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公开(公告)号：US20210098127A1
公开(公告)日：2021-04-01
申请号：US16588080
申请日：2019-09-30
Applicant: GE Precision Healthcare LLC , Partners HealthCare System, Inc. , The General Hospital Corporation , The Brigham and Women?s Hospital, Inc.
Inventor： John Francis Kalafut , Bernardo Bizzo , Stefano Pedemonte , Christopher Bridge , Neil Tenenholtz , Ramon Gilberto Gonzalez
Abstract: Systems and techniques for generating and/or employing a medical imaging stroke model are presented. In one example, a system employs a convolutional neural network to generate output data regarding a brain anatomical region based on diffusion-weighted imaging (DWI) data associated with the brain anatomical region and apparent diffusion coefficient (ADC) data associated with the brain anatomical region. The system also detects presence or absence of a medical stroke condition associated with the brain anatomical region based on the output data.
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Patent Agency Ranking
公开(公告)号：US20130287857A1
公开(公告)日：2013-10-31
申请号：US13844100
申请日：2013-03-15
Applicant: Massachusetts Institute of Technology , Immune Disease Institute , President and Fellows of Harvard College , Partners Healthcare System, Inc.
Inventor： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
CPC classification number: A61K9/14 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K47/6937 , A61K2039/555 , A61K2039/60 , Y02A50/464 , Y02A50/472
Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
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公开(公告)号：US20230031328A1
公开(公告)日：2023-02-02
申请号：US17559282
申请日：2021-12-22
Applicant: GE Precision Healthcare LLC , Partners Healthcare System, Inc. , The General Hospital Corporation , The Brigham and Women's Hospital, Inc.
Inventor： Hariharan Ravishankar , Abhijit Patil , Rohit Pardasani , Dirk Johannes Varelmann , Pankaj Sarin , Marcio Aloisio Bezerra Cavalcanti Rockenbach , Quanzheng Li
Abstract: Systems and techniques for monitoring, predicting and/or alerting for short-term oxygen support needs of patients are presented. A system can include a data collection component that receives multimodal patient data for a patient having a respiratory condition in association with monitoring and treating the respiratory condition in real-time, the multimodal patient data comprising at least physiological data regarding physiological parameters tracked for the patient over a period of time, and current oxygen support data regarding a current oxygen support mechanism of the patient. The system can further include an oxygen support forecasting component that processes the multimodal patient data using an oxygen support forecasting model to generate an output forecast that indicates whether a change to the current oxygen support mechanism is recommended for the patient within a defined upcoming timeframe
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公开(公告)号：US11331056B2
公开(公告)日：2022-05-17
申请号：US16588013
申请日：2019-09-30
Applicant: GE Precision Healthcare LLC , Partners HealthCare System, Inc. , The General Hospital Corporation , The Brigham and Women's Hospital, Inc.
Inventor： John Francis Kalafut , Bernardo Bizzo , Romane Gauriau , Michael Lev , Mark Heinz Michalski
Abstract: Systems and techniques for generating and/or employing a computed tomography (CT) medical imaging stroke model are presented. In one example, a system employs a convolutional neural network to generate learned medical imaging stroke data regarding a brain anatomical region based on CT data associated with the brain anatomical region and diffusion-weighted imaging (DWI) data associated with one or more segmentation masks for the brain anatomical region. The system also detects presence or absence of a medical stroke condition in a CT image based on the learned medical imaging stroke data.
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公开(公告)号：US20210097678A1
公开(公告)日：2021-04-01
申请号：US16587923
申请日：2019-09-30
Applicant: GE Precision Healthcare LLC , Partners HealthCare System, Inc. , The General Hospital Corporation , The Brigham and Women's Hospital, Inc.
Inventor： Sandeep Dutta , Ryan Christian King , Bradley Wright , Mitchel Harris , Bharti Khurana , Robert Kevin Moreland
Abstract: Systems and techniques for generating and/or employing a computed tomography (CT) medical imaging fracture model are presented. In one example, a system employs a first convolutional neural network associated with vertebrae segmentation to generate learned vertebrae segmentation data regarding a spine anatomical region related to a CT image. The system also employs a second convolutional neural network associated with fracture segmentation to generate, based on the learned vertebrae segmentation data, learned fracture segmentation data regarding the spine anatomical region. Furthermore, the system detects presence or absence of a medical fracture condition in the CT image based on the learned vertebrae segmentation data and the learned fracture segmentation data.
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公开(公告)号：US20140314865A1
公开(公告)日：2014-10-23
申请号：US13844382
申请日：2013-03-15
Applicant: Massachusetts Institute of Technology , Partners Healthcare System, Inc. , President and Fellows of Harvard College , Immune Disease Institute
Inventor： Ulrich H. von Andrian , Omid C. Farokhzad , Robert S. Langer , Tobias Junt , Elliott Ashley Moseman , Liangfang Zhang , Pamela Basto , Matteo Iannacone , Frank Alexis
CPC classification number: A61K9/14 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K47/6937 , A61K2039/555 , A61K2039/60 , Y02A50/464 , Y02A50/472
Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.
Abstract translation: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供了在一些实施方案中能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，其包含至少一种免疫调节剂，并且任选地包含最后一个靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。
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