公开(公告)号：US20150284364A1

公开(公告)日：2015-10-08

申请号：US14430304

申请日：2013-11-06

Applicant: Nicole Bieri ,  Jörg Brozio ,  Wenjie Li ,  Michael Mutz ,  Rita Ramos ,  Lei Zhang

Inventor： Nicole Bieri ,  Jörg Brozio ,  Wenjie Li ,  Michael Mutz ,  Rita Ramos ,  Lei Zhang

IPC: C07D401/14 ,  C07F9/141

CPC classification number: C07D401/14 ,  C07B2200/13 ,  C07D403/14 ,  C07F9/141 ,  C07F9/65583

Abstract: The present invention relates to substituted indole derivatives, to processes for their production, to new stable forms, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及取代的吲哚衍生物，其制备方法，新的稳定形式，它们作为药物的用途以及包含它们的药物组合物。

公开(公告)号：US20150018338A1

公开(公告)日：2015-01-15

申请号：US14324883

申请日：2014-07-07

Applicant: Sangamesh BADIGER ,  Murali CHEBROLU ,  Mathias FREDERIKSEN ,  Philipp HOLZER ,  Konstanze HURTH ,  Rainer Martin LEUOEND ,  Rainer MACHAUER ,  Henrik MOEBITZ ,  Ulf NEUMANN ,  Rita RAMOS ,  Henrich RUEEGER ,  Michael SCHAEFER ,  Marina TINTELNOT-BLOMLEY ,  Siem Jacob VEENSTRA ,  Markus VOEGTLE

Inventor： Sangamesh BADIGER ,  Murali CHEBROLU ,  Mathias FREDERIKSEN ,  Philipp HOLZER ,  Konstanze HURTH ,  Rainer Martin LEUOEND ,  Rainer MACHAUER ,  Henrik MOEBITZ ,  Ulf NEUMANN ,  Rita RAMOS ,  Henrich RUEEGER ,  Michael SCHAEFER ,  Marina TINTELNOT-BLOMLEY ,  Siem Jacob VEENSTRA ,  Markus VOEGTLE

IPC: C07D487/04 ,  A61K31/5377 ,  C07D413/14 ,  C07D471/04 ,  C07D417/12 ,  A61K31/553 ,  C07D413/12

CPC classification number: C07D487/04 ,  A61K31/5377 ,  A61K31/553 ,  A61K45/06 ,  C07D265/30 ,  C07D267/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。

公开(公告)号：US08524897B2

公开(公告)日：2013-09-03

申请号：US13347067

申请日：2012-01-10

Applicant: Rita Ramos

Inventor： Rita Ramos

IPC: C07D413/12

CPC classification number: A61K45/06 ,  C07D413/12

Abstract: The invention relates to 5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((3R,6R)-5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide in crystalline form, to its preparation, its medical use and to medicaments comprising said compound in crystalline form.

Abstract translation: 本发明涉及5-氰基-3-甲基 - 吡啶-2-甲酸[3 - （（3R，6R）-5-氨基-3,6-二甲基-6-三氟甲基-3,6-二氢-2H- [1,4]恶嗪-3-基）-4-氟 - 苯基] - 酰胺，其制备方法及其医疗用途以及包含结晶形式的所述化合物的药物。

公开(公告)号：US20110288045A1

公开(公告)日：2011-11-24

申请号：US13129676

申请日：2009-11-19

Applicant: Rita Ramos ,  Evanthia Dova ,  Samir Kulkarni ,  Marcel Hoffmann

Inventor： Rita Ramos ,  Evanthia Dova ,  Samir Kulkarni ,  Marcel Hoffmann

IPC: A61K31/7068 ,  A61P31/18 ,  A61P31/12

CPC classification number: A61K9/1652 ,  A61K9/2054 ,  A61K31/513 ,  A61K31/536 ,  A61K31/675 ,  A61K2300/00

Abstract: The present invention describes a method and composition for a pharmaceutical product based on Tenofovir disoproxil hemifumarate, Emtricitabine and Efavirenz. The composition can be prepared by a process comprising a wet granulation step to produce a stable dosage form suitable for the treatment of HIV in essential absence of known degradation products.

Abstract translation: 本发明描述了一种基于替诺福韦替夫昔伐半富马酸盐，恩曲他滨和依法韦仑的药物产品的方法和组合物。 组合物可以通过包括湿法制粒步骤的方法制备，以产生适合于在已知降解产物基本不存在下治疗HIV的稳定剂型。

公开(公告)号：US08703782B2

公开(公告)日：2014-04-22

申请号：US13471512

申请日：2012-05-15

Applicant: Nigel Graham Cooke ,  Maurice Van Eis ,  Rita Ramos ,  Karen Kammertoens

Inventor： Nigel Graham Cooke ,  Maurice Van Eis ,  Rita Ramos ,  Karen Kammertoens

IPC: A01N43/54 ,  A61K31/517 ,  C07D239/72 ,  C07D401/00

CPC classification number: A61K31/499 ,  A61K31/675 ,  A61K45/06 ,  C07D401/14 ,  C07F9/65583

Abstract: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及取代的吲哚衍生物，其制备方法，它们作为药物的用途以及包含它们的药物组合物。

公开(公告)号：US20120178745A1

公开(公告)日：2012-07-12

申请号：US13347067

申请日：2012-01-10

Applicant: Rita RAMOS

Inventor： Rita RAMOS

IPC: A61K31/5377 ,  A61P25/28 ,  A61P25/00 ,  C07D413/12

CPC classification number: A61K45/06 ,  C07D413/12

Abstract: The invention relates to 5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((3R,6R)-5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide in crystalline form, to its preparation, its medical use and to medicaments comprising said compound in crystalline form.

Abstract translation: 本发明涉及5-氰基-3-甲基 - 吡啶-2-甲酸[3 - （（3R，6R）-5-氨基-3,6-二甲基-6-三氟甲基-3,6-二氢-2H- [1,4]恶嗪-3-基）-4-氟 - 苯基] - 酰胺，其制备方法及其医疗用途以及包含结晶形式的所述化合物的药物。

公开(公告)号：US09029396B2

公开(公告)日：2015-05-12

申请号：US14194879

申请日：2014-03-03

Applicant: Nigel Graham Cooke ,  Rita Ramos ,  Karen Kammertoens ,  Maurice Van Eis

Inventor： Nigel Graham Cooke ,  Rita Ramos ,  Karen Kammertoens ,  Maurice Van Eis

IPC: C07D215/04 ,  A61K31/47 ,  A61K31/499 ,  C07D401/14 ,  C07F9/6558 ,  A61K31/675

CPC classification number: A61K31/499 ,  A61K31/675 ,  A61K45/06 ,  C07D401/14 ,  C07F9/65583

Abstract: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及取代的吲哚衍生物，其制备方法，它们作为药物的用途以及包含它们的药物组合物。

公开(公告)号：US20120302558A1

公开(公告)日：2012-11-29

申请号：US13255036

申请日：2011-07-13

Applicant: Sangamesh Badiger ,  Murali Chebrolu ,  Mathias Frederiksen ,  Philipp Holzer ,  Konstanze Hurth ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Henrik Moebitz ,  Ulf Neumann ,  Rita Ramos ,  Heinrich Rueeger ,  Michael Schaefer ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle ,  Lei Li ,  Hui Liu ,  Xin Xiong

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Mathias Frederiksen ,  Philipp Holzer ,  Konstanze Hurth ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Henrik Moebitz ,  Ulf Neumann ,  Rita Ramos ,  Heinrich Rueeger ,  Michael Schaefer ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle ,  Lei Li ,  Hui Liu ,  Xin Xiong

IPC: A61K31/5377 ,  A61P25/28 ,  C07D413/12

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。

公开(公告)号：US20110021520A1

公开(公告)日：2011-01-27

申请号：US12842360

申请日：2010-07-23

Applicant: Sangamesh BADIGER ,  Murali CHEBROLU ,  Mathias FREDERIKSEN ,  Philipp HOLZER ,  Konstanze HURTH ,  Rainer Martin LUEOEND ,  Rainer MACHAUER ,  Henrik MOEBITZ ,  Ulf NEUMANN ,  Rita RAMOS ,  Heinrich RUEEGER ,  Marina TINTELNOT-BLOMLEY ,  Siem Jacob VEENSTRA ,  Markus VOEGTLE

Inventor： Sangamesh BADIGER ,  Murali CHEBROLU ,  Mathias FREDERIKSEN ,  Philipp HOLZER ,  Konstanze HURTH ,  Rainer Martin LUEOEND ,  Rainer MACHAUER ,  Henrik MOEBITZ ,  Ulf NEUMANN ,  Rita RAMOS ,  Heinrich RUEEGER ,  Marina TINTELNOT-BLOMLEY ,  Siem Jacob VEENSTRA ,  Markus VOEGTLE

IPC: A61K31/5377 ,  C07D413/12 ,  C07D419/12 ,  C07D265/30 ,  A61K31/5375 ,  A61P25/28

CPC classification number: C07D487/04 ,  A61K31/5377 ,  A61K31/553 ,  A61K45/06 ,  C07D265/30 ,  C07D267/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。

公开(公告)号：US20140179634A1

公开(公告)日：2014-06-26

申请号：US14194879

申请日：2014-03-03

Applicant: Nigel Graham COOKE ,  Rita RAMOS ,  Karen KAMMERTOENS ,  Maurice VAN EIS

Inventor： Nigel Graham COOKE ,  Rita RAMOS ,  Karen KAMMERTOENS ,  Maurice VAN EIS

IPC: C07F9/6558 ,  C07D401/14

CPC classification number: A61K31/499 ,  A61K31/675 ,  A61K45/06 ,  C07D401/14 ,  C07F9/65583

Abstract: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及取代的吲哚衍生物，其制备方法，它们作为药物的用途以及包含它们的药物组合物。