公开(公告)号：US20100179174A1

公开(公告)日：2010-07-15

申请号：US12647210

申请日：2009-12-24

Applicant: Tobias WUNBERG ,  Judith Baumeister ,  Mario Jeske ,  Frank Sûssmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

Inventor： Tobias WUNBERG ,  Judith Baumeister ,  Mario Jeske ,  Frank Sûssmeier ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang

IPC: A61K31/519 ,  C07D487/04 ,  A61P31/12

CPC classification number: C07D471/04

Abstract: This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

Abstract translation: 本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

公开(公告)号：US07709491B2

公开(公告)日：2010-05-04

申请号：US10534138

申请日：2003-10-25

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Susanne Nikolic ,  Frank Süβmeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jörg Keldenich ,  Dieter Lang ,  Tse-I Lin

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Susanne Nikolic ,  Frank Süβmeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jörg Keldenich ,  Dieter Lang ,  Tse-I Lin

IPC: A61K31/517 ,  C07D239/74 ,  C07D405/10

CPC classification number: C07D239/74

Abstract: The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及取代喹唑啉及其生产方法，除了其用于生产用于治疗和/或预防疾病的药物，特别是用作抗病毒剂，特别是抗巨细胞病毒的药物。

公开(公告)号：US07569563B2

公开(公告)日：2009-08-04

申请号：US12006086

申请日：2007-12-28

Applicant: Rudolf Schohe-Loop ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner

Inventor： Rudolf Schohe-Loop ,  Holger Zimmermann ,  Kerstin Henninger ,  Dieter Lang ,  Kai Thede ,  Chantal Fuerstner ,  David Brueckner

IPC: A61K31/5365 ,  A61K31/496 ,  C07D215/56 ,  C07D498/061 ,  A61K31/551

CPC classification number: C07D215/56

Abstract: The invention relates to substituted quinolones of formula (I) and to methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

Abstract translation: 本发明涉及式（I）的取代喹诺酮及其制备方法及其用于生产药物的用途，所述药物用于治疗和/或预防疾病，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

公开(公告)号：US07405201B2

公开(公告)日：2008-07-29

申请号：US10490192

申请日：2002-09-06

Applicant: Berthold Hinzen ,  Heike Brötz-Oesterhelt ,  Rainer Endermann ,  Kerstin Henninger ,  Holger Paulsen ,  Siegfried Raddatz ,  Thomas Lampe ,  Veronika Hellwig ,  Andreas Schumacher

Inventor： Berthold Hinzen ,  Heike Brötz-Oesterhelt ,  Rainer Endermann ,  Kerstin Henninger ,  Holger Paulsen ,  Siegfried Raddatz ,  Thomas Lampe ,  Veronika Hellwig ,  Andreas Schumacher

IPC: A61K38/12 ,  C07K5/12 ,  C07K1/00

CPC classification number: C07K7/06 ,  A61K38/00

Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions comprising them, and their use in the treatment of diseases in humans or animals.

Abstract translation: 本发明涉及通式（I）的化合物，其制备方法，包含它们的药物组合物及其在治疗人或动物疾病中的用途。

公开(公告)号：US20080004275A1

公开(公告)日：2008-01-03

申请号：US10594343

申请日：2005-03-11

Applicant: Holger Zimmermann ,  David Bruckner ,  Dirk Heimbach ,  Martin Hendrix ,  Kerstin Henninger ,  Guy Hewlett ,  Ulrich Rosentreter ,  Jorg Keldenich ,  Dieter Lang ,  Martin Radtke

Inventor： Holger Zimmermann ,  David Bruckner ,  Dirk Heimbach ,  Martin Hendrix ,  Kerstin Henninger ,  Guy Hewlett ,  Ulrich Rosentreter ,  Jorg Keldenich ,  Dieter Lang ,  Martin Radtke

IPC: A61K31/5377 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61P31/12 ,  C07D233/88 ,  C07D249/12 ,  C07D403/12 ,  C07D413/12 ,  C07D401/12 ,  C07D249/04 ,  C07D233/44 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/4439

CPC classification number: C07D233/90 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及式（I）的取代的咪唑及其制备方法，用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒药物，特别是针对巨细胞病毒。

公开(公告)号：US20060235032A1

公开(公告)日：2006-10-19

申请号：US10534138

申请日：2003-10-25

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Susanne Nikolic ,  Frank Submeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jorg Keldenich ,  Dieter Lang ,  Tse-I Lin

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Mario Jeske ,  Susanne Nikolic ,  Frank Submeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jorg Keldenich ,  Dieter Lang ,  Tse-I Lin

IPC: A61K31/517 ,  C07D239/72 ,  C07D405/02

CPC classification number: C07D239/74

Abstract: The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及取代喹唑啉及其生产方法，除了其用于生产用于治疗和/或预防疾病的药物，特别是用作抗病毒剂，特别是抗巨细胞病毒的药物中。

公开(公告)号：US20050085549A1

公开(公告)日：2005-04-21

申请号：US10486054

申请日：2002-07-24

Applicant: Tobias Wunberg ,  Wolfgang Bender ,  Peter Eckenberg ,  Sabine Hallenberger ,  Kerstin Henninger ,  Jorg Keldenich ,  Armin Kern ,  Siegfried Raddatz ,  Jurgen Reefschlager ,  Gunter Schmidt ,  Holger Zimmermann ,  Franz Zumpe ,  Martin Radtke

Inventor： Tobias Wunberg ,  Wolfgang Bender ,  Peter Eckenberg ,  Sabine Hallenberger ,  Kerstin Henninger ,  Jorg Keldenich ,  Armin Kern ,  Siegfried Raddatz ,  Jurgen Reefschlager ,  Gunter Schmidt ,  Holger Zimmermann ,  Franz Zumpe ,  Martin Radtke

IPC: A61K31/4245 ,  A61K31/4439 ,  A61K31/454 ,  A61P31/12 ,  A61P31/18 ,  C07D271/06 ,  C07D401/04 ,  C07D413/06 ,  A61K31/18

CPC classification number: C07D271/06

Abstract: The invention relates to novel sulfonamides of general formula (I) where the substituents R1, R2, R3, R4, A and X have the given meanings, pharmaceutical compositions containing them, and a method of using them as antiviral agents, in particular against cytomegaloviruses.

Abstract translation: 本发明涉及通式（I）的新型磺酰胺，其中取代基R 1，R 2，R 3，R 4， A和X具有给定的含义，含有它们的药物组合物，以及使用它们作为抗病毒剂，特别是针对巨细胞病毒的方法。

公开(公告)号：US08513255B2

公开(公告)日：2013-08-20

申请号：US11728896

申请日：2007-03-26

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Ulrich Betz ,  Mario Jeske ,  Thomas Lampe ,  Susanne Nikolic ,  Juergen Reefschlaeger ,  Rudolf Schohe-Loop ,  Frank Suessmeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Joerg Keldenich ,  Dieter Lang ,  Peter Nell

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Ulrich Betz ,  Mario Jeske ,  Thomas Lampe ,  Susanne Nikolic ,  Juergen Reefschlaeger ,  Rudolf Schohe-Loop ,  Frank Suessmeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Joerg Keldenich ,  Dieter Lang ,  Peter Nell

IPC: A61K31/497 ,  C07D401/00

CPC classification number: C07D239/84

Abstract: The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

Abstract translation: 本发明涉及取代的二氢喹唑啉及其制备方法，也涉及其用于制备用于治疗和/或预防疾病，特别是用作抗病毒剂，特别是针对巨细胞病毒的药物的用途。

公开(公告)号：US08410090B2

公开(公告)日：2013-04-02

申请号：US11988911

申请日：2006-07-01

Applicant: Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Martin Hendrix ,  Martin Radtke

Inventor： Holger Zimmermann ,  David Brueckner ,  Kerstin Henninger ,  Martin Hendrix ,  Martin Radtke

IPC: A61P31/12 ,  A61K31/38 ,  A61K31/40 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

CPC classification number: C07D409/12 ,  C07D401/12 ,  C07D417/12

Abstract: The invention relates to heterocyclylamide-substituted thiazoles, pyrroles and thiophenes and processes for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及杂环酰胺取代的噻唑，吡咯和噻吩及其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒 。

公开(公告)号：US08314089B2

公开(公告)日：2012-11-20

申请号：US12884113

申请日：2010-09-16

Applicant: Rudolf Schohe-Loop ,  Reinhold Welker ,  Arnold Paessens ,  Marcus Bauser ,  Friederike Stoll ,  Frank Dittmer ,  Kerstin Henninger ,  Daniela Paulsen ,  Dieter Lang

Inventor： Rudolf Schohe-Loop ,  Reinhold Welker ,  Arnold Paessens ,  Marcus Bauser ,  Friederike Stoll ,  Frank Dittmer ,  Kerstin Henninger ,  Daniela Paulsen ,  Dieter Lang

IPC: A61K31/4155 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/553 ,  A61K31/496 ,  C07D413/06 ,  C07D417/06 ,  C07D403/06 ,  A61P31/12

CPC classification number: C07D231/14 ,  A61K31/4155 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D451/06 ,  C07D491/08 ,  C07D498/08

Abstract: The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.

Abstract translation: 本发明涉及新型取代的吡唑啉酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病尤其是逆转录病毒疾病的药物的用途 ，在人类和/或动物中。