公开(公告)号：US20050124844A1

公开(公告)日：2005-06-09

申请号：US11009501

申请日：2004-12-10

Applicant: Michael Forman

Inventor： Michael Forman

IPC: A61F2/958 ,  A61K51/12 ,  A61M25/00 ,  A61M29/02 ,  A61N5/10 ,  A61N5/00 ,  A61M29/00

CPC classification number: A61K51/1282 ,  A61M25/002 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1097 ,  A61N5/1001 ,  A61N2005/1003 ,  A61N2005/1004

Abstract: The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled radiosensitizer delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and radiosensitizer delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and means coupleable to the catheter body or the radiation source for releasing a radiosensitizer to the body lumen.

Abstract translation: 本发明提供用于在血管内干预后抑制再狭窄和增生的改进的装置，方法和试剂盒。 特别地，本发明提供与电离辐射组合的受控放射增敏剂递送至患者脉管系统内的选定位置，以减少和/或抑制再狭窄和增生率与增加的功效。 在一个实施方案中，用于抑制增生的组合辐射和放射增敏剂递送导管包括具有近端和远端的导管主体，可耦合到导管体的电离辐射源，用于向体腔施加辐射剂量，以及可耦合到 导管体或用于将放射增敏剂释放到体腔的辐射源。

公开(公告)号：US20070016179A1

公开(公告)日：2007-01-18

申请号：US11385255

申请日：2006-03-20

Applicant: Darius Francescatti ,  Michael Forman

Inventor： Darius Francescatti ,  Michael Forman

IPC: A61B18/04

CPC classification number: A61N5/1015 ,  A61B90/04 ,  A61B2090/0445 ,  A61N2005/1094

Abstract: A flexible, relatively flat and thin patch, optionally made of biodegradable material, substantially attenuates ionizing radiation from normal but sensitive anatomy during radio-therapy, particularly breast brachytherapy. The patch is of such a thickness as to substantially attenuate radiation by distance or consists of a material that has been formulated with radio-attenuating filler or is of radio-attenuating material. An alternative version consists of a thin patch that is coated with radio-attenuating material.

Abstract translation: 可选地由可生物降解材料制成的柔性，相对平坦和薄的贴片在放射治疗期间，特别是乳房近距离放射治疗中，基本上减弱了来自正常但敏感的解剖结构的电离辐射。 该贴片具有如此厚度以使辐射基本上被距离缩短或由已经用无线电衰减填料配制的材料或具有无线电衰减材料的材料组成。 替代版本由涂有无线电衰减材料的薄贴片组成。

公开(公告)号：US20070010746A1

公开(公告)日：2007-01-11

申请号：US11520400

申请日：2006-09-12

Applicant: Michael Forman ,  Paul Lovoi ,  Peter Smith

Inventor： Michael Forman ,  Paul Lovoi ,  Peter Smith

IPC: A61N5/00 ,  A61N5/02 ,  A61B19/00

CPC classification number: A61N5/1001 ,  A61B2090/306 ,  A61F9/0079 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/1017 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/1022 ,  A61N2005/1098

Abstract: Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube inserted via a catheter around the globe of the eye, to a position behind the macula. The process can employ an applicator with several parallel guides, inserted around the eye to receive the catheter with x-ray tube (or an isotope) at a matrix of different positions. Methods are described for properly locating the catheter and x-ray tube, using illumination on the catheter and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent material excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube from the target tissue, and for achieving prescription radiation dose in the choroid while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.

Abstract translation: 年龄相关性黄斑变性通过从通过眼睛周围的导管插入的微型X射线管递送到黄斑后面的位置进行治疗。 该过程可以使用具有多个平行引导件的施用器，其插入眼睛周围以在不同位置的基质处接收具有x射线管（或同位素）的导管。 描述了用于适当地定位导管和X射线管的方法，使用导管上的照明和通过眼睛前方观察，或导管上的传感器以及从眼前方照射的扫描光束。 也可以使用由X射线激发的荧光材料。 还描述了一旦适当地定位在眼睛中来固定探针的方法和装置，用于X射线管与靶组织的间隔，并且用于在消除相邻组织的剂量的同时获得脉络膜中的处方辐射剂量。 可以使用放射增敏药物来增强X射线治疗，并且可以与PDT组合。

公开(公告)号：US20050232579A1

公开(公告)日：2005-10-20

申请号：US11057645

申请日：2005-02-14

Applicant: David Monroe ,  Randall Hoeffer ,  Stephen Baker ,  Michael Forman

Inventor： David Monroe ,  Randall Hoeffer ,  Stephen Baker ,  Michael Forman

IPC: H04N5/761 ,  H04N5/782 ,  H04N9/804 ,  H04N9/82 ,  H04N5/76 ,  H04N5/781

CPC classification number: H04N5/782 ,  H04N9/8042 ,  H04N9/8205

Abstract: A multifunction remote controlled video recording, transmission and playback system includes a still frame generator adapted for selecting and generating still frames on the fly while a full motion video signal is being recorded, without interrupting the recording function. Audio and data signals, such as cockpit audio in an aircraft and gps and telemetry signals may also be incorporated in the recorded full motion video recording on a real time synchronized basis. The still frames are digitally enhanced, producing a full field frame from the analog video signal. Still frames can be produced in single, burst and snap modes without interrupting the full motion video recording function.

Abstract translation: 一种多功能遥控视频记录，传输和播放系统，包括一个静止帧发生器，适用于在记录全运动视频信号的同时，在飞行中选择和产生静止帧，而不会中断记录功能。 音频和数据信号，例如飞机中的驾驶舱音频和GPS以及遥测信号也可以以实时同步的方式结合在所记录的全运动视频记录中。 静止帧被数字增强，从模拟视频信号产生全场帧。 静止框架可以以单一，突发和拍摄模式生成，而不会中断全动态视频录制功能。

公开(公告)号：US20050049508A1

公开(公告)日：2005-03-03

申请号：US10635421

申请日：2003-08-06

Applicant: Michael Forman ,  Paul Lovoi ,  Peter Smith

Inventor： Michael Forman ,  Paul Lovoi ,  Peter Smith

IPC: A61B6/00 ,  A61B19/00 ,  A61K20060101 ,  A61N5/00 ,  A61N5/06 ,  A61N5/10

CPC classification number: A61N5/1001 ,  A61B2090/306 ,  A61F9/0079 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/1017 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/1022 ,  A61N2005/1098

Abstract: Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube inserted via a catheter around the globe of the eye, to a position behind the macula. Methods are described for properly locating the catheter and x-ray tube, using illumination on the catheter and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent material excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube from the target issue, and for achieving prescription radiation dose in the choroid while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.

Abstract translation: 年龄相关性黄斑变性通过从通过眼睛周围的导管插入的微型X射线管递送到黄斑后面的位置进行治疗。 描述了用于适当地定位导管和X射线管的方法，使用导管上的照明和通过眼睛前方观察，或导管上的传感器以及从眼前方照射的扫描光束。 也可以使用由X射线激发的荧光材料。 还描述了一旦适当地定位在眼睛中来固定探针的方法和装置，用于X射线管与目标问题的对接，并且在消除相邻组织的剂量的同时实现脉络膜中的处方辐射剂量。 可以使用放射增敏药物来增强X射线治疗，并且可以与PDT组合。