公开(公告)号：US6050990A

公开(公告)日：2000-04-18

申请号：US984892

申请日：1997-12-04

Applicant: Nikolai I. Tankovich ,  Kurt A. Dasse ,  David H. Fine ,  Paul W. Fairchild ,  Zhong-Quan Zhao ,  Mike Lefebvre ,  John Lee, Jr. ,  Jonathan L. Rolfe ,  Susan Murrell ,  Allen Hunter, II ,  Amanda J Reynolds ,  Vladimir G. Kolinko

Inventor： Nikolai I. Tankovich ,  Kurt A. Dasse ,  David H. Fine ,  Paul W. Fairchild ,  Zhong-Quan Zhao ,  Mike Lefebvre ,  John Lee, Jr. ,  Jonathan L. Rolfe ,  Susan Murrell ,  Allen Hunter, II ,  Amanda J Reynolds ,  Vladimir G. Kolinko

IPC: A61B17/00 ,  A61B18/00 ,  A61B18/20 ,  A61B19/00 ,  A61N5/06 ,  A61B17/36

CPC classification number: A61B18/203 ,  A61B2017/00026 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61B2090/0436 ,  A61B2090/049 ,  A61N5/0616 ,  A61N5/0617 ,  A61N5/062

Abstract: Methods of applying laser light to the skin, and apparatus therefor, include methods for removing hair, for synchronizing hair growth, for stimulating hair growth, for treating Herpes virus, for reducing sweat and body odor, for in situ formation of a chromophore in hair ducts, for reducing light loss at the skin surface, for grafting of hair stem cells, and for removing keloid or hypertrophic scars. The hair removal methods include controlling the proportions of photomechanical and photothermal damage by selection of laser parameters, chromophore particle size and/or pulse duration, with optional dynamic skin cooling. Additional hair removal methods include infiltrating a photoactivated drug into hair ducts and exposing the skin to sunlight or administering an anti-proliferative agent into hair ducts, for example, by encapsulating the anti-proliferative agent in a slow release vehicle. The methods of treating Herpes virus, reducing sweat or body odor, and removing keloid or hypertrophic scars include infiltrating a light-absorbing contaminant into hair ducts or other openings in the skin and illuminating the contaminated skin section. The methods for stimulating hair growth include grafting of cloned auto hair stem cells the hair ducts or administering methionine to a skin section to increase hair growth. Apparatus useful in performing these methods include devices for making a smooth optical boundary between skin and air or for dividing a light beam into a plurality of smaller light beams, and dressings for use before, during and after laser illumination.

Abstract translation: 将激光施加到皮肤上的方法及其装置包括用于去除头发的方法，用于同步毛发生长，刺激毛发生长，用于治疗疱疹病毒，减少汗液和体臭，用于原位形成发丝中的发色团 导管，用于减少皮肤表面的光损失，用于移植毛干细胞，以及用于去除瘢痕疙瘩或肥大性瘢痕。 毛发去除方法包括通过选择激光参数，发色团粒度和/或脉冲持续时间来选择动态皮肤冷却来控制光机械和光热损伤的比例。 额外的脱毛方法包括将光活化药物渗透到毛发管道中，并将皮肤暴露于阳光下或将抗增殖剂施用于毛发管道中，例如通过将抗增殖剂包封在缓释载体中。 治疗疱疹病毒，减少汗液或身体异味，以及去除瘢痕疙瘩或肥大性瘢痕的方法包括将光吸收污染物浸入毛发管道或皮肤中的其他开口并照亮被污染的皮肤部分。 用于刺激头发生长的方法包括将克隆的自发性发干细胞移植到毛发管道中，或将甲硫氨酸施用于皮肤部分以增加毛发生长。 用于执行这些方法的装置包括用于在皮肤和空气之间形成平滑的光学边界或用于将光束分成多个更小的光束的装置，以及在激光照射之前，期间和之后使用的敷料。

公开(公告)号：US07821624B2

公开(公告)日：2010-10-26

申请号：US11447500

申请日：2006-06-05

Applicant: Zhong-Quan Zhao ,  Daniel H. Leslie ,  Michael Joseph Lefebure

Inventor： Zhong-Quan Zhao ,  Daniel H. Leslie ,  Michael Joseph Lefebure

IPC: G01B11/26

CPC classification number: H01S3/1303 ,  G01J1/4257 ,  H01S5/0014 ,  H01S5/02438 ,  H01S5/06837 ,  H01S5/0687

Abstract: A tracking system utilizing an excited state atomic line filter. The filter includes a metal vapor cell having an optical entrance port and an optical exit port and containing a metal vapor having a first excited energy state with a resonant frequency, and a second excited energy state. The cell has an absorption line, at or near a desired filter wavelength. The platform to be tracked, which could be an un-manned aerial vehicle has a beacon laser system located on it for producing a beacon laser beam at a wavelength within the narrow spectral band. The present invention solves the problem of lack of ground state resonant lines in at wavelengths substantially longer than those of visible light. Atomic line filters of the Faraday or Voigt crossed polarizer type are provided in which alkali metal atomic vapor in a vapor cell is excited with a pump beam to an intermediate excited state where a resonant absorption line, at a desired wavelength, is available. A magnetic field is applied to the cell producing a polarization rotation for polarized light at wavelengths near the resonant absorption lines. Thus, all light is blocked by the cross polarizers except light near one of the spaced apart resonant lines. However, the polarization of light at certain wavelengths near the resonant is rotated in the cell and therefore passes through the output polarizer.

Abstract translation: 利用激发态原子线滤波器的跟踪系统。 过滤器包括具有光入口和光出口的金属蒸汽池，并且包含具有共振频率的第一激发能态和第二激发能态的金属蒸汽。 电池具有吸收线，处于或接近所需的滤波器波长。 要跟踪的平台，可以是无人载客的飞行器，其上具有信标激光系统，用于在窄频带内的波长处产生信标激光束。 本发明解决了在基本上长于可见光的波长的波长下缺少基态谐振线路的问题。 提供了法拉第或Voigt正交偏振器类型的原子线滤光器，其中在蒸气室中的碱金属原子蒸汽被泵浦光束激发到中间激发态，其中所需波长的谐振吸收线可用。 向细胞施加磁场，产生在谐振吸收线附近的波长的偏振光的偏振旋转。 因此，所有的光被交叉偏振器阻挡，除了靠近一个间隔开的谐振线之外的光。 然而，谐振附近的特定波长的光的偏振在单元中旋转，因此通过输出偏振器。

公开(公告)号：US06251671B1

公开(公告)日：2001-06-26

申请号：US08808346

申请日：1997-02-28

Applicant: Brigid L. M. Hogan ,  Guang-Quan Zhao

Inventor： Brigid L. M. Hogan ,  Guang-Quan Zhao

IPC: C12N500

CPC classification number: G01N33/5073 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/1875 ,  C07K14/51 ,  C12N5/061 ,  C12N15/8509 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/155 ,  C12N2501/235 ,  G01N33/5008 ,  G01N33/5017 ,  G01N33/5044 ,  G01N33/689 ,  G01N2510/00 ,  G01N2800/367

Abstract: The invention relates to cell proliferation, cell differentiation, male infertility, male fertility and to compositions and methods involved therein. Also methods of culturing spermatogonial stem cells with bone morphogenetic protein 8 are disclosed.

Abstract translation: 本发明涉及细胞增殖，细胞分化，男性不育症，男性生殖力以及涉及其中的组合物和方法。 还公开了用骨形态发生蛋白8培养精原干细胞的方法。