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公开(公告)号：US5942507A
公开(公告)日：1999-08-24
申请号：US895968
申请日：1997-07-17
Applicant: Judith A. Kelleher , Kirk R. Maples , Lowell David Waterbury , Allan L. Wilcox , Hong Xu , Yong-Kang Zhang
Inventor： Judith A. Kelleher , Kirk R. Maples , Lowell David Waterbury , Allan L. Wilcox , Hong Xu , Yong-Kang Zhang
IPC: A61K31/341 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/02 , C07D307/64 , C07D307/52 , A61K31/34 , C07D405/12 , C07D413/12
CPC classification number: A61K31/341 , C07D307/64
Abstract: Disclosed are furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compounds are useful as analytical reagents for detecting free radicals and as therapeutics for treating a wide variety of medical dysfunctions and diseases.
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公开(公告)号：US20130064783A1
公开(公告)日：2013-03-14
申请号：US13607405
申请日：2012-09-07
Applicant: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
Inventor： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC: C07F5/04 , A61K31/7076 , A61K31/70 , A61K31/69 , C07F5/06
CPC classification number: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20130059802A1
公开(公告)日：2013-03-07
申请号：US13607250
申请日：2012-09-07
Applicant: Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
Inventor： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC: A61K31/69 , A61P31/10 , A61K31/7034 , A61K31/7024 , A61K31/7076
CPC classification number: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20120214765A1
公开(公告)日：2012-08-23
申请号：US13236543
申请日：2011-09-19
Applicant: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
Inventor： Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
CPC classification number: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
Abstract translation: 公开了治疗抗炎症状的化合物和方法。
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公开(公告)号：US08039450B2
公开(公告)日：2011-10-18
申请号：US12399015
申请日：2009-03-05
Applicant: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert Jacobs , Daitao Chen , Michael Richard Kevin Alley
Inventor： Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert Jacobs , Daitao Chen , Michael Richard Kevin Alley
CPC classification number: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
Abstract translation: 公开了治疗抗炎症状的化合物和方法。
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Patent Agency Ranking
16.发明授权公开(公告)号：US07968752B2
公开(公告)日：2011-06-28
申请号：US12270636
申请日：2008-11-13
Applicant: Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
Inventor： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
IPC: C07F9/02
CPC classification number: C07F5/025
Abstract: Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
Abstract translation: 公开了用于治疗由细菌或病毒引起的疾病的治疗剂的硼烷衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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17.发明授权Methods for preventing and treating autoimmune and inflammatory diseases using thioether furan nitrone compounds 失效使用硫醚呋喃硝酮化合物预防和治疗自身免疫性和炎性疾病的方法
公开(公告)号：US6127408A
公开(公告)日：2000-10-03
申请号：US408126
申请日：1999-09-29
Applicant: Judith A. Kelleher , Kirk R. Maples , Yong-Kang Zhang
Inventor： Judith A. Kelleher , Kirk R. Maples , Yong-Kang Zhang
IPC: A61K31/341 , A61P1/00 , A61P11/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P37/02 , A61P43/00 , C07D307/64 , A61K31/34
CPC classification number: C07D307/64
Abstract: Disclosed are methods for preventing and/or treating autoimmune and inflammatory diseases in mammals using a pharmaceutical composition containing a pharmaceutically acceptable carrier and an effective amount of a thiether furan nitrone compound.
Abstract translation: 公开了使用含有药学上可接受的载体和有效量的呋喃呋喃酮化合物的药物组合物来预防和/或治疗哺乳动物的自身免疫性和炎性疾病的方法。
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公开(公告)号：US08461135B2
公开(公告)日：2013-06-11
申请号：US13236543
申请日：2011-09-19
Applicant: Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
Inventor： Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
CPC classification number: C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
Abstract: Compounds and methods of treating anti-inflammatory conditions are disclosed.
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公开(公告)号：US20120264714A1
公开(公告)日：2012-10-18
申请号：US13453682
申请日：2012-04-23
Applicant: Stephen J. BAKER , Virginia SANDERS , Tsutsomu AKAMA , Carolyn BELLINGER-KAWAHARA , Yvonne FREUND , Kirk R. MAPLES , Jacob J. PLATTNER , Yong-Kang ZHANG , Huchen ZHOU , Vincent S. HERNANDEZ
Inventor： Stephen J. BAKER , Virginia SANDERS , Tsutsomu AKAMA , Carolyn BELLINGER-KAWAHARA , Yvonne FREUND , Kirk R. MAPLES , Jacob J. PLATTNER , Yong-Kang ZHANG , Huchen ZHOU , Vincent S. HERNANDEZ
IPC: A61K31/69 , A61P1/00 , A61P17/06 , A61P25/28 , A61P9/04 , A61P13/12 , A61P1/18 , A61P37/08 , A61P9/10 , A61P3/00 , A61P19/08 , A61P3/10 , A61P1/16 , A61P11/00 , A61P25/16 , A61P19/02
CPC classification number: A61K31/69 , C07F5/027 , Y02A50/411
Abstract: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
Abstract translation: 公开了通过使用含硼小分子治疗抗炎症状况的方法。
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20.发明授权公开(公告)号：US08106031B2
公开(公告)日：2012-01-31
申请号：US11743665
申请日：2007-05-02
Applicant: Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
Inventor： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
CPC classification number: C07F5/025
Abstract: Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
Abstract translation: 公开了用于治疗由真菌，酵母，细菌或病毒引起的疾病的治疗剂的硼衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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