公开(公告)号：US06620976B2

公开(公告)日：2003-09-16

申请号：US10106219

申请日：2002-03-27

Applicant: Kenji Sakanoue ,  Kouzoh Sanchika ,  Tohru Yasukohchi

Inventor： Kenji Sakanoue ,  Kouzoh Sanchika ,  Tohru Yasukohchi

IPC: C07C4311

CPC classification number: C08G65/2609 ,  C08L2203/02

Abstract: Polyethylene glycol for use in fields with application to a living body wherein the sum of the contents of ethylene glycol and diethylene glycol in the polyethylene glycol is less than or equal to that expressed in the following formula [I]: Sum ⁢   ⁢ of ⁢   ⁢ ethylene ⁢   ⁢ glycol ⁢   ⁢ and ⁢   ⁢ diethylene ⁢   ⁢ glycol ⁢   ⁢ contents ⁢   ⁢ ( ppm ) = 150 × 2900 × 0.85 ( x - 150 ) / 44 x [ I ] wherein x represents the average molecular weight of the polyethylene glycol, and the polyethylene glycol has an average molecular weight ranging from 190 to 1,050.

Abstract translation: 聚乙二醇用于应用于生物体的领域，其中聚乙二醇中乙二醇和二甘醇的含量之和小于或等于下式[I]表示：其中x表示平均分子量 聚乙二醇的重量，聚乙二醇的平均分子量为190〜1050。

公开(公告)号：US08828373B2

公开(公告)日：2014-09-09

申请号：US11142683

申请日：2005-06-02

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: A61K31/765 ,  C08F283/00 ,  C08G65/329 ,  C08G65/333 ,  C08G65/26 ,  A61K47/48

CPC classification number: C08G65/2609 ,  A61K47/48215 ,  A61K47/60 ,  C08G65/329 ,  C08G65/333

Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.

Abstract translation: 含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA1和OA2分别为碳原子数2〜4的氧化烯基，由R表示的基团相同 或在一个分子中彼此不同，在一个分子中由OA2表示的基团相同或不同，m为上述加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示官能团 能够与生物相关物质进行化学反应的基团，Y为连接基，表示醚键，酰胺键，氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些基团的亚烷基 键，多分散性上述聚亚烷基二醇衍生物的Mw / Mn满足以下关系式：Mw / Mn＆nlE 1.08其中Mw表示重均分子量，Mn表示数均mol 精神重量

公开(公告)号：US20090192320A1

公开(公告)日：2009-07-30

申请号：US12399249

申请日：2009-03-06

Applicant: Ken-ichiro NAKAMOTO ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro NAKAMOTO ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: C07D207/404 ,  C07C43/13 ,  C07C309/68

CPC classification number: C08G65/329 ,  A61K47/60 ,  C08G65/2609

Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Abstract translation: 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US20050120540A1

公开(公告)日：2005-06-09

申请号：US11033655

申请日：2005-01-13

Applicant: Kenji Sakanoue ,  Koji Hachii ,  Toshiyuki Horiguchi ,  Takeshi Sasaki

Inventor： Kenji Sakanoue ,  Koji Hachii ,  Toshiyuki Horiguchi ,  Takeshi Sasaki

IPC: E06B3/70 ,  B21D22/26 ,  B21D53/00 ,  G07F9/00 ,  G07F9/10 ,  B23P11/00 ,  B21D39/03

CPC classification number: G07F9/10 ,  Y10T29/49826 ,  Y10T29/49906

Abstract: A single sheet of a metal member is pressed to form an integrally molded structure of a front, a side, and a top of a door body without any joint. In addition, the front of the door body and a concave for displaying sample products or the like are integrally produced by molding. By virtue of this constitution, a door device for a vending machine can be realized which can be easily produced and possesses excellent appearance and strength.

公开(公告)号：US08071712B2

公开(公告)日：2011-12-06

申请号：US12529043

申请日：2008-02-28

Applicant: Kenji Sakanoue ,  Hiroki Yoshioka ,  Tomohiro Shirosaki

Inventor： Kenji Sakanoue ,  Hiroki Yoshioka ,  Tomohiro Shirosaki

IPC: C08G65/34

CPC classification number: C08G65/2609 ,  A61K47/60 ,  C08G65/327 ,  C08G65/3317 ,  C08G65/3318 ,  C08G65/33337 ,  C08G65/33372 ,  C08G65/33396 ,  C08L2203/02

Abstract: An object of the present invention is to provide a novel multibranched polyoxyalkylene derivative, and an intermediate for the production thereof. Specifically, the object is to provide a multibranched polyoxyalkylene derivative which can keep a high activity of a bio-related substance modified with the multibranched polyoxyalkylene derivative and which can easily produce the modified substance; an intermediate thereof; and a bio-related substance to which the multibranched polyoxyalkylene derivative is bonded. The novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (1) having a functional group reactive with a bio-related substance and the bio-related substance according to the invention has a structure modified with the above polyoxyalkylene derivative (1) by a reaction. Furthermore, the intermediate for the production of the novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (A). wherein A1O and A2O independently represent an oxyalkylene group having 2 to 4 carbon atoms, m represents 20 to 500, n represents 15 to 700, R represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, X represents a functional group reactive with a bio-related substance, and X1 represents a hydroxyl group which may be protected.

Abstract translation: 本发明的目的是提供一种新型的多分支聚氧化烯衍生物及其生产用中间体。 具体地说，本发明提供一种能够保持由多支化聚氧化烯衍生物改性的生物相关物质的高活性的多分支聚氧化烯衍生物，能够容易地生成改性物质。 其中间体; 和多支链聚氧化烯衍生物所结合的生物相关物质。 根据本发明的新型多支链聚氧化烯衍生物是具有与生物相关物质反应的官能团的聚氧化烯衍生物（1），根据本发明的生物相关物质具有通过上述聚氧化烯衍生物（1）改性的结构 一个反应。 此外，用于生产根据本发明的新型多支链聚氧化烯衍生物的中间体是聚氧化烯衍生物（A）。 其中，AlO和A2O独立地表示碳原子数2〜4的氧化烯基，m表示20〜500，n表示15〜700，R表示氢原子或碳原子数1〜20的烃基，X表示官能团的反应性 与生物相关物质，X1表示可被保护的羟基。

公开(公告)号：US20110082277A1

公开(公告)日：2011-04-07

申请号：US12942554

申请日：2010-11-09

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yammamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yammamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: C08G65/28 ,  C08G63/06

CPC classification number: C08G65/329 ,  A61K47/60 ,  C08G65/2609

Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Abstract translation: 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US20090023859A1

公开(公告)日：2009-01-22

申请号：US11816611

申请日：2006-02-17

Applicant: Kenji Sakanoue ,  Kenichiro Nakamoto ,  Yuji Yamamoto ,  Hiroki Yoshioka

Inventor： Kenji Sakanoue ,  Kenichiro Nakamoto ,  Yuji Yamamoto ,  Hiroki Yoshioka

IPC: C08L89/00

CPC classification number: C07K1/1077 ,  A61K47/60 ,  A61K47/65

Abstract: A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided.

Abstract translation: 提供了由下式（1）表示的新型聚氧化烯衍生物，其中每个符号如说明书中所定义，其具有能够与根据该目的的各种生理活性物质反应的官能团。

公开(公告)号：US07205508B2

公开(公告)日：2007-04-17

申请号：US11055108

申请日：2005-02-11

Applicant: Kenji Sakanoue ,  Kouji Hayase ,  Kazuo Tetsukawa

Inventor： Kenji Sakanoue ,  Kouji Hayase ,  Kazuo Tetsukawa

IPC: H05B3/84 ,  A47J36/24 ,  A47F3/00 ,  A47F5/00

CPC classification number: A47F5/0056 ,  A47F3/001 ,  A47F3/06

Abstract: A showcase including an electric heater in a rack. The rack can be inexpensively constituted to be light in weight, and processing of an electric heater leader line can be facilitated. The showcase includes the electric heater in the rack for displaying commercial goods. The rack includes a metal main body and edge members made of resins. The edge members are mounted to front and rear parts of the main body. An insertion hole for mounting a partition member to partition the rack is formed in the edge member. An insertion hole for mounting a guard to prevent falling of the commercial goods is formed in the edge member mounted to a front edge of the main body.

Abstract translation: 包括机架中的电加热器的展示柜。 该机架可以廉价地构成为重量轻，并且可以方便地加热电加热器引线。 展示柜包括用于显示商品的机架中的电加热器。 机架包括金属主体和由树脂制成的边缘部件。 边缘构件安装在主体的前部和后部。 在边缘部件上形成有用于安装用于分隔齿条的分隔部件的插入孔。 在安装到主体的前缘的边缘部件中形成有用于安装护罩以防止商品落下的插入孔。

公开(公告)号：US07168285B2

公开(公告)日：2007-01-30

申请号：US11033655

申请日：2005-01-13

Applicant: Kenji Sakanoue ,  Koji Hachii ,  Toshiyuki Horiguchi ,  Takeshi Sasaki

Inventor： Kenji Sakanoue ,  Koji Hachii ,  Toshiyuki Horiguchi ,  Takeshi Sasaki

IPC: B21D31/00 ,  E06B5/00

CPC classification number: G07F9/10 ,  Y10T29/49826 ,  Y10T29/49906

Abstract: A single sheet of a metal member is pressed to form an integrally molded structure of a front, a side, and a top of a door body without any joint. In addition, the front of the door body and a concave for displaying sample products or the like are integrally produced by molding. By virtue of this constitution, a door device for a vending machine can be realized which can be easily produced and possesses excellent appearance and strength.

Abstract translation: 压制单片金属构件以形成门体的正面，侧面和顶部的整体模制结构，而没有任何接头。 此外，通过模制一体地制造门体的前部和用于显示样品的凹部等。 根据该结构，可以实现能够容易地制造并且具有优异的外观和强度的自动贩卖机的门装置。

公开(公告)号：US20050194368A1

公开(公告)日：2005-09-08

申请号：US11055108

申请日：2005-02-11

Applicant: Kenji Sakanoue ,  Kouji Hayase ,  Kazuo Tetsukawa

Inventor： Kenji Sakanoue ,  Kouji Hayase ,  Kazuo Tetsukawa

IPC: A47F3/04 ,  A47F3/00 ,  A47F3/06 ,  A47F5/00 ,  F25D21/06 ,  H05B1/00 ,  H05B3/00 ,  H05B11/00

CPC classification number: A47F5/0056 ,  A47F3/001 ,  A47F3/06

Abstract: There is provided a showcase comprising an electric heater in a rack. The rack can be inexpensively constituted to be light in weight, and processing of an electric heater leader line can be facilitated. The showcase comprises the electric heater in the rack for displaying commercial goods. The rack comprises a metal main body and edge members made of resins. The edge members are mounted to front and rear parts of the main body. An insertion hole for mounting a partition member to partition the rack is formed in the edge member. An insertion hole for mounting a guard to prevent falling of the commercial goods is formed in the edge member mounted to a front edge of the main body.

Abstract translation: 提供了一种在机架中包括电加热器的陈列柜。 该机架可以廉价地构成为重量轻，并且可以方便地加热电加热器引线。 展示架包括用于展示商品的机架中的电加热器。 机架包括金属主体和由树脂制成的边缘部件。 边缘构件安装在主体的前部和后部。 在边缘部件上形成有用于安装用于分隔齿条的分隔部件的插入孔。 在安装到主体的前缘的边缘部件中形成有用于安装护罩以防止商品落下的插入孔。