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公开(公告)号：US08865712B2
公开(公告)日：2014-10-21
申请号：US14136855
申请日：2013-12-20
Applicant: Sangamesh Badiger , Murali Chebrolu , Konstanze Hurth , Sebastien Jacquier , Rainer Martin Lueoend , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
Inventor： Sangamesh Badiger , Murali Chebrolu , Konstanze Hurth , Sebastien Jacquier , Rainer Martin Lueoend , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC: A61K31/5377 , C07D413/14 , C07D487/04 , C07D471/04
CPC classification number: C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
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![DIAZA-SPIRO[5.5]UNDECANES USEFUL AS OREXIN RECEPTOR ANTAGONISTS](/abs-image/US/2013/10/24/US20130281463A1/abs.jpg.150x150.jpg)
12.发明申请DIAZA-SPIRO[5.5]UNDECANES USEFUL AS OREXIN RECEPTOR ANTAGONISTS 审中-公开DIAZA-SPIRO [5.5]有机质作为OREXIN受体拮抗剂公开(公告)号：US20130281463A1
公开(公告)日：2013-10-24
申请号：US13880994
申请日：2011-10-25
Applicant: Sangamesh Badiger , Dirk Behnke , Claudia Betschart , Simona Cotesta , Samuel Hintermann , Silvio Ofner , Chetan Pandit , Bernard Lucien Roy
Inventor： Sangamesh Badiger , Dirk Behnke , Claudia Betschart , Simona Cotesta , Samuel Hintermann , Silvio Ofner , Chetan Pandit , Bernard Lucien Roy
IPC: C07D471/10 , A61K45/06 , A61K31/444 , A61K31/506
CPC classification number: C07D471/10 , A61K31/444 , A61K31/506 , A61K45/06 , C07D519/00
Abstract: The invention relates to compound of the formula (I), in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I）化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
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![Diaza-spiro[5.5]undecanes](/abs-image/US/2013/09/10/US08530648B2/abs.jpg.150x150.jpg)
公开(公告)号：US08530648B2
公开(公告)日：2013-09-10
申请号：US13517111
申请日：2010-12-20
Applicant: Sangamesh Badiger , Dirk Behnke , Claudia Betschart , Vinod Chaudhari , Simona Cotesta , Jürgen Hans-Hermann Hinrichs , Silvio Ofner , Chetan Pandit , Jürgen Wagner
Inventor： Sangamesh Badiger , Dirk Behnke , Claudia Betschart , Vinod Chaudhari , Simona Cotesta , Jürgen Hans-Hermann Hinrichs , Silvio Ofner , Chetan Pandit , Jürgen Wagner
IPC: C07D471/10 , A61P3/00 , A61P25/00 , A61P25/28 , A61P25/30
CPC classification number: C07D471/10
Abstract: The invention relates to compound of the formula (I), in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式（I）化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
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Patent Agency Ranking
14.发明申请Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders 有权新型杂环衍生物及其在神经障碍治疗中的应用公开(公告)号：US20120184539A1
公开(公告)日：2012-07-19
申请号：US13348039
申请日：2012-01-11
Applicant: Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sébastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
Inventor： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sébastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC: A61K31/5377 , A61P25/28 , A61P9/12 , A61P3/10 , A61P3/04 , C07D413/14 , A61P25/00
CPC classification number: C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。
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公开(公告)号：US20120165331A1
公开(公告)日：2012-06-28
申请号：US13329868
申请日：2011-12-19
Applicant: Sangamesh BADIGER , Dirk BEHNKE , Claudia BETSCHART , Vinod CHAUDHARI , Simona COTESTA , Samuel HINTERMANN , Andreas LERCHNER , Fatma LIMAM , Silvio OFNER , Chetan PANDIT , Jürgen WAGNER
Inventor： Sangamesh BADIGER , Dirk BEHNKE , Claudia BETSCHART , Vinod CHAUDHARI , Simona COTESTA , Samuel HINTERMANN , Andreas LERCHNER , Fatma LIMAM , Silvio OFNER , Chetan PANDIT , Jürgen WAGNER
IPC: A61K31/5386 , A61K31/498 , A61K31/501 , A61K31/499 , A61K31/497 , A61K31/517 , A61K31/506 , A61K31/438 , A61K31/427 , A61K31/423 , C07D487/10 , C07D498/04 , C07D471/10 , A61P25/28 , C07D498/10 , A61K31/502
CPC classification number: C07D471/10
Abstract: The invention relates to compounds of the formula I A-D-C(R1)2—B (I), in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
Abstract translation: 本发明涉及式I A-D-C（R 1）2 -B（I）的化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备，用作药物和包含它的药物。
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16.发明授权Heterocyclic derivatives and their use in the treatment of neurological disorders 有权杂环衍生物及其在治疗神经系统疾病中的应用公开(公告)号：US09550758B2
公开(公告)日：2017-01-24
申请号：US14482662
申请日：2014-09-10
Applicant: Sangamesh Badiger , Murali Chebrolu , Konstanze Hurth , Sebastien Jacquier , Rainer Martin Lueoend , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
Inventor： Sangamesh Badiger , Murali Chebrolu , Konstanze Hurth , Sebastien Jacquier , Rainer Martin Lueoend , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC: A61K31/5377 , C07D413/14 , C07D471/04 , C07D487/04 , C07B59/00
CPC classification number: C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。
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17.发明授权Heterocyclic derivatives and their use in the treatment of neurological disorders 有权杂环衍生物及其在治疗神经系统疾病中的应用公开(公告)号：US08637508B2
公开(公告)日：2014-01-28
申请号：US13348039
申请日：2012-01-11
Applicant: Sangamesh Badiger , Murali Chebrolu , Konstanze Hurth , Sébastien Jacquier , Rainer Martin Lueoend , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
Inventor： Sangamesh Badiger , Murali Chebrolu , Konstanze Hurth , Sébastien Jacquier , Rainer Martin Lueoend , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC: A61K31/5377 , C07D413/14
CPC classification number: C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。
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18.发明申请Oxazine Derivatives and their Use in the Treatment of Neurological Disorders 审中-公开恶嗪衍生物及其在神经障碍治疗中的应用公开(公告)号：US20120172359A1
公开(公告)日：2012-07-05
申请号：US13414440
申请日：2012-03-07
Applicant: Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LUEOEND , Lei LI , Hui LIU , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Heinrich RUEEGER , Michael SCHAEFER , Siem Jacob VEENSTRA , Marina TINTELNOT-BLOMLEY , Markus VOEGTLE , Xin XIONG
Inventor： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LUEOEND , Lei LI , Hui LIU , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Heinrich RUEEGER , Michael SCHAEFER , Siem Jacob VEENSTRA , Marina TINTELNOT-BLOMLEY , Markus VOEGTLE , Xin XIONG
IPC: A61K31/5377 , A61P25/18 , A61P25/00 , A61P35/00 , A61P25/22 , A61P25/08 , A61P25/06 , A61P25/24 , A61P25/28 , A61P29/00 , A61P17/04 , A61P1/08 , A61P3/04 , A61P21/02 , A61P27/16 , A61P27/06 , A61P25/30 , C07D413/12
CPC classification number: C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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