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    RAPID PHENOTYPE TESTS FOR ANTITUBERCULAR DRUG SENSITIVITY AND RESISTANCE
    13.
    发明申请
    RAPID PHENOTYPE TESTS FOR ANTITUBERCULAR DRUG SENSITIVITY AND RESISTANCE 审中-公开
    用于抗真菌药敏感性和耐药性的快速反应试验

    公开(公告)号：US20170010272A1

    公开(公告)日：2017-01-12

    申请号：US15119519

    申请日：2015-02-18

    Applicant: STC, UNM

    Inventor： Graham Timmins ,  Seong Won Choi ,  Louis Pete A. Silks

    IPC: G01N33/58

    CPC classification number: G01N33/58 ,  A61K49/0004 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2458/15 ,  G01N2800/52

    Abstract: In one embodiment, the invention provides methods of identifying the sensitivity and resistance to therapeutic drug regimens in a subject who suffers from, or who is suspected of suffering from, a Mycobacterium infection, the method comprising administering (1) isotopically labeled Pretomanid and/or Delaminid, or (2) isotopically labeled ethionamide and/or prothionamide, or (3) isotopically labeled pyrazinamide, or (4) isotopically-labeled isoniazid to the subject and thereafter measuring levels in a subject-derived sample of one or more isotopically-labeled markers corresponding to Mycobacterium-actiwated drug metabolites or degradation products, wherein the absence of detectable levels of Mycobacterium-activated drug metabolites or degradation products indicates either that the subject does not suffer from a Mycobacterium infection or suffers from a Mycobacterium infection which is resistant to treatment with the administered drug regimen.

    Abstract translation: 在一个实施方案中，本发明提供鉴定患有或疑似患有分枝杆菌感染的受试者的治疗药物方案的敏感性和抗性的方法，所述方法包括施用（1）同位素标记的假单胞菌素和/或 （2）同位素标记的乙硫氨酰胺和/或丙硫氨酰胺，或（3）同位素标记的吡嗪酰胺或（4）同位素标记的异烟肼，然后测定受试者衍生的样品中一种或多种同位素标记 对应于分枝杆菌活化的药物代谢物或降解产物的标记，其中不存在可检测水平的分枝杆菌激活的药物代谢物或降解产物表明受试者不患有分枝杆菌感染或遭受耐受治疗的分枝杆菌感染 与施用的药物方案。

    SYSTEMS AND METHODS FOR INTEGRATING DISTRIBUTED ENERGY RESOURCES
    14.
    发明申请
    SYSTEMS AND METHODS FOR INTEGRATING DISTRIBUTED ENERGY RESOURCES 审中-公开
    用于集成分布式能源资源的系统和方法

    公开(公告)号：US20160336752A1

    公开(公告)日：2016-11-17

    申请号：US15112252

    申请日：2015-01-16

    Applicant: Andrea A. MAMMOLI ,  Yasser YASAEI ,  STC. UNM

    Inventor： Andrea A. MAMMOLI ,  Yasser YASAEI

    IPC: H02J3/38 ,  H02J7/00

    CPC classification number: H02J3/382 ,  H02J3/381 ,  H02J3/383 ,  H02J3/386 ,  H02J3/387 ,  H02J7/0068

    Abstract: The present invention is an apparatus and method for using aggregated loads from a plurality of distributed energy resources to perform a function at a power distribution feeder. The invention includes a plurality of distributed energy resources, wherein at least one distributed energy resource includes a renewable energy resource, a communication network, a control device, a power distribution feeder coupled to the control device, and an energy storage system coupled to the power distribution feeder. The control device sends a signal to the plurality of distributed energy resources via the communication network. The signal is a request to switch a status of one or more of the distributed energy resources if one or more distributed energy resources is within a predetermined condition. Loads from the one or more of the distributed energy resources that switched status are aggregated to perform a function at the power distribution feeder.

    Abstract translation: 本发明是一种用于使用来自多个分布式能量资源的聚合负载来执行配电馈线的功能的装置和方法。 本发明包括多个分布式能量资源，其中至少一个分布式能源包括可再生能源，通信网络，控制设备，耦合到控制设备的配电馈线以及耦合到电力的能量存储系统 配送给料机 控制装置经由通信网络向多个分散能源发送信号。 该信号是如果一个或多个分布式能量资源处于预定条件内，则切换一个或多个分布式能量资源的状态的请求。 从交换状态的一个或多个分布式能源中加载，以在配电馈线上执行功能。

    BIOMARKER SENSING BASED ON NANOFLUIDIC AMPLIFICATION AND RESONANT OPTICAL DETECTION
    17.
    发明申请
    BIOMARKER SENSING BASED ON NANOFLUIDIC AMPLIFICATION AND RESONANT OPTICAL DETECTION 有权
    基于纳米荧光放大和共振光学检测的生物标记感知

    公开(公告)号：US20150024507A1

    公开(公告)日：2015-01-22

    申请号：US14380350

    申请日：2013-03-15

    Applicant: STC. UNM

    Inventor： Sang M. Han ,  Cornellius F. Ivory ,  Mani Hossein-Zadeh

    IPC: G01N33/53 ,  G01N21/75

    CPC classification number: G01N33/5302 ,  B01L3/502753 ,  G01N21/75 ,  G01N21/7746 ,  G01N33/54373 ,  G01N33/5438 ,  G01N2021/755

    Abstract: Provided is a sensor platform that includes a substrate, a plurality of nanochannels disposed on the substrate, and a plurality of electrodes, a waveguide disposed on the substrate and an analysis chamber and a reference chamber disposed on the substrate. Each electrode extends substantially across a width of the plurality of nanochannels. At least one analysis optical resonator is disposed in the analysis chamber and is optically coupled to at least a portion of the waveguide. The at least one analysis optical resonator is in fluid communication with at least one of the plurality of nanochannels. At least one reference optical resonator is disposed in the reference chamber and is optically coupled to at least a portion of the waveguide. The at least one reference optical resonator is in fluid communication with at least one other of the plurality of nanochannels.

    Abstract translation: 提供了一种传感器平台，其包括基板，设置在基板上的多个纳米通道，以及多个电极，设置在基板上的波导管和设置在基板上的分析室和基准室。 每个电极基本上跨越多个纳米通道的宽度延伸。 至少一个分析光学谐振器设置在分析室中并且光耦合到波导的至少一部分。 所述至少一个分析光学谐振器与所述多个纳米通道中的至少一个流体连通。 至少一个参考光学谐振器设置在参考室中并且光耦合到波导的至少一部分。 所述至少一个参考光学谐振器与所述多个纳米通道中的至少另一个流体连通。

    TREATMENT AND PREVENTION OF STROKE AND OTHER NEUROLOGICAL DISORDERS
    20.
    发明申请
    TREATMENT AND PREVENTION OF STROKE AND OTHER NEUROLOGICAL DISORDERS 审中-公开

    公开(公告)号：US20190133975A1

    公开(公告)日：2019-05-09

    申请号：US16242404

    申请日：2019-01-08

    Applicant: STC UNM

    Inventor： Jeff Wade Hill

    IPC: A61K31/138 ,  A61K31/325 ,  A61K9/00 ,  A61K45/06 ,  A61K31/27 ,  G01N33/50

    Abstract: Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.

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