公开(公告)号：US07563905B2

公开(公告)日：2009-07-21

申请号：US11076960

申请日：2005-03-11

Applicant: Matthew Olson ,  Martin Di Grandi

Inventor： Matthew Olson ,  Martin Di Grandi

IPC: C07D249/08

CPC classification number: C07D409/04 ,  C07D249/12 ,  C07D401/04 ,  C07D405/04

Abstract: The present invention is directed to compounds of formula (I): wherein R1, R2 and R3 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl and X1 and X2 are independently a bond or an linker group of 1 to 6 atoms and may be optional substituted or oxidized, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof. The invention is also directed to methods of using the same for treating HIV infections, or AIDs or preventing viral replication.

Abstract translation: 本发明涉及式（I）化合物：其中R 1，R 2和R 3独立地选自烷基，烯基，炔基，环烷基，芳基和杂芳基，X 1和X 2独立地是键或连接基团 1至6个原子，并且可以是任选的取代或氧化的，或其前药，药学上可接受的盐或其药物活性代谢物。 本发明还涉及使用该方法治疗HIV感染或AID或预防病毒复制的方法。

公开(公告)号：US20080005760A1

公开(公告)日：2008-01-03

申请号：US11855763

申请日：2007-09-14

Applicant: RICHARD KAY ,  GREGORY TEMKIN ,  MATTHEW OLSON ,  DAVID HENDRICKSON

Inventor： RICHARD KAY ,  GREGORY TEMKIN ,  MATTHEW OLSON ,  DAVID HENDRICKSON

IPC: H04N7/16

CPC classification number: H04N21/47202 ,  G06Q30/04 ,  H04N7/17336 ,  H04N21/2143 ,  H04N21/25435 ,  H04N21/25891 ,  H04N21/478 ,  H04N21/4781 ,  H04N21/4784 ,  H04N21/6587

Abstract: A system for delivering digital content on demand in a multiple unit environment includes a server local to the multiple unit environment. The server stores, in its memory, the digital content, and is capable of supporting multiple simultaneous asynchronous accesses to the digital content. A billing system tracks the bill for each unit in the multiple unit environment, based on the accessed digital content. Within each unit that supports access to the digital content, an access system (preferably a set-top box) allows a user to access the digital content.

Abstract translation: 用于在多单元环境中按需传送数字内容的系统包括多单元环境本地的服务器。 服务器在其存储器中存储数字内容，并且能够支持对数字内容的多个同时异步访问。 计费系统基于所访问的数字内容来跟踪多单元环境中的每个单元的账单。 在支持访问数字内容的每个单元内，访问系统（优选地是机顶盒）允许用户访问数字内容。

公开(公告)号：US20050203176A1

公开(公告)日：2005-09-15

申请号：US11076929

申请日：2005-03-11

Applicant: Matthew Olson ,  Martin Grandi ,  Amarnauth Prashad

Inventor： Matthew Olson ,  Martin Grandi ,  Amarnauth Prashad

IPC: A61K31/325 ,  C07C333/20 ,  C07C333/24

CPC classification number: C07C333/20 ,  C07C333/24

Abstract: The present invention relates to carbamate derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

Abstract translation: 本发明涉及具有RNA酶H，聚合酶和/或HIV逆转录酶调节的氨基甲酸酯衍生物，特别涉及抑制活性。 本发明包括氨基甲酸酯衍生物，含有衍生物的组合物，衍生物的合成方法，鉴定衍生物的筛选方法以及使用氨基甲酸酯衍生物的治疗方法，包括治疗HIV，AIDS和逆转录病毒相关癌症。

公开(公告)号：US06349166B1

公开(公告)日：2002-02-19

申请号：US09222260

申请日：1998-12-28

Applicant: Andrew Kaliszek ,  Matthew Olson

Inventor： Andrew Kaliszek ,  Matthew Olson

IPC: G02B616

CPC classification number: G02B6/4457 ,  G01C19/722

Abstract: An adhesive system for use in minimizing the negative environmental influences on a fiber optic gyroscope comprises a free-standing substantially cylindrical sensing coil 12 having an inner coil surface, a rigid substantially cylindrical coil-supporting structure or hub 10 having a cylindrical wall and an outer surface, a plurality of grooves 16 formed into the hub's outer surface, a plurality of slots 24 formed into the outer surface of hub 10 and an adhesive 14 affixing hub 10 to coil 12. Adhesive 14 may be injected into manifolds 18 located in the cylindrical wall of hub 10, travel through the slots 24 into a gap existing between coil 12 and hub 10. Excess adhesive 14 may flow into grooves 16. Different orientations and sizes of grooves 16 and slots 24, different types and amounts of adhesive 14, and different thicknesses of adhesive between the coil 12 and hub 10 may be used to achieve suitable adhesion. The adhesive system may further include a stress buffer 22 and an additional adhesive 20 to further minimize environmental influences on coil 12. Specifically, a first adhesive 14 affixes the inner surface of buffer 22 to the outer surface of hub 10. A second adhesive 20 affixes the outer surface of buffer 22 to the inner surface of coil 12.

Abstract translation: 用于最小化对光纤陀螺仪的负面环境影响的粘合剂系统包括具有内部线圈表面的独立的大致圆柱形的感测线圈12，具有圆柱形壁和外部线圈支撑结构的刚性大致圆柱形的线圈支撑结构或轮毂10 表面，形成在毂的外表面中的多个槽16，形成在轮毂10的外表面中的多个槽24和将轮毂10固定到线圈12的粘合剂14.粘合剂14可以被注入到位于圆柱体 轮毂10的壁穿过狭槽24进入线圈12和轮毂10之间的间隙中。过多的粘合剂14可能流入凹槽16.凹槽16和狭槽24的不同取向和尺寸，不同类型和数量的粘合剂14和 可以使用线圈12和轮毂10之间的不同厚度的粘合剂来实现合适的粘附。 粘合剂系统还可以包括应力缓冲器22和附加粘合剂20，以进一步最小化对线圈12的环境影响。具体地，第一粘合剂14将缓冲器22的内表面固定到轮毂10的外表面。第二粘合剂20固定 缓冲器22的外表面到线圈12的内表面。

公开(公告)号：US09045930B2

公开(公告)日：2015-06-02

申请号：US13090456

申请日：2011-04-20

Applicant: Matthew Olson ,  Paul Kubinski ,  Romell Alaman

Inventor： Matthew Olson ,  Paul Kubinski ,  Romell Alaman

IPC: E05F15/00

CPC classification number: E05F15/50 ,  E05F15/53 ,  E05F15/565 ,  E05Y2400/36 ,  E05Y2400/40 ,  E05Y2400/452 ,  E05Y2900/51 ,  Y10T307/76

Abstract: An electric circuit with speed control and diode separation for use with an electrically actuatable mechanism. An operator input provides a signal to a controller of the electric circuit. The controller causes a MOSFET relay to provide a voltage to the electrically actuatable mechanism. The relay is adapted to vary the voltage in response to pulse width modified signals from the controller.

Abstract translation: 具有速度控制和二极管分离的电路，可与电致动机构一起使用。 操作员输入向电路的控制器提供信号。 控制器使MOSFET继电器向电致动机构提供电压。 继电器适于响应于来自控制器的脉冲宽度修改信号来改变电压。

公开(公告)号：US20120090307A1

公开(公告)日：2012-04-19

申请号：US13090456

申请日：2011-04-20

Applicant: MATTHEW OLSON ,  Paul Kubinski ,  Romell Alaman

Inventor： MATTHEW OLSON ,  Paul Kubinski ,  Romell Alaman

IPC: F15B13/044 ,  H01H47/00

CPC classification number: E05F15/50 ,  E05F15/53 ,  E05F15/565 ,  E05Y2400/36 ,  E05Y2400/40 ,  E05Y2400/452 ,  E05Y2900/51 ,  Y10T307/76

Abstract: An electric circuit with speed control and diode separation for use with an electrically actuatable mechanism. An operator input provides a signal to a controller of the electric circuit. The controller causes a MOSFET relay to provide a voltage to the electrically actuatable mechanism. The relay is adapted to vary the voltage in response to pulse width modified signals from the controller.

Abstract translation: 具有速度控制和二极管分离的电路，可与电致动机构一起使用。 操作员输入向电路的控制器提供信号。 控制器使MOSFET继电器向电致动机构提供电压。 继电器适于响应于来自控制器的脉冲宽度修改信号来改变电压。

公开(公告)号：US20110087654A1

公开(公告)日：2011-04-14

申请号：US12578560

申请日：2009-10-13

Applicant: James Matthew Olson ,  Ken Sun ,  Suchisubhra Sinha ,  Rangaraj Keshavamurthy Belur

Inventor： James Matthew Olson ,  Ken Sun ,  Suchisubhra Sinha ,  Rangaraj Keshavamurthy Belur

IPC: G06F17/30

CPC classification number: G06Q30/02

Abstract: The present disclosure relates to methods and systems for managing how merchandise listings satisfying a search query are processed and presented to a user of a computer-based trading or e-commerce application when the listings are of heterogeneous types. Consistent with some embodiments, in response to a user-initiated search query, item listings and product listings are displayed intermingled in a set of search results pages. The item listings and product listings are positioned relative to one another, in part, based on a level of demand associated with the product listings and the item listings, where demand is measured by monitoring user-initiated activities in connection with the item and product listings.

Abstract translation: 本公开涉及用于管理当列表是异构类型时，满足搜索查询的商品列表如何被处理并呈现给基于计算机的交易或电子商务应用的用户的方法和系统。 与一些实施例一致，响应于用户发起的搜索查询，项目列表和产品列表被显示在一组搜索结果页中。 项目列表和产品列表相对于彼此定位，部分地基于与产品列表和项目列表相关联的需求级别，其中通过监视与项目和产品列表相关的用户发起的活动来测量需求 。

公开(公告)号：US20100136594A1

公开(公告)日：2010-06-03

申请号：US12603372

申请日：2009-10-21

Applicant: Matthew Olson ,  Matthew Todd

Inventor： Matthew Olson ,  Matthew Todd

IPC: C12Q1/37 ,  C12N9/48

CPC classification number: C12Q1/37 ,  C07K5/06026 ,  C12N9/6483 ,  C12Y304/23004 ,  G01N2333/948 ,  G01N2500/02

Abstract: A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.

Abstract translation: 筛选调节二肽基肽酶I（DPPI）活性的化合物的方法包括以下步骤：将DPPI的肽底物加入到包含DPPI和化合物的反应混合物中，其中DPPI的肽底物具有至少3个氨基酸并且结合 除了S1-S2位点之外，还与DPPI的结合位点; 并测量底物的分子量，其中底物分子量的变化表明存在DPPI活性。

公开(公告)号：US20070215769A1

公开(公告)日：2007-09-20

申请号：US11376682

申请日：2006-03-15

Applicant: Michael Nebeker ,  Matthew Olson ,  Anthony Anderson ,  James Ebner

Inventor： Michael Nebeker ,  Matthew Olson ,  Anthony Anderson ,  James Ebner

IPC: A47B96/06

CPC classification number: F16B5/07 ,  B60R13/0206 ,  B60R13/0237 ,  Y10T24/45089 ,  Y10T24/45099 ,  Y10T403/60 ,  Y10T403/606

Abstract: A retaining component for securing an external structure or panel to a seat track within a mobile platform, such as an aircraft. The retaining component includes a pair of flexible flanges that are adapted to engage an external component or panel, in one example a seat track in a commercial aircraft cabin area. The retaining component also includes a base portion having a flexible portion with at least one locking tab protruding therefrom. One or more hook-shaped engaging tabs also protrude from the base portion. The engaging tabs and the locking tab enable the retaining component to be secured to a flange of a seat track having a plurality of spaced apart holes in a manner that does not require any external threaded or rivet style fastening elements, or the use of separate assembly tools. The retaining component, in one form, is a single piece, lightweight, integrally formed component that is ideally suited for use in mobile platforms such as commercial aircraft where assembly time and costs are important considerations in the manufacture of a commercial aircraft.

Abstract translation: 用于将外部结构或面板固定到诸如飞行器的移动平台内的座椅轨道的保持部件。 保持部件包括一对柔性凸缘，其适于接合外部部件或面板，在一个示例中是商用飞机机舱区域中的座椅轨道。 保持部件还包括具有柔性部分的基部部分，其中至少一个锁定突片从其突出。 一个或多个钩形接合突片也从基部突出。 接合突片和锁定突舌使得保持部件能够以不需要任何外部螺纹或铆钉式紧固元件的方式固定到具有多个间隔开的孔的座椅轨道的凸缘上，或者使用单独的组件 工具 一种形式的保持部件是单件，重量轻，整体形成的部件，其理想地适用于诸如商用飞机的移动平台，其中组装时间和成本是制造商用飞机的重要考虑因素。

公开(公告)号：US20060268280A1

公开(公告)日：2006-11-30

申请号：US11139818

申请日：2005-05-27

Applicant: Andrew Kaliszek ,  Matthew Olson ,  Clarence Laskoskie

Inventor： Andrew Kaliszek ,  Matthew Olson ,  Clarence Laskoskie

IPC: G01C19/72

CPC classification number: G01C19/722

Abstract: A sensing coil is provided for optically guiding counter-propagating light beams in a fiber optic gyroscope. The sensing coil comprises a plurality of layers of an optical fiber having a winding direction. The plurality of layers comprises inner layers, middle layers, and outer layers. The middle layers comprise first and second input ends configured to receive the counter-propagating light beams. At least one of the inner layers, middle layers, and outer layers is coupled with a different one of the inner layers, middle layers, and outer layers while maintaining the winding direction. A method is provided for winding an optical fiber, having first and second connecting ends, to form a sensing coil for a fiber optic gyroscope having a winding direction. The method comprises excluding first and second segments from a middle layer of the sensing coil to produce first and second inputs and third and fourth connecting ends respectively adjacent to the first and second inputs, and coupling each of the connecting ends with a different one of the connecting ends while maintaining the winding direction.

Abstract translation: 提供感测线圈用于在光纤陀螺仪中光学引导反向传播的光束。 感测线圈包括具有卷绕方向的多个光纤层。 多个层包括内层，中间层和外层。 中间层包括被配置为接收反向传播光束的第一和第二输入端。 内层，中层和外层中的至少一层与内层，中层和外层中的不同的一层耦合，同时保持卷绕方向。 提供一种用于卷绕具有第一和第二连接端的光纤的方法，以形成具有卷绕方向的光纤陀螺仪的感测线圈。 该方法包括从感测线圈的中间层排除第一和第二段以产生第一和第二输入以及分别与第一和第二输入相邻的第三和第四连接端，并且将每个连接端与不同的一个 同时保持卷绕方向。