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公开(公告)号：US08399416B2
公开(公告)日：2013-03-19
申请号：US13405742
申请日：2012-02-27
Applicant: Margaret Dah-Tsyr Chang , Tan-chi Fan , Shu-Chuan Lin
Inventor： Margaret Dah-Tsyr Chang , Tan-chi Fan , Shu-Chuan Lin
IPC: A61K38/08
Abstract: The present invention is for an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9 and using the peptide for treating asthma by reducing cytotoxicity of eosinophil derived toxins in bronchial epithelial cells of the subject suffers from asthma. The method comprises preparing a pharmaceutical composition having the peptide of SEQ ID NO: 9 and administering an effective amount of the composition to the subject.
Abstract translation: 本发明涉及由SEQ ID NO：9的氨基酸序列组成的分离的肽，并且通过降低患有哮喘的受试者的支气管上皮细胞中嗜酸性粒细胞来源的毒素的细胞毒性，并且使用该肽来治疗哮喘。 该方法包括制备具有SEQ ID NO：9的肽的药物组合物，并向受试者施用有效量的组合物。
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12.发明授权Method for the detection of human immunodeficiency virus envelope (HIV) glycoprotein utilizing carbohydrate binding module (CBM) 20 or 21 有权利用碳水化合物结合模块（CBM）20或21检测人类免疫缺陷病毒包膜（HIV）糖蛋白的方法公开(公告)号：US08293465B2
公开(公告)日：2012-10-23
申请号：US12755242
申请日：2010-04-06
Applicant: Margaret Dah-Tsyr Chang , Yuan-Chuan Lee , Rong-Yuan Huang , Shu-Chuan Lin , Wei-I Chou , Shi-Hwei Liu
Inventor： Margaret Dah-Tsyr Chang , Yuan-Chuan Lee , Rong-Yuan Huang , Shu-Chuan Lin , Wei-I Chou , Shi-Hwei Liu
CPC classification number: C07K16/1045
Abstract: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.
Abstract translation: 本发明涉及与HIV糖蛋白上的表位特异性结合的碳水化合物结合模块（CBM）的抗体模拟物。 本发明还涉及检测HIV糖蛋白的方法。
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公开(公告)号：US20100291601A1
公开(公告)日：2010-11-18
申请号：US12755242
申请日：2010-04-06
Applicant: Margaret Dah-Tsyr Chang , Yuan-Chuan Lee , Rong-Yuan Huang , Shu-Chuan Lin , Wei-I Chou , Shi-Hwei Liu
Inventor： Margaret Dah-Tsyr Chang , Yuan-Chuan Lee , Rong-Yuan Huang , Shu-Chuan Lin , Wei-I Chou , Shi-Hwei Liu
IPC: G01N33/53
CPC classification number: C07K16/1045
Abstract: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.
Abstract translation: 本发明涉及与HIV糖蛋白上的表位特异性结合的碳水化合物结合模块（CBM）的抗体模拟物。 本发明还涉及检测HIV糖蛋白的方法。
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Patent Agency Ranking
公开(公告)号：US20090292118A1
公开(公告)日：2009-11-26
申请号：US12387754
申请日：2009-05-08
Applicant: Kwang-Chung Lee , Ping-Shu Chen , Shu-Chuan Lin , Tzu-Ai Lee
Inventor： Kwang-Chung Lee , Ping-Shu Chen , Shu-Chuan Lin , Tzu-Ai Lee
IPC: C07D498/18
CPC classification number: C07D498/18
Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.
Abstract translation: 制备Biolimus A9的方法包括在催化有机碱和有机溶剂的存在下，使西罗莫司（或雷帕霉素）与烷基苯磺酸盐反应进行亲核取代反应，以高产率获得Biolimus A9， 即使在过程扩增后，也可以实现高产率的再现性。
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公开(公告)号：US20110280798A1
公开(公告)日：2011-11-17
申请号：US12780497
申请日：2010-05-14
Applicant: Margaret Dah-Tsyr Chang , Shun-Lung Fang , Wei-I Chou , Shu-Chuan Lin
Inventor： Margaret Dah-Tsyr Chang , Shun-Lung Fang , Wei-I Chou , Shu-Chuan Lin
Abstract: The present invention provides a cell penetrating peptide which has following sequence: NYBX1BX2BNQX3, wherein B represents a basic amino acid, X1 represents an amino acid with an aromatic, a hydrophobic or an uncharged side chain, X2 represents any amino acid, and X3 represents N or none. The present invention also provides a method for delivering a cargo into a subject by administrating a complex comprising the cell penetrating peptide and the desired cargo to the subject.
Abstract translation: 本发明提供了具有以下序列的细胞穿透肽：NYBX1BX2BNQX3，其中B表示碱性氨基酸，X1表示具有芳香族，疏水性或不带电侧链的氨基酸，X2表示任何氨基酸，X3表示N 或无。 本发明还提供了一种通过向受试者施用包含细胞穿透肽和所需货物的复合物将货物递送到受试者中的方法。
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公开(公告)号：US07872122B2
公开(公告)日：2011-01-18
申请号：US12387754
申请日：2009-05-08
Applicant: Kwang-Chung Lee , Ping-Shu Chen , Shu-Chuan Lin , Tzu-Ai Lee
Inventor： Kwang-Chung Lee , Ping-Shu Chen , Shu-Chuan Lin , Tzu-Ai Lee
IPC: C07D498/18
CPC classification number: C07D498/18
Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.
Abstract translation: 制备Biolimus A9的方法包括在催化有机碱和有机溶剂的存在下，使西罗莫司（或雷帕霉素）与烷基苯磺酸盐反应进行亲核取代反应，以高产率获得Biolimus A9， 即使在过程扩增后，也可以实现高产率的再现性。
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17.发明申请BIDIRECTIONAL TRANSMISSION NETWORK APPARATUS BASED ON TUNABLE RARE-EARTH-DOPED FIBER LASER 审中-公开基于TUNABLE RARE-DEDED光纤激光器的双向传输网络设备公开(公告)号：US20100322624A1
公开(公告)日：2010-12-23
申请号：US12196378
申请日：2008-08-22
Applicant: CHENG-KUANG LIU , SAN-LIANG LEE , CHIH-LUNG TSENG , JAU-JI JOU , SHU-CHUAN LIN
Inventor： CHENG-KUANG LIU , SAN-LIANG LEE , CHIH-LUNG TSENG , JAU-JI JOU , SHU-CHUAN LIN
CPC classification number: H04B10/27 , H01S3/06791 , H01S3/106 , H01S3/2375 , H01S5/50 , H01S2301/02
Abstract: The present invention discloses a bidirectional transmission network apparatus based on a tunable rare-earth-doped fiber laser source. It is useful in wavelength-division-multiplexing access networks. The fiber ring laser not only generates downstream data traffic but also serves as the wavelength-selecting injection light source for the Fabry-Pérot lasers (or vertical cavity surface emitting lasers) located at the subscriber site. The fiber laser is constructed based on optical filtering, polarization control and noise suppression techniques.
Abstract translation: 本发明公开了一种基于可调稀土掺杂光纤激光源的双向传输网络设备。 它在波分复用接入网络中很有用。 光纤环激光器不仅产生下行数据流量，而且还用作位于用户位置的法布里 - 珀罗激光器（或垂直腔表面发射激光器）的波长选择注入光源。 光纤激光器是基于光学滤波，偏振控制和噪声抑制技术构成的。
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18.发明申请公开(公告)号：US20120214730A1
公开(公告)日：2012-08-23
申请号：US13405742
申请日：2012-02-27
Applicant: Margaret Dah-Tsyr Chang , Tan-chi Fan , Shu-Chuan Lin
Inventor： Margaret Dah-Tsyr Chang , Tan-chi Fan , Shu-Chuan Lin
Abstract: The present invention is for an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9 and using the peptide for treating asthma by reducing cytotoxicity of eosinophil derived toxins in bronchial epithelial cells of the subject suffers from asthma. The method comprises preparing a pharmaceutical composition having the peptide of SEQ ID NO: 9 and administering an effective amount of the composition to the subject.
Abstract translation: 本发明涉及由SEQ ID NO：9的氨基酸序列组成的分离的肽，并且通过降低患有哮喘的受试者的支气管上皮细胞中嗜酸性粒细胞来源的毒素的细胞毒性，并且使用该肽来治疗哮喘。 该方法包括制备具有SEQ ID NO：9的肽的药物组合物，并向受试者施用有效量的组合物。
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