公开(公告)号：US07010340B2

公开(公告)日：2006-03-07

申请号：US10078310

申请日：2002-02-18

Applicant: Charles W. Scarantino ,  H. Troy Nagle ,  Lester C. Hall ,  Jeffrey Mueller ,  Bahram Ghaffarzadeh Kermani

Inventor： Charles W. Scarantino ,  H. Troy Nagle ,  Lester C. Hall ,  Jeffrey Mueller ,  Bahram Ghaffarzadeh Kermani

IPC: A61B6/00 ,  A61B5/07

CPC classification number: A61B5/14539 ,  A61B5/0031 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/417 ,  A61B6/507 ,  A61B2562/028 ,  A61B2562/085 ,  A61N5/1048 ,  A61N5/1071 ,  G06F19/00 ,  G06F19/3481 ,  Y10S128/903 ,  Y10S128/904 ,  Y10S128/92

Abstract: Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.