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公开(公告)号:US11260027B2
公开(公告)日:2022-03-01
申请号:US15745913
申请日:2016-06-24
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: Satish Nadig , Carl Atkinson , Ann-Marie Broome , Suraj K. Dixit
IPC: A61K9/107 , A61K9/127 , A61K38/13 , A61K9/51 , A01N1/02 , A61K31/436 , A61K31/365 , A61K38/20 , A61K31/713 , A61P37/06 , A61K31/343 , A61K47/10 , A61K31/453 , B82Y5/00
Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.
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公开(公告)号:US20210322128A1
公开(公告)日:2021-10-21
申请号:US16496495
申请日:2018-03-19
Applicant: MUSC Foundation for Research Development
Inventor: Raymond Turner , Mark E. Semler , Aquilla Turk , Alex Spiotta , Imran Chaudry
IPC: A61B90/10
Abstract: A cranial anchor system configured to attach to an opening in a cranium includes an anchor member. The anchor member has a middle anchor portion and a lower anchor portion coupled to and disposed in a downward direction relative to the middle anchor portion. The lower anchor portion has a plurality of contact members, each of which have a leg that extends at least partially in the downward direction, a tab connected to the leg, and a rib disposed between the leg and the tab. The system further includes an outer sheath and an inner sheath disposed within the outer sheath and slidable relative to the outer sheath.
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公开(公告)号:US11150251B2
公开(公告)日:2021-10-19
申请号:US15726766
申请日:2017-10-06
Inventor: Ying Mei , Jia Jia , Chung-Jen James Chou
IPC: G01N33/68 , C07K7/06 , C07K7/08 , A61P9/10 , G01N33/74 , C07K14/78 , C07K17/02 , C07K14/71 , C07K14/755 , C07K14/52 , C07K14/75 , C07K14/705 , A61K38/00
Abstract: The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.
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公开(公告)号:US20210220148A1
公开(公告)日:2021-07-22
申请号:US17225436
申请日:2021-04-08
Applicant: MUSC Foundation for Research Development
Inventor: Stephen Kalhorn , Mark E. Semler , Joseph Ruscito , Christopher Hapstack
Abstract: The present invention provides expandable devices and insertion tools for deploying the expandable devices. The expandable devices are capable of increasing in height and width when expanded from a closed configuration to an open configuration to occupy a larger volume and to present a larger surface area. The expandable devices are lockable and are capable of rigidly occupying a space after expansion. In some embodiments, the expandable devices are useful as interbody devices for spinal fusions.
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公开(公告)号:US20210208156A1
公开(公告)日:2021-07-08
申请号:US17059660
申请日:2019-06-03
Inventor: Anand Mehta , Richard R. Drake , Brian Haab , Peggi M. Angel
IPC: G01N33/68
Abstract: The present invention provides methods and compositions for glycan analysis of complex solutions, including proteins and cells in a biological sample. The method includes the preparation of substrates for the capture of proteins and cells for multiplexed analysis. Cells and proteins may be captured by antibody arrays, culture, or direct deposition. The invention further relates to the use of protein and cell glycan analysis in the diagnosis and screening of disease states and disease progression.
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公开(公告)号:US20210108221A1
公开(公告)日:2021-04-15
申请号:US17092539
申请日:2020-11-09
Applicant: iBio, Inc. , Novici Biotech LLC , MUSC Foundation for Research Development
Inventor: Carol Feghali-Bostwick , Terence E. Ryan , Hal S. Padgett , Matthew McGee
IPC: C12N15/82
Abstract: Materials and methods for using polypeptides containing fragments and variants of endostatin to treat fibrosis are described herein.
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公开(公告)号:US10932683B2
公开(公告)日:2021-03-02
申请号:US15291448
申请日:2016-10-12
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: Jonathan Edwards , Jessica Barley , Mark Semler
IPC: A61B5/04 , A61B5/00 , A61B5/0492
Abstract: A needle electrode fixation device is configured to secure a transdermal needle electrode to a patient. The device includes a base having a body that defines a first portion and a second portion. The first and second portions are rotatable relative to each other. The first portion defines a channel configured to fit a portion of the transdermal needle electrode. The second portion defines a recess configured to fit a tip of the needle electrode. The device further includes an adhesive layer configured to affix the base to the patient.
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公开(公告)号:US20200281190A1
公开(公告)日:2020-09-10
申请号:US16339179
申请日:2018-12-26
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: Satish N. Nadig , Carl Atkinson , Danh T. Tran
IPC: A01N1/02 , C07C251/86 , C07D239/95
Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation and for inducing mitochondrial morphological alterations.
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公开(公告)号:US20200237522A1
公开(公告)日:2020-07-30
申请号:US16847320
申请日:2020-04-13
Applicant: MUSC Foundation for Research Development
Inventor: Mark Evald SEMLER , Bruce FRANKEL , Joseph RUSCITO
Abstract: An expandable vertebral body device, system, instrument, and methods of assembly and using the device, system, and instrument are disclosed. The vertebral body device includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, a second rotating member rotatably coupled to the second end, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body device and an insertion instrument. Methods for assembling and using the vertebral body device and instrument are also disclosed.
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公开(公告)号:US10703737B2
公开(公告)日:2020-07-07
申请号:US16351809
申请日:2019-03-13
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor: Donald R. Menick , Chung-Jen James Chou , Daniel Herr , Xiaoyang Li
IPC: C07D311/82 , A61P9/10
Abstract: The present invention relates to histone deacetylase inhibitors, and to pharmaceutical compositions comprising the compounds, useful for the treatment of ischemia-reperfusion injury and for cardioprotection.
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