公开(公告)号：US07920672B2

公开(公告)日：2011-04-05

申请号：US12374391

申请日：2007-07-10

Applicant: Jan Timmer ,  Peter George Van De Haar

Inventor： Jan Timmer ,  Peter George Van De Haar

IPC: G01D18/00 ,  H05G1/64

CPC classification number: G01D18/00 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/4291 ,  A61B6/5258 ,  A61B6/5282 ,  A61B6/583 ,  A61B6/585

Abstract: It is described a gain calibration for a two-dimensional X-ray detector (315), in which the gain coefficients for scattered radiation (307b) and direct radiation (307a) are measured or estimated separately. A weighed average may be applied on the appropriate scatter fraction. The scatter fraction depending gain calibration method produces less ring artifacts in X-ray images as compared to known gain calibration methods, which do not take into account the fraction of scattered radiation reaching the X-ray detector (315).

Abstract translation: 描述了用于二维X射线检测器（315）的增益校准，其中散射辐射（307b）和直接辐射（307a）的增益系数被分别测量或估计。 加权平均值可以应用于适当的分散分数。 与已知的增益校准方法相比，散射分数依赖性增益校准方法在X射线图像中产生较少的环形伪影，其不考虑到到达X射线检测器的散射辐射的分数（315）。

公开(公告)号：US07919765B2

公开(公告)日：2011-04-05

申请号：US12077792

申请日：2008-03-20

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: A61N5/10

CPC classification number: A61N5/10 ,  A61N5/1043 ,  A61N2005/1087 ,  H05H13/04

Abstract: Method and apparatus are disclosed for treating a non-continuous particle beam produced by an accelerator in order to irradiate a target volume, wherein an irradiation spot located in the target volume is formed from this beam, and wherein the location of the irradiation spot is controlled by location controlling elements. The setting of the location controlling elements may take place in between subsequent particle bunches of the beam, for example.

Abstract translation: 公开了用于处理由加速器产生的非连续粒子束以照射目标体积的方法和装置，其中由该光束形成​​位于目标体积中的照射点，并且其中照射斑点的位置被控制 通过位置控制元素。 例如，位置控制元件的设置可以在后续的束的粒子束之间进行。

公开(公告)号：US07660450B2

公开(公告)日：2010-02-09

申请号：US10563921

申请日：2004-07-06

Applicant: Peter George Van De Haar ,  Jan Timmer

Inventor： Peter George Van De Haar ,  Jan Timmer

IPC: G06K9/00

CPC classification number: A61B6/4225 ,  A61B6/583 ,  A61B6/585 ,  G06T5/009 ,  G06T5/50 ,  G06T2200/04 ,  G06T2207/10116

Abstract: An imaging system including an artifact reducer arranged to correct for a ring-shaped artifact in a three-dimensional reconstructed volume. The artifact reducer includes a first stage correction arranged to eliminate structured noise of an output screen of an image intensifier of an X-ray imaging apparatus using a first corrective image. A raw image of a patient is first processed with the first corrective image. The gain-corrected images are forwarded to an image deformation correction where a suitable unwarping function performed. The gain-corrected unwarped images are then made available to a second stage gain correction where a second corrective image is applied resulting in a final set of images with a substantially reduced ring-shaped artifact. The final set of images is made available to an image reconstructor arranged for further processing of the final set of images, the result thereof being visualized on a computer monitor for inspection purposes.

Abstract translation: 一种成像系统，包括伪像减速器，其被布置为校正三维重建体积中的环形伪像。 神器减速器包括第一级校正，其布置成消除使用第一校正图像的X射线成像设备的图像增强器的输出屏幕的结构噪声。 首先用第一校正图像处理患者的原始图像。 增益校正图像被转发到执行适当的不正确功能的图像变形校正。 然后，增益校正的未被绘制的图像可用于第二阶段增益校正，其中施加第二校正图像导致具有基本上减小的环形伪影的最终图像组。 最后一组图像可用于布置成进一步处理最终图像组的图像重建器，其结果在计算机监视器上可视化以用于检查目的。

公开(公告)号：US20090236545A1

公开(公告)日：2009-09-24

申请号：US12077792

申请日：2008-03-20

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: G21G5/00

CPC classification number: A61N5/10 ,  A61N5/1043 ,  A61N2005/1087 ,  H05H13/04

Abstract: Method and apparatus are disclosed for treating a non-continuous particle beam produced by an accelerator in order to irradiate a target volume, wherein an irradiation spot located in the target volume is formed from this beam, and wherein the location of the irradiation spot is controlled by location controlling elements. The setting of the location controlling elements may take place in between subsequent particle bunches of the beam, for example.

Abstract translation: 公开了用于处理由加速器产生的非连续粒子束以照射目标体积的方法和装置，其中由该光束形成​​位于目标体积中的照射点，并且其中照射斑点的位置被控制 通过位置控制元素。 例如，位置控制元件的设置可以在后续的束的粒子束之间进行。

公开(公告)号：US20090202127A1

公开(公告)日：2009-08-13

申请号：US12305983

申请日：2007-06-13

Applicant: Matthias Bertram ,  Jens Wiegert ,  Jan Timmer ,  Nicolaas Jan Noordhoek

Inventor： Matthias Bertram ,  Jens Wiegert ,  Jan Timmer ,  Nicolaas Jan Noordhoek

IPC: G06K9/00

CPC classification number: G06T11/005 ,  G06T5/003 ,  G06T2207/10081 ,  G06T2207/30004

Abstract: A method for generating a set of kernels for convolution error compensation of a projection image of a physical object recorded by an imaging system comprises calculating the set of kernels in such a way that for each pixel of the projection image an asymmetric scatter distribution for error compensation is calculated representing a X-ray scatter originating along a ray from an X-ray source to the pixel.

Abstract translation: 用于生成用于由成像系统记录的物理物体的投影图像的卷积误差补偿的一组内核的方法包括以对投影图像的每个像素进行误差补偿的不对称散布分布的方式来计算该组内核 表示沿着从X射线源到像素的射线发生的X射线散射。

公开(公告)号：US20060227928A1

公开(公告)日：2006-10-12

申请号：US10564571

申请日：2004-07-16

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: H05G1/60 ,  A61B6/00 ,  G01N23/00 ,  G21K1/12

CPC classification number: G06T11/005 ,  G06T5/005 ,  G06T7/13 ,  G06T2207/10081 ,  G06T2207/20192 ,  G06T2207/30004 ,  Y10S378/901

Abstract: An artifact correcting image reconstruction apparatus includes a reconstruction processor (70) that reconstructs acquired projection data (60) into an uncorrected reconstructed image (74). A classifying processor (78) classifies pixels of the uncorrected reconstructed image (74) at least into high, medium, and low density pixel classes. A pixel replacement processor (88) replaces pixels of the uncorrected reconstructed image (74) that are of the high density and low density classes with pixel values of the low density pixel class to generate a synthetic image (90). A forward projecting processor (94) forward projects the synthetic image (90) to generate synthetic projection data (96). A projection replacement processor (100, 110) replaces acquired projection data (60) contributing to the pixels of the high density class with corresponding synthetic projection data (96) to generate corrected projection data (112). The reconstruction processor (70) reconstructs the corrected projection data (112) into a corrected reconstructed image (120).

Abstract translation: 伪像校正图像重建装置包括将获取的投影数据（60）重建成未校正的重建图像（74）的重建处理器（70）。 分类处理器（78）将未校正的重建图像（74）的像素至少分类为高，中和低密度像素类。 像素替换处理器（88）用低密度像素类别的像素值代替具有高密度和低密度类别的未校正重建图像（74）的像素，以生成合成图像（90）。 前向投影处理器（94）向前投影合成图像（90）以产生合成投影数据（96）。 投影替换处理器（100,110）用对应的合成投影数据（96）代替对高密度类别的像素有贡献的所获取的投影数据（60），以产生校正投影数据（112）。 重建处理器（70）将经校正的投影数据（112）重建为校正后的重建图像（120）。

公开(公告)号：US20060159363A1

公开(公告)日：2006-07-20

申请号：US10563921

申请日：2004-07-06

Applicant: Peter Van De Haar ,  Jan Timmer

Inventor： Peter Van De Haar ,  Jan Timmer

IPC: G06K9/40

CPC classification number: A61B6/4225 ,  A61B6/583 ,  A61B6/585 ,  G06T5/009 ,  G06T5/50 ,  G06T2200/04 ,  G06T2207/10116

Abstract: The invention relates to an imaging system (15) comprising artifact reduction means (20) arranged to correct for a ring-shaped artifact in the three-dimensional reconstructed volume. The artifact reduction means (20) comprises a first stage correction means (21) arranged to eliminate the structured noise of the output screen of the image intensifier of an X-ray imaging apparatus (10) using a first corrective image. Preferably, the first corrective image (21a) is pre-calculated and is stored in a suitable memory unit of a computer (not shown). A raw image of the patient is first processed with the first corrective image (21a). The thus obtained gain-corrected image is forwarded to an image deformation correction means (23), where a suitable unwarping function (23a) is being pre-stored. The resulting gain-corrected unwarped images are then made available to the second stage gain correction means (25), where a second corrective image (25a) is applied to the images resulting in a final set of images with a substantially reduced ring-shaped artifact. The final set of images is made available to the image reconstruction means (26) arranged for further processing of the final set of images, the result thereof being visualized on a computer monitor (30) for inspection purposes. The invention further relates to an X-ray imaging apparatus, a method for reducing an artifact in a three-dimensional reconstructed volume and a computer program.

Abstract translation: 本发明涉及一种成像系统（15），其包括伪像减少装置（20），其被布置为校正三维重建体积中的环形伪影。 人造物减少装置（20）包括第一级校正装置（21），其被布置成使用第一校正图像来消除X射线成像装置（10）的图像增强器的输出屏幕的结构噪声。 优选地，第一校正图像（21a）被预先计算并存储在计算机（未示出）的适当的存储器单元中。 首先用第一校正图像（21a）处理患者的原始图像。 如此获得的增益校正图像被转发到图像变形校正装置（23），其中正在预先存储适当的不正确功能（23a）。 然后将所得到的增益校正的未被绘制的图像提供给第二级增益校正装置（25），其中将第二校正图像（25a）应用于图像，得到具有基本上减小的环形的最终图像集 神器 为了进一步处理最终图像集，图像重建装置（26）可以获得最终图像，其结果在计算机监视器（30）上可视化以供检查。 本发明还涉及X射线成像装置，用于减少三维重建体积中的伪影的方法和计算机程序。

公开(公告)号：US5825841A

公开(公告)日：1998-10-20

申请号：US895252

申请日：1997-07-16

Applicant: Jan Timmer

Inventor： Jan Timmer

IPC: A61B6/03 ,  G06T1/00 ,  G06T5/00 ,  G06T11/00

CPC classification number: G06T5/008 ,  G06T2207/10081 ,  G06T2207/30004 ,  Y10S378/901

Abstract: A computer tomography device is provided with a reconstruction unit (1) for deriving brightness values of an image from density values. An image processing system (2) for deriving corrected brightness values from the brightness values of the image is arranged to calculate the variation of brightness values of the image in the radial direction and in the tangential direction. The image processing system is also arranged to calculate the deviation between the variation in the radial direction and the variation in the tangential direction and to derive corrected brightness values from brightness values of the image and the deviation.

Abstract translation: 计算机断层摄影装置设置有用于从密度值导出图像的亮度值的重建单元（1）。 用于从图像的亮度值导出校正的亮度值的图像处理系统（2）被布置成计算图像在径向方向和切线方向上的亮度值的变化。 图像处理系统还被布置为计算径向方向的变化和切线方向的变化之间的偏差，并且从图像的亮度值和偏差导出校正的亮度值。

公开(公告)号：US20130303824A1

公开(公告)日：2013-11-14

申请号：US13887071

申请日：2013-05-03

Applicant: Thomas STEPHANI ,  Uwe BEHRENS ,  Heinrich ROECKEN ,  Jan TIMMER ,  Christian BAUMGARTEN

Inventor： Thomas STEPHANI ,  Uwe BEHRENS ,  Heinrich ROECKEN ,  Jan TIMMER ,  Christian BAUMGARTEN

IPC: H05H7/02 ,  A61N5/10

CPC classification number: H05H7/02 ,  A61N5/10 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J3/14 ,  H05H13/005 ,  H05H2007/122 ,  H05H2277/11

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

Abstract translation: 提供系统和方法来执行有效的自动回旋加速器初始化，校准和波束调整。 提供了一个过程，允许自动化过夜后的回旋加速器的初始化或维护关闭。 在一个实施例中，定义了五个独立的回旋加速器系统状态，并且一个状态与另一个状态之间的转换可以例如由回旋加速器的控制系统自动化。 根据这些实施例，由此可以在最少的手动输入之后实现停机后的光束操作。 通过应用自动程序，回旋加速器的所有有源装置（例如，RF系统，提取偏转器，离子源）分别斜坡到预定参数。

公开(公告)号：US20120223246A1

公开(公告)日：2012-09-06

申请号：US13225045

申请日：2011-09-02

Applicant: Thomas STEPHANI ,  Uwe BEHRENS ,  Heinrich ROECKEN ,  Jan TIMMER ,  Christian BAUMGARTEN

Inventor： Thomas STEPHANI ,  Uwe BEHRENS ,  Heinrich ROECKEN ,  Jan TIMMER ,  Christian BAUMGARTEN

IPC: A61N5/10 ,  H01J3/14 ,  G21K5/00

CPC classification number: H05H7/02 ,  A61N5/10 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J3/14 ,  H05H13/005 ,  H05H2007/122 ,  H05H2277/11

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

Abstract translation: 提供系统和方法来执行有效的自动回旋加速器初始化，校准和波束调整。 提供了一个过程，允许自动化过夜后的回旋加速器的初始化或维护关闭。 在一个实施例中，定义了五个独立的回旋加速器系统状态，并且一个状态与另一个状态之间的转换可以例如由回旋加速器的控制系统自动化。 根据这些实施例，由此可以在最少的手动输入之后实现停机后的光束操作。 通过应用自动程序，回旋加速器的所有有源装置（例如，RF系统，提取偏转器，离子源）分别斜坡到预定参数。