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    A SHORT PEPTIDE TARGETING EPS8 BINDING WITH EGFR AND USE THEREOF
    11.
    发明申请
    A SHORT PEPTIDE TARGETING EPS8 BINDING WITH EGFR AND USE THEREOF 有权
    一种短肽靶向EPS8与EGFR的结合及其用途

    公开(公告)号：US20160145302A1

    公开(公告)日：2016-05-26

    申请号：US14758955

    申请日：2014-12-25

    Applicant: SOUTHERN MEDICAL UNIVERSITY

    Inventor： Yu Hua LI ,  Tong Yuan XUE

    IPC: C07K7/06

    CPC classification number: C07K7/06 ,  A61K38/00

    Abstract: The present invention discloses a short peptide targeting EPS8 binding with EGFR and use thereof, and sequence of the short peptide is N′-Arg-Lys-Lys-Asn-Lys-Pro-Pro-Pro-Pro-Lys-Lys-C′. The short peptide can effectively inhibit proliferation of EPS8 positive tumors, and can also be used to make a pharmaceutical preparation for treating EPS8 positive tumors, which has the potential of being developed into anti-cancer peptide inhibitor drugs.

    Abstract translation: 本发明公开了一种针对EPS8的靶向EPS8的短肽及其用途，短肽序列为N'-Arg-Lys-Lys-Asn-Lys-Pro-Pro-Pro-Pro-Lys-Lys-C' 。 短肽能有效抑制EPS8阳性肿瘤的增殖，也可用于制备治疗EPS8阳性肿瘤的药物制剂，具有发展为抗癌肽抑制药物的潜力。

    CONSTRUCTION OF HIGH-FIDELITY CRISPR/ASCPF1 MUTANT AND USES THEREOF
    14.
    发明申请
    CONSTRUCTION OF HIGH-FIDELITY CRISPR/ASCPF1 MUTANT AND USES THEREOF 有权

    公开(公告)号：US20230056843A1

    公开(公告)日：2023-02-23

    申请号：US17794263

    申请日：2019-08-19

    Applicant: SOUTHERN MEDICAL UNIVERSITY

    Inventor： Zhili RONG ,  Ying LIN ,  Hongxin HUANG ,  Lin SHAN

    IPC: C12N9/22 ,  C12N15/11 ,  C12N15/85 ,  C12N15/90

    Abstract: A high-fidelity AsCpf1 mutant is obtained by performing a mutation on arginine at position 951 and/or 955 of a AsCpf1 protein amino acid sequence and replacing the same with an amino acid free of forming a hydrogen bond with DNA of a target site; and the amino acid sequence thereof is shown in SEQ ID NOS: 1-3. The encoding gene of the AsCpf1 mutant has a nucleotide sequence as shown in SEQ ID NO: 4 and can be used in the construction of a CRISPR/AsCpf1 gene editing system. A CRISPR/AsCpf1 gene editing system includes a gene encoding a AsCpf1 protein, and the AsCpf1 protein is the AsCpf1 mutant mentioned above. The CRISPR/AsCpf1 gene editing system can be used in lowering an off-target effect of gene editing. The novel AsCpf1 mutant not only retains the gene editing efficiency of wild-type AsCpf1, but also has a higher specificity than the wild-type AsCpf1.

    Extraction method for radiomics feature information of knee joint effusion
    18.
    发明授权
    Extraction method for radiomics feature information of knee joint effusion 有权

    公开(公告)号：US12154269B2

    公开(公告)日：2024-11-26

    申请号：US17483747

    申请日：2021-09-23

    Applicant: Zhujiang Hospital of Southern Medical University

    Inventor： Zhaohua Zhu ,  Qiushun Bai ,  Jieying Chen ,  Yuping Zeng ,  Qiang Song ,  Changhai Ding

    IPC: G06T7/00 ,  A61B6/00 ,  A61B6/50

    Abstract: The disclosure belongs to the technical field of radiomics, and particularly relates to an extraction method for radiomics feature information of knee joint effusion. each layer of an image is segmented into a plurality of regions, the interference of image noises in each region is removed, then whether each region after interference removal is an effusion region or not is judged, finally, the radiomics features of each effusion region are calculated, interpolation processing is respectively implemented on the obtained image position and the area of the effusion regions, an effusion area simulation change curve is drawn, curve integration is implemented to obtain volume information, and all the extracted information is stored in a cell array of a MATLAB. thus the effusion information in the MRI image of the knee joint is automatically extracted, and meanwhile, the method is fast in speed, high in accuracy, good in repeatability.

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