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公开(公告)号：US4944882A
公开(公告)日：1990-07-31
申请号：US341646
申请日：1989-04-21
Applicant: Roderick J. Ray , David D. Newbold
Inventor： Roderick J. Ray , David D. Newbold
CPC classification number: B01D61/58 , B01D61/025 , B01D61/027 , B01D61/362 , B01D61/364
Abstract: Hybrid membrane-based separation systems are disclosed that are useful in separating solvents and solutes. The hybrid systems combine any of the solvent removal processes reverse osmosis, nanofiltration, membrane distillation and pervaporation with any one of more of the solute removal processes utilizing pervaporation membranes, supported-liquid membranes, coupled transport membranes, and membrane contactors, the solvent and solute removal processes forming part of a recycle stream that utilizes membrane separation retentates as feeds and as recycle feed stream make-up.
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12.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US08343550B2
公开(公告)日：2013-01-01
申请号：US13165732
申请日：2011-06-21
Applicant: Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
Inventor： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC classification number: A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Abstract translation: 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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13.发明申请METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS 有权使用改性喷雾干燥装置制备均匀喷雾干燥固体非晶态药物分散体的方法公开(公告)号：US20110277339A1
公开(公告)日：2011-11-17
申请号：US13165732
申请日：2011-06-21
Applicant: Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
Inventor： Ronald A. Beyerinck , Heather L. M. Deibele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
IPC: F26B3/12
CPC classification number: A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Abstract translation: 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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公开(公告)号：US07736672B2
公开(公告)日：2010-06-15
申请号：US11003664
申请日：2004-12-03
Applicant: Roderick J. Ray , Leah E. Appel , Dwayne Thomas Friesen , Marshall D. Crew , Joshua R. Shockey
Inventor： Roderick J. Ray , Leah E. Appel , Dwayne Thomas Friesen , Marshall D. Crew , Joshua R. Shockey
IPC: A61K9/14
CPC classification number: A61K9/1617 , A61K9/1635 , A61K9/1694
Abstract: A process is described for producing drug-containing multiparticulates with improved stability, characterized by an improvement in one or more of chemical stability, physical stability, or dissolution stability.
Abstract translation: 描述了用于生产具有改进的稳定性的含药多颗粒的方法，其特征在于改进一种或多种化学稳定性，物理稳定性或溶解稳定性。
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公开(公告)号：US6059857A
公开(公告)日：2000-05-09
申请号：US199993
申请日：1998-11-24
Applicant: Roderick J. Ray , David D. Newbold , Dwayne T. Friesen , Scott B. McCray , Lori A. Ray
Inventor： Roderick J. Ray , David D. Newbold , Dwayne T. Friesen , Scott B. McCray , Lori A. Ray
CPC classification number: B01D53/22 , B01D53/229
Abstract: A system for the ultrapurification of organic solvents comprising (1) a membrane-based vapor permeation step for selective removal of water vapor from the solvent, wherein a countercurrent sweep stream is used that has a particular partial pressure of water vapor, (2) a filtration step for selective removal of particulates, and (3) an ion exchange step for selective removal of ionic species.
Abstract translation: 一种用于有机溶剂超纯化的系统，包括（1）用于从溶剂中选择性除去水蒸气的膜基蒸汽渗透步骤，其中使用具有特定分子水蒸气的逆流吹扫流，（2） 用于选择性去除颗粒的过滤步骤，和（3）用于选择性去除离子物质的离子交换步骤。
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Patent Agency Ranking
公开(公告)号：US5464540A
公开(公告)日：1995-11-07
申请号：US165446
申请日：1993-12-09
Applicant: Dwayne T. Friesen , David D. Newbold , Scott B. McCray , Roderick J. Ray
Inventor： Dwayne T. Friesen , David D. Newbold , Scott B. McCray , Roderick J. Ray
IPC: B01D61/36
CPC classification number: B01D61/362
Abstract: There is described a process for the removal of at least one component of a liquid mixture, the basic process comprising directing a liquid mixture against the feed side of a membrane, directing a condensable vapor sweep stream past the permeate side of the membrane in a manner such that the flow of the condensable vapor sweep is substantially countercurrent to the flow of the liquid mixture, thereby transporting at least a portion of at least one component of the liquid mixture from the feed side to the permeate side of the membrane to form a combined permeate side mixture of condensable vapor and at least one transported component.
Abstract translation: 描述了去除液体混合物的至少一种组分的方法，其基本方法包括将液体混合物引导到膜的进料侧，引导可冷凝的蒸气吹扫流以膜的渗透侧流过膜的渗透侧 使得可冷凝蒸汽吹扫的流动基本上与液体混合物的流动逆流，从而将至少一部分液体混合物的组分从进料侧输送到膜的渗透侧，以形成组合 可冷凝蒸汽的渗透侧混合物和至少一个输送组分。
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公开(公告)号：US4725359A
公开(公告)日：1988-02-16
申请号：US704868
申请日：1985-02-25
Applicant: Roderick J. Ray
Inventor： Roderick J. Ray
CPC classification number: C02F1/16 , B01D53/268 , Y10S55/30
Abstract: A method of and apparatus for obtaining potable water from the exhaust of an internal combustion engine is disclosed essentially comprising separating a water vapor permeate containing water vapor and noncondensable gases from the exhaust by a nonporous nonionic hydrophilic membrane, then separating the water vapor from noncondensable gases by either condensing the water vapor or compressing the entire water vapor permeate followed by condensation of the water vapor contained in the permeate.
Abstract translation: 公开了一种从内燃机的排气中获得饮用水的方法和设备，其基本上包括通过非离子非离子亲水膜从废气中分离含有水蒸气和不凝气体的水蒸气渗透物，然后将水蒸汽与不可冷凝气体 通过冷凝水蒸汽或压缩整个水蒸气渗透物，随后包含在渗透物中的水蒸气冷凝。
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18.发明授权公开(公告)号：US07625507B2
公开(公告)日：2009-12-01
申请号：US11004165
申请日：2004-12-03
Applicant: Roderick J. Ray , Leah E. Appel , David D. Newbold , Dwayne T. Friesen , Scott B. McCray , David K. Lyon , James B. West , Marshall D. Crew , Joshua R. Shockey
Inventor： Roderick J. Ray , Leah E. Appel , David D. Newbold , Dwayne T. Friesen , Scott B. McCray , David K. Lyon , James B. West , Marshall D. Crew , Joshua R. Shockey
IPC: B29B9/00
CPC classification number: A61K9/1664 , A61K9/0095 , A61K9/1617 , A61K9/1641 , A61K9/1694 , A61K31/00
Abstract: Reduced levels of drug degradation in drug-containing multiparticulates are obtained by an extrusion/melt-congeal process.
Abstract translation: 通过挤出/熔融凝结过程获得含药多颗粒药物降解水平降低。
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19.发明授权Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus 有权使用改进的喷雾干燥装置制备均匀喷雾干燥的固体无定形药物分散体的方法公开(公告)号：US06973741B2
公开(公告)日：2005-12-13
申请号：US10766450
申请日：2004-01-27
Applicant: Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
Inventor： Ronald A. Beyerinck , Heather L. M. Diebele , Dan E. Dobry , Roderick J. Ray , Dana M. Settell , Ken R. Spence
CPC classification number: A61K9/1682 , A61J3/02 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K31/404 , A61K31/47 , B01J2/04
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Abstract translation: 传统的喷雾干燥方法通过结合压力喷嘴和扩散板来改善干燥气体的流动和干燥室延伸以增加干燥时间，这样的改进导致药物浓度增强的均匀固体分散体形成 聚合物。
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公开(公告)号：US5753008A
公开(公告)日：1998-05-19
申请号：US501403
申请日：1995-07-12
Applicant: Dwayne T. Friesen , Scott B. McCray , David D. Newbold , Roderick J. Ray
Inventor： Dwayne T. Friesen , Scott B. McCray , David D. Newbold , Roderick J. Ray
IPC: B01D63/02 , B01D69/02 , B01D71/62 , B01D71/64 , B01D71/68 , C08G73/10 , B01D53/22 , B01D61/36 , B01D69/08
CPC classification number: B01D71/64 , C08G73/1042
Abstract: A vapor permeation method and apparatus for removing a vapor from a vaporous feed stream, the method and apparatus utilizing highly solvent-resistant composite hollow fiber membranes and a permeate flow countercurrent to the feed flow, wherein the support of the composite membrane is formed by solution casting and has been rendered sufficiently solvent-resistant by a post-casting step to retain at least 20 of its burst pressure when soaked in the solvent used to cast the support.
Abstract translation: 一种用于从蒸气进料流中除去蒸汽的蒸汽渗透方法和装置，该方法和设备利用高耐溶剂性复合中空纤维膜和与进料流逆流的渗透流，其中复合膜的载体由溶液形成 并且通过后铸造步骤使其具有足够的耐溶剂性，以在浸泡在用于浇铸载体的溶剂中时保持其爆裂压力的至少20。
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