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17 条记录 (耗时 0.015 秒)

    MEDICATION FOR ORAL ADMINISTRATION, COMPRISING AT LEAST ONE ESTROGEN AND/OR AT LEAST ONE GESTAGEN AND AT LEAST ONE PROBIOTIC BACTERIAL STRAIN
    11.
    发明申请
    MEDICATION FOR ORAL ADMINISTRATION, COMPRISING AT LEAST ONE ESTROGEN AND/OR AT LEAST ONE GESTAGEN AND AT LEAST ONE PROBIOTIC BACTERIAL STRAIN 审中-公开
    用于口服给药的药物，包括至少一种雌激素和/或至少一种Gestagen和至少一种生物细菌菌株

    公开(公告)号：US20120189599A1

    公开(公告)日：2012-07-26

    申请号：US13322131

    申请日：2010-05-14

    申请人： Stefanie Lindemann ,  Sascha General

    发明人： Stefanie Lindemann ,  Sascha General

    IPC分类号： A61K35/74 ,  A61P15/02 ,  A61P5/34 ,  A61P13/00 ,  A61P5/30 ,  A61P15/18 ,  A61P13/10

    CPC分类号： A61K31/57 ,  A61K31/565 ,  A61K35/744 ,  A61K35/747

    摘要： The present invention relates to a medicament for oral administration containing at least one estrogen and/or one gestagen and at least one probiotic bacterial strain, such as for example lactobacillus species.The medicament according to the invention is used either for oral contraception or for hormone therapy (HT), during which it can simultaneously serve for the stabilization of the vaginal environment and hence the prevention of infectious diseases, such as for example vaginal mycosis, bacterial vaginosis and/or bladder inflammation (bacterial cystitis) or the prevention of urogenital symptoms, e.g. dyspareunia and dysuria.The present invention further relates to pharmaceutical combination preparations which contain dosage units containing an aforesaid medicament and further dosage units containing exclusively a probiotic bacterial strain.

    摘要翻译： 本发明涉及含有至少一种雌激素和/或一种孕激素和至少一种益生菌菌株（例如乳杆菌属）的口服给药药物。 根据本发明的药物用于口服避孕或激素治疗（HT），其中它可以同时用于稳定阴道环境，从而预防感染性疾病，例如阴道真菌病，细菌性阴道炎 和/或膀胱炎（细菌性膀胱炎）或预防泌尿生殖系统症状，例如 性交痛和排尿困难。 本发明还涉及包含含有前述药物的剂量单位和仅含有益生菌菌株的另外的剂量单位的药物组合制剂。

    Optically fluorescent nanoparticles
    14.
    发明申请
    Optically fluorescent nanoparticles 审中-公开
    光学荧光纳米粒子

    公开(公告)号：US20070104649A1

    公开(公告)日：2007-05-10

    申请号：US11514319

    申请日：2006-09-01

    申请人： Katrin Fischer ,  Sascha General ,  Kai Licha

    发明人： Katrin Fischer ,  Sascha General ,  Kai Licha

    IPC分类号： A61K49/00

    CPC分类号： G01N33/588 ,  A61K9/5138 ,  A61K9/5146 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0093 ,  B82Y15/00 ,  G01N33/533 ,  G01N33/582

    摘要： The present invention refers to nanoparticles having optically fluorescent activity. In more detail, the invention refers to a nanoparticle matrix comprising a co-aggregate of at least one charged polyelectrolyte and at least one oppositely charged active agent, wherein the active agent is a hydrophilic optically fluorescent agent, and the invention further refers to a nanoparticle comprising said nanoparticle matrix. Optionally, the nanoparticle is surface modified. The invention also refers to a method for preparing said nanoparticle, and to a method of surface modification. Furthermore, the invention refers to uses of said nanoparticle in vitro and in vivo, and to methods for in vitro and in vivo diagnosis.

    摘要翻译： 本发明涉及具有光学荧光活性的纳米颗粒。 更详细地，本发明涉及包含至少一种带电聚电解质和至少一种相反电荷的活性剂的共聚集体的纳米颗粒基质，其中活性剂是亲水性光学荧光剂，本发明还涉及纳米颗粒 包括所述纳米颗粒基质。 任选地，纳米颗粒被表面改性。 本发明还涉及一种制备所述纳米颗粒的方法和一种表面改性方法。 此外，本发明涉及体外和体内所述纳米颗粒的用途，以及用于体外和体内诊断的方法。

    Wafer comprising steroid hormones
    15.
    发明申请
    Wafer comprising steroid hormones 有权
    晶体包含类固醇激素

    公开(公告)号：US20060222708A1

    公开(公告)日：2006-10-05

    申请号：US11391646

    申请日：2006-03-28

    申请人： Markus Krumme ,  Albert Radlmaier ,  Sascha General ,  Michael Dittgen ,  Keith Jensen

    发明人： Markus Krumme ,  Albert Radlmaier ,  Sascha General ,  Michael Dittgen ,  Keith Jensen

    IPC分类号： A61K9/22 ,  A61K31/57

    CPC分类号： A61K31/56 ,  A61K31/568

    摘要： The invention relates to a pharmaceutical composition in the form of a system in film form for transmucosal administration of steroid hormones. An administration system for steroid hormones which dissolves in the mouth and which releases with a high bioavailability is disclosed. The administration system in film form dissolves in the mouth preferably in a period of less than 30 min, and the steroid hormone entering the bloodstream transmucosally from the administration system leads to a rapid rise in the concentration in the blood. It is thus possible to achieve a maximum concentration of this steroid hormone in the blood in a period of less than 60 min after administration.

    摘要翻译： 本发明涉及以类固醇激素经粘膜给药的薄膜形式的药物组合物。 公开了一种溶解在口中并以高生物利用度释放的类固醇激素的给药系统。 薄膜形式的给药系统优选在小于30分钟的时间内溶解于口腔内，并且通过管理系统经粘膜进入血液的类固醇激素导致血液中浓度的快速上升。 因此，可以在给药后小于60分钟的时间内实现血液中该类固醇激素的最大浓度。

    PARTICLES COMPRISING DROSPIRENONE ENCAPSULATED IN A POLYMER
    16.
    发明申请
    PARTICLES COMPRISING DROSPIRENONE ENCAPSULATED IN A POLYMER 审中-公开
    包含在聚合物中包含的DROSPIRENONE的颗粒

    公开(公告)号：US20120114757A1

    公开(公告)日：2012-05-10

    申请号：US13202322

    申请日：2010-02-12

    申请人： Sascha General ,  Filip Novak

    发明人： Sascha General ,  Filip Novak

    IPC分类号： A61K9/14 ,  A61P5/30 ,  A61P15/00 ,  A61K31/585 ,  A61P15/18

    CPC分类号： A61K9/1647 ,  A61K9/0024 ,  A61K31/565

    摘要： The present invention relates to particles comprising Drospirenone encapsulated in a polymer selected from the group consisting of glycolic acid polymer, lactic acid polymer, poly caprolactones, poly anhydrides and any copolymer of these, e.g., poly(lactic acid-co-glycolic acid) polymer and any combination of these. Furthermore, the present invention also relates to compositions comprising such particles. The present invention also relates to the use of such particles or compositions as contraceptives and for treatment of diseases, disorders and symptoms associated with deficient endogenous levels of estrogen in women.

    摘要翻译： 本发明涉及包含旋糖司膦的颗粒，其包封在选自乙醇酸聚合物，乳酸聚合物，聚己内酯，聚酐及其任何共聚物的聚合物中，例如聚（乳酸 - 共 - 乙醇酸）聚合物 和这些的任何组合。 此外，本发明还涉及包含这种颗粒的组合物。 本发明还涉及这种颗粒或组合物作为避孕用具的用途以及用于治疗与女性内源性雌激素水平不足相关的疾病，病症和症状。

    PROGESTIN-CONTAINING DRUG DELIVERY SYSTEM
    17.
    发明申请
    PROGESTIN-CONTAINING DRUG DELIVERY SYSTEM 审中-公开
    含PROGESTIN的药物递送系统

    公开(公告)号：US20110293720A1

    公开(公告)日：2011-12-01

    申请号：US13057299

    申请日：2009-08-07

    申请人： Sascha General ,  Ildikó Terebesi ,  Stefan Bracht ,  Adrian Funke

    发明人： Sascha General ,  Ildikó Terebesi ,  Stefan Bracht ,  Adrian Funke

    IPC分类号： A61K9/00 ,  A61P15/18 ,  A61K31/58

    CPC分类号： A61K9/7007 ,  A61K9/0056 ,  A61K9/1664 ,  A61K31/565 ,  A61K2300/00

    摘要： The present invention relates to drug delivery compositions in the form of thin water-soluble films (wafers), which contain small particles that comprise at least one progestin and at least one protective agent. The protective agent provides effective taste-masking of the progestin due to limited release of the progestin in the mouth. The progestin is hence not absorbed via the buccal route, but rather via the enteral (per-oral) route.

    摘要翻译： 本发明涉及薄水溶性薄膜（晶片）形式的药物递送组合物，其含有包含至少一种孕激素和至少一种保护剂的小颗粒。 保护剂由于孕激素在口中的有限释放而提供了对孕激素的有效掩蔽。 因此，孕激素不能通过口腔途径吸收，而是通过肠内（每口服）途径吸收。