat faces defining an opening where the second plurality of faces are coextensive with the faces of the socket when the retaining member is in the first position and are offset from the faces of the socket when the retaining member is in the second position.

    Abstract translation: 扳手具有由多个平面和手柄限定的插座。 提供具有适合于插座的形状和尺寸的第一穿线工具。 保持第二穿线工具的适配器包括具有与第一穿线工具相适配的插座中具有相同形状和尺寸的连接器。 保持构件可旋转地安装到主体上，用于在第一位置和第二位置之间移动，以将适配器和模具锁定在插座中。 保持构件具有限定开口的第二多个平面，当保持构件处于第一位置时，第二多个面与插座的表面共同延伸，并且当保持构件为 处于第二位置。

    Immunomodulatory compositions
    12.
    发明授权
    Immunomodulatory compositions 有权
    免疫调节组合物

    公开(公告)号：US08383665B2

    公开(公告)日：2013-02-26

    申请号：US10543014

    申请日：2004-01-21

    Applicant: Alison Ann Watson ,  Robert James Nash ,  Emma Louisa Evinson

    Inventor： Alison Ann Watson ,  Robert James Nash ,  Emma Louisa Evinson

    IPC: A61K31/407 ,  C07D487/04

    CPC classification number: A61K47/26 ,  A61K31/407 ,  A61K31/7028 ,  A61K35/15 ,  A61K36/185 ,  A61K36/61 ,  A61K45/06 ,  C07D487/04 ,  C07H3/02 ,  Y02A50/409 ,  Y02A50/411 ,  A61K2300/00

    Abstract: Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula are disclosed. In these compounds R is selected from hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups. The compounds are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, hemorestoration, alleviation of immunosuppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.

    Abstract translation: 公开了具有下式的分离的免疫调节（例如免疫刺激）多羟基化吡咯烷酮化合物。 在这些化合物中，R选自氢，直链或支链，未取代或取代的，饱和或不饱和的酰基，烷基（例如环烷基），烯基，炔基和芳基。 这些化合物可用于治疗和预防，包括增加Th1：Th2应答率，荟萃，免疫抑制减轻，细胞因子刺激，增殖性疾病（例如癌症）治疗，疫苗接种，刺激先天免疫反应和提高活性 内源NK细胞。

    Filling and Sealing of Beverage Containers
    13.
    发明申请
    Filling and Sealing of Beverage Containers 审中-公开
    饮料容器的灌装和密封

    公开(公告)号：US20130042578A1

    公开(公告)日：2013-02-21

    申请号：US13659457

    申请日：2012-10-24

    Applicant: Guy JACKSON-EBBEN ,  James Nash

    Inventor： Guy JACKSON-EBBEN ,  James Nash

    IPC: B65B31/04 ,  B65B51/10 ,  B65B3/06

    CPC classification number: B65B31/043 ,  A47G19/2205 ,  B65B3/04 ,  B65B7/2878 ,  B65B31/00 ,  B65D81/2076

    Abstract: The present invention provides, inter alia, a method of filling and sealing a beverage container, the method comprising the steps of: a) dispensing a predetermined amount of beverage, preferably wine, into an open-topped container having a circular rim, preferably a plastics wine glass, to leave a headspace above the beverage in the container; b) temporarily tacking a generally flat flexible film lid sized to fit over the open top to the rim of the container at at least one position around the rim while leaving the remainder of the rim free; c) engaging the tacked lid to cause flexure thereof to create a gap between the lid and the rim on one side; d) dispensing an inert gas, preferably nitrogen, through the gap so created and into the headspace to displace air therefrom; and e) bringing a heat sealer into engagement with the lid to heat seal the lid to the rim about its entire circumference, thereby trapping the inert gas within the headspace.

    Abstract translation: 本发明尤其提供一种填充和密封饮料容器的方法，该方法包括以下步骤：a）将预定量的饮料（优选葡萄酒）分配到具有圆形边缘的开顶容器中，优选为 塑料酒杯，在容器中的饮料上方留下顶部空间; b）临时固定大致平坦的柔性薄膜盖，其尺寸适于在围绕边缘的至少一个位置处装配在容器的边缘上方，同时使边缘的其余部分自由; c）与固定的盖接合以使其弯曲以在一侧在盖和轮辋之间产生间隙; d）通过如此产生的间隙分配惰性气体，优选氮气，并进入顶部空间以从其中移出空气; 和e）使热封机与盖接合，以将盖子围绕其整个周边热封密封到轮辋上，从而将惰性气体捕获在顶部空间内。

    ADJUVANT COMPOSITIONS
    14.
    发明申请
    ADJUVANT COMPOSITIONS 审中-公开
    补充剂组合物

    公开(公告)号：US20090047306A1

    公开(公告)日：2009-02-19

    申请号：US10597296

    申请日：2005-01-21

    Applicant: Robert James Nash ,  Alison Ann Watson ,  Emma Louisa Evinson

    Inventor： Robert James Nash ,  Alison Ann Watson ,  Emma Louisa Evinson

    IPC: A61K39/12 ,  A61K47/22 ,  A61K47/44 ,  A61K39/002 ,  A61P37/04 ,  A61K39/39 ,  A61K39/02

    CPC classification number: A61K39/39 ,  A61K31/40 ,  A61K31/407 ,  A61K31/7028 ,  A61K38/208 ,  A61K45/06 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/57 ,  C07D487/04 ,  A61K2300/00

    Abstract: An adjuvant composition comprises a Th1-activating alkaloid, optionally further comprising an auxiliary adjuvant selected from a type 2 adjuvant (e.g. alum and/or MF59), a type 1 adjuvant and/or a balanced adjuvant. Vaccines comprising the adjuvant composition include nucleic acid(s) which encode one or more antigenic protein(s); protein(s) or peptide(s); glycoprotein(s); polysaccharide(s) (e.g. carbohydrate(s)); fusion protein(s); lipid(s); glycolipid(s); peptide mimic(s) of polysaccharides carbohydrate(s) and a protein(s) in admixture; carbohydrate-protein conjugate(s); cells or extracts thereof; dead or attenuated cells or extracts thereof; tumour cells or extracts thereof; viral particles (e.g. attenuated viral particles or viral components); allergen(s) mixtures thereof.

    Abstract translation: 佐剂组合物包含Th1-活化生物碱，任选地还包含选自2型佐剂（例如明矾和/或MF59），1型佐剂和/或平衡佐剂的辅助佐剂。 包含佐剂组合物的疫苗包括编码一种或多种抗原蛋白质的核酸; 蛋白质或肽; 糖蛋白; 多糖（例如碳水化合物）; 融合蛋白; 脂质; 糖脂; 多糖碳水化合物的多肽模拟物和一种或多种混合物的蛋白质; 碳水化合物 - 蛋​​白质缀合物; 细胞或其提取物; 死亡或减毒细胞或其提取物; 肿瘤细胞或其提取物; 病毒颗粒（例如减毒的病毒颗粒或病毒组分）; 变应原混合物。

    Method and system for long term care insurance product
    16.
    发明申请
    Method and system for long term care insurance product 审中-公开
    长期护理保险产品的方法和制度

    公开(公告)号：US20070214022A1

    公开(公告)日：2007-09-13

    申请号：US11374243

    申请日：2006-03-13

    Applicant: Ronald Hagelman ,  James Nash ,  Barry Fisher

    Inventor： Ronald Hagelman ,  James Nash ,  Barry Fisher

    IPC: G06Q40/00

    CPC classification number: G06Q40/08

    Abstract: A method includes providing a long-term care insurance product to an insured, determining a benefit pool associated with the long-term care insurance product, the benefit pool based on benefits available to the insured at a future point in time after issuance of the long-term care insurance product and calculated by number of days of benefit chosen multiplied by daily benefit chosen increased over time from issuance until the future point in time by an inflation protection factor, providing an accelerated benefit rider providing for making available the benefit pool associated with the insurance product upon issuance of the product to pay for claims for long-term care, and providing a return of premium rider wherein the return of premium rider provides for returning at least a portion of premiums paid by the insured upon election of the insured provided such election is made before occurrence of a future event.

    Abstract translation: 一种方法包括向被保险人提供长期护理保险产品，确定与长期护理保险产品相关的福利储蓄金，基于被保险人在长期发行后的未来时间可获得的利益的利益池 根据通货膨胀保护因素，由选择的天数乘以日常福利金计算的期限随着时间的推移而增加，并提供加速优惠乘客，提供与之相关的利益池 保险产品在发放产品时支付长期照护的索赔，并提供优质车手的退货，其中优惠车手的退货规定在被保险人选举后提供至少一部分被保险人支付的保险费 这种选举是在未来事件发生之前作出的。

    Bit holder
    20.
    发明授权
    Bit holder 有权
    钻头架

    公开(公告)号：US08069984B2

    公开(公告)日：2011-12-06

    申请号：US12536825

    申请日：2009-08-06

    Applicant: Matthew Steven Larson ,  Derek James Nash

    Inventor： Matthew Steven Larson ,  Derek James Nash

    IPC: B65D85/20

    CPC classification number: B25H3/023 ,  B25H3/003

    Abstract: A bit holder comprises a body defining at least one cavity. The cavity includes a first pathway for receiving a bit and a second pathway for holding a bit. The first and second pathways intersect to define an open area between the first pathway and the second pathway such that a bit can be rotated between the first pathway and to a locked position in second pathway. The first pathway is disposed at an angle relative to the second pathway. The bit is retained by an interference fit with the body. The holder may be releasably retained in a case using mating structures on the case and holder. In a method for retaining a bit in a holder, the bit is inserted into the holder along the first pathway. The bit is rotated through the open area to position the bit in the second pathway where it is held.

    Abstract translation: 一个位保持器包括限定至少一个空腔的主体。 空腔包括用于接收钻头的第一路径和用于保持钻头的第二路径。 第一和第二路径相交以限定第一路径和第二路径之间的开放区域，使得钻头可以在第一路径和第二路径中的锁定位置之间旋转。 第一路径相对于第二路径以一定角度设置。 该位通过与身体的过盈配合保持。 保持器可以可拆卸地保持在使用壳体和保持器上的配合结构的壳体中。 在用于将一位保持在保持器中的方法中，钻头沿着第一路径插入保持器中。 该钻头旋转通过打开的区域将钻头定位在其被保持的第二路径中。

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