公开(公告)号：US12042276B2

公开(公告)日：2024-07-23

申请号：US17883518

申请日：2022-08-08

申请人： ABBOTT DIABETES CARE INC.

发明人： Yongjin Xu ,  Timothy C. Dunn ,  Gary Hayter

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61M5/172 ,  G01N33/557 ,  G01N33/72 ,  G16H20/17

CPC分类号： A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/14865 ,  A61B5/417 ,  A61B5/4836 ,  A61B5/4839 ,  A61B5/6833 ,  A61B5/7221 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746 ,  A61M5/1723 ,  G01N33/557 ,  G01N33/723 ,  G16H20/17

摘要： Methods, devices, and systems may use a kinetic model to determine physiological parameters related to the kinetics of red blood cell glycation, elimination, and generation. Such physiological parameters can be used, for example, to determine a more reliable calculated HbA1c. In another example, a method may comprise: receiving a plurality of glucose levels over a time period; receiving a glycated hemoglobin (HbA1c) level corresponding to an end of the time period; determining at least one physiological parameter selected from the group consisting of: a red blood cell glycation rate constant (kgly), a red blood cell generation rate constant (kgen), a red blood cell elimination constant (kage), and an apparent glycation constant (K), based on (1) the plurality of glucose levels and (2) the HbA1c level; and adjusting a glucose level target based on the at least one physiological parameter.

公开(公告)号：US20170314056A1

公开(公告)日：2017-11-02

申请号：US15487320

申请日：2017-04-13

申请人： Xiaojian Yang ,  Haiyen E. Zhau ,  Ruoxiang Wang ,  Leland W.K. Chung

发明人： Xiaojian Yang ,  Haiyen E. Zhau ,  Ruoxiang Wang ,  Leland W.K. Chung

IPC分类号： C12Q1/04 ,  G01N33/50 ,  G01N21/64 ,  C09B23/08 ,  A61B5/00 ,  C09B23/01 ,  A61K49/00 ,  G01N33/574

CPC分类号： C12Q1/04 ,  A61B5/0059 ,  A61B5/417 ,  A61B2503/40 ,  A61K49/006 ,  C09B23/0016 ,  C09B23/0033 ,  C09B23/0066 ,  C09B23/086 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/574

摘要： The present invention describes methods of identifying, detecting, imaging, isolating and locating cancer cells in a subject. The method involves the use of near-infrared (NIR) organic carbocyanine dyes, particularly, near infrared heptamethine cyanine dyes and the detection of the fluorescence of these NIR dyes. The uptake of these dyes by cancer cells and not by normal cells, as well as their high intensity, among other things, allow for the detection of cancerous cells in a subject and facilitate their subsequent isolation. Further, detection of many tumor types and tumor cell populations under cell culture and in vivo conditions are described.

公开(公告)号：US09662059B2

公开(公告)日：2017-05-30

申请号：US12110135

申请日：2008-04-25

申请人： Jogeshwar Mukherjee ,  George Chandy ,  Norah Milne ,  Ping H. Wang ,  Balu Easwaramoorthy ,  Joseph Mantil ,  Adriana Garcia

发明人： Jogeshwar Mukherjee ,  George Chandy ,  Norah Milne ,  Ping H. Wang ,  Balu Easwaramoorthy ,  Joseph Mantil ,  Adriana Garcia

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B5/145 ,  A61B6/03 ,  A61B5/055

CPC分类号： A61B5/417 ,  A61B5/055 ,  A61B5/14532 ,  A61B6/037

摘要： The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.

公开(公告)号：US09483613B2

公开(公告)日：2016-11-01

申请号：US14855987

申请日：2015-09-16

申请人： International Business Machines Corporation

发明人： Joanna L. Fueyo ,  Robert L. Angell ,  Robert R. Friedlander ,  James R. Kraemer

IPC分类号： A61B5/05 ,  G06F19/00 ,  A61B5/055 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  G06F17/30 ,  G06K9/46 ,  G06K9/62 ,  G06T7/00

CPC分类号： G06F19/321 ,  A61B5/055 ,  A61B5/411 ,  A61B5/417 ,  A61B6/037 ,  A61B6/501 ,  A61B6/56 ,  A61B6/563 ,  A61B6/566 ,  G06F17/30011 ,  G06F17/30864 ,  G06F19/00 ,  G06F19/324 ,  G06F19/3481 ,  G06K9/46 ,  G06K9/6215 ,  G06K2009/4666 ,  G06T7/0012 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/30016 ,  G16H50/20 ,  G16H50/70

摘要： A computer implemented method, apparatus, and computer program product of determining mechanisms of action for therapies. A first set of brain scans for each subject in a plurality of subjects generated at a first time period and a second set of brain scans for each subject generated at a second time period are received. Each subject is diagnosed with a given condition and received a given therapy. A set of changes in the set of brain scans is identified for the each subject based on a comparison of a first set of regions of interest in the first set of scans for each subject with a second set of regions of interest in the second set of scans for each subject. A set of typical changes attributable to the given therapy is identified. A mechanism of action for the given therapy is generated based on the set of typical changes.

公开(公告)号：US09402955B2

公开(公告)日：2016-08-02

申请号：US14468873

申请日：2014-08-26

申请人： Dr. Oestreich & Partner GmbH

发明人： Wolfgang Oestreich

IPC分类号： A61M5/172 ,  A61B5/0402 ,  A61B5/00 ,  A61N1/39 ,  A61H31/00 ,  A61B5/024 ,  A61B5/044 ,  A61B5/113 ,  A61B7/04 ,  A61B8/08

CPC分类号： A61M5/1723 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/02433 ,  A61B5/0402 ,  A61B5/044 ,  A61B5/1135 ,  A61B5/417 ,  A61B5/4839 ,  A61B5/6804 ,  A61B5/6805 ,  A61B5/7405 ,  A61B5/746 ,  A61B5/747 ,  A61B7/04 ,  A61B8/0883 ,  A61H31/006 ,  A61H2201/0157 ,  A61H2201/105 ,  A61H2201/1645 ,  A61H2201/5058 ,  A61H2201/5097 ,  A61H2205/084 ,  A61H2230/045 ,  A61M2210/02 ,  A61N1/39 ,  A61N1/3968 ,  A61N1/3987 ,  G06F19/00 ,  G16H40/67

摘要： A device (1) for the medical care of a patient in an emergency which comprises an item of clothing (2) which may be worn by the patient on the body and monitoring devices (8, 9) arranged on the item of clothing (2), which may monitor at least one physiological function of the patient, in order to detect an emergency. The device further comprises a cardiac compression device (3, 4) arranged on the item of clothing (2), which is operatively connected to the monitoring device (8, 9), in order to treat the patient with a cardiac resuscitation when the monitoring device (3, 4) determines an emergency, and a defibrillator (5, 6, 7) as well as the intraosseous delivery of drugs into the bone marrow cavity of the breast bone. Moreover, a device (1) for the medical care of a patient in an emergency, which comprises as a therapeutic device a respiratory therapeutic device (10, 11, 12, 13) which is able to supply oxygen and/or a drug for pulmonary resuscitation into the respiratory system of the patient.

摘要翻译： 一种用于紧急情况下的患者的医疗护理的装置（1），其包括可由患者在身体上穿戴的衣服（2）和布置在衣服（2）上的监视装置（8,9） ），其可以监测患者的至少一个生理功能，以便检测紧急情况。 该装置还包括布置在衣服（2）上的心脏压缩装置（3,4），该心脏压缩装置可操作地连接到监视装置（8,9），以便在监视时对患者进行心脏复苏 装置（3,4）确定紧急情况，除颤器（5,6,7）以及将骨骼内骨髓内的药物输送到骨髓腔内。 此外，一种用于紧急情况下的患者的医疗护理的装置（1），其包括作为治疗装置的能够供应氧气和/或药物用于肺部的呼吸治疗装置（10,11,12,13） 复苏进入患者的呼吸系统。

公开(公告)号：US20160068918A1

公开(公告)日：2016-03-10

申请号：US14942479

申请日：2015-11-16

申请人： VIRUS IKAGAKU KENKYUSHO, INC.

发明人： Kazuhiro KONDO

IPC分类号： C12Q1/70

CPC分类号： C12Q1/705 ,  A61B5/14546 ,  A61B5/16 ,  A61B5/165 ,  A61B5/417 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/56994 ,  G01N2800/306

摘要： Level of fatigue that accompanies everyday life or a disease can be simply, easily, and quantitatively assessed by obtaining a body fluid from a test subject and measuring the amount of human herpesvirus in the body fluid. Furthermore, the anti-fatigue potency of anti-fatigue substances and anti-fatigue food products can be measured.

摘要翻译： 伴随日常生活​​或疾病的疲劳程度可以通过从测试对象获得体液并测量体液中的人疱疹病毒的量来简单，容易和定量地评估。 此外，可以测量抗疲劳物质和抗疲劳食品的抗疲劳能力。

公开(公告)号：US09117133B2

公开(公告)日：2015-08-25

申请号：US12370557

申请日：2009-02-12

申请人： Michael Barnes ,  Zhihong Pan ,  Sizhong Zhang

发明人： Michael Barnes ,  Zhihong Pan ,  Sizhong Zhang

IPC分类号： A61B6/00 ,  G06K9/20 ,  A61B5/00 ,  G06T7/00

CPC分类号： H04N5/332 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/417 ,  A61B5/442 ,  A61B5/444 ,  A61B5/445 ,  A61B5/7246 ,  A61B5/726 ,  A61B5/7267 ,  A61B5/742 ,  G06K9/2018 ,  G06K2209/05 ,  G06T7/0012 ,  G06T2207/30088 ,  G06T2207/30096 ,  H04N5/2256 ,  H04N5/2351 ,  H04N5/238

摘要： An apparatus for analyzing a subject including a hyperspectral image module is provided. It is used to identify a suspect region of a subject by using a hyperspectral sensor (for obtaining a hyperspectral image of the subject), a control computer including a processor unit (PU) and a computer readable memory (CRM) (for controlling and is in electronic communication with the sensor), a control software module including instructions stored in the CRM and executed by the PU (for controlling said at least one operating parameter of the sensor), a spectral calibrator module including instructions stored in the CRM and executed by the PU (for applying a wavelength dependent spectral calibration standard constructed for the sensor to a hyperspectral image), and a light source for illuminating the subject. An optional contact probe module is used to collect a signal of the suspect region for medical diagnosis.

摘要翻译： 提供了一种用于分析包括高光谱图像模块的对象的装置。 它用于通过使用高光谱传感器（用于获得对象的高光谱图像）来识别受试者的可疑区域，包括处理器单元（PU）和计算机可读存储器（CRM）的控制计算机（用于控制并且是 与传感器电子通信），包括存储在CRM中并由PU执行的指令（用于控制传感器的所述至少一个操作参数）的控制软件模块，包括存储在CRM中的指令并由 PU（用于将针对传感器构建的波长相关光谱校准标准应用于高光谱图像）以及用于照亮被摄体的光源。 可选的接触探针模块用于收集可疑区域的信号用于医疗诊断。

公开(公告)号：US08882703B2

公开(公告)日：2014-11-11

申请号：US11727575

申请日：2007-03-27

申请人： Randall S. Hickle

发明人： Randall S. Hickle

IPC分类号： A61M31/00 ,  G06Q50/24 ,  A61M16/01 ,  G06F19/00 ,  A61B5/00 ,  G06Q50/22 ,  A61B5/16 ,  A61B5/11 ,  A61M16/00

CPC分类号： A61M19/00 ,  A61B5/1106 ,  A61B5/162 ,  A61B5/417 ,  A61B5/4821 ,  A61M16/0051 ,  A61M16/0078 ,  A61M16/0084 ,  A61M16/009 ,  A61M16/0093 ,  A61M16/01 ,  A61M16/026 ,  A61M16/1015 ,  A61M16/107 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/1025 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3303 ,  A61M2205/3379 ,  A61M2205/3561 ,  A61M2205/505 ,  A61M2209/084 ,  A61M2230/205 ,  A61M2230/43 ,  A61M2230/432 ,  G06F19/00 ,  G06F19/3468 ,  G06Q50/22 ,  G06Q50/24 ,  Y10T428/24355

摘要： Disclosed are various methods and devices for facilitating medical and/or procedures that are performed without “general anesthesia,” which is also described in the specification as the state of patient “unconsciousness” resulting from a drug administered by an anesthetist or anesthesiologist. The devices safely and effectively provide and maintain drug infusions that do not push the patient into unconsciousness and/or general anesthesia. Devices according to embodiments of the invention include the use of stored parameters and/or values that correlate to drug delivery during a procedure, and a patient health monitor to measure and send signals regarding a patient health condition to a processor or other computational device.

摘要翻译： 公开了用于促进在没有“全身麻醉”的情况下进行的医疗和/或程序的各种方法和装置，其在说明书中也被描述为由麻醉师或麻醉师施用的药物引起的患者“无意识”的状态。 这些装置安全有效地提供并保持不会将患者置于无意识和/或全身麻醉中的药物输注。 根据本发明的实施例的装置包括使用在过程期间与药物递送相关联的存储的参数和/或值，以及患者健康监测器，以测量和发送关于患者健康状况的信号到处理器或其他计算设备。

公开(公告)号：US20140222447A1

公开(公告)日：2014-08-07

申请号：US14080727

申请日：2013-11-14

申请人： Theranos, Inc.

发明人： ELIZABETH A. HOLMES ,  Ian Gibbons ,  John Howard ,  Shaunak Roy ,  Chengwang Wang ,  Tim Kemp

IPC分类号： G06F19/00

CPC分类号： G01N21/76 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150251 ,  A61B5/150763 ,  A61B5/150854 ,  A61B5/15142 ,  A61B5/157 ,  A61B5/412 ,  A61B5/417 ,  B01L3/50273 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  G01N33/50 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54386 ,  G01N2500/00 ,  G16H40/63 ,  Y02A90/26 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/143333

摘要： This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

摘要翻译： 本发明在医疗器械领域。 具体地说，本发明提供允许从生物流体实时检测分析物的便携式医疗装置。 所述方法和装置对于为各种医疗应用提供点护理测试特别有用。

公开(公告)号：US08644910B2

公开(公告)日：2014-02-04

申请号：US11989223

申请日：2006-07-19

申请人： Benny Rousso ,  Dalia Dickman ,  Yael Nir ,  Michael Nagler ,  Zohar Bronshtine ,  Shankar Vallabhajosula ,  Shlomo Ben-Haim ,  Simona Ben-Haim

发明人： Benny Rousso ,  Dalia Dickman ,  Yael Nir ,  Michael Nagler ,  Zohar Bronshtine ,  Shankar Vallabhajosula ,  Shlomo Ben-Haim ,  Simona Ben-Haim

IPC分类号： A61B5/05

CPC分类号： A61B5/02755 ,  A61B5/06 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/4088 ,  A61B5/411 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  A61B6/037 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4291 ,  A61B6/4488 ,  A61B6/501 ,  A61B6/502 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5247 ,  A61B6/583 ,  A61B8/0891 ,  A61B8/4416 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0476 ,  A61K51/0478 ,  A61K51/048 ,  A61K51/0489 ,  A61K51/0491 ,  A61K51/1203

摘要： Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

摘要翻译： 提供用于放射成像事件或障碍的协议。 示例性方案包括放射成像心肌灌注的方法，该方法依次包括：（a）向受试者施用约3mCi Tl201硫酸氯化物; （b）允许所述受试者休息; （c）对所述受试者的心脏进行放射成像; （d）使所述受试者受到身体压力; （e）在所述身体应激的峰值处施用约20-30mCi Tc99m sestamibi的所述受试者; 和（f）对所述受试者的所述心脏进行放射成像，从而放射成像心肌灌注。