公开(公告)号：US20070197385A1

公开(公告)日：2007-08-23

申请号：US10592750

申请日：2005-03-09

Applicant: Ganit Levy-Ruso ,  Ofer Toledano

Inventor： Ganit Levy-Ruso ,  Ofer Toledano

IPC: A01N25/02 ,  A01N33/02 ,  A01N37/18 ,  A01N43/64 ,  A01N47/28

CPC classification number: A01N25/04 ,  A01N43/653 ,  A01N47/34 ,  A01N25/02 ,  A01N2300/00

Abstract: The present invention discloses a process for the preparation of an aqueous pesticide dispersion comprising the steps of: a) dissolving a pesticidal active ingredient in a water miscible organic solvent to obtain a pesticide solution; b) mixing the pesticide solution with water in the presence of surface active agents to form aqueous pesticide dispersion. This invention further discloses a method for controlling pests comprising of diluting the aqueous pesticide dispersion of the present invention in water to obtain diluted aqueous pesticide dispersions and applying an effective amount of said diluted dispersion to a site.

Abstract translation: 本发明公开了一种制备含水农药分散体的方法，包括以下步骤：a）将杀虫活性成分溶解在水混溶性有机溶剂中以获得农药溶液; b）在表面活性剂存在下将农药溶液与水混合，形成含水农药分散体。 本发明还公开了一种防治害虫的方法，包括将本发明的含水农药分散体在水中稀释以获得稀释的含水农药分散体并将有效量的所述稀释分散体施用于部位。

公开(公告)号：US20050169951A1

公开(公告)日：2005-08-04

申请号：US10507103

申请日：2003-03-13

Applicant: Yoel Sasson ,  Ofer Toledano ,  Ganit Levi-Ruso

Inventor： Yoel Sasson ,  Ofer Toledano ,  Ganit Levi-Ruso

IPC: A01N25/22 ,  A01N43/653 ,  A01N47/38 ,  A01N43/64 ,  A01N25/00 ,  A01N37/02 ,  A01N43/50

CPC classification number: A01N25/22 ,  A01N43/653 ,  A01N37/36 ,  A01N25/02 ,  A01N2300/00

Abstract: The present invention is a method of preventing crystallization of pesticidal compositions during applications by adding a lactate ester as a crystallization preventing agent.

Abstract translation: 本发明是通过添加乳酸酯作为结晶化防止剂来防止农药组合物结晶的方法。

公开(公告)号：US12053546B2

公开(公告)日：2024-08-06

申请号：US13537646

申请日：2012-06-29

Applicant: Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook

IPC: A61K9/107 ,  A61K9/00 ,  A61K9/06 ,  A61K9/50 ,  A61K31/203 ,  A61K31/327 ,  A61K47/14

CPC classification number: A61K9/107 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/501 ,  A61K9/5084 ,  A61K31/203 ,  A61K31/327 ,  A61K47/14

Abstract: The present disclosure relates to compositions for topical application, where the compositions comprise microcapsules having a core that comprises benzoyl peroxide and a shell that comprises an inorganic polymer, microcapsules having a core that comprises a retinoid and a shell that comprises an inorganic polymer, and a stabilizing agent. The composition can be in a variety of forms, such as emulsion and gel.

公开(公告)号：US20110177951A1

公开(公告)日：2011-07-21

申请号：US13056952

申请日：2009-08-02

Applicant: Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Raed Abu-Reziq

Inventor： Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Raed Abu-Reziq

IPC: A01N37/22 ,  A61K9/50 ,  A61K8/11 ,  A61K31/327 ,  A61K31/07 ,  A01N25/08 ,  A01P3/00 ,  A01P7/04 ,  A61P17/06 ,  A61P17/04 ,  A61P17/10 ,  A61P17/08 ,  A61P17/00 ,  A61P31/10 ,  A61P31/04 ,  A61P29/00 ,  A61Q19/00 ,  A01P13/00 ,  B82Y5/00

Abstract: The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.

Abstract translation: 本发明提供一种制备微胶囊的方法，其包含由金属氧化物壳包封的芯材料，由其获得的微胶囊及其用途。

公开(公告)号：US20100016443A1

公开(公告)日：2010-01-21

申请号：US12525331

申请日：2008-02-03

Applicant: Ofer Toledano ,  Haim Bar-Simantov ,  Nissim Bilman ,  Leora Shapiro ,  Raed Abu-Reziq ,  Srikanth Sriadibhatla ,  William T. Sommer

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Nissim Bilman ,  Leora Shapiro ,  Raed Abu-Reziq ,  Srikanth Sriadibhatla ,  William T. Sommer

IPC: A61K31/327 ,  B05D7/00 ,  B32B5/16 ,  A61K47/02 ,  A01N25/26 ,  A61K31/11 ,  A01N31/04 ,  A01N35/02 ,  A61K31/07 ,  A01P7/04 ,  A61P17/00 ,  A61P17/10 ,  A61P17/04 ,  A61P17/06

CPC classification number: A61K9/5073 ,  A01N25/26 ,  A01N53/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/38 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5021 ,  A61K9/5026 ,  A61K2800/412 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/22 ,  C09C3/063 ,  Y10T428/2991 ,  A01N2300/00

Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.

Abstract translation: 本发明涉及一种用金属氧化物涂覆固体，不溶于水的颗粒物质的方法，包括：（a）使固体，水不溶性颗粒物质与离子添加剂和水性介质接触，以获得所述颗粒的分散体 表面上有正面指控的事情; （b）对颗粒状物质进行包括在金属氧化物表面上析出金属氧化物盐以形成金属氧化物层的涂覆方法，从而获得由金属氧化物涂层涂覆的颗粒状物质; （c）重复步骤（b）至少4次以上; 和（d）老化所述涂层。 本发明还涉及包含由金属氧化物层涂覆的颗粒物质，使用该颗粒用于局部给药的颗粒，以及使用该颗粒来防止，减少或消除某些场所的害虫的方法。

公开(公告)号：US20090081262A1

公开(公告)日：2009-03-26

申请号：US11997823

申请日：2006-08-02

Applicant: Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Hiam Bar-Simantov

Inventor： Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Hiam Bar-Simantov

IPC: A01N25/28 ,  A61K8/02 ,  A01N31/00 ,  A01N53/02 ,  A01N47/10 ,  A01N57/00 ,  A01P3/00 ,  A01P7/00 ,  A01P13/00 ,  A61K31/66 ,  A61K31/203 ,  A61K31/12 ,  A61K9/50

CPC classification number: B01J13/22 ,  A01N25/26 ,  A61K8/11 ,  A61K9/1676 ,  A61K9/5078 ,  A61K2800/412 ,  A61K2800/434 ,  A61K2800/57 ,  A61Q19/00 ,  B01J13/02 ,  A01N51/00 ,  A01N53/00

Abstract: The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.

Abstract translation: 本发明涉及一种用金属氧化物涂覆固体，不溶于水的颗粒物质的方法，包括：（a）将固体不溶于水的颗粒物质与阳离子添加剂接触在水性介质中，以获得具有 正ζ电位; （b）通过将金属氧化物盐沉淀到颗粒物质的表面上来涂覆固体不溶于水的颗粒物质，在其上形成金属氧化物层; 和（c）老化所述涂层本发明还涉及通过该方法获得的包覆颗粒物质和包含由金属氧化物层涂覆的固体，水不溶性颗粒物质的组合物，所述颗粒物质是皮肤病学活性剂或农药 。 本发明还涉及使用包含由金属氧化物层涂覆的固体，水不溶性皮肤病学活性剂的组合物来治疗受试者的表面状况的方法。

公开(公告)号：US09868103B2

公开(公告)日：2018-01-16

申请号：US11997823

申请日：2006-08-02

Applicant: Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Haim Bar-Simantov

Inventor： Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Haim Bar-Simantov

IPC: A01N25/28 ,  A01N31/00 ,  A01N47/10 ,  A01N53/02 ,  A01N57/00 ,  A01P13/00 ,  A01P3/00 ,  A01P7/00 ,  A61K31/12 ,  A61K31/203 ,  A61K31/66 ,  A61K8/02 ,  A61K9/50 ,  B01J13/22 ,  A01N25/26 ,  A61K8/11 ,  A61K9/16 ,  A61Q19/00 ,  B01J13/02

CPC classification number: B01J13/22 ,  A01N25/26 ,  A61K8/11 ,  A61K9/1676 ,  A61K9/5078 ,  A61K2800/412 ,  A61K2800/434 ,  A61K2800/57 ,  A61Q19/00 ,  B01J13/02 ,  A01N51/00 ,  A01N53/00

Abstract: The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer. The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.

公开(公告)号：US20130095185A1

公开(公告)日：2013-04-18

申请号：US13537646

申请日：2012-06-29

Applicant: Ofer TOLEDANO ,  Haim BAR-SIMANTOV

Inventor： Ofer TOLEDANO ,  Haim BAR-SIMANTOV

IPC: A61K9/107

CPC classification number: A61K9/107 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/501 ,  A61K9/5084 ,  A61K31/203 ,  A61K31/327 ,  A61K47/14

Abstract: The present disclosure relates to compositions for topical application, where the compositions comprise microcapsules having a core that comprises benzoyl peroxide and a shell that comprises an inorganic polymer, microcapsules having a core that comprises a retinoid and a shell that comprises an inorganic polymer, and a stabilizing agent. The composition can be in a variety of forms, such as emulsion and gel.

Abstract translation: 本公开内容涉及用于局部应用的组合物，其中组合物包含具有包含过氧化苯甲酰的核的微胶囊和包含无机聚合物的壳，具有包含类视黄醇的核的微胶囊和包含无机聚合物的壳，以及 稳定剂。 组合物可以是各种形式，例如乳液和凝胶。

公开(公告)号：US20100047357A1

公开(公告)日：2010-02-25

申请号：US12525329

申请日：2008-02-03

Applicant: Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Haim Bar-Simantov ,  Leora Shapiro ,  Raed Abu-Reziq

Inventor： Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Haim Bar-Simantov ,  Leora Shapiro ,  Raed Abu-Reziq

IPC: A61K9/14 ,  A61K31/327 ,  A61K31/202 ,  A61K31/192 ,  A61K31/4436 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10

CPC classification number: A61K9/0014 ,  A61K9/28 ,  A61K47/34

Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.

Abstract translation: 本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质， 所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。 本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。

公开(公告)号：US5785969A

公开(公告)日：1998-07-28

申请号：US600988

申请日：1996-07-22

Applicant: Shlomo Magdassi ,  Zichria Zazkay Rones ,  Ofer Toledano

Inventor： Shlomo Magdassi ,  Zichria Zazkay Rones ,  Ofer Toledano

IPC: A61K47/48 ,  A61K49/00 ,  G01N33/543 ,  G01N33/569 ,  G01N33/94 ,  A61K39/395 ,  A61K47/44

CPC classification number: A61K49/0052 ,  A61K47/48038 ,  A61K47/48507 ,  A61K47/488 ,  A61K49/0043 ,  G01N33/5432 ,  G01N33/56966 ,  G01N33/94 ,  Y10S514/943 ,  Y10S977/808 ,  Y10S977/906 ,  Y10S977/918 ,  Y10S977/927

Abstract: The new pharmaceutical and diagnostic compositions comprise antibody-aggregates and hydrophobic drug or marker molecules. The drug or marker molecules are solubilized inside micelle-like antibody-aggregates. In a process for preparing such types of compositions, hydrophobic residues are attached to the antibodies in the presence of a surface active agent. After removal of this agent the hydrophobic drug or marker molecules are solubilized inside the resulting antibody aggregates. A method for targeting molecules towards specific cells and sites within a living body is also disclosed.

Abstract translation: PCT No.PCT / EP94 / 02827 Sec。 371日期：1996年7月22日 102（e）日期1996年7月22日PCT 1994年8月25日PCT公布。 公开号WO95 / 06483 日期1995年3月9日新的药物和诊断组合物包含抗体聚集体和疏水性药物或标记分子。 药物或标记分子溶解在胶束样抗体聚集体内。 在制备这种类型的组合物的方法中，疏水残基在表面活性剂存在下连接到抗体上。 除去该试剂后，疏水性药物或标记物分子溶解在所得抗体聚集体内。 还公开了将分子靶向生物体内的特定细胞和位点的方法。