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公开(公告)号：US20080004275A1
公开(公告)日：2008-01-03
申请号：US10594343
申请日：2005-03-11
申请人： Holger Zimmermann , David Bruckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Jorg Keldenich , Dieter Lang , Martin Radtke
发明人： Holger Zimmermann , David Bruckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Jorg Keldenich , Dieter Lang , Martin Radtke
IPC分类号： A61K31/5377 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61P31/12 , C07D233/88 , C07D249/12 , C07D403/12 , C07D413/12 , C07D401/12 , C07D249/04 , C07D233/44 , A61K31/4192 , A61K31/4196 , A61K31/4439
CPC分类号： C07D233/90 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
摘要翻译： 本发明涉及式（I）的取代的咪唑及其制备方法，用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒药物，特别是针对巨细胞病毒。
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公开(公告)号：US07767704B2
公开(公告)日：2010-08-03
申请号：US10594343
申请日：2005-03-11
申请人： Holger Zimmermann , David Brueckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Joerg Keldenich , Dieter Lang , Martin Radtke
发明人： Holger Zimmermann , David Brueckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Joerg Keldenich , Dieter Lang , Martin Radtke
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D233/90 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
摘要翻译： 本发明涉及式（I）的取代的咪唑及其制备方法，用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒剂，特别是抗巨细胞病毒。
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公开(公告)号：US07919489B2
公开(公告)日：2011-04-05
申请号：US11894307
申请日：2007-08-20
申请人： Holger Zimmermann , David Brueckner , Kerstin Henninger , Ulrich Rosentreter , Martin Hendrix , Joerg Keldenich , Dieter Lang , Martin Radtke , Daniela Paulsen , Armin Kern
发明人： Holger Zimmermann , David Brueckner , Kerstin Henninger , Ulrich Rosentreter , Martin Hendrix , Joerg Keldenich , Dieter Lang , Martin Radtke , Daniela Paulsen , Armin Kern
IPC分类号： A61P31/12 , A61K31/4178 , A61K31/4164 , C07D401/12 , C07D233/90
CPC分类号： C07D233/90 , C07D401/12
摘要： The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.
摘要翻译： 本发明涉及杂环基酰胺取代的咪唑及其制备方法，它们用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 作为抗病毒剂，特别是针对巨细胞病毒。
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4.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 审中-公开取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20060217373A1
公开(公告)日：2006-09-28
申请号：US11443693
申请日：2006-05-30
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/4439 , A61K31/44
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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5.发明授权Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-selective ligands 失效取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并将其用作腺苷受体选择配体公开(公告)号：US07045631B2
公开(公告)日：2006-05-16
申请号：US10484133
申请日：2002-07-03
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
IPC分类号： C07D213/62 , C07D417/12
CPC分类号： C07D417/12 , C07D213/85
摘要： Compounds of the formula (I) a process for preparing them, and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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公开(公告)号：US20080269300A1
公开(公告)日：2008-10-30
申请号：US11661820
申请日：2005-08-30
申请人： Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人： Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号： A61K31/4439 , C07D417/12 , A61P9/12
CPC分类号： C07D417/12
摘要： The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。
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公开(公告)号：US08691850B2
公开(公告)日：2014-04-08
申请号：US11661820
申请日：2005-08-30
申请人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号： A61K31/4436 , C07D417/12
CPC分类号： C07D417/12
摘要： The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。
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公开(公告)号：US07109218B2
公开(公告)日：2006-09-19
申请号：US10497120
申请日：2002-11-28
申请人： Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： C07D417/12 , A61K31/4418
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
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9.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 有权取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20050227972A1
公开(公告)日：2005-10-13
申请号：US10497120
申请日：2002-11-28
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D213/85 , C07D417/12 , C07D417/14 , A61K31/541 , A61K31/444 , A61K31/496 , C07D413/14
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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公开(公告)号：US20060100207A1
公开(公告)日：2006-05-11
申请号：US10525608
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07F7/1804
摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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