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公开(公告)号：US07723050B2
公开(公告)日：2010-05-25
申请号：US12501385
申请日：2009-07-10
IPC分类号： G01N33/53
CPC分类号： G06F19/3431 , G01N33/48714 , G01N33/6893 , G01N2800/042 , G01N2800/52 , G06Q50/22 , G16H50/30 , Y02A90/22
摘要： The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
摘要翻译： 本发明描述了可用于预测个体将发展成为糖尿病的可能性的生物标志物。 生物标志物也可用于筛选大群体，以鉴定患有糖尿病发展风险的个体。
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公开(公告)号：US08858974B2
公开(公告)日：2014-10-14
申请号：US12270695
申请日：2008-11-13
申请人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney Brenneman , Danielle L. Biggs
发明人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney Brenneman , Danielle L. Biggs
IPC分类号： A61F13/00 , A61N1/30 , A61B17/08 , A61K31/573 , A61K31/58 , A61B17/24 , A61K9/70 , A61K9/00 , A61F2/18 , A61K9/16
CPC分类号： A61B17/24 , A61F2/186 , A61K9/0043 , A61K9/1647 , A61K9/70 , A61K31/573 , A61K31/58 , A61K47/14 , A61K47/34 , A61M29/00
摘要： Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
摘要翻译： 这里描述了用于治疗鼻旁窦状况的鼻旁窦装置。 这些装置包括空腔构件，口部构件和鼻部。 空腔构件，口腔构件和鼻部分中的一个或多个可以递送用于持续释放的活性剂以治疗鼻旁窦状况。 由于功能性内镜鼻窦手术（FESS）和鼻鼻窦炎，示例性的鼻旁窦状况是鼻窦炎症。
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公开(公告)号：US20140147850A1
公开(公告)日：2014-05-29
申请号：US13826398
申请日：2013-03-14
IPC分类号： G06F19/00
CPC分类号： G06F19/3431 , G01N33/48714 , G01N33/6893 , G01N2800/042 , G01N2800/52 , G06Q50/22 , G16H50/30 , Y02A90/22
摘要： The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
摘要翻译： 本发明描述了可用于预测个体将发展成为糖尿病的可能性的生物标志物。 生物标志物也可用于筛选大群体，以鉴定患有糖尿病发展风险的个体。
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14.发明授权公开(公告)号：US09057736B2
公开(公告)日：2015-06-16
申请号：US12755146
申请日：2010-04-06
CPC分类号： G01N33/6893 , G01N33/6845 , G01N33/74 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50 , G01N2800/52 , G06F19/00 , G16H50/30 , Y02A90/24 , Y02A90/26
摘要： Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease.
摘要翻译： 公开了确定具有动脉血管疾病的受试者，处于发展中的动脉血管疾病风险的受试者的方法，与其他疾病相关的疾病相关的疾病或其他疾病的亚分类的方法，评估患者的血管事件风险的方法 动脉血管疾病，评估治疗在动脉血管疾病患者中的有效性的方法，以及选择治疗动脉血管疾病疗法的方法。
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公开(公告)号：US08740839B2
公开(公告)日：2014-06-03
申请号：US12883071
申请日：2010-09-15
申请人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney A. Brenneman , Danielle L. Biggs
发明人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney A. Brenneman , Danielle L. Biggs
IPC分类号： A61M31/00
CPC分类号： A61B17/24 , A61F2/186 , A61K9/0043 , A61K9/1647 , A61K9/70 , A61K31/573 , A61K31/58 , A61K47/14 , A61K47/34 , A61M29/00
摘要： Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
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公开(公告)号：US20140072571A1
公开(公告)日：2014-03-13
申请号：US13793791
申请日：2013-03-11
CPC分类号： G01N33/6893 , A61K45/00 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N33/82 , G01N2800/108 , G01N2800/50 , G01N2800/52 , G01N2800/60 , Y02A90/26
摘要： Disclosed are methods of identifying subjects with osteoporosis or osteopenia, subjects at risk for developing osteoporosis, osteopenia, and bone fractures, methods of evaluating the effectiveness of osteoporosis treatments in subjects with osteoporosis or osteopenia, and methods of selecting therapies for treating osteoporosis or osteopenia, using biomarkers.
摘要翻译： 公开了确定骨质疏松症或骨质减少症的受试者的方法，有发展骨质疏松症的受试者，骨质减少症和骨折，评价骨质疏松症或骨质减少患者骨质疏松症治疗效果的方法，以及选择治疗骨质疏松症或骨质减少症的方法， 使用生物标志物。
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17.发明授权公开(公告)号：US08535707B2
公开(公告)日：2013-09-17
申请号：US11775157
申请日：2007-07-09
申请人： Patrick A. Arensdorf , Danielle L. Biggs , Rodney Brenneman , David B. Downie , Donald J. Eaton , Thomas R. Tice
发明人： Patrick A. Arensdorf , Danielle L. Biggs , Rodney Brenneman , David B. Downie , Donald J. Eaton , Thomas R. Tice
CPC分类号： A61M31/00 , A61K9/0043 , A61L31/08 , A61L31/148 , A61L31/16
摘要： Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.
摘要翻译： 这里描述的是用于通过在持续的时间段内将活性剂局部递送至骨产卵复合物来治疗鼻窦炎和相关呼吸状况的装置，方法和试剂盒。 所述装置可以被动地固定在骨产卵复合体内和/或包括将其固定在骨产生复合体内的一个或多个特征。 装置可以可选地包括延伸到窦口，窦腔和/或鼻通道中以递送活性剂的部分。
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公开(公告)号：US08337454B2
公开(公告)日：2012-12-25
申请号：US12437374
申请日：2009-05-07
申请人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney Brenneman , Danielle L. Biggs
发明人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney Brenneman , Danielle L. Biggs
IPC分类号： A61M31/00
CPC分类号： A61B17/24 , A61F2/186 , A61K9/0043 , A61K9/1647 , A61K9/70 , A61K31/573 , A61K31/58 , A61K47/14 , A61K47/34 , A61M29/00
摘要： Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
摘要翻译： 这里描述了用于治疗鼻旁窦状况的鼻旁窦装置。 这些装置包括空腔构件，口部构件和鼻部。 空腔构件，口腔构件和鼻部分中的一个或多个可以递送用于持续释放的活性剂以治疗鼻旁窦状况。 由于功能性内镜鼻窦手术（FESS）和鼻鼻窦炎，示例性的鼻旁窦状况是鼻窦炎症。
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公开(公告)号：US20120179484A1
公开(公告)日：2012-07-12
申请号：US13253578
申请日：2011-10-05
CPC分类号： G06F19/3431 , G01N33/48714 , G01N33/6893 , G01N2800/042 , G01N2800/52 , G06Q50/22 , G16H50/30 , Y02A90/22
摘要： The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
摘要翻译： 本发明描述了可用于预测个体将发展成为糖尿病的可能性的生物标志物。 生物标志物也可用于筛选大群体，以鉴定患有糖尿病发展风险的个体。
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公开(公告)号：US20090306624A1
公开(公告)日：2009-12-10
申请号：US12541840
申请日：2009-08-14
申请人： Patrick A. ARENSDORF , Danielle L. Biggs , Rodney Brenneman , David B. Downie , Donald J. Eaton , Thomas R. Tice
发明人： Patrick A. ARENSDORF , Danielle L. Biggs , Rodney Brenneman , David B. Downie , Donald J. Eaton , Thomas R. Tice
IPC分类号： A61M37/00
CPC分类号： A61M31/00 , A61K9/0043 , A61L31/08 , A61L31/148 , A61L31/16
摘要： Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.
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