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公开(公告)号：US20160266311A1
公开(公告)日：2016-09-15
申请号：US15065126
申请日：2016-03-09
Applicant: Medlumics S.L.
Inventor： José Luis Rubio Guivernau , Juan Sancho Durá , Eduardo Margallo Balbás
CPC classification number: G02B6/122 , G02B6/12 , G02B6/12004 , G02B6/124 , G02B6/2861 , G02B6/29331 , G02B6/29332 , G02B6/29344 , G02B6/29352 , G02B2006/12104 , G02B2006/12142 , G02B2006/12147 , H01S5/1028
Abstract: A photonic integrated circuit is presented that includes a substrate, and a first and second waveguide patterned on the substrate. The first waveguide guides an input beam of radiation. The photonic integrated circuit also includes a coupling region, wherein the first and second waveguides each pass through the coupling region. One or more modulating elements are coupled to each of the first and second waveguides. The first waveguide and the second waveguide have a first facet and a second facet, respectively, and first and second reflections are generated at the first and second facets within the first and second waveguides, respectively. The one or more modulating elements coupled to each of the first and second waveguides are designed to adjust the phase of the first and second reflections before the first and second reflections pass through the coupling region.
Abstract translation: 提出了一种光子集成电路，其包括衬底和在衬底上图案化的第一和第二波导。 第一波导引导输入的辐射束。 光子集成电路还包括耦合区域，其中第一和第二波导各自通过耦合区域。 一个或多个调制元件耦合到第一和第二波导中的每一个。 第一波导和第二波导分别具有第一刻面和第二面，并且第一和第二反射分别在第一和第二波导内的第一和第二面产生。 耦合到第一和第二波导中的每一个的一个或多个调制元件被设计成在第一和第二反射通过耦合区域之前调节第一和第二反射的相位。
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12.发明授权Electro-optical silicon-based phase modulator with null residual amplitude modulation 有权具有零残余幅度调制的电光硅基相位调制器公开(公告)号：US09310185B2
公开(公告)日：2016-04-12
申请号：US14299725
申请日：2014-06-09
Applicant: MEDLUMICS, S.L.
CPC classification number: G01B9/02091 , A61B5/0066 , G01B9/0201 , G02B2006/12142 , G02F1/025 , G02F1/2257 , G02F2201/06 , G02F2203/50
Abstract: Systems and methods are presented for modulating a beam of radiation, such that the modulated beam exhibits substantially null residual amplitude modulation (RAM). An electro-optical modulator is presented that includes a waveguide, a first region associated with the waveguide and a second region associated with the waveguide. The waveguide is designed to guide a beam of radiation. A first electric potential applied to the first region causes a first modulation to the beam of radiation while a second electric potential applied to the second region causes a second modulation to the beam of radiation. The first modulation combined with the second modulation provides substantially null residual amplitude modulation of the beam of radiation.
Abstract translation: 呈现用于调制辐射束的系统和方法，使得调制的光束呈现基本上为零的残余幅度调制（RAM）。 提出了一种电光调制器，其包括波导，与波导相关联的第一区域和与波导相关联的第二区域。 波导被设计成引导辐射束。 施加到第一区域的第一电位对辐射束进行第一调制，而施加到第二区的第二电位对辐射束施加第二调制。 与第二调制组合的第一调制提供辐射束的基本上零的剩余幅度调制。
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公开(公告)号：US20150247720A1
公开(公告)日：2015-09-03
申请号：US14715182
申请日：2015-05-18
Applicant: Medlumics S.L.
Inventor： José Luis Rubio Guivernau , Eduardo Margallo Balbás
CPC classification number: G01B9/02091 , A61B5/0066 , G01B9/02049 , G02B6/06 , G02B6/1221 , G02B6/13 , G02B6/136 , G02B6/262 , G02B6/32 , G02B6/3596
Abstract: A system and method for depth-resolved imaging of a sample are presented. The system for depth-resolved imaging of a sample includes a substrate of substantially flexible material, a plurality of waveguides disposed on the substrate, an optical element disposed at a distal end of the plurality of waveguides, and one or more interferometers. Light is collected from the sample through the optical element and plurality of waveguides on the flexible substrate on its path to the one or more interferometers. The interferometers are configured to combine a reference light with the light received by at least a portion of the plurality of waveguides to resolve contributions from one or more depths of the sample. The system further includes a light guiding element coupled between the plurality of waveguides and the one or more interferometers.
Abstract translation: 提出了一种用于样本深度分辨成像的系统和方法。 用于样品的深度分辨成像的系统包括基本上柔性材料的衬底，设置在衬底上的多个波导，设置在多个波导的远端的光学元件以及一个或多个干涉仪。 通过光学元件和柔性基板上的多个波导在其通向一个或多个干涉仪的路径上从样本收集光。 干涉仪被配置为将参考光与由多个波导的至少一部分接收的光结合以解决来自样本的一个或多个深度的贡献。 该系统还包括耦合在多个波导与一个或多个干涉仪之间的导光元件。
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公开(公告)号：US09062960B2
公开(公告)日：2015-06-23
申请号：US13761054
申请日：2013-02-06
Applicant: Medlumics S.L.
Inventor： José Luis Rubio Guivernau , Eduardo Margallo Balbás
CPC classification number: G01B9/02091 , A61B5/0066 , G01B9/02049 , G02B6/06 , G02B6/1221 , G02B6/13 , G02B6/136 , G02B6/262 , G02B6/32 , G02B6/3596
Abstract: A system and method for depth-resolved imaging of a sample are presented. The system for depth-resolved imaging of a sample includes a substrate of substantially flexible material, a plurality of waveguides disposed on the substrate, an optical element disposed at a distal end of the plurality of waveguides, and one or more interferometers. Light is collected from the sample through the optical element and plurality of waveguides on the flexible substrate on its path to the one or more interferometers. The interferometers are configured to combine a reference light with the light received by at least a portion of the plurality of waveguides to resolve contributions from one or more depths of the sample. The system further includes a light guiding element coupled between the plurality of waveguides and the one or more interferometers.
Abstract translation: 提出了一种用于样本深度分辨成像的系统和方法。 用于样品的深度分辨成像的系统包括基本上柔性材料的衬底，设置在衬底上的多个波导，设置在多个波导的远端的光学元件以及一个或多个干涉仪。 通过光学元件和柔性基板上的多个波导在其通向一个或多个干涉仪的路径上从样本收集光。 干涉仪被配置为将参考光与由多个波导的至少一部分接收的光结合以解决来自样本的一个或多个深度的贡献。 该系统还包括耦合在多个波导与一个或多个干涉仪之间的导光元件。
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15.发明申请Diagnostic Device for Dermatology with Merged OCT and Epiluminescence Dermoscopy 审中-公开用于合并OCT和发光皮肤镜的皮肤病诊断装置公开(公告)号：US20150133778A1
公开(公告)日：2015-05-14
申请号：US14530054
申请日：2014-10-31
Applicant: Medlumics S.L.
CPC classification number: A61B5/444 , A61B5/0013 , A61B5/0017 , A61B5/0022 , A61B5/0035 , A61B5/0066 , A61B5/0077 , A61B5/7246 , A61B5/7425 , A61B2576/02 , G01B9/02091 , G16H40/67
Abstract: Systems and methods for use of the imaging system are presented. In an embodiment, the imaging system includes a first optical path, a second optical path, a plurality of optical elements, a detector, and a processor. The first optical path guides a first beam of radiation associated with epiluminescence while the second optical path guides a second beam of radiation associated with optical coherence tomography. The plurality of optical elements transmit the first and second beams of radiation onto a sample. The detector generates optical data associated with the first and second beams of radiation returning from the sample. The optical data associated with the first and second beams of radiation correspond to substantially non-coplanar regions of the sample. The processor correlates the optical data of the first beam with the optical data of the second beam and generates an image of the sample.
Abstract translation: 介绍了使用成像系统的系统和方法。 在一个实施例中，成像系统包括第一光路，第二光路，多个光学元件，检测器和处理器。 第一光路引导与外发光相关联的第一辐射束，而第二光路引导与光学相干断层摄影相关联的第二辐射束。 多个光学元件将第一和第二辐射束发射到样品上。 检测器产生与从样品返回的第一和第二辐射束相关联的光学数据。 与第一和第二辐射束相关联的光学数据对应于样品的基本非共面区域。 处理器将第一光束的光学数据与第二光束的光学数据相关联，并生成样本的图像。
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Patent Agency Ranking
公开(公告)号：US12232807B2
公开(公告)日：2025-02-25
申请号：US17686873
申请日：2022-03-04
Applicant: Medlumics S.L.
Inventor： Sara Mas Gómez , Juan Sancho Dúra , David González Villar , Matthieu Duperron , Carlos Sanz Moreno , Alexandre Romoscanu , Jorge H. Jiménez
Abstract: A catheter includes proximal and distal sections, a shaft coupled between the proximal and distal sections, and optical fibers extending through the shaft and to the distal section of the catheter. The distal section includes a support structure that includes a proximal end, a distal end, reflective elements, and a cap disposed over a portion of the distal end of the support structure. The proximal end includes alignment receptacles. Each of the optical fibers is inserted into corresponding ones of the alignment receptacles and the alignment receptacles are shaped to maintain the optical fibers straight in the support structure. The distal end includes orifices facing different directions. Each of the optical fibers is optically aligned with corresponding ones of the lenses, reflective elements, and orifices such that the optical fibers in the support structure are straight. The cap includes optical ports aligned with the orifices.
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公开(公告)号：US20230397942A1
公开(公告)日：2023-12-14
申请号：US18205962
申请日：2023-06-05
Applicant: Medlumics S.L.
Inventor： Juan SANCHO , David HERRANZ , Christophe BAILLEUL , James GREENE
CPC classification number: A61B18/00 , G16H40/63 , A61B2017/00057
Abstract: Disclosed herein are system, method, and computer-readable medium aspects for improving the accuracy of an ablation model through synchronization. An aspect operates by activating a catheter energy source, acquiring a catheter energy signal from the catheter energy source, assigning an activation time stamp and deactivation time stamp to the catheter energy signal, and determining a time of ablation based on a time period between the activation time stamp and deactivation time stamp. The aspect continues to operate by acquiring an optical measurement signal from a catheter optical port, assigning an input time stamp and switching time stamp to the optical measurement signal, and processing the optical measurement signal in order to acquire a denaturation result. The aspect concludes by synchronizing the time of ablation and the denaturation result using the time stamps in order to generate a synchronized model and generating an estimated lesion depth from the synchronized model.
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公开(公告)号：US11523740B2
公开(公告)日：2022-12-13
申请号：US17148480
申请日：2021-01-13
Applicant: Medlumics S.L.
Inventor： Juan Sancho Durá , Sara Mas Gómez , David Gonzalez , Matthieu Duperron , Carlos Sanz Moreno , Jorge Jimenez , Alexandre Romoscanu , David Herranz Aragoncillo
IPC: A61B5/00 , A61B18/02 , A61B18/14 , A61B18/20 , A61B18/24 , A61B90/30 , A61B90/00 , A61B17/00 , A61B18/00
Abstract: Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.
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公开(公告)号：US11464412B2
公开(公告)日：2022-10-11
申请号：US17084056
申请日：2020-10-29
Applicant: Medlumics S.L.
IPC: A61B5/00 , G02B6/122 , G02B6/126 , G02B6/024 , A61B90/00 , G02B6/12 , A61B90/30 , G01B9/02091 , G01B9/0209
Abstract: A medical instrument is described that includes an optical source, an optical fiber, and a waveguide patterned upon a substrate. The optical fiber receives radiation from the optical source and includes a first segment and a second segment. The second segment is rotated about an optical axis relative to the first segment. The waveguide receives radiation from the optical source and guides a beam of radiation. The waveguide includes a first waveguide segment designed to impart a first differential group delay on the beam of radiation and a second waveguide segment designed to impart a second differential group delay on the beam of radiation. A sum of the first differential group delay and the second differential group delay is substantially zero.
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公开(公告)号：US11331142B2
公开(公告)日：2022-05-17
申请号：US17148524
申请日：2021-01-13
Applicant: Medlumics S.L.
Inventor： Juan Sancho Durá , Sara Mas Gómez , David Gonzalez , Matthieu Duperron , Carlos Sanz Moreno , Jorge Jimenez , Alexandre Romoscanu
Abstract: Described herein are methods, devices, and support structures for assembling optical fibers in catheter tips and facilitating alignment and structural support. A method for assembling a plurality of optical fibers and lenses in a support structure for an ablation catheter includes providing a support structure with a proximal end, a body, and a distal end, wherein the distal end includes a plurality of alignment orifices or slits. A plurality of optical fibers are threaded through the alignment orifices or slits, such that each optical fiber is threaded through a corresponding alignment orifice or slit. An adhesive material is applied at each alignment orifice or slit to secure the optical fibers, and the plurality of optical fibers are then cleaved at the distal end to remove portions of the fibers extending out of the distal end. Finally, a lens is attached to each of the ends of the plurality of optical fibers.
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