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    STABLE IMMUNOGENIC PROTEIN HAVING MULTIPLE CYSTEINES MOLECULES PROCESS THEREFOR AND COMPOSITION THEREOF
    13.
    发明申请
    STABLE IMMUNOGENIC PROTEIN HAVING MULTIPLE CYSTEINES MOLECULES PROCESS THEREFOR AND COMPOSITION THEREOF 审中-公开
    具有多种CYSTEINES分子的稳定的免疫原性蛋白及其组合物

    公开(公告)号：US20120269856A1

    公开(公告)日：2012-10-25

    申请号：US13376660

    申请日：2009-07-23

    Applicant: Krishna Murthy Ella ,  Ganapathy Ravi

    Inventor： Krishna Murthy Ella ,  Ganapathy Ravi

    IPC: A61K39/015 ,  A61P37/04 ,  A61P33/06 ,  C12P21/00 ,  C07K14/00

    CPC classification number: C07K14/445 ,  A61K39/015 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  Y02A50/412

    Abstract: The invention describes a stable immunogenic protein having multiple cysteines molecules wherein the protein is having stability up to two years and purity more than 98% particularly rPvRII and/or rPfF2. It also discloses a method for producing said immunogenic protein comprising the following steps: culturing the host E. coli cells containing a desired recombinant gene construct comprising a codon optimized gene sequence of rPvRII and/or rPfF2 to produce cells in high density; inducing expression rPvRII and/or rPfF2 as inclusion bodies; harvesting the cells and isolating the said inclusion bodies; separating rPvRII and/or rPfF2 from inclusion bodies by repeated sequential washing and solubilizing with chaotrophic agents comprising guanidine hydrochloride and/or urea; purifying the protein by subjecting to metal-chelate affinity chromatography; re-folding of the purified rPvRII and/or rPfF2 obtained in step e) with a redox system to recover a high yield of the soluble protein, followed by further purifying the desired protein by removing impurities by subjecting to chromatography. Further the invention discloses formulation comprising rPvRII or rPfF2, preferably being lyophilized using polysaccharides preferably sucrose, lactose, and pharmaceutically acceptable adjuvants such as aluminum hydroxide, aluminum phosphate, CpG nucleotides, non-CpG nucleotides, Montanide ISA-720, MF-59, Mono-phosphoryl Lipid-A (MPL-A) and QS-21.

    Abstract translation: 本发明描述了具有多个半胱氨酸分子的稳定的免疫原性蛋白质，其中蛋白质具有至多两年的稳定性，纯度大于98％，特别是rPvRII和/或rPfF2。 本发明还公开了一种生产所述免疫原性蛋白的方法，包括以下步骤：培养含有包含rPvRII和/或rPfF2的密码子优化的基因序列的所需重组基因构建体的宿主大肠杆菌细胞以高密度产生细胞; 诱导表达rPvRII和/或rPfF2作为包涵体; 收集细胞并分离所述包涵体; 通过重复顺序洗涤和与包含盐酸胍和/或尿素的混合营养剂溶解来分离rPvRII和/或rPfF2从包涵体中分离; 通过金属螯合亲和层析纯化蛋白质; 用氧化还原系统将步骤e）中获得的纯化rPvRII和/或rPfF2重新折叠，以回收高产量的可溶性蛋白质，随后通过色谱除去杂质进一步纯化所需蛋白质。 此外，本发明公开了包含rPvRII或rPfF2的制剂，优选使用多糖优选蔗糖，乳糖和药学上可接受的辅剂如氢氧化铝，磷酸铝，CpG核苷酸，非CpG核苷酸，Montanide ISA-720，MF-59，Mono - 磷脂脂酸（MPL-A）和QS-21。

    System and Method for Data Transfer of Object Properties
    14.
    发明申请
    System and Method for Data Transfer of Object Properties 有权
    对象属性的数据传输的系统和方法

    公开(公告)号：US20120079094A1

    公开(公告)日：2012-03-29

    申请号：US12888863

    申请日：2010-09-23

    Applicant: Javeed Nizami ,  Krishna Murthy Rao Terala

    Inventor： Javeed Nizami ,  Krishna Murthy Rao Terala

    IPC: G06F15/173

    CPC classification number: H04L43/08 ,  G06F11/3476 ,  G06F11/3495 ,  G06F2201/81 ,  G06F2201/875 ,  H04L41/0816 ,  H04L67/22 ,  H04M1/253 ,  H04M1/65 ,  H04M1/654

    Abstract: A system, method, and computer readable medium. A method includes monitoring calls from a client system to a server system for properties associated with an object, each call having a context. The method includes storing call data related to the calls as a property-retrieval history, including storing the context of each call. The method includes analyzing a policy associated with at least one context based on the property-retrieval history. The method includes updating the policy associated with the at least one context based on the analysis, and transferring data corresponding to the at least one context based on the policy.

    Abstract translation: 一种系统，方法和计算机可读介质。 一种方法包括监视从客户机系统到服务器系统的与对象相关联的属性的呼叫，每个呼叫具有上下文。 该方法包括将与呼叫相关的呼叫数据存储为属性检索历史，包括存储每个呼叫的上下文。 该方法包括基于属性检索历史来分析与至少一个上下文相关联的策略。 该方法包括基于分析更新与至少一个上下文相关联的策略，以及基于策略来传送与至少一个上下文相对应的数据。

    Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics
    15.
    发明申请
    Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics 审中-公开
    合成高活性二元金属氟化物作为芳香族氟化剂的方法

    公开(公告)号：US20100016607A1

    公开(公告)日：2010-01-21

    申请号：US12518751

    申请日：2007-12-11

    Applicant: William R. Dolbier, JR. ,  Krishna Murthy Janmanchi

    Inventor： William R. Dolbier, JR. ,  Krishna Murthy Janmanchi

    IPC: C07D213/61 ,  C01F7/50 ,  C07D213/26 ,  C07C25/13

    CPC classification number: B01J37/03 ,  B01J27/122 ,  C01G3/04 ,  C01P2002/72 ,  C01P2002/85 ,  C01P2004/03 ,  C01P2004/82 ,  C07B39/00 ,  C07C17/12 ,  C07C17/208 ,  Y02P20/582 ,  C07C25/13 ,  C07C25/22

    Abstract: The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O2 and HF.

    Abstract translation: 本发明涉及用于合成芳族化合物氟化的高活性二元金属氟化物体系的方法。 氟化芳族化合物是用于化学合成药物和新型聚合物的有价值的合成物。 氟苯用于控制钢铁制造中的碳含量，是药物，农药和其他有机化合物的中间体。 氟苯通常通过苯胺和亚硝酸钠在氟化氢存在下的反应来制备。 本发明涉及一种合成高活性二元金属氟化物体系的方法，其由氟化铜（II）和氟化铝（III）组成，用于在气相中氟化芳族化合物，并使用O2原位再循环试剂 和HF。

    INSURANCE EXCHANGE
    17.
    发明申请
    INSURANCE EXCHANGE 失效
    保险交易所

    公开(公告)号：US20120284058A1

    公开(公告)日：2012-11-08

    申请号：US13179349

    申请日：2011-07-08

    Applicant: Radhavenkata Krishna Murthy Varanasi ,  Ravikumar Gananath Shenoy Kumble ,  Hetash Bipin Master ,  Harish Jethani

    Inventor： Radhavenkata Krishna Murthy Varanasi ,  Ravikumar Gananath Shenoy Kumble ,  Hetash Bipin Master ,  Harish Jethani

    IPC: G06Q40/00

    CPC classification number: G06Q10/10 ,  G06Q40/08

    Abstract: An insurance exchange for providing a neutral, unbiased and automated lead generating platform for interaction, relating to insurance products and services, between a set of users and a set of providers. The system integrates the processes involved in an insurance lifecycle including quote management, endorsement and claims assistance using a single unique code. The unique code captures minute details of the insurance product's lifecycle which can be tracked and retrieved for processing requisitions at any stage of the insurance lifecycle by the system. Moreover, the system gives a user the flexibility to use/enroll to the system at any time within the life of purchased Insurance product. Thus, the insurance exchange is a one-stop shop for a user for any insurance stream including life, non-life, takaful or micro to compare benefits and prices, choose and avail any insurance product or service and also to redress his grievances.

    Abstract translation: 保险交易所提供一个中立的，无偏见的和自动化的铅生成平台，用于与一组用户和一组提供商之间的保险产品和服务相互作用。 该系统使用单独的唯一代码来整合保险生命周期中涉及的流程，包括报价管理，认可和索赔协助。 唯一的代码捕获了保险产品生命周期的细节，可以在系统的保险生命周期的任何阶段跟踪和检索保险产品的生命周期。 此外，系统给用户在购买的保险产品的任何时间内随时使用/注册系统的灵活性。 因此，保险交易是为用户提供一站式服务，包括生活，非生活，伊斯兰保险或微型保险，以比较利益和价格，选择并利用任何保险产品或服务，并纠正他的不满。

    VENTED FILTER CARTRIDGE FOR WATER TREATMENT DEVICE
    19.
    发明申请
    VENTED FILTER CARTRIDGE FOR WATER TREATMENT DEVICE 有权
    用于水处理设备的通风过滤器盒

    公开(公告)号：US20110089103A1

    公开(公告)日：2011-04-21

    申请号：US12603505

    申请日：2009-10-21

    Applicant: Govind Bommi ,  Krishna Murthy Bommi

    Inventor： Govind Bommi ,  Krishna Murthy Bommi

    IPC: B01D29/15 ,  B01D35/02 ,  B01D35/30 ,  C02F1/28

    CPC classification number: B01D36/001 ,  B01D29/13 ,  B01D39/2062 ,  C02F1/003 ,  C02F1/283 ,  C02F2201/006 ,  C02F2307/04

    Abstract: A filter cartridge has a shell defining an upper portion with an upper interior volume and a lower portion with a lower interior volume. The cartridge is for use in gravity-fed water treatment systems have an upper untreated supply and a lower filtered container. A hydrophilic porous particulate carbon powder block filter in a polymeric binder is disposed in the cartridge. The filter has a central opening and is open on both ends. The top end of the block is fitted with an air vent tube. The lower end of the block is fitted into a rubber gasket to direct water flow into the lower container. As water flow through the filter cartridge, air is vented through the block filter central opening and out through the vent tube.

    Abstract translation: 滤筒具有限定具有上部内部容积的上部的外壳和具有较低内部容积的下部。 墨盒用于重力给水处理系统，具有上未经处理的供应和较低过滤的容器。 聚合物粘合剂中的亲水性多孔颗粒碳粉末块状过滤器设置在筒中。 过滤器有一个中心开口，两端都是开口的。 该块的顶端配有排气管。 块的下端装配在橡胶垫圈中，以引导水流入下容器。 当水流过过滤器滤芯时，空气通过堵塞过滤器中心孔排出，并通过排气管排出。

    DISTRIBUTED CONTACT INFORMATION DISCOVERY AND SHARING
    20.
    发明申请
    DISTRIBUTED CONTACT INFORMATION DISCOVERY AND SHARING 审中-公开
    分销联系人信息发现和共享

    公开(公告)号：US20100299340A1

    公开(公告)日：2010-11-25

    申请号：US12470508

    申请日：2009-05-22

    Applicant: Narayan Krishna Murthy ,  Deepak Achuthan Menon ,  Kannan Ramasubramanian

    Inventor： Narayan Krishna Murthy ,  Deepak Achuthan Menon ,  Kannan Ramasubramanian

    IPC: G06F17/30

    CPC classification number: G06Q10/10

    Abstract: A contact sharing system is described herein that allows multiple people to share their address books of contact information so that a person can search for contact information among the address books of the person's existing contacts in addition to any publicly available searchable sources of contact information. Because at least one of a person's contacts is likely to have contact information for the person or business that the person is trying to reach, searching the contacts of contacts is more likely to produce relevant search results than searching anonymous or public sources of contact information alone. Thus, the contact sharing system makes it easier for people to find contact information for people and businesses that they are trying to reach.

    Abstract translation: 本文描述了一种联系人共享系统，其允许多个人共享他们的联系人信息的地址簿，使得除了任何公开可搜索的联系人信息源之外，人们可以在该人的现有联系人的地址簿之间搜索联系人信息。 因为一个人的联系人中至少有一个人有可能拥有该人正试图达成的个人或企业的联系信息，因此搜索联系人的联系人更有可能产生相关的搜索结果，而不是单独搜索匿名或公开的联系信息来源 。 因此，联系人共享系统使人们更容易找到他们试图达到的人和企业的联系信息。

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